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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | 中国预期寿命与癌症发病率和死亡率的相互影响:基于人群的聚类分析显示文摘背景与目的在发达国家和发展中国家中,癌症和预期寿命之间的相关性均得到了良好的确立。中国幅员辽阔,人口结构和医疗保健有着显著的地理差异,这为分析预期寿命与癌症发病率和死亡率之间复杂的相关性提供了难得的机会。方法提取全国肿瘤登记中心2013年共255个单位(城市或县)的癌症数据。单位水平的预期寿命数据从国家疾病预防控制中心获得。采用线性回归分析方法分析癌症粗发病率和死亡率与预期寿命的相关性。在另一项分析中,预期寿命被定级为低(<76岁)、中(76–80岁)或高(>80岁)。结果总体而言,癌症发病和死亡率均与男性和女性的预期寿命呈正相关(R分别为0.37和0.50,P<0.001)。这种相关性在下列癌症中显著:男性的肺癌、结直肠癌、前列腺癌、膀胱癌、胰腺癌与淋巴瘤(R:0.36–0.58,P <0.001);女性的肺癌、乳腺癌、结直肠癌、甲状腺癌、子宫癌与卵巢癌(R:0.18–0.51,P<0.001)。我们未观察到上消化道癌症与预期寿命相关。预期寿命为低、中、高水平的肿瘤登记点个数分别为110、101和44个。在预期寿命水平高的地区观察到的癌症年龄标准化发病率(192.83/100,000)最高。在预期寿命最低的地区年龄标准化死亡率(118.44/100,000)最高。胃癌、肝癌和食管癌是低、中预期寿命地区的主要癌症类型。相比之下,预期寿命高的地区结直肠癌、女性乳腺癌和男性前列腺癌的发病率和死亡率高。结论在中国,预期寿命越长总体癌症发病率和死亡率越高。不同预期寿命水平地区的癌症模式不同。在制订预防和治疗癌症策略时必须考虑预期寿命水平的影响。 | Xiuying Gu Rongshou Zheng Changfa Xia Hongmei Zeng Siwei Zhang Xiaonong Zou Zhixun Yang He Li Wanqing Chen | 2019 | 癌症2019，38，1： | 18 |
| 3 | The epidemiology of colorectal cancer in China显示文摘Objective:Colorectal cancer(CRC)is one of the most common cancers and the major cause of cancer death in China.The aim of this study was to estimate the burden of CRC in China.Materials and methods:Data from the National Cancer Center(NCC)of China was used and stratified by area(urban/rural),sex(male/female)for analyzing the age-speci c incidence and mortality rates.Time trend of colorectal cancer was calculated based on the 22 high-quality cancer registries in China.National new cases and deaths of colorectal cancer were estimated using age-speci c rates multiplied by the corresponding national population in 2014.The Chinese population in 2000 and Segi’s world population were used to calculate age-standardized rates of colorectal cancer in China.Results:Overall,370,400 new colorectal cancer cases and 179,600 deaths were estimated in China in 2014,with about 214,100 new cases in men and 156,300 in women.Meanwhile,104,000 deaths cases of colorectal cancer were men and 75,600 deaths were women,which accounted for 9.74%and 7.82%of all cancer incidence and deaths in China,separately.Relatively higher incidence and mortality was observed in urban areas of China.And the Eastern areas of China showed the highest incidence and mortality.The age-standardized incidence and mortality rate of colorectal cancer has increased by about 1.9%per year for incidence and about 0.9%per year for mortality rate from 2000 to 2014.Conclusion:With gradually higher incidence and mortality rate in the past 15 years,colorectal cancer became a major challenge to China’s public health.E ective control strategies are needed in China. | Rongshou Zheng Hongmei Zeng Siwei Zhang Xiuying Gu Kexin Sun Changfa Xia Zhixun Yang He Li Wanqing Chen | 2018 | Global Health Journal2018，2，3： | 12 |
| 4 | Interactions between life expectancy and the incidence and mortality rates of cancer in China: a population-based cluster analysis显示文摘Background:The relationship between cancer and life expectancy is well established in both developed and developing countries.China is a vast country with significant geographical differences in population structure and healthcare,and thus provides a unique opportunity to analyze the complex relationship between life expectancy and cancer incidence and mortality rates.Methods:Cancer data were extracted for a total of 255 units(cities or counties)from the 2013 National Central Cancer Registry.Life expectancy data at the unit level were obtained from the National Centers for Disease Control and Prevention.Linear regression analysis was used to analyze the relationship between life expectancy and crude incidence and mortality rates of cancer.In a separate analysis,life expectancy was rated as low(<76.0 years),middle(76-80 years),or high(>80 years).Results:Overall,the cancer incidence and mortality rates positively correlated with life expectancy in both sexes(R at 0.37 and 0.50,P<0.001).The correlation was significant for the following cancers:lung,colorectal,prostate,blad-der and pancreas,as well as for lymphoma in men(R 0.36-0.58,P<0.001),lung,breast,colorectal,thyroid,uterus,and ovary in women(R 0.18-0.51,P<0.001).We failed to observe an association between upper gastrointestinal cancer and life expectancy.The number of cities/counties with low,middle and high life expectancy levels were 110,101 and 44,respectively.The highest age-standardized cancer incidence rate was observed in areas with a high life expec-tancy level(192.83/100,000).The highest age-standardized mortality rate was in areas with the lowest life expectancy(118.44/100,000).Cancers of the stomach,liver and esophagus are major cancer types in areas with low and middle life expectancy.In contrast,areas with high life expectancy had high incidence and mortality rates of colorectal can-cer,breast cancer in women and prostate cancer in men.Conclusions:Longer life expectancy is associated with higher overall cancer incidence and mortality in China.The cancer pattern also varies substantially across areas with different life expectancy levels.Life expectancy levels must be considered when developing strategies to prevent and treat cancers. | Xiuying Gu Rongshou Zheng Changfa Xia Hongmei Zeng Siwei Zhang Xiaonong Zou Zhixun Yang He Li Wanqing Chen | 2018 | Cancer Communications2018，38，1： | 12 |
| 5 | Assessment of pollutant loads discharged from aquaculture ponds around Taihu Lake, China显示文摘 | Chunfang Cai Xiaohong Gu Yuantu Ye Caigeng Yang Xiuying Dai Dongxing Chen Chao Yang | 2012 | Aquac Res2012，，5： | 1 |
| 6 | A tandem segmental duplication (TSD) in green revolution gene Rht‐D1b region underlies plant height variation显示文摘 | Yiyuan Li Jianhui Xiao Jiajie Wu Jialei Duan Yue Liu Xingguo Ye Xin Zhang Xiuping Guo Yongqiang Gu Lichao Zhang Jizeng Jia Xiuying Kong | 2012 | New Phytologist2012，，1： | 1 |
| 7 | A tandem segmental duplication (TSD) in green revolution gene Rht‐D1b region underlies plant height variation显示文摘 | Yiyuan Li Jianhui Xiao Jiajie Wu Jialei Duan Yue Liu Xingguo Ye Xin Zhang Xiuping Guo Yongqiang Gu Lichao Zhang Jizeng Jia Xiuying Kong | 2012 | New Phytologist2012，，1： | 1 |
| 8 | The Warming Climate Aggravates Atmospheric NitrogenPollution in Australia显示文摘Australia is a warm country with well-developed agriculture and a highly urbanized population.How these specific features impact the nitrogen cycle,emissions,and consequently affect environmental and human health is not well understood.Here,we find that the ratio of reactive nitrogen(Nr)losses to air over losses to water in Australia is 1.6 as compared to values less than 1.1 in the USA,the European Union,and China.Australian Nr emissions to air increased by more than 70%between 1961 and 2013,from 1.2 Tg N yr^(-1) to 2.1 Tg N yr^(-1).Previous emissions were substantially underestimated mainly due to neglecting the warming climate.The estimated health cost from atmospheric Nr emissions in Australia is 4.6 billion US dollars per year.Emissions of Nr to the environment are closely correlated with economic growth,and reduction of Nr losses to air is a priority for sustainable development in Australia. | Yi Sun Baojing Gu Hans JMvan Grinsven Stefan Reis Shu Kee Lam Xiuying Zhang Youfan Chen Feng Zhou Lin Zhang Rong Wang Deli Chen Jianming Xu | 2021 | Research2021，，1： | 1 |
| 9 | Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway显示文摘Background Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments.Mori fructus aqueous extracts(MFAEs)have served as successful treatments for many types of liver injury including fibrosis although the molecular mechanisms are unknown at present.Purpose To investigate the effect of MFAEs in alleviating acute and chronic liver injury and tried to decipher the underlying mechanism.Methods and results Mice were divided into 5 groups(n ps:contro=8)for acute(groups:control,0.3%CCl_(4),bifendate(BD),100 and 200 mg/kg MFAEs,7 d)and chronic(groul,10%CCl_(4),BD,100 and 200 mg/kg MFAEs,4 weeks)liver injury study.Each mouse was injected intraperitoneally with 10μL/g corn oil containing CCl_(4)expect the control group.HepG2 cells were used in vitro study.Eighteen communal components were identified by UPLC-LTQOrbitrap-MS.We utilized a mouse model for acute and chronic liver injury using CCl_(4)and MFAEs administration effectively blocked fibrosis and significantly inhibited inflammation in the liver.MFAEs activated the nuclear factor erythroid derived 2 like 2/heme oxygenase 1(Nrf2/HO-1)pathway and promoted the synthesis of the antioxidants glutathione(GSH),superoxidedismutase(SOD)and glutathione peroxidase(GSH-Px)that resulted in reduced levels of CCl_(4)-induced oxidative stress molecules including reactive oxygen species.These extracts administered to mice also inhibited ferroptosis in the liver by regulating the expression of Acyl-CoA synthetase long chain family member 4(ACSL4),solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),thus reducing the occurrence of liver fibrosis.Both in vivo and in vitro tests indicated that the mechanism of MFAEs protection against liver fibrosis was linked to activation of Nrf2 signaling.These effects were blocked in vitro by the addition of a specific Nrf2 inhibitor.Conclusion MFAEs inhibited oxidative stress,ferroptosis and inflammation of the liver by activating Nrf2 signal pathway and provided a significant protective effect against CCl_(4)-induced liver fibrosis. | Yuanyuan Wei Chen Gao Huiru Wang Yannan Zhang Jinhua Gu Xiuying Zhang Xuhao Gong Zhihui Hao | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 10 | Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro显示文摘Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested.Here,wereport thatmousehaESCs can differentiate in vitro into haploid epiblast stem cells(haEpiSCs),which maintain an intact haploid genome,unlimited self-renewal potential,and durable pluripotency to differentiate into various tissues in vitro and in vivo.Mechanistically,the maintenance of self-renewal potential depends on the Activin/bFGF pathway.We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.When injected into the cytoplasm of an oocyte,androgenetic haEpiSC(ahaEpiSCs)can support embryonic development until midgestation(E12.5).Together,these resultsdemonstrate durable pluripotency inmousehaESCs andhaEpiSCs,aswell asthe valuable potential of using these haploid pluripotent stem cells in high-throughput genetic screening. | Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2015 | Journal of Molecular Cell Biology2015，7，4： | 1 |
| 11 | The Presence of Helicobacter pylori in Colorectal Polyps Detected by Immunohistochemical Methods in Children显示文摘 | Haiying Cheng Ting Zhang Weizhong Gu Xiaoli Shu Yanyi Zhang Xuping Zhang Xiuying Wu Jie Chen Mizu Jiang | 2012 | The Pediatric Infectious Disease Journal2012，，4： | 1 |
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