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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 3 | Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients显示文摘背景尿酸( UA )被怀疑在 Parkinson .This 学习试图评估浆液 UA 水平是否在中国 patients.Methods 浆液 UA 层次的一张相对大的人口与 PD 的疾病前进被联系的疾病( PD )起一个neuro保护的作用从 411 个中国 PD 病人被测量并且 396 匹配年龄的控制;跟随尿酸比色的方法,浆液 creatinine (Scr ) 层次也被测量减少可能的差别在肾的排泄 function.The 引起的偏爱疾病前进被 Hoehn 和 Yahr (H&Y ) 规模和疾病持续时间获得; PD 组根据 H&Y scales.Independent样品 ttest 被划分成 3 亚群被执行分析 PD 组之间的差别,协变性的控制 group.Multiple 分析被执行分析 PD subgroups.Spearman 等级关联之间的差别被执行评估在水平和疾病 progression.Results PD 病人被发现的浆液 UA 或 Scr 之间的协会显著地比控制有浆液 UA 的底层(( 243. | Sun Cong-cong Luo Fei-fei Wei Lei Lei Mi Li Guo-fei Liu Zhuo-lin Le Wei-dong Xu Ping-yi | 2012 | Chinese Medical Journal2012，，4： | 43 |
| 4 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 5 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 6 | Characterization of hepatitis B virus genotypes/subgenotypes in 1301 patients with chronic hepatitis B in North China显示文摘在那里的背景仍然是 hepati tis B 上的数据的少量在诺思中国的病毒( HBV ) subgenotype 流行基于大尺寸的 samples.In 增加定序, HBV 遗传型是否与长期的肝炎 B ( CHB )在病人影响 drug-resistance-associated 和 HBV e 抗原( HBeAg ) -Ioss-associated 变化,仍然在学习试图在方面 t 在诺思中国和 HBV 遗传型分类的临床的含意揭示 HBV genotypes/subgenotypes 的临床的流行的 investigation.This 下面并且 HBV 遗传型流行被移民 population.HBV/C 感染影响是可能的吃更长的疾病持续时间和 severer 肝功能的缺陷并且可能更易受影响与 HBV/B 感染相比开发 lamivudine 抵抗。 | LI Xiao-dong WANG Lin LIU Yan XU Zhi-hui DAI Jiu-zeng LI Le YAO Zeng-tao XIN Shao-jie XU Dong-ping ZHAO Jing-ming | 2011 | Chinese Medical Journal2011，，24： | 24 |
| 7 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 8 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 9 | Piriformospora indica confers drought tolerance on Zea mays L.through enhancement of antioxidant activity and expression of drought-related genes显示文摘Drought stress is one of the most severe environmental constraints to plant growth and crop productivity. Plant growth is greatly affected by drought stress, and plants, to survive,adapt to this stress by invoking different pathways. Piriformospora indica, a root-colonizing endophytic fungus of Sebacinales, promotes plant growth and confers resistance to biotic and abiotic stresses, including drought stress, by affecting the physiological properties of the host plant. The fungus strongly colonizes the roots of maize(Zea mays L.) and promotes shoot and root growth under both normal growth conditions and drought stress. We used polyethylene glycol(PEG-6000) to mimic drought stress and found that root fresh and dry weight, leaf area, SPAD value, and leaf number were increased in P. indica-colonized plants.The antioxidative activities of catalases and superoxide dismutases were upregulated within 24h in the leaves of P. indica-colonized plants. Drought-related genes DREB2A, CBL1,ANAC072, and RD29A were upregulated in drought-stressed leaves of P. indica-colonized plants. Furthermore, after drought treatment, proline content increased, whereas accumulation of malondialdehyde(MDA), an indicator of membrane damage, decreased in P. indica-colonized maize. We conclude that P. indica-mediated plant protection against the detrimental effects of drought may result from enhanced antioxidant enzyme activity,proline accumulation, and expression of drought-related genes and lower membrane damage in maize plants. | Le Xu Aiai Wang Jun Wang Qiao Wei Wenying Zhang | 2017 | The Crop Journal2017，5，3： | 17 |
| 10 | 经腹股沟及腹股沟下显微精索静脉结扎术:精索静脉曲张的最佳手术治疗方式的荟萃分析显示文摘以往精索静脉曲张各种治疗方法疗效的荟萃分析存在不一致的结果。因此,我们进行了多种干预措施的荟萃分析,评估10种精索静脉曲张栓塞/硬化治疗方法的有效性和安全性,包括腹腔镜、腹膜后开放、经腹股沟开放和腹股沟下开放静脉结扎,腹股沟下显微和经腹股沟显微精索静脉结扎术,经皮静脉栓塞,TauberJl~行硬化,硬化逆行和期待治疗(无处理)。我们系统回顾了从1966年至2013年8月的35个随机对照试验和观察性研究。经腹股沟、腹股沟下显微手术、腹股沟开放、腹腔镜精索静脉结扎与期待治疗相比显著提高夫妻怀孕率(优势比[OR]分别为:3.48,2.68,2.92和2.9)。与腹膜后开放手术相比,经腹股沟显微手术显著提高患者的精子密度(平均差【MD]:10.60,95%CI:1.92—19.60)并改善精子运动(MD:9.09,95%CI:4.88—13.30)。经腹股沟下和腹股沟显微手术在复发率方面的表现优于开放腹膜后手术(OR分别为0.05,O.06)。Tauber顺行硬化和腹股沟下显微精索静脉结扎术的鞘膜积液形成的风险最低。与腹膜后开放精索静脉曲张术相比,腹股沟显微精索静脉结扎术的总的并发症率最低(OR=O.07,95%CI:0.02。0.19)。其次是腹股沟下显微(OR:O.09,95%CI:0.02.0.19)。经腹股沟显微和腹股沟下显微精索静脉曲张结扎术对提高患者怀孕率有良好的效果,能显著增加精子数量,并有着较低的并发症率。本文研究结果仍需要经过良好设计的随机对照临床研究进一步证实。 | Jun Wang Shu-Jie Xia Zhi-Hong Liu Le Tao Ji-Fu Ge Chen-Min Xu Jian-Xin Qiu | 2015 | Asian Journal of Andrology2015，17，1： | 16 |
| 11 | The estimate of sea ice resources quantity in the Bohai Sea based on NOAA/AVHRR data显示文摘The research on sea ice resources is the academic base of sea ice exploitation in the Bohai Sea. According to the ice-water spectrum differences and the correlation between ice thickness and albedo, this paper comes up with a sea ice thickness inversion model based on the NOAA/AVHRR data. And then a sea ice resources quantity (SIQ) time series of Bohai Sea is established from 1987 to 2009. The results indicate that the average error of inversion sea ice thickness is below 30%. The maximum sea ice resources quantity is about 6 × 10 9 m 3 and the minimum is 1.3 × 10 9 m 3 . And a preliminary analysis has been made on the errors of the estimate of sea ice resources quantity (SIQ). | YUAN Shuai GU Wei XU Yingjun WANG Ping HUANG Shuqing LE Zhangyan CONG Jianou | 2012 | Acta Oceanologica Sinica2012，31，1： | 15 |
| 12 | Controllable preparation of particles with microfluidics显示文摘This paper reviews recent development and achievements in controllable preparation of nanoparticles, micron spherical and non-spherical particles, using microfluidics. A variety of synthesis strategies are presented and compared, including single-phase and multiphase microflows. The main structures of microfluidic devices and the fundamental principles of microflows for particle preparation are summarized and identifled. The controllability of particle size, size distribution, crystal structure, morphology, physical and chemical properties, is examined in terms of the special features of microfluidic reactors. An outlook on opinions and predictions concerning the future development of powder technology with microfluidics is specially provided. | Guangsheng Luo Le Du Yujun Wang Yangcheng Lu Jianhong Xu | 2011 | Particuology2011，9，6： | 15 |
| 13 | Inflammatory airway features and hypothalamic-pituitary- adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease显示文摘背景支气管的气喘(BA ) 和长期的妨碍的肺的疾病(COPD ) 两个都是有不同特征的煽动性的航线疾病。然而,有许多病人,受不了 BA 和 COPD。这研究是在与科普德梅索兹·布朗挪威( BN )老鼠相结合的气喘的老鼠评估煽动性的航线特征和 hypothalamic-pituitary-adrenal ( HPA )轴功能的变化被用来为 BA , COPD 和 COPD+BA.These 的煽动性的航线疾病建模三个模型关于临床的症状被比较并且评估,肺的组织病理学说,航线 hyperresponsiveness ( AHR ),煽动性的 cytokines 和煽动性的航线展示的 HPA 轴 function.Results 和 HPA 轴趣事在这个模型组的老鼠显示出煽动性的疾病 BA 和 COPD 的特征。在这个模型组的煽动性的 cytokines 的表示可能起来或 downregulated 当两个疾病过程是在场的时。在这个模型组释放荷尔蒙 mRNA 和皮质脂酮的 corticotrophin 的层次显著地是两个在控制组比那些减少了(P < 0.05 ).Conclusions BN 老鼠能被用作 COPD+BA 的一个动物模型。由评估这个动物模型,我们发现在在这个模型组的老鼠的发炎的特征似乎被夸大。在在这个模型组的老鼠的 HPA 轴功能被扰乱了或损害,它在 hypothalamic 水平是突出的。 | CAI Cui ZHANG Hong-ying LE Jing-jing DONG Jing-cheng CUI Yan XU Chang-qing LIU Bao-jun WU Jin-feng DUAN Xiao-hong CAO Yu-xue | 2010 | Chinese Medical Journal2010，，13： | 14 |
| 14 | Crop 3D a LiDAR based platform for 3D high-throughput crop phenotyping显示文摘With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis.As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging(LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional(3 D) data accurately,and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China,we developed a high-throughput crop phenotyping platform, named Crop 3 D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager. Compared with traditional crop phenotyping techniques, Crop 3 D can acquire multi-source phenotypic data in the whole crop growing period and extract plant height, plant width, leaf length, leaf width, leaf area, leaf inclination angle and other parameters for plant biology and genomics analysis. In this paper, we described the designs,functions and testing results of the Crop 3 D platform, and briefly discussed the potential applications and future development of the platform in phenotyping. We concluded that platforms integrating LiDAR and traditional remote sensing techniques might be the future trend of crop high-throughput phenotyping. | Qinghua Guo Fangfang Wu Shuxin Pang Xiaoqian Zhao Linhai Chen Jin Liu Baolin Xue Guangcai Xu Le Li Haichun Jing Chengcai Chu | 2018 | Science China(Life Sciences)2018，61，3： | 14 |
| 15 | Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)显示文摘Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China.TBC is semi-volatile and can accumulate in the lipid of some species,but little is known about its effect on aquatic organisms.We exposed adult zebrafish to 0,0.25,1 and 4mg/L TBC for 28 d and measured the effect on survival,growth,histopathology,hormone levels,enzyme activity,and gene expression.TBC exposure had no effect on survival or growth.We observed significant damage to the liver and gill,including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills.In addition,exposure to 4mg/L TBC induced proliferation of goblet cells in the intestine of both sexes,acellular areas in the testis,and thinly scattered vitellogenic granules in vitellogenic oocytes.TBC exposure had no effect on the levels of thyroid hormones,testosterone,estradiol,liver superoxide dismutase activity,malondialdehyde content,and brain cholinesterase activity.By contrast,hepatic vitellogenin and cytochrome P4501A gene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure.Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects. | ZHANG Xu LI Juan CHEN MinJie WU Le ZHANG Chi ZHANG Jie ZHOU QunFang LIANG Yong | 2011 | Chinese Science Bulletin2011，56，15： | 13 |
| 16 | Molecular mechanism of icariin on rat asthmatic model显示文摘在气喘的老鼠和 LPS 的干预的航线发炎上的 icariin 的背景效果导致了发炎与 icariin 的 machanism 被介入。我们的学习试图在 Th1/Th2 cytokine 表示和它的 mechanism.Methods 的 导致ovalbumin 的不平衡上观察 icariin 的效果六十只男 SD 老鼠随机被划分成控制组( PBS ),气喘组( ovalbumin (卵) -induced),dexamethasone 组,和 OVA+icariin 低、中等、高的剂量组( 5 , 10 , 20 mg/kg ,分别地)。每个组有十只老鼠。卵促进感受性的模型是一个老鼠气喘模型。连接酶的 immunosorbent 试金( ELISA )方法被用来在 interleukin-4 ( IL-4 )上观察 icariin 的效果,在老鼠染色的肺 tissue.Immunohistochemical 的 inerferon Y ( IFN-Y )被使用在 T 房间(T赌注)和 gatabinding 蛋白质上检测 icariin 的干预效果 3 ( GATA-3 )在里面老鼠肺的织物。实时 RT-PCR 被用来在老鼠在 T 赌注和 GATA-3 mRNA 表示上观察 icariin 的干预效果肺的织物和怒气淋巴细胞。西方的弄污被用来在老鼠在T赌注, GATA-3 和原子 factor-Kappa B ( NF-B ) p65 蛋白质表情上观察 icariin 干预效果从肺的织物的 ELISA 结果显示出的肺的 tissue.Results 那 IL-4 表情显著地被减少( P 0.05 ),当 IFN-y 表示增加了时然而并非当我们把 OVA+icariin 中等、高的剂量组与气喘作比较时,显著地组织。当染色的 T 赌注没在 OVA+icariin 高剂量组变化时,肺的织物染色的 Immunohistochemical 证明 GATA-3 显著地减少了。在肺的组织和脾淋巴细胞, T 赌注和 GATA-3 mRNA 表情显著地被减少(P 0.05 ) 在 icariin,治疗与气喘模型组相比组织。在在气喘组的老鼠怒气淋巴细胞的 GATA-3 和 T 赌注 mRNA 比在控制组高。在肺的织物的 GATA-3 mRNA 表示显著地减少了( P 0.05 )当T赌注 mRNA 表示减少了然而并非显著地,在 icariin 处理组,与气喘相比,在肺的织物的group.T赌注和 GATA-3 蛋白质表情与气喘相比显著地增加了时,组织,它意味着 icariin 能禁止 GATA-3 蛋白质,然而并非T赌注的增加。支气管,血容器和圆周当 NF-B p65 房间被减少时,肺的织物在 OVA+icariin 高剂量组有煽动性的房间的渗入,并且在这个组的 NF-B p65 的表示是不到在里面气喘组。当细胞质的 p65 蛋白质 increased.Conclusions Icariin 的表示能在气喘的老鼠调整 Th1/Th2 cytokines 的不平衡时,全部的 p65 蛋白质的表示与 icariin 处理减少了肺的织物。Icariin 能调整 Th1/Th2 的不平衡在气喘的老鼠的联系抄写因素 T 赌注和 GATA-3 肺的织物和怒气淋巴细胞。Icariin 能在气喘的老鼠禁止 NF-B p65 蛋白质的激活肺的织物。 | XU Chang-qing LE Jing-jing DUAN Xiao-hong DU Wei-jing LIU Bao-jun WU Jing-feng CAO Yu-xue DONG Jing-cheng | 2011 | Chinese Medical Journal2011，，18： | 13 |
| 17 | Topographic differentiations of biological soil crusts and hydraulic properties in fixed sand dunes, Tengger Desert显示文摘Biological soil crusts(BSCs) play an important role in surface soil hydrology. Soils dominated with moss BSCs may have higher infiltration rates than those dominated with cyanobacteria or algal BSCs. However, it is unnown whether improved infiltration in moss BSCs is accompanied by an increase in soil hydraulic conductivity or water retention capacity. We investigated this question in the Tengger Desert, where a 43-year-old revegetation program has promoted the formation of two distinct types of BSCs along topographic positions, i.e. the moss-dominated BSCs on the interdune land and windward slopes of the fixed sand dunes, and the algal-dominated BSCs on the crest and leeward slopes. Soil water retention capacity and hydraulic conductivity were measured using an indoor evaporation method and a field infiltration method. And the results were fitted to the van Genuchten–Mualem model. Unsaturated hydraulic conductivities under greater water pressure(<–0.01 MPa) and water retention capacities in the entire pressure head range were higher for both crust types than for bare sand. However, saturated and unsaturated hydraulic conductivities in the near-saturation range(>–0.01 MPa) showed decreasing trends from bare sand to moss crusts and to algal crusts. Our data suggested that topographic differentiation of BSCs significantly affected not only soil water retention and hydraulic conductivities, but also the overall hydrology of the fixed sand dunes at a landscape scale, as seen in the reduction and spatial variability in deep soil water storage. | Zhi Shan ZHANG Yong Le CHEN Bin Xing XU Lei HUANG Hui Juan TAN Xue Jun DONG | 2015 | Journal of Arid Land2015，7，2： | 13 |
| 18 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 19 | Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways显示文摘OBJECTIVE: To examine whether electroacupuncture(EA) treatment inhibited cell apoptosis of intervertebral annulus fibrosis(AF) via tumor necrosis factor-α(TNF-α)-tumor necrosis factor receptor 1(TNFR1)-caspase-8 and integrin β1/Akt signaling pathways in a rat model of cervical intervertebral disc degeneration caused by unbalanced dynamic and static forces.METHODS: Thirty-two Sprague-Dawley rats were included in this study, of which 24 rats underwent surgery to induce cervical intervertebral disc degeneration, while eight rats received EA treatment at Dazhui(GV 14). Immunohistochemical staining was used to detect TNF-α, TNFR1, and caspase-8Apoptosis of AF cells was examined with terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The m RNA and protein expression levels of integrin β1 andAkt were evaluated with real-time polymerase chain reaction and western blot analysis, respectively.RESULTS: Treatment with EA decreased TUNEL-positive AF cells and lowered TNF-α, TNFR1 and caspase-8 positive cells compared with control groups. EA treatment also increased integrin β1and Akt m RNA and protein levels compared with controls.CONCLUSION: Treatment with EA inhibits AF cell apoptosis through suppression of the TNF-α-TNFR1-caspase-8 signal pathway and increases the expression of integrin β1 and Akt. EA may be a good alternative therapy for treating cervical spondylosis. | Jun Liao Le Zhang Jiaxuan Zheng Debiao Yu Meigui Ke Teng Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 12 |
| 20 | Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer显示文摘AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29(EORTC QLQ-CR29) in Chinese patients with colorectal cancer(CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire(EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale(KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.RESULTS The EORTC QLQ-CR29 showed satisfactory reliability(α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability(α = 0.608). The multitrait scaling analyses showed good convergent(r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups(KPS ≤ 80; KPS > 80). body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients. | Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang Qia-Qia Li xue-Ying Zhang Yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei | 2017 | World Journal of Gastroenterology2017，23，10： | 12 |
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