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| 1 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 2 | Contribution of Temperature Increase to Restrain the Transmission of COVID-19显示文摘The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons. | Mengyuan Ren Rongjuan Pei Bahabaike Jiangtulu Junxi Chen Tao Xue Guofeng Shen Xiaoru Yuan Kexin Li Changxin Lan Zhen Chen Xinwen Chen Yun Wang Xiaoqian Jia Zewu Li Audil Rashid Tippawan Prapamontol Xiuge Zhao Zhaomin Dong Yali Zhang Le Zhang Rongwei Ye Zhiwen Li Wuxiang Guan Bin Wang | 2021 | The Innovation2021，2，1： | 2 |
| 3 | Towards a bright future:The versatile applications of organic solar cells显示文摘Due to the mechanical flexibility,light weight,aesthetics,absorption tunability and environmental friendliness,organic solar cells(OSCs)have superior application potential over their inorganic counterparts including silicon and perovskite solar cells(PSCs).Thanks to these benefits,the past decade have witnessed the rapid growth of flexible OSCs,semitransparent OSCs and indoor OSCs.In this progress report,we firstly overview the recent advance of the applications of the three promising OSCs.Subsequently,we sketch the critical points for the three classes of OSCs and highlight the efforts paid by the research community to address these issues.Besides,we discuss some popular strategies to afford great performance of each kind of OSC,respectively,and underline the corresponding breakthrough directions.Last but not least,we present the remaining challenges for advancing the commercial applications of these three classes of OSCs. | Junjiang Wu Mengyuan Gao Yubo Chai Pengke Liu Bo Zhang Junwei Liu Long Ye | 2021 | Materials Reports(Energy)2021，1，4： | 1 |
| 4 | A review of the application of machine learning in water quality evaluation显示文摘With the rapid increase in the volume of data on the aquatic environment,machine learning has become an important tool for data analysis,classification,and prediction.Unlike traditional models used in water-related research,data-driven models based on machine learning can efficiently solve more complex nonlinear problems.In water environment research,models and conclusions derived from machine learning have been applied to the construction,monitoring,simulation,evaluation,and optimization of various water treatment and management systems.Additionally,machine learning can provide solutions for water pollution control,water quality improvement,and watershed ecosystem security management.In this review,we describe the cases in which machine learning algorithms have been applied to evaluate the water quality in different water environments,such as surface water,groundwater,drinking water,sewage,and seawater.Furthermore,we propose possible future applications of machine learning approaches to water environments. | Mengyuan Zhu Jiawei Wang Xiao Yang Yu Zhang Linyu Zhang Hongqiang Ren Bing Wu Lin Ye | 2022 | Eco-Environment & Health2022，1，2： | 1 |
| 5 | Experi- mental study of shear behavior of screw connections in CFSsheathing显示文摘 | YE Jihong WANG Xingxing ZHAO Mengyuan | 2016 | Journal of Constructional Steel Research2016，121，： | 1 |
| 6 | On-chip WDM mode-di- vision multiplexing interconnection with optional demodulation function 显示文摘 | YE Mengyuan YU Yu CHEN Guanyu | 2015 | OPTICS EXPRESS2015，23，32： | 1 |
| 7 | A generic approach yields organic solar cells with enhanced efficiency and thermal stability显示文摘The use of deuterium are critical for promoting the fundamental understanding of aggregate materials and their new functions.Particularly,the solution structure of conjugated polymers can be hardly resolved without deuteration.However,studies about the isotopic effects of casting solvents on the aggregated structures of photovoltaic polymers and their bulk-heterojunction blends are deficient.Here,the impact of deuterated solvents on the thermal behavior,aggregated structures,and device performance of photovoltaic polymers is clearly delineated for the first time by multiple techniques.The enhanced π-π stacking order of photovoltaic polymers is highly relevant to their relatively poor miscibility with deuterated solvents.Benefiting from higher crystallinity and optimized morphology of deuterated solvents processed films,the devices are able to achieve better efficiency and notable improvement in thermal stability.Our results highlight the isotopic effects of solvents on the aggregated structure of conjugated polymer systems and reveal the potential of innovative approaches to fabricate thermally stable high-efficiency solar cells. | Mengyuan Gao Kai Zhang Chunyong He Hanqiu Jiang Xiong Li Qingchun Qi Kangkang Zhou Yu Chen Wenchao Zhao Long Ye | 2023 | Aggregate2023，4，2： | 0 |
| 8 | Triplet bismuthinidenes featuring unprecedented giant and positive zero field splittings显示文摘Isolation of triplet pnictinidenes,which bear two unpaired electrons at the pnictogen centers,has long been a great challenge due to their intrinsic high reactivity.Herein,we report the syntheses and characterizations of two bismuthinidenes MsFluindtBu-Bi(3)and MsFluind*-Bi(4)stabilized by sterically encumbered hydrindacene ligands.They were facilely prepared through reductions of the corresponding dichloride precursors with 2 molar equivalents of potassium graphite.The structural analyses revealed that 3 and 4contain a one-coordinate bismuth atom supported by a Bi-C singleσbond.As a consequence,the remaining two Bi 6p orbitals are nearly degenerate,and 3 and 4 possess triplet ground states.Experimental characterizations with multinuclear magnetic resonance,magne tome try and near infrared spectroscopy coupled to wavefunction based ab initio calculations concurred to evidence that there exist giant and positive zero field splittings(>4300 cm-1)in their S=1 ground states.Hence even at room temperature the systems almost exclusively populate the lowest-energy nonmagnetic Ms=0 level,which renders them seemingly diamagnetic. | Mengyuan Wu Wang Chen Dongmin Wang Yizhen Chen Shengfa Ye Gengwen Tan | 2023 | National Science Review2023，10，10： | 0 |
| 9 | Advances and prospective in thermally stable nonfullerene polymer solar cells显示文摘Polymer solar cells(PSCs)featuring nonfullerene acceptors have attracted a great deal of attention in the research community.Exposure of these active layers to sunlight during operation demands excellent thermal stability.Optimizing PSCs often requires a step of thermal annealing,while long-term annealing often places a constraint on their stable operation at elevated temperature and results in a progressive loss of photovoltaic performance.Hence,it is crucial to understand and control the fundamental affecting factors on the thermal stability of nonfullerene PSCs.This review highlights the relationships between microstructure and thermal stability of PSCs and summarizes promising strategies to push this technology toward the level of practical application.Finally,we present the current challenges and prospective of this research area,intending to advance the practical applications of stable PSCs based on nonfullerene acceptors. | Long Ye Mengyuan Gao Jianhui Hou | 2021 | Science China Chemistry2021，64，11： | 0 |
| 10 | 8.30%Efficiency P3HT-based all-polymer solar cells enabled by a miscible polymer acceptor with high energy levels and efficient electron transport显示文摘P3HT stands out from numerous polymer donors owing to the merits of low cost and high scalability of synthesis.However,the photovoltaic performance of P3HT-based blends lags significantly behind the state-of-the-art systems,especially for all-polymer solar cells(APSCs) that generally show efficiency of around 3%–4% due to the lack of matched polymer acceptors.Herein,a polymer acceptor,named IDTBTC8-CN,was designed and synthesized with indacenodithiophene(IDT) and mono-cyano(CN)-substituted benzothiadiazole(BT-CN) as building blocks.Introducing a CN group endowed the polymer with decreased bandgap,and apparent n-type charge transport character despite the relatively high energy levels.Additionally,IDTBTC8-CN showed largely improved miscibility with P3HT,compared with that of BT-based control polymer IDTBTC8.The high miscibility between P3HT and IDTBTC8-CN as well as the amorphous aggregation behavior of IDTBTC8-CN enabled a broad manipulation room for the blend film to acquire favorable morphology.Eventually,a champion efficiency of 8.30% was achieved,in sharp contrast to that of the IDTBTC8-based system(1.21%).Such efficiency is a new record for P3HT-based APSCs reported so far.Moreover,P3HT:IDTBTC8-CN blend film also exhibited excellent mechanical robustness.This study implies the guidance of molecular design of the polymer acceptors and morphology control for P3HT-based APSCs. | Ziqi Liang Jiangting He Bin Zhao Mengyuan Gao Yu Chen Long Ye Miaomiao Li Yanhou Geng | 2023 | Science China Chemistry2023，66，1： | 0 |
| 11 | High T_(g) Polymer Insulator Yields Organic Photovoltaic Blends with Superior Thermal Stability at 150℃显示文摘Record-breaking organic solar cells(OSCs)based on blends of polymer donors and small molecule acceptors often show undesirable degradati on,which severely precludes their practical use.Herei n,we demonstrate a facile and cost-effective approach to con struct thermally stable OSCs at 150℃ by incorporating a small amount of a polymer insulator polyacenaphthylene(PAC)with high glass-transition temperature over 230℃ into polymer:acceptor blends.The model PTB7-Th:EH-IDTBR blend with 10 wt%PAC maintained above 85%of its initial efficiency upon continuous heating at 150℃ for over 800 h,while the efficiency of the blend without PAC sharply dropped by 70%after-300 h.Owing to high miscibility with acceptors,PAC confines the motion of the acceptor molecules and suppresses the acceptor crystallization at elevated temperatures,leading to significantly improved stability.Importantly,the effectiveness of this blending approach was also validated in many other OSC systems,showing great potential for achieving high-performance thermally stable electronics. | Fei Chen Ying Zhang Qi Wang Mengyuan Gao Nigel Kirby Zhongxiang Peng Yunfeng Deng Miaomiao Li Long Ye | 2021 | Chinese Journal of Chemistry2021，39，9： | 0 |
| 12 | Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection显示文摘Japanese encephalitis virus(JEV) is a leading cause of viral encephalitis in endemic regions of Asia. The neurotropism of JEV and its high-efficiency replication in neurons are the key events for pathogenesis. Revealing the interplay between virus and host cells in metabolic facet is of great importance both for unraveling the pathogenesis mechanisms and providing novel antiviral targets. This study took advantage of the integration analysis of metabolomics and transcriptomics to depict the metabolic profiles of neurons during the early stage of JEV infection. Increased glycolysis and its branched pentose phosphate pathway(PPP) flux and impaired oxidative phosphorylation(OXPHOS) in glucose utilization,and the catabolic patterns of lipid metabolism were created to facilitate the biosynthesis of precursors needed for JEV replication in neurons. Pharmacological inhibitions of both glycolysis pathway and PPP in neurons suggested its indispensable role in maintaining the optimal propagation of JEV. In addition, analysis of metabolomic-transcriptomic regulatory network showed the pivotal biological function of lipid metabolism during JEV infection. Several pro-inflammatory lipid metabolites were significantly up-regulated and might partially be responsible for the progression of encephalitis.These unique metabolic reprogramming features might give deeper insight into JEV infected neurons and provide promising antiviral approaches targeting metabolism. | Mengyuan Li Jiali Yang Chuantao Ye Peiyu Bian Xiaofei Yang Haijun Zhang Chuanyu Luo Zhifeng Xue Yingfeng Lei Jianqi Lian | 2021 | Virologica Sinica2021，36，6： | 0 |
| 13 | Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan显示文摘Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains.It also serves as the corridor of Sino Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period(3300-2000 BC).However,the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear.Thus,we genotyped 30 insertion-deletion(InDel)markers in 444 samples from four ethnic groups(Han,Tibetan,Hui and Yi)from Sichuan Province using the Investigator■ DIPplex kit to explore the characteristics of population genetics and forensic genetic focuses.All the loci were found to be in Hardy-Weinberg Equlibrium(HWE)after applying a Bonferroni correction and no pairwise loci showed prominent linkage disequilibrium.The combined matching probability(CMP)and the combined power of discrimination(CPD)are larger than 1.8089×10^(11)and 0.9999999995,respectively.Principal component analysis,multi-dimen-sional scaling plots and Neighbour-Joining tree among 65 worldwide populations indicated that Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking popula-tions,and Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burman-speaking populations.The model-based genetic structure further supports the genetic affinity between the studied populations and linguistically close populations. | Fei Wang Guanglin He Zheng Wang Mengge Wang Jing Liu Xing Zou Shouyu Wang Mengyuan Song Ziwei Ye Mingkun Xie Yiping Hou | 2022 | Forensic Sciences Research2022，7，3： | 0 |
| 14 | Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection显示文摘Correction to:Virologica Sinica https://doi.org/10.1007/s12250-021-00445-0 In the original version of this article,one image in Fig.4 was accidently duplicated during figure layout and the dilution rate was mislabeled. | Mengyuan Li Jiali Yang Chuantao Ye Peiyu Bian Xiaofei Yang Haijun Zhang Chuanyu Luo Zhifeng Xue Yingfeng Lei Jianqi Lian | 2021 | Virologica Sinica2021，36，6： | 0 |
| 15 | Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy:a comprehensive review显示文摘Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an ability to elicit curative effects via systemic administration.Tumor cells often create an unfavorable immunosuppressive microenvironment that degrade viral structures and impede viral replication;however,recent studies have established that viruses altered via genetic modifications can serve as effective oncolytic agents to combat hostile tumor environments.Specifically,oncolytic vaccinia virus(OVV)has gained popularity owing to its safety,potential for systemic delivery,and large gene insertion capacity.This review highlights current research on the use of engineered mutated viruses and gene-armed OVVs to reverse the tumor microenvironment and enhance antitumor activity in vitro and in vivo,and provides an overview of ongoing clinical trials and combination therapies.In addition,we discuss the potential benefits and drawbacks of OVV as a cancer therapy,and explore different perspectives in this field. | Mengyuan Li Minghuan Zhang Qian Ye Yunhua Liu Wenbin Qian | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 16 | CORRECTION:Correction to:Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘In the original version of Fig.41 and 4J,the cutoff lines were accidently shifted during figure layout.Figures 41 and 4J are re-drawn and provided below. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 0 |
| 17 | Control of aggregated structure of photovoltaic polymers for high-efficiency solar cells显示文摘π-Conjugated organic/polymer materials-based solar cells have attracted tremendous research interest in the fields of chemistry,physics,materials science,and energy science.To date,the best-performance polymer solar cells(PSCs)have achieved power conversion efficiencies exceeding 18%,mostly driven by the molecular design and device structure optimization of the photovoltaic materials.This review article provides a comprehensive overview of the key advances and current status in aggregated structure research of PSCs.Here,we start by providing a brief tutorial on the aggregated structure of photovoltaic polymers.The characteristic parameters at different length scales and the associated characterization techniques are overviewed.Subsequently,a variety of effective strategies to control the aggregated structure of photovoltaic polymers are discussed for polymer:fullerene solar cells and polymer:nonfullerene small molecule solar cells.Particularly,the control strategies for achieving record efficiencies in each type of PSCs are highlighted.More importantly,the in-depth structure-performance relationships are demonstrated with selected examples.Finally,future challenges and research prospects on understanding and optimizing the aggregated structure of photovoltaic polymers and their blends are provided. | Mengyuan Gao Wenxuan Wang Jianhui Hou Long Ye | 2021 | Aggregate2021，2，5： | 0 |
| 18 | Thermally stable poly(3-hexylthiophene):Nonfullerene solar cells with efficiency breaking 10%显示文摘Solar cells featuring polythiophenes as donors are one of the optoelectronic devices that hold notable promises for commercial application,profiting from the lowest synthetic complexity and excellent scalability.However,the complex phase behaviors of polythiophenes and their blends put constraints on modulating electrical performance and thus realizing stable performance under thermal stress.In this contribution,we present a multi-technique approach that combines calorimetry,scattering,spectroscopy,and microscopy to thoroughly probe the thermodynamic mixing,thermal properties of materials,the evolution of nanoscale domain structure,and device performance of poly(3-hexylthiophene)(P3HT)with a range of nonfullerene acceptors(NFAs)such as ITIC,IDTBR,and ZY-4Cl.Accordingly,two blending guidelines are established for matching these popular NFAs with P3HT to enable highly efficient and thermally stable cells.First,blend systems with weak vitrification and hypo-miscibility are excellent candidates for efficient solar cells.Furthermore,high thermal stability can be achieved by selecting NFAs with diffusion-limited crystallization.The P3HT:ZY-4Cl blend was found to endow the best performance of over 10%efficiency and an exceptionally high T_(80) lifetime of>6000 h under continuous thermal annealing,which are among the highest values for P3HT-based solar cells.This realization of high thermal stability and efficiency demonstrates the remarkable potentials of simple polythiophene:nonfullerene pairs in electronic applications. | Mengyuan Gao Yang Liu Kaihu Xian Zhongxiang Peng Kangkang Zhou Junwei Liu Saimeng Li Fei Xie Wenchao Zhao Jidong Zhang Xuechen Jiao Long Ye | 2022 | Aggregate2022，3，5： | 0 |
| 19 | Case study of a rhizosphere microbiome assay on a bamboo rhizome with excessive shoots显示文摘Young moso bamboo shoots are a popular seasonal food and an important source of income for farmers,with value for cultivation estimated at$30,000 per hectare.Bamboo also has great environmental importance and its unique physiology is of scientific interest.A rare and valuable phenomenon has recently appeared where a large number of adjacent buds within a single moso bamboo rhizome have grown into shoots.Although of practical importance for the production of edible shoots,such occurrences have not been scientifically studied,due to their rarity.Analysis of collected reports from enhanced shoot production events in China showed no evidence that enhanced shoot development was heritable.We report the analysis of the rhizosphere microbiome from a rhizome with 18 shoots,compared to rhizomes having one or no shoots as controls.The community of prokaryotes,but not fungi,correlated with the shoot number.Burkholderia was the most abundant genus,which was negatively correlated with rhizome shoot number,while Clostridia and Ktedonobacteria were positively correlated.Two Burkholderia strains were isolated and their plant-growth promoting activity was tested.The isolated Burkholderia strains attenuated the growth of bamboo seedlings.These data provide the first study on excessive shoot development in bamboo,which will facilitate hypothesis building for future studies. | Fuqiang Cui Yifan Yang Mengyuan Ye Wei Wei Wenqian Huang Ying Wu Xi Jiao Xiaoxue Ye Shutong Zhou Zhubing Hu Yinhai Zhang Renyi Gui Wenwu Wu Kim Yrjala Kirk Overmyer Shenkui Liu | 2021 | Forestry Research2021，1，1： | 0 |
| 20 | A ratiometric fluorescent nanoprobe based on ZIF-8@AuNCs-Tb for visual detection of 2,6-pyridinedicarboxylic acid显示文摘The rapid and sensitive detection of 2,6-pyridinedicarboxylic acid(DPA),one of the main biomarkers of Bacillus anthracis,is of great significance for the screening and diagnosing of anthrax.Herein,a ratiometric fluorescent nanoprobe based on zeolite imidazolate framework-8(ZIF-8)@AuNCs-Tb was constructed by embedding both gold nanoclusters(AuNCs)and terbium ions(Tb^(3+))into ZIF-8 for highresolution visual detection of DPA.Due to the aggregation induced emission enhancement(AIE)effect,AuNCs embedded in ZIF-8 emit a strong orange fluorescence.When Tb^(3+)is coordinated with DPA added to the nanoprobe,it will emit a strong green fluorescence owing to the antenna effect.The results reveal that ZIF-8@AuNCs-Tb nanoprobe can detect DPA effectively with a good linear relationship in the range of 40-200 and 200-1000μmol/L,the limit of detection(LOD)is estimated at 1.8μmol/L(3σ/k).The proposed nanoprobe shows a remarkable selectivity for DPA and is quite easy to realize visualization based on the fluorescent color changing from orange to green,which has potential application in clinical diagnosis.The feasibility of this method was verified by standard addition recovery experiments simulating the release of DPA from spores. | Kang Shao Siyu Wen Mengyuan Zhang Jing Wang Shiyi Ye Zaifa Pan | 2022 | Journal of Rare Earths2022，40，8： | 0 |
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