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| 1 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 2 | Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020显示文摘On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of NCIP.These guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing. | Wenxiao Tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng | 2020 | China CDC weekly2020，2，6： | 15 |
| 3 | Crop 3D a LiDAR based platform for 3D high-throughput crop phenotyping显示文摘With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis.As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging(LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional(3 D) data accurately,and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China,we developed a high-throughput crop phenotyping platform, named Crop 3 D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager. Compared with traditional crop phenotyping techniques, Crop 3 D can acquire multi-source phenotypic data in the whole crop growing period and extract plant height, plant width, leaf length, leaf width, leaf area, leaf inclination angle and other parameters for plant biology and genomics analysis. In this paper, we described the designs,functions and testing results of the Crop 3 D platform, and briefly discussed the potential applications and future development of the platform in phenotyping. We concluded that platforms integrating LiDAR and traditional remote sensing techniques might be the future trend of crop high-throughput phenotyping. | Qinghua Guo Fangfang Wu Shuxin Pang Xiaoqian Zhao Linhai Chen Jin Liu Baolin Xue Guangcai Xu Le Li Haichun Jing Chengcai Chu | 2018 | Science China(Life Sciences)2018，61，3： | 14 |
| 4 | Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection显示文摘Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six a helices and two WY motifs. The first two a helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity. | Baodian Guo Haonan Wang Bo Yang Wenjing Jiang Maofeng Jing Haiyang Li Yeqiang Xia Yuanpeng Xu Qinli Hu Fangfang Wang Feng Yu Yan Wang Wenwu Ye Suomeng Dong Weiman Xing Yuanchao Wang | 2019 | Molecular Plant2019，12，4： | 12 |
| 5 | Streamflow response to climate variability and human activities in the upper catchment of the Yellow River Basin显示文摘Both sensitivity-based method and simulation method are used to analyze the streamflow response to climate variability and human activities in the upper catchment of the Yellow River Basin (UYRB) in this study. The separation regime of effects from climate variability and human activities is investigated. Results show that the changes of streamflow are more sensitive to precipitation than potential evapotranspiration (PET). Effect of climate variability on streamflow estimated using the sensitivity-based method is weak in the upper catchment of Jimai station, and strong in the upper catchment of Lanzhou station, where the climate effects accounted for about 50% of total streamflow changes. Effects of human activities on streamflow accounted for about 40% in the UYRB, with weaker effects in the upper catchment of Tangnaihai station than those in the upper catchment of Lanzhou station. Both climate variability and human activities are main factors to affect the changes of streamflow in the UYRB. | ZHAO FangFang XU ZongXue ZHANG Lu ZUO DePeng | 2009 | Science China(Technological Sciences)2009，52，11： | 12 |
| 6 | Practical performance and its efficiency of arsenic removal from groundwater using Fe-Mn binary oxide显示文摘A treatment unit packed by granular adsorbent of Fe-Mn binary oxide incorporated into diatomite (FMBO(1:1)-diatomite) was studied to remove arsenic from anaerobic groundwater without any pre-treatment or post-treatment. The raw anaerobic groundwater containing 35-45 μg/L of arsenic was collected from suburb of Beijing. Arsenic(III) constituted roughly 60%-80% of the total arsenic content. Approximately 7,000 bed volumes (ratio of efluent volume to adsorbent volume) treated water with arsenic concentration below 10 μg/L were produced in the operation period of four months. The regeneration of FMBO(1:1)-diatomite had been operated for 15 times. In the first stage, the regeneration process significantly improved the adsorption capacity of FMBO(1:1)-diatomite. With increased loading amount of Fe-Mn binary oxide, the adsorption capacity for arsenic decreased 20%-40%. Iron and manganese in anaerobic groundwater were oxidized and adsorptive filtrated by FMBO(1:1)-diatomite efficiently. The final concentrations of iron and manganese in efluents were nearly zero. The continued safe performance of the treatment units proved that adsorbent FMBO(1:1)-diatomite had high oxidation ability and exhibited strong adsorptive filtration. | Fangfang Chang Jiuhui Qu Ruiping Liu Xu Zhao Pengju Lei | 2010 | Journal of Environmental Sciences2010，22，1： | 11 |
| 7 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 8 | Genome-wide identification of OSCA gene family and their potential function in the regulation of dehydration and salt stress in Gossypium hirsutum显示文摘Background:Cotton(Gossypium hirsutum) provides the largest natural fiber for the textile manufacturing industries,but its production is on the decline due to the effects of salinity.Soil salt-alkalization leads to damage in cotton growth and a decrease in yields.Hyperosmolality-gated calcium-permeable channels(OSCA) have been found to be involved in the detection of extracellular changes which trigger an increase in cytosolic free calcium concentration.Hyperosmolality-induced calcium ion increases have been widely speculated to be playing a role in osmosensing in plants.However,the molecular nature of the corresponding calcium ion channels remains unclearly.In this research work,we describe the OSCA genes and their putative function in osmosensing in plants by carrying out genomewide identification,characterization and functional analysis of the significantly up-regulated OSCA gene,GhOSCA1.1 through reverse genetics.Result:A total of 35,21 and 22 OSCA genes were identified in G.hirsutum,G.arboreum,and G.raimondii genomes,respectively,and were classified into four different clades according to their gene structure and phylogenetic relationship.Gene and protein structure analysis indicated that 35 GhOSCA genes contained a conserved RSN17 TM(PF02714) domain.Moreover,the cis-regulatory element analysis indicated that the OSCA genes were involved in response to abiotic stress.Furthermore,the knockdown of one of the highly up-regulated genes,GhOSCA1.1 showed that the virus-induced gene silenced(VIGS) plants were highly sensitive to dehydration and salinity stresses compared with the none VIGS plants as evident with higher concentration levels of oxidant enzymes compared with the antioxidant enzymes on the leaves of the stressed plants.Conclusion:This study provides the first systematic analysis of the OSCA gene family and will be important for understanding the putative functions of the proteins encoded by the OSCA genes in cotton.These results provide a new insight of defense responses in general and lay the foundation for further investigation of the molecular role played by the OSCA genes,thereby providing suitable approaches to improve crop performance under salinity and drought stress conditions. | YANG Xiu XU Yanchao YANG Fangfang MAGWANGA Richard Odongo CAI Xiaoyan WANG Xingxing WANG Yuhong HOU Yuqing WANG Kunbo LIU Fang ZHOU Zhongli | 2019 | Journal of Cotton Research2019，2，2： | 7 |
| 9 | Epitaxial growth of large-area and highly crystalline anisotropic ReSe2 atomic layer显示文摘各向异性二维(2D ) 分层的材料金来二硫化物(因为它的不平常的性质和有希望的应用, ReSe 2) 吸引了可观的注意在电子并且 optoelectronic 设备。因为它的低格子对称和夹层去耦,各向异性的生长和 out-of-plane 生长不管多么容易发生,产出厚薄片,树枝状的结构,或象花的结构。在这研究,我们表明了一个自底向上的方法为控制并且由货车 der Waals 取向附生的 ReSe 2 的可伸缩的合成。完成可控制的生长,一与一个限制反应空格微反应堆被在化学蒸汽免职系统叠二云母底层构造。在限制反应空间以内, ReSe 2 的成核密度和生长率显著地被减少,赞成有一致单层厚度的 ReSe 2 的大区域的合成。有生长温度的 ReSe 2 的词法进化显示各向异性的生长在低生长温度被压制(< 600 吗? | Fangfang Cui Xiaobo Li Qingliang Feng Jianbo Yin Lin Zhou Dongyan Liu Kaiqiang Liu Xuexia He Xing Liang Shengzhong Liu Zhibin Lei Zonghuai Liu Hailin Peng Jin Zhang Jing Kong Hua Xu | 2017 | Nano Research2017，10，8： | 6 |
| 10 | Co0.85Se hollow spheres constructed of ultrathin 2D mesoporous nanosheets as a novel bifunctional-electrode for supercapacitor and water splitting显示文摘Hollow spheres of Co0.85Se con structed by two-dime nsional(2D)mesoporous ultrathi nnanosheets were synthesized via simple and costeffective approach.Their bifunctional electrocatalytic-supercapacitive properties were obtained simultaneously due to synergistic effects betweenmacroscopic morphological features and microscopic atomic/electronic structure of Co0.85Se.The as-synthesized hollow spheres of Co0.85Sethat are con structed by 2D mesoporous ultrathin nanosheets exhibit in spiring electrochemical performance for supercapacitor,presenting maximum energy density at high power density(54.66 Wh·kg^-1 at 1.6 kW·kg^-1)and long cycle stability(88%retention after 8,000 cycles).Atthe same time,the hollow spheres of Co0.85Se constructed by 2D mesoporous ultrathin nanosheets display excellent catalytic performaneefor oxygen evolution reaction(OER)due to special structure,high surface area and mesoporous nature of sheets,which achieve lowoverpotential(290 mV at 10 mA·g^-1)and low Tafel slope(81 mV·dec^-1)for Iong-term operation(only 7.8%decay in current density after 9 h).It could be envisioned that the proposed simple approach will pave a new way to synthesize other metal chalcoge nides for energy conversionand storage technology. | Nadeem Hussain Fangfang Wu Liqiang Xu Yitai Qian | 2019 | Nano Research2019，12，12： | 5 |
| 11 | A MEMS Device for in-situ TEM Test of SCS Nanobeam显示文摘In-situ tensile testing in TEM (transmission electron microscopy) is a useful tool for studying mechanical properties of nano-structures because it can provide quanti-tative information on sample deformation at atomic scale. To facilitate in-situ TEM tensile tests of SCS (single crystal silicon) nanobeam, a MEMS tensile-testing chip was designed and fabricated. The chip was fabricated by means of bulk micro-machining and wafer bonding techniques. An SCS nanobeam, a comb drive ac-tuator, a force sensor beam and an electron beam window were integrated into the chip. With the on-chip comb-drive-actuator stretching the nanobeam and in-situ TEM observation, tensile test on a 90 nm-thick nanobeam was performed and the strain-stress relationship was obtained. The Young's modulus was fitted to be 161 GPa and did not show the size effect. | JIN QinHua WANG YueLin LI Tie LI XinXin XU FangFang | 2008 | Science China(Technological Sciences)2008，51，9： | 5 |
| 12 | Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives显示文摘To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized.Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12 v and 12 w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12 w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3 D-QSAR and SARs statistical analysis revealed that title compounds with R^2 fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran. | Weijie Liu Jiao Li Kai He Fangfang Huang Yi Ma Yuxin Li Qingshan Li Fengbo Xu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 13 | Isolation and phylogenetic study of Rift Valley fever virus from the first imported case to China显示文摘Dear Editor,Rift Valley fever(RVF)is an anthropozoonosis caused by Rift Valley fever virus(RVFV).RVFV belongs to the Phlebovirus genus in the family Bunyaviridae,which is circulating among ruminants.Human infection with RVFV is generally asymptomatic,however,minority of patients develop severe RVF diseases like encephalitis | Yongxia Shi Kui Zheng Xiaobo Li Liqiang Li Shufen Li Jinmin Ma Jun Dai Jingkai Ji Shuai Yuan Haorong Lu Jiandong Li Fangfang Sun Xun Xu Jicheng Huang | 2017 | Virologica Sinica2017，32，3： | 4 |
| 14 | Identification and gene mapping of a narrow and upper-albino leaf mutant in rice(Oryza sativa L.)显示文摘The leaf blade consists of color and shape traits.Studies of leaf-blade development are important for improvement of rice yield and quality because it is an essential organ for photosynthesis.A narrow and upper-albino leaf mutant(nul1) was identified from among progeny of the indica restorer line Jinhui10 raised from seeds treated with ethyl methane sulfonate.Under field conditions,the mutant displayed narrow and upper-albino leaf blades with significantly decreased photosynthetic pigment contents throughout their development.The narrow-leaf trait is caused by a decreased number of small veins.In contrast to the wild type,the growth period was extended by approximately 8 d and agronomic traits,such as effective panicle number,percentage seed set and 1000-grain weight,declined significantly in the nul1 mutant.Genetic analysis suggested that the narrow and upper-albino leaf characteristics showed coseparation and were controlled by one recessive gene.The Nul1 gene was mapped onto chromosome 7 between the Indel marker Ind07-1 and the Simple Sequence Repeat marker RM21637.The physical distance between the markers was 75 kb and eight genes were annotated in this region based on the rice Nipponbare genome sequence.These results provide a foundation for cloning and function analysis of Nul1. | WANG Feng TANG YanQiang MIAO RunLong XU FangFang LIN TingTing HE GuangHua SANG XianChun | 2012 | Chinese Science Bulletin2012，57，28： | 4 |
| 15 | Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants显示文摘As shown in our previous study, two alternatively spliced androgen receptor(AR) variants, which are exclusively expressed in the granulosa cells of patients with polycystic ovary syndrome, exhibit retarded nuclear translocation compared with wild-type AR. However, researchers have not yet determined whether these abnormalities correlate with heat shock protein 90(HSP90)and importin α(the former is a generally accepted co-chaperone of AR, and the latter is a component of classical nuclear import complexes). Here, these two variants were mainly retained in cytoplasm with HSP90 and importin α in the presence of dihydrotestosterone(DHT), and their levels in nucleus were significantly reduced, according to the immunofluorescence staining. The binding affinity of two AR variants for importin α was consistently decreased, while it was increased in WT-AR following DHT stimulation, leading to reduced nuclear import, particularly for the insertion-AR(Ins-AR). However, the binding affinities of two AR variants for HSP90 were increased in the absence of DHT compared with WT-AR, which functioned to maintain spatial structural stability, particularly for the deletion-AR(Del-AR). Therefore, the retarded nuclear translocation of two AR variants is associated with HSP90 and importin α, and the abnormal binding affinities for them play critical roles in this process. | Ye Liu Yinyu Wang Fangfang Wang Jiexue Pan Jingjing Xu Jingyi Li Chengliang Zhou Guolian Ding Yanting Wu Xinmei Liu Jianzhong Sheng Hefeng Huang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 16 | Health-related quality of life among rural residents aged 45-69 years in Hua County, Henan Province, China: Results of ESECC Trial for esophageal cancer screening with endoscopy显示文摘Objective: There have been few population-based studies evaluating health related quality of life(HRQOL) in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods: From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China(ESECC) trial(Clinical Trials.gov:NCT01688908) randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results: Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort(25.52%) was the most frequently reported problem followed by anxiety/depression(7.97%), mobility(5.82%), usual activities(2.61%) and self-care(1%). These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions: Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial. | Hui Wang Yaqi Pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He | 2018 | Chinese Journal of Cancer Research2018，30，2： | 3 |
| 17 | Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study显示文摘Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China.The oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy controls.DESeq analysis was performed to identify taxa of differential abundance.Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.Results:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P<0.05&false discovery rate-adjusted Q<0.10).A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve(AUC)of 0.89(95%CI,0.84-0.93).Cross-validation and sensitivity analysis,excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls,or restriction to screenendoscopic-detected or clinically diagnosed case-control triads,or using only bacterial data measured at the baseline,yielded AUCs>0.84.Conclusions:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs. | Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 18 | Differentially private high-dimensional data publication via grouping and truncating techniques显示文摘The count of one column for high-dimensional datasets, i.e., the number of records containing this column, has been widely used in nuinerous applications such as analyzing popular spots based on check-in location information and mining valuable items from shopping records. However, this poses a privacy threat when directly publishing this information. Differential privacy (DP), as a notable paradigm for strong privacy guarantees, is thereby adopted to publish all column counts. Prior studies have verified that truncating records or grouping columns can effectively improve the accuracy of published results. To leverage the advantages of the two techniques, we combine these studies to further boost the accuracy of published results. However, the traditional penalty function, which measures the error imported by a given pair of parameters including truncating length and group size, is so sensitive that the derived parameters deviate from the optimal parameters significantly. To output preferable parameters, we first design a smart penalty function that is less sensitive than the traditional function. Moreover, a two-phase selection method is proposed to compute these parameters efficiently, together with the improvement in accuracy. Extensive experiments on a broad spectrum of real-world datasets validate the effectiveness of our proposals. | Ning WANG Yu GU Jia XU Fangfang LI Ge YU | 2019 | Frontiers of Computer Science2019，13，2： | 3 |
| 19 | Compositional and structural study of ash deposits spatially distributed in superheaters of a large biomass-fired CFB boiler显示文摘Recognizing the nature and formation progress of the ash deposits is essential to resolve the deposition problem hindering the wide application of large-scale biomass-fired boilers.Therefore,the ash deposits in the superheaters of a 220 t/h biomass-fired CFB boiler were studied,including the platen(PS),the high-temperature(HTS),the upper and the lower low-temperature superheaters(LTS).The results showed that the deposits in the PSs and HTSs were thin(several millimeters)and compact,consisting of a yellow outer layer and snow-white inner layer near the tube surface.The deposits in the upper LTS appeared to be toughly sintered ceramic,while those in the lower LTS were composed of dispersive coarse ash particles with an unsintered surface.Detailed characterization of the cross-section and the initial layers in the deposits revealed that the dominating compositions in both the PSs and the HTSs were Cl and K(approximately 70%)in the form of KCl.Interestingly,the cross-section of the deposition in the upper LTS exhibited a unique lamellar structure with a major composition of Ca and S.The contents of Ca and Si increased from approximately 10%to approximately 60%in the deposits from the high temperature surfaces to the low temperature ones.It was concluded that the vaporized mineral matter such as KCl played the most important role in the deposition progress in the PS and the HTS.In addition,although the condensation of KCl in the LTSs also happened,the deposition of ash particles played a more important role. | Yishu XU Xiaowei LIU Jiuxin QI Tianpeng ZHANG Minghou XU Fangfang FEI Dingqing LI | 2021 | Frontiers in Energy2021，15，2： | 3 |
| 20 | Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma显示文摘Methyltransferase like 13(METTL13),a kind of methyltransferase,is implicated in protein binding and synthesis.The upregulation of METTL13 has been reported in a variety of tumors.However,little was known about its potential function in head and neck squamous cell carcinoma(HNSCC)so far.In this study,we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level.Increased METTL13 was negatively associated with clinical prognosis.And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro.Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail,the key transcription factor in EMT,hence regulating the progression of EMT.Furthermore,Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes.Altogether,our study had revealed the oncogenic role of METTL13 in HNSCC,and provided a potential therapeutic strategy. | Xiaochen Wang Kang Li Yuehan Wan Fangfang Chen Maosheng Cheng Gan Xiong Ganping Wang Shuang Chen Zhi Chen Jianwen Chen Xiuyun Xu Cheng Wang Liang Peng Demeng Chen | 2021 | International Journal of Oral Science2021，13，3： | 3 |
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