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| 1 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 2 | Parenting stress and affective symptoms in parents of autistic children显示文摘We examined parenting stress and mental health status in parents of autistic children and assessed factors associated with such stress. Participants were parents of 188 autistic children diagnosed with DSM-IV criteria and parents of 144 normally developing children. Parents of autistic children reported higher levels of stress, depression, and anxiety than parents of normally developing children. Mothers of autistic children had a higher risk of depression and anxiety than that did parents of normally developing children. Mothers compared to fathers of autistic children were more vulnerable to depression. Age, behavior problems of autistic children, and mothers' anxiety were significantly associated with parenting stress. | GONG Yun DU YaSong LI HuiLin ZHANG XiYan AN Yu WU Bai-Lin | 2015 | Science China(Life Sciences)2015，58，10： | 3 |
| 3 | Impact of diabetes on prognosis of gastric cancer patients performed with gastrectomy显示文摘Objective: This study aimed to determine the impact of type 2 diabetes mellitus(T2 DM) on clinical outcomes of gastric cancer(GC) patients and explore whether metformin use and good glycemic control could reverse it.Methods: Clinicopathologic data of consecutive GC patients who underwent gastrectomy at Nanfang Hospital between October 2004 and December 2015 were included. Propensity score matching(PSM) was performed to balance the important factors of the disease status between non-T2 DM and T2 DM group. The last follow-up time was January 2019.Results: A total of 1,692 eligible patients(1,621 non-T2 DM vs. 71 T2 DM) were included. After PSM, nonT2 DM group(n=139) and T2 DM group(n=71) were more balanced in baseline variables. The 5-year cancerspecific survival(CSS) rate in T2 DM group(47.0%) was inferior to that in non-T2 DM group(58.0%), but did not reach statistical significance [hazard ratio(HR)=1.319, 95% confidence interval(95% CI): 0.868-2.005, P=0.192].While the 5-year progress-free survival(PFS) rate of T2 DM group(40.6%) is significantly worse than that in nonT2 DM group(56.3%)(HR=1.516, 95% CI: 1.004-2.290, P=0.045). Univariate and multivariate analyses showed that T2 DM was an independent risk factor for PFS but not for CSS. In T2 DM group, metformin use subgroup was associated with superior 5-year CSS and PFS in compared with non-metformin use subgroup, although the difference was not statistically significant(5-year CSS: 48.0% vs. 45.4%, HR=0.680, 95% CI: 0.352-1.313,P=0.246;5-year PFS: 43.5% vs. 35.7%, HR=0.763, 95% CI: 0.400-1.454, P=0.406). The 5-year CSS rate was47.5% in good glycemic control subgroup and 44.1% in poor glycemic control subgroup(HR=0.826, 95% CI:0.398-1.713, P=0.605). And both two subgroups yielded a similar 5-year PFS rate(42.2% vs. 36.3%, HR=0.908,95% CI: 0.441-1.871, P=0.792).Conclusions: DM promoted disease progress of GC after gastrectomy but had not yet led to the significant discrepancy of CSS. For GC patients with T2 DM, metformin use was associated with superior survival but without statistical significance, while better glycemic control could not improve the prognosis. | Xinhua Chen Yuehong Chen Tao Li Luo Jun Tian Lin Yanfeng Hu Huilin Huang Hao Chen Hao Liu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 2 |
| 4 | Effect and mechanism of YB-1 knockdown on glioma cell growth,migration,and apoptosis显示文摘Ybox binding protein 1(YB-1)is manifested as its involvement in cell proliferation and differ-entiation and malignant cell transformation.Overexpression of YB-1 is associated with glioma progression and patient survival.The aim of this study is to investigate the influence of YB-1 knockdown on glioma cell progression and reveal the mechanisms of YB-1 knockdown on glioma cell growth,migration,and apoptosis.It was found that the knockdown of YB-1 decreased the mRNA and protein levels of YB-1 in U251 glioma cells.The knockdown of YB-1 significantly inhibited cell proliferation,colony formation,and migration in vitro and tumor growth in vivo.Proteome and phosphoproteome data revealed that YB-1 is involved in glioma progression through regulating the expression and phosphorylation of major proteins involved in cell cycle,adhesion,and apoptosis.The main regulated proteins included CCNB1,CCNDBP1,CDK2,CDK3,ADGRG1,CDH-2,MMP14,AIFM1,HO-1,and BAX.Furthermore,it was also found that YB-1 knockdown is associated with the hypo-phosphorylation of ErbB,mTOR,HIF-1,cGMP-PKG,and insulin signaling pathways,and proteoglycans in cancer.Our findings indicated that YB-1 plays a key role in glioma progression in multiple ways.including regulating the expression and phosphorylation of major proteins associated with cell cycle,adhesion,and apoptosis. | Huilin Gong Shan Gao Chenghuan Yu Meihe Li Ping Liu Guanjun Zhang Jinning Song Jin Zheng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 2 |
| 5 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 6 | Optimisation of enzy- matic hydrolysis of the by-products of marine crab processing using mixed enzymes显示文摘 | L1U Guangming CAO Minjie YU Huilin | 2010 | Food science and Technology2010，45，6： | 1 |
| 7 | Direct electro- chemistry and electrocatalysis of hemoglobin on nanostruc- tured gold colloid-silk fibroin modified glassy carbon electrode 显示文摘 | Guo Huilin Liu Deye Yu Xiaodong | 2009 | Sensors and Actuators B2009，139，2： | 1 |
| 8 | Strain induced martensitic transformation in fatigue crack tip zone for an ultra-high strength steel 显示文摘 | Gao Huilin Tan Yu xun Wang Xiaotian | 1988 | ActaMetallurgica Sinica1988，24，1： | 1 |
| 9 | Distinct effects of mutations on biophysical properties of human prion protein monomers and oligomers显示文摘 | Yuanhui Yu Ziyao Yu Zhen Zheng Huilin Wang Xueji Wu Chenyun Guo Donghai Lin | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 1 |
| 10 | Improved Fatigue Behavior of Pipeline Steel Welded Joint by Surface Mechanical Attrition Treatment(SMAT)显示文摘A pipeline steel X80 with welded joint was subjected to surface mechanical attrition treatment(SMAT).After SMAT,a nanostructure surface layer with an average grain size of about 10 nm was formed in the treated sample,and the fatigue limit of the welded joint was elevated by about 13% relative to the untreated joints.In the low and the high amplitude stress regimes,both fatigue strength and fatigue life were enhanced.Formation of the nanostructured surface layer played more important role in the enhanced fatigue behavior than that of residual stress induced by the SMAT. | Yu Wang Min Huang Lei Zhou Zhixin Cong Huilin Gao | 2009 | Journal of Materials Science & Technology2009，25，4： | 1 |
| 11 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 12 | Progress on nanostructured gel catalysts for oxygen electrocatalysis显示文摘Driven by the serious ecological problems,it is urgent to explore high-efficiency sustainable energy technologies.Oxygen electrocatalysis acts as important half-reactions in the emerging electrochemical energy techniques including electrolysis and batteries.Gel composites exhibit the merits of rich porous,superior hydrophilic,and large specific surface area,which can significantly improve the electrolyte penetration and boost the kinetics process of oxygen electrocatalysis.In this invited contribution,the advances and challenges of a novel gel materials for oxygen electrocatalysis are summarized.Starting from the structure-activity-performance relationship of gel materials,synthetic routes of nanostructured gel materials,namely,radical polymerization,sol-gel method,hydrothermal/solvothermal reactions,and ligand-substitution method,are introduced.Afterward,the gel composites are divided into polymer-based,metal-based,and carbon-based materials in turn,and their applications in oxygen electrocatalysis are discussed respectively.At the end,the perspective and challenges for advanced gel oxygen electrocatalysts are proposed. | Huan Yang Huilin Hu Chenfeng Xia Feng You Junlong Yao Xueliang Jiang Bao Yu Xia | 2022 | Nano Research2022，15，12： | 1 |
| 13 | Diabetes mellitus promoted lymph node metastasis in gastric cancer: a 15-year single-institution experience显示文摘Background: Previous studies have revealed that diabetes mellitus (DM) promotes disease progress of gastric cancer (GC). This study aimed to further investigating whether DM advanced lymph nodes (LNs) metastasis in GC.Methods: The clinicopathologic data of GC patients with >15 examined LN (ELN) between October 2004 and December 2019 from a prospectively maintained database were included. The observational outcomes included the number (N3b status) and anatomical distribution (N3 stations) of metastatic LN (MLN).Results: A total of 2142 eligible patients were included in the study between October 2004 and December 2019. N3 stations metastasis (26.8% in DMvs. 19.3% in non-DM,P = 0.026) and N3b status (18.8% in DMvs. 12.8% in non-DM,P = 0.039) were more advanced in the DM group, and multivariate logistic regression analyses confirmed that DM was an independent factor of developing N3 stations metastasis (odds ratio [OR] = 1.771,P= 0.011) and N3b status (OR= 1.752,P= 0.028). Also, multivariate analyses determined DM was independently associated with more MLN (β = 1.424,P = 0.047). The preponderance of N3 stations metastasis (DMvs. non-DM, T1-2: 2.2%vs. 4.9%, T3: 29.0%vs. 20.3%, T4a: 38.9%vs. 25.8%, T4b: 50.0%vs. 36.6%;ELN16-29: 8.6%vs. 10.4%, ELN30-44: 27.9%vs. 20.5%, ELN ≥ 45: 37.7%vs. 25.3%), N3b status (DMvs. non-DM, T1-2: 0%vs. 1.7%, T3: 16.1%vs. 5.1%, T4a: 27.8%vs. 19.1%, T4b: 44.0%vs. 28.0%;ELN16-29: 8.6%vs. 7.9%, ELN30-44: 18.0%vs. 11.8%, ELN ≥ 45: 26.4%vs. 17.3%), and the number of MLN (DMvs. non-DM, T1-2: 0.4vs. 1.1, T3: 8.6vs. 5.2, T4a: 9.7vs. 8.6, T4b: 17.0vs. 12.8;ELN16-29: 3.6vs. 4.6, ELN30-44: 5.8vs. 5.5, ELN ≥ 45: 12.0vs. 7.7) of DM group increased with the advancement of primary tumor depth stage and raising of ELN.Conclusions: DM was an independent risk factor for promoting LN metastasis. The preponderance of LN involvement in the DM group was aggravated with the advancement of tumor depth. | Xinhua Chen Yuehong Chen Tao Li Weiqi Liang Huilin Huang Hongtao Su Chuyang Sui Yanfeng Hu Hao Chen Tian Lin Tao Chen Liying Zhao Hao Liu Guoxin Li Jiang Yu | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 14 | Effects of different processing methods on digestibility of Scylla paramamosain allergen (tropomyosin)显示文摘 | YU Huilin CAO Minjie CAI Qiufeng | 2011 | Food and Chemical Toxicology2011，，49： | 1 |
| 15 | Effects of different processing methods on digestibility of Scylla paramamosain allergen (tropomyosin)显示文摘 | YU Huilin CAO Minjie CAI Qiufeng | | 0，，04： | 1 |
| 16 | Evaluating ecotourism sustainability from the integrated perspeetive of resouree, eommunity and tourism 显示文摘 | Sheng HshiungTsaur Yu ChiangLin jo HuiLin | 2006 | Tourism Management2006，，27： | 1 |
| 17 | Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats显示文摘 | Haojie Hao Jiejie Liu Jing Shen Yali Zhao Huilin Liu Qian Hou Chuan Tong Dongdong Ti Liang Dong Yu Cheng Yiming Mu Jianping Liu Xiaobing Fu Weidong Han | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 1 |
| 18 | Impact of preoperative therapy on surgical outcomes of laparoscopic total gastrectomy for gastric/gastroesophageal junction cancer显示文摘Objective: As laparoscopic surgery is widely applied for primarily treated gastric cancer(GC)/gastroesophageal junction cancer(GEJC) and gains many advantages, the feasibility of laparoscopic total gastrectomy(LTG) for GC/GEJC patients who have received preoperative therapy(PT) has come to the fore. This study aims to analyze the safety and feasibility of LTG after PT for GC/GEJC patients.Methods: We retrospectively analyzed the data of 511 patients with GC/GEJC undergoing LTG, of which 405received LTG(LTG group) and 106 received PT+LTG(PT-LTG group) at Nanfang Hospital between June 2018and September 2022. The surgical outcomes were compared between the two groups.Results: The surgical duration was significantly longer in the PT-LTG group(P<0.001), while the incidence of intraoperative complications(P=1.000), postoperative complications(LTG group vs. PT-LTG group: 26.2% vs.23.6%, P=0.587), the classification of complication severity(P=0.271), and postoperative recovery was similar between two groups. Notably, the incidence of anastomotic complications of esophagojejunostomy was also comparable between the two groups(LTG group vs. PT-LTG group: 5.9% vs. 5.7%, P=0.918). The univariate and multivariate analysis confirmed that positive proximal margin [positive vs. negative: odds ratio(OR)=14.094, 95%confidence interval(95% CI): 2.639-75.260, P=0.002], rather than PT, has an impact on anastomotic complications after LTG(OR=0.945, 95% CI: 0.371-2.408, P=0.905).Conclusions: PT did not increase the surgical risk of LTG for GC/GEJC. Therefore, considering the positive effect of PT on long-term survival, the broader application of PT and LTG for GC/GEJC is supported by our findings. | Yuehong Chen Zhijing Yang Mingli Zhao Chuanjin Xu Yuxuan Zhu Huimin Zhang Huilin Huang Yanmei Peng Yanfeng Hu Tian Lin Tao Chen Hao Chen Liying Zhao Hao Liu Guoxin Li Jiang Yu Xinhua Chen | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 19 | Ambient-condition strategy for rapid mass production of crystalline gallium oxide nanoarchitectures toward device application显示文摘Currently,the synthesis of nanostructures still encounters two grand challenges:one is the often-required high temperatures and/or high pressures,and the other is the scalable fabrication.Here,to break through such bottlenecks,we demonstrate an ambient-condition strategy for rapid mass production of fourthgeneration semiconductor Ga_(2)O_(3)nanoarchitectures assembled by single-crystalline nanosheets in a controlled manner based on sonochemistry.Their growth is fundamentally determined by the introduced ethanediamine in rationally designed source materials,which could not only protect the metal Ga against reacting with H_(2)O into GaOOH,but facilitate the reaction of Ga with OH·radicals for target crystalline Ga_(2)O_(3)nanostructures.As a proof of concept for applications,the as-fabricated Ga_(2)O_(3)nanoarchitectures exhibit superb performances for electromagnetic wave absorption with a reflection loss value of 52.2 dB at 8.1 GHz,and ammonia sensing with high sensitivity and selectivity at room temperature,representing their bright future to be commercially applied in modern devices. | Dongdong Zhang Hao Yu Guiqin You Gang Shao Zhi Fang Zhao Liang Tian Zhang Huilin Hou Lin Wang Qiaochu Chen Jie Teng Weiyou Yang | 2023 | Journal of Materials Science & Technology2023，，32： | 0 |
| 20 | Strategies for high-performance perovskite solar cells from materials, film engineering to carrier dynamics and photon management显示文摘In recent years,halide perovskite solar cells(HPSCs)have attracted a great atten-tion due to their superior photoelectric performance and the low-cost of processing their quality films.In order to commercialize HPSCs,the researchers are focusing on developing high-performance HPSCs.Many strategies have been reported to increase the power conversion efficiency and the long-term stability of HPSCs over the past decade.Herein,we review the latest efforts and the chemical-physical principles for preparing high-efficiency and long-term stability HPSCs in particu-lar,concentrating on the perovskite materials,technologies for perovskite films,charge transport materials and ferroelectric effect to reduce the carrier loss,and photon management via plasmonic and upconversion effects.Finally,the key issues for future researches of HPSCs are also discussed with regard to the require-ments in practical application. | Huilin Li Chong Chen Hangyu Hu Yu Li Zhitao Shen Fumin Li Ying Liu Rong Liu Junwei Chen Chao Dong Sally Mabrouk Raja Sekhar Bobba Abiral Baniya Mingtai Wang Quinn Qiao | 2022 | InfoMat2022，4，7： | 0 |
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