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| 1 | Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury显示文摘Cell-based technologies are used as a therapeutic strategy in spinal cord injury(SCI). Mesenchymal stem cells(MSCs), which secrete various neurotrophic factors and cytokines, have immunomodulatory, anti-apoptotic and anti-inflammatory effects, modulate reactivity/phenotype of astrocytes and the microglia, thereby promoting neuroregeneration seem to be the most promising. The therapeutic effect of MSCs is due to a paracrine mechanism of their action, therefore the survival of MSCs and their secretory phenotype is of particular importance. Nevertheless, these data are not always reported in efficacy studies of MSC therapy in SCI. Here, we provide a review with summaries of preclinical trials data evaluating the efficacy of MSCs in animal models of SCI. Based on the data collected, we have tried(1) to establish the behavior of MSCs after transplantation in SCI with an evaluation of cell survival, migration potential, distribution in the area of injured and intact tissue and possible differentiation;(2) to determine the effects MSCs on neuronal microenvironment and correlate them with the efficacy of functional recovery in SCI;(3) to ascertain the conditions under which MSCs demonstrate their best survival and greatest efficacy. | Yana O.Mukhamedshina Olga A.Gracheva Dina M.Mukhutdinova Yurii A.Chelyshev Albert A.Rizvanov | 2019 | Neural Regeneration Research2019，14，2： | 25 |
| 2 | Cloning, expression, and protective immunity in mice of a gene encoding the diagnostic antigen P-29 of Echinococcus granulosus显示文摘Taeniid 绦虫包虫 granulosus 是包虫病的原因的代理人,有世界范围的分发的重要动物病。在这研究,诊断抗原 P-29 从 E 被克隆。granulosus 并且在 Escherichia 表示了 coli。顺序分析证明 EgP-29 包含 717-bp 开的读框架并且与 27.1 kDa 的预言的分子的重量编码 238 氨基酸残余的蛋白质。recombinant EgP-29 (rEgP-29 ) 能在西方的弄污与反老鼠 sera 被认出。特定的抗体被连接酶的 immunosorbent 试金检测。老鼠与 rEgP-29 种牛痘并且与 E intraperitoneally 质问了。granulosus protoscoleces 揭示了 96.6% 的重要保护的免疫(P < 0.05 ) ,与控制组相比。因此, rEgP-29 蛋白质是一个有希望的候选人让一支有效疫苗阻止第二等的包虫病。 | Zhiyun Shi Yana Wang Zongji Li Zhaoyu Li Yang Bo Rui Ma Wei Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 19 |
| 3 | Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach显示文摘Despite advances in treatment and the declining incidence,gastric cancer remains the second leading cause of cancer-related deaths in the world.Understanding the progression from inflammation to cancer in the stomach is crucial in the development of novel therapies and strategies for treating this disease.Chronic inflammation of the stomach is typically caused by Helicobacter pylori(H.pylori)and resulting lesions may lead to gastric cancer.During the progression from inflammation to cancer,the stomach epithelium changes with evidence of the disruption of normal epithelial cell differentiation and infiltrating inflammatory cells.Coincident with the development of atrophic gastritis and metaplasia,is the loss of the gastric morphogen Sonic Hedgehog(Shh).Given its critical role as a regulator of gastric tissue homeostasis,the disruption of Shh expression during inflammation correlates with the loss of normal epithelial cell differentiation,but this has only recently been rigorously tested in vivo using a unique mouse model of targeted gastric Shh deletion.While pre-neoplastic lesions such as atrophic gastritis and in-testinal metaplasia are associated with the loss of Shh within the acid-secreting glands of the stomach,there is a clear link between elevated Shh and signaling to gastric cancers.The current review focuses on the effects of aberrant Shh expression and its role in the development of gastric cancer,specifically in response to H.pylori infection. | Alexander E Sherman Yana Zavros | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 14 |
| 4 | Research progress on electrical signals in higher plants显示文摘This review introduces the characteristics of electrical signals in higher plants and their corresponding physiological significance, and describes in detail the impact of environmental factors (e.g. light and temperature) on the electrical potential of the plants. Also, we evaluate the measurement techniques used for electrical signals in plants, including intracellular measurement, extracellular measurement, measurement of the ion channel based on the patch-clamp technique and on the non-invasive microelectrode vibrating probe technique. We also give a brief review of the applications of these methods for investigating electrical signals in plants. The ionic mechanism of electrical activity in plants is then discussed in terms of environmental response in higher plants, and this is used to provide a theoretical basis for quantitative description of the electrical signals in plants. A model for interpretation of the electrical signal mechanisms in higher plants is discussed, but further experiments are required for the verification of this model. | Xiaofei Yana, Zhongyi Wang a, Lan Huang a, Cheng Wang b, Ruifeng Hou b, Zhilong Xu b, Xiaojun Qiao b a College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China b National Engineering Research Center for Information Technology in Agriculture, Beijing 100097, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 13 |
| 5 | Digitized Outcrop Geomodeling of Ramp Shoals and its Reservoirs: as an Example of Lower Triassic Feixianguan Formation of Eastern Sichuan Basin显示文摘Numerous hydrocarbon accumulations are found in ramp crest shoals worldwide and therefore this depositional setting has a high potential of being the hydrocarbon reservoir.In this paper,we combined digital outcrop geology and traditional geological mapping to build an outcrop-based geocellular model of the ramp-crest shoal complex of the Lower Triassic Feixianguan Formation in the Eastern Sichuan Basin.The outcrop model serves as an analogue for the subsurface reservoir of the Feixianguan Formation and illustrates the complexity of the lithofacies types,stratigraphic architecture,and reservoir heterogeneities at a scale below conventional subsurface data resolution.The studied ramp-crest shoal complex consists of thirteen types of lithofacies that can be grouped into three facies-groups corresponding to subtidal intraclastic shoal,sub-to inter-tidal oolitic shoal,and tidal flat depositional environments respectively.The stratigraphic architecture of the shoal complex shows mostly a strong progradation of the high energy facies associated with an overall decrease of accommodation space associated with relative sea level still stand.Two reservoir facies associations have been recognized.The first one consists of supratidal dolomudstone and upper intertidal partially dolomitized oolitic packstone with anhydrite or nodules.These facies were deposited above the high energy oolitic grainstones and occurs as thin-bedded and laterally continuous layers,characterized by high porosity and low permeability.The second reservoir facies association is composed of intertidal crystalline dolomite and subtidal intraclastic bindstone that occurs stratigraphically below the oolitic grainstones.These deposits consist of massive laterally discontinuously beds,and are characterized by high porosity and high permeability.Both types of reservoir facies tend to be stacked vertically and migrated laterally with the progradation of the shoal complex.The construction of the outcrop-based 3D geological model provide a description and quantification of the facies distribution within a robust stratigraphic framework and the style and amount of reservoir heterogeneities associated with a ramp-crest shoal complex reservoir such as the one found in Lower Triassic Feixianguan Formation and Cambrian Longwangmiao Formation in Sichuan Basin or other ramp-crest reservoir worldwide. | QIAO Zhanfeng SHEN Anjiang ZHENG Jianfeng Xavier JANSON CHANG Shaoying WANG Xiaofang CHEN Yana LIAO Yisha | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 8 |
| 6 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 7 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 8 | Comparing the Diagnostic Criteria of MAFLD and NAFLD in the Chinese Population:A Population-based Prospective Cohort Study显示文摘Background and Aims:Metabolic dysfunction-associ-ated fatty liver disease(MAFLD)is a new concept,pro-posed in 2020;however,its applicability in Asia populations has yet to be evaluated.Therefore,we aimed to compare the difference in epidemiological and clinical characteris-tics between MAFLD and non-alcoholic fatty liver disease(NAFLD)among Asian populations.Methods:Based on the Jinchang cohort,30,633 participants were collected.The prevalence and incidence of MAFLD and NAFLD were used to analyze the epidemic characteristics and its overlapping effects.In addition,the corresponding clinical character-istics of the two diagnostic criteria populations were com-pared.Results:The prevalence rates of MAFLD and NAFLD were 21.03%and 18.83%,respectively.After an average 2.28-year follow-up,the incidence densities of MAFLD and NAFLD were 41.58 per 1,000 person-years and 37.69 per 1,000 person-years,respectively.With the increase of baseline age,body mass index(BMI),and waist circumfer-ence(WC)levels,the prevalence and incidence of MAFLD and NAFLD were on the rise(all ptrend<0.05).Among the total patients diagnosed at baseline or follow-up,most pa-tients had both MAFLD and NAFLD,accounting for 78.84%and 82.88%,respectively.Compared with NAFLD,MAFLD patients had greater proportions of males and metabolic diseases(diabetes,dyslipidemia),and had higher BMI,WC,liver enzymes,blood glucose,and lipid levels in the base-line diagnosis patients(p<0.05).Additionally,lean MAFLD patients had higher metabolic disorders than lean NAFLD patients(p<0.05).Conclusions:Compared with NAFLD,the newly proposed definition of MAFLD is more practical and accurate,and it can help identify more fatty liver pa-tients with high-risk diseases. | Cheng Yu Minzhen Wang Shan Zheng Miao Xia Hongyan Yang Desheng Zhang Chun Yin Ning Cheng Yana Bai | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 7 |
| 9 | Genetic Analysis of ele Mutants and Comparative Mapping of ele1 Locus in the Control of Organ Internal Asymmetry in Garden Pea显示文摘Previous study has shown that during zygomorphic development in garden pea(Pisum sativum L.),the organ internal(IN) asymmetry of lateral and ventral petals was regulated by a genetic locus,SYMMETRIC PETAL 1(SYP1),while the dorsoventral(DV) asymmetry was determined by two CYC-like TCP genes or the PsCYC genes,KEELED WINGS(K) and LOBED STANDARD 1(LST1).In this study,two novel loci,ELEPHANT EAR-LIKE LEAF 1(ELE1) and ELE2 were characterized.These mutants exhibit a similar defect of IN asymmetry as syp1 in lateral and ventral petals,but also display pleiotropic effects of enlarged organ size.Genetic analysis showed that ELE1 and ELE2 were involved in same genetic pathway and the enlarged size of petals but not compound leaves in ele2 was suppressed by introducing k and lst1,indicating that the enlargement of dorsal petal in ele2 requires the activities of K and LST1.An experimental framework of comparative genomic mapping approach was set up to map and clone LjELE1 locus in Lotus japonicus.Cloning the ELE1 gene will shed light on the underlying molecular mechanism during zygomorphic development and further provide the molecular basis for genetic improvement on legume crops. | Xin Li Li-Li Zhuang Mike Ambrose M. Phil. Catherine Rameau Xiao-He Hu Jun Yana Da Luo | 2010 | Journal of Integrative Plant Biology2010，52，6： | 6 |
| 10 | HFC-245fa性质及应用综述显示文摘HFC-245fa是近年来发展起来的一种碳氟氢化合物,它在发泡剂、溶剂、气溶胶及制冷设备工质等领域有着广阔的应用前景。本文回顾了美国环保署(EPA)对HFC-245fa各种应用的批准使用情况。由于具备良好的热物理特性,HFC-245fa在导热和制冷设备工质中有很多应用。文中总结了HFC-245fa的热物理特性,并根据几个实例对HFC-245fa的各种应用进行了讨论,包括在离心式冷冻器、有机兰金循环(Or-ganicRankineCycle)中的能源再生、低温制冷中的显热转换以及被动式冷却设备中的应用等。此外,还讨论了HFC-245fa的热稳定性、化学稳定性及其和建筑材料的相容性,并介绍了迄今为止所进行的一些热、化学稳定性测试及测试结果。讨论还涉及了金属、工程塑料、人造橡胶等几种普通建筑材料对HFC-245fa的可接收性。关于使用HFC-245fa可能带来的健康、安全和环境问题,如毒性、相关部门的参考使用暴露极限值、易燃性。此外对臭氧层的破坏、对全球变暖趋势的影响以及产品的安全管理等,文章也进行了相应的介绍。 | Gary J.Zyhowski Sr. Mark W.Spatz Samuel Yana Motta 张社 | 2003 | 家电科技2003，，8： | 4 |
| 11 | Three-dimensional nitrogen-doped graphene hydrogel supported Co-CeOx nanoclusters as efficient catalysts for hydrogen generation from hydrolysis of ammonia borane显示文摘The development of highly active noble-metal-free catalysts for catalytic hydrolysis of ammonia borane is mandatory for its application in hydrogen storage.Herein,Co-CeO_xnanoclusters have been successfully anchored on a three-dimensional nitrogen-doped graphene hydrogel(NGH)by a simple coreduction method and further used as efficient catalysts to catalytic hydrolysis of ammonia borane at room temperature.Thanks to the strong synergistic electronic effect between Co and CeO_x,as well as the strong metal-support interaction between Co-CeO_xand 3D NGH,the as-synthesized Co-(CeO_x)_(0.91)/NGH catalyst exhibits superior catalytic activity toward hydrolysis of ammonia borane,with the turnover frequency(TOF)value of 79.5 min^(-1),which is almost 13 times higher than that of Co/NGH,and higher than most of the reported noble-metal-free catalysts. | Yana Men Jun Su Chaozhang Huang Lijing Liang Ping Cai Gongzhen Cheng Wei Luo | 2018 | Chinese Chemical Letters2018，29，11： | 3 |
| 12 | NiPt nanoparticles supported on CeO_2 nanospheres for efficient catalytic hydrogen generation from alkaline solution of hydrazine显示文摘Searching for highly efficient catalysts toward dehydrogenation of hydrazine for chemical hydrogen storage is highly desirable for the development of hydrogen economy. Herein, we report a simple in situ co-reduction synthesis of NiPt nanoparticles supported on CeO_2 nanospheres and their superior catalytic performance for hydrogen generation from alkaline solution of hydrazine at room temperature. Thanks to the strong electronic interaction arising from synergistic effect at atomic lever and support-metal interaction between NiPt and CeO_2.The obtained Ni_5Pt_5-CeO_2 catalyst exhibits 100% hydrogen selectivity and superior catalytic performance for hydrogen generation from alkaline solution of hydrazine at room temperature, with a TOF value of 416 h 1. | Yana Men Jun Su Xiangli Wang Ping Cai Gongzhen Cheng Wei Luo | 2019 | Chinese Chemical Letters2019，30，3： | 3 |
| 13 | SilkRoute: A Framework for Publishing Relational Data in XML显示文摘 | Mary Fernández Yana Kadiyska | 2002 | ACM Transactions on Database Systems2002，27，3： | 3 |
| 14 | Contrastive Analysis of Software Networks Based on Different Coupling Relationships显示文摘Several software network models are constructed based on the relationships between classes in the object-oriented software systems.Then,a variety of well-known open source software applications are statistically analyzed by using these models.The results show that: (1) Dependency network does play a key role in software architecture;(2) The exponents of in-degree and total-degree distribution functions of different networks differ slightly,while the exponent of out-degree varies obviously;(3) Weak-coupling relationships have greater impact on software architecture than strong-coupling relationships.Finally,a theoretically analysis on these statistical phenomena is proposed from the perspectives of software develop technology,develop process and developer’s habits,respectively. | XU Guoai GAO Yang QI Yana PENG Junhao TANG Xianjing | 2010 | China Communications2010，7，4： | 3 |
| 15 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 16 | Genetically modified human umbilical cord blood cells as a promising strategy for treatment of spinal cord injury显示文摘Spinal cord injury(SCI)continues to be a pressing health and social problem.The injury leads to neuronal and glial cell death accompanied by degeneration of nerve fibers.There are currently no particularly effective treatments.SCI causes profound disability of people affected and has attracted increased attention in the international field of neuroregeneration.For the past two decades, | Yana O. Mukhamedshina Albert A. Rizvanov | 2016 | Neural Regeneration Research2016，11，9： | 2 |
| 17 | Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis显示文摘AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro.METHODS:Helicobacter felis(H.felis)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 wk.After treatment,mice were analyzed for morphological changes and gastric acid content.Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of H.felis infection.Interestingly, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented H.felis-induced inflammation and atrophy.Compared to the uninfected controls,infected mice also had significantly decreased gastric acid.After eradication of H.felis with THIO treatment,gastric acidity was restored.Compared to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection.Despite elevated gastric acid levels, after eradication of H.felis with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was suppressed.Immunofluorescence revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during H.felis infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation.The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin. | Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 2 |
| 18 | Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections显示文摘As a typical human pathogenic fungus,Cryptococcus neoformans is a life-threatening invasive fungal pathogen with a worldwide distribution causing w700,000 deaths annually.Cryptococcosis is not just an infection with multi-organ involvement,intracellular survival and extracellular multiplication of the fungus also play important roles in the pathogenesis of C.neoformans infections.Because adequate accumulation of drugs at target organs and cells is still difficult to achieve,an effective delivery strategy is desperately required to treat these infections.Here,we report a bioresponsive micro-to-nano(MTN)system that effectively clears the C.neoformans in vivo.This strategy is based on our in-depth study of the overexpression of matrix metalloproteinase 3(MMP-3)in infectious microenvironments(IMEs)and secreted protein acidic and rich in cysteine(SPARC)in several associated target cells.In this MTN system,bovine serum albumin(BSA,a natural ligand of SPARC)was used for the preparation of nanoparticles(NPs),and then microspheres were constructed by conjugation with a special linker,which mainly consisted of a BSA-binding peptide and an MMP-3-responsive peptide.This MTN system was mechanically captured by the smallest capillaries of the lungs after intravenous injection,and then hydrolyzed into BSA NPs by MMP-3 in the IMEs.The NPs further targeted the lung tissue,brain and infected macrophages based on the overexpression of SPARC,reaching multiple targets and achieving efficient treatment.We have developed a size-tunable strategy where microspheres'shrink'to NPs in IMEs,which effectively combines active and passive targeting and may be especially powerful in the fight against complex fungal infections. | Liting Cheng Miao-Miao Niu Tong Yana Zhongyi Ma Kexin Huang Ling Yang Xin Zhong Chong Li | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 19 | Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota显示文摘Decreased muscle mass and function,also known as sarcopenia,is common in patients with cirrhosis and is associated with a poor prognosis.Although the pathogenesis of this disorder has not been fully elucidated,a disordered gutmuscle axis probably plays an important role.Decreased barrier function of the gut and liver,gut dysbiosis,and small intestinal bacterial overgrowth(SIBO)can lead to increased blood levels of ammonia,lipopolysaccharides,pro-inflammatory mediators,and myostatin.These factors have complex negative effects on muscle mass and function.Drug interventions that target the gut microbiota(long-term use of rifaximin,lactulose,lactitol,or probiotics)positively affect most links of the compromised gut-muscle axis in patients with cirrhosis by decreasing the levels of hyperammonemia,bacterial translocation,and systemic inflammation and correcting gut dysbiosis and SIBO.However,although these drugs are promising,they have not yet been investigated in randomized controlled trials specifically for the treatment and prevention of sarcopenia in patients with cirrhosis.No data exist on the effects of fecal transplantation on most links of gut-muscle axis in cirrhosis;however,the results of animal experimental studies are promising. | Roman Maslennikov Aliya Alieva Elena Poluektova Yury Zharikov Andrey Suslov Yana Letyagina Ekaterina Vasileva Anna Levshina Evgenii Kozlov Vladimir Ivashkin | 2023 | World Journal of Gastroenterology2023，29，27： | 2 |
| 20 | Chemical analysis of As- tragalus mongholicus polysaeeharides and antioxidartt activity of the pol- ysaccharides显示文摘 | Hui Yana Yupeng Xiea Shiguang Sun | 2010 | Carbohydrate Polymers2010，82，： | 1 |
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