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| 1 | Unmanned aerial systems coordinate target allocation based on wolf behaviors显示文摘Unmanned aerial systems (UASs), especially the cluster of UAS, are highly focused and widely used in various domains. The application of small and inexpensive UAS with a large-scale group to perform complex tasks has become a mainstream trend. Thus, collaborative task assignment of UAS has become a problem that must be solved. | Haibin DUAN Qing YANG Yimin DENG Pei LI Huaxin QIU Tianjie ZHANG Daifeng ZHANG Mengzhen HUO Yankai SHEN | 2019 | Science China(Information Sciences)2019，62，1： | 22 |
| 2 | Hepatic macrophages in liver homeostasis and diseasesdiversity,plasticity and therapeutic opportunities显示文摘Macrophages,which are key cellular components of the liver,have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases.Upon liver injury,resident Kupffer cells(KCs)sense disturbances in homeostasis,interact with hepatic cell populations and release chemokines to recruit circulating leukocytes,including monocytes,which subsequently differentiate into monocyte-derived macrophages(MoMφs)in the liver.Both KCs and MoMφs contribute to both the progression and resolution of tissue inflammation and injury in various liver diseases.The diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver diseases.In this review,we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease. | Yankai Wen Joeri Lambrecht Cynthia Ju Frank Tacke | 2021 | Cellular & Molecular Immunology2021，18，1： | 21 |
| 3 | Effects of pneumoperitoneum of laparoscopic cholecystectomy on the coagulation system of patients: a prospective observational study显示文摘 | Amin Buhe Zhang Chengcai Yan Wei Sun Zhipeng Zhang Yankai Du Dexiao Gong Ke | 2014 | Chinese Medical Journal2014，，14： | 16 |
| 4 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 5 | Park7 interacts with p47phox to direct NADPH oxidase- dependent ROS production and protect against sepsis显示文摘 | Wenjun Liu Hailong Wu Lili Chen Yankai Wen Xiaoni Kong Wei-Qiang Gao | 2015 | Cell Research2015，25，6： | 5 |
| 6 | Post-synthesis modification of porous organic polymers with amine: a task-specific microenvironment for CO2 capture显示文摘 | Yankai Li Li Yang Xiang Zhu Jun Hu Honglai Liu | 2017 | International Journal of Coal Science & Technology2017，4，1： | 2 |
| 7 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 8 | Ecological City Planning in Urban Planning and Design显示文摘Based on the actual situation,this paper summarizes and analyzes the key points of eco-city planning in urban planning and design,and hopes to provide help to researchers in related fields after the discussion. | Yitong Li Yankai Wang | 2019 | Journal of Architectural Research and Development2019，3，6： | 2 |
| 9 | Linking key intervention timings to rapid declining effective reproduction number to quantify lessons against COVID-19显示文摘Coronavirus disease 2019(COVID-19)is currently under a global pandemic trend.The efficiency of containment measures and epidemic tendency of typical countries should be assessed.In this study,the efficiency of prevention and control measures in China,Italy,Iran,South Korea,and Japan was assessed,and the COVID-19 epidemic tendency among these countries was compared.Results showed that the effective reproduction number(Re)in Wuhan,China increased almost exponentially,reaching a maximum of 3.98 before a lockdown and rapidly decreased to below 1 due to containment and mitigation strategies of the Chinese government.The Re in Italy declined at a slower pace than that in China after the implementation of prevention and control measures.The Re in Iran showed a certain decline after the establishment of a national epidemic control command,and an evident stationary phase occurred because the best window period for the prevention and control of the epidemic was missed.The epidemic in Japan and South Korea reoccurred several times with the Re fluctuating greatly.The epidemic has hardly rebounded in China due to the implementation of prevention and control strategies and the effective enforcement of policies.Other countries suffering from the epidemic could learn from the Chinese experience in containing COVID-19. | Zhihang Peng Wenyu Song Zhongxing Ding Quanquan Guan Xu Yang Qiaoqiao Xu Xu Wang Yankai Xia | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 10 | Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hcgc-terminal peptide carried by mycobacterial heat-shock protein Hsp65 显示文摘 | Yi H Rong Y Yankai Z | 2006 | Vaccine2006，24，14： | 1 |
| 11 | Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection Clusters显示文摘A novel RNA virus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is responsible for the ongoing outbreak of coronavirus disease 2019(COVID-19).Population genetic analysis could be useful for investigating the origin and evolutionary dynamics of COVID-19.However,due to extensive sampling bias and existence of infection clusters during the epidemic spread,direct applications of existing approaches can lead to biased parameter estimations and data misinterpretation.In this study,we first present robust estimator for the time to the most recent common ancestor(TMRCA)and the mutation rate,and then apply the approach to analyze 12,909 genomic sequences of SARS-CoV-2.The mutation rate is inferred to be 8.69×10^(−4) per site per year with a 95%confidence interval(CI)of[8.61×10^(−4),8.77×10^(−4)],and the TMRCA of the samples inferred to be Nov 28,2019 with a 95%CI of[Oct 20,2019,Dec 9,2019].The results indicate that COVID-19 might originate earlier than and outside of Wuhan Seafood Market.We further demonstrate that genetic polymorphism patterns,including the enrichment of specific haplotypes and the temporal allele frequency trajectories generated from infection clusters,are similar to those caused by evolutionary forces such as natural selection.Our results show that population genetic methods need to be developed to efficiently detangle the effects of sampling bias and infection clusters to gain insights into the evolutionary mechanism of SARS-CoV-2.Software for implementing VirusMuT can be downloaded at https://bigd.big.ac.cn/biocode/tools/BT007081. | Qi Liu Shilei Zhao Cheng-Min Shi Shuhui Song Sihui Zhu Yankai Su Wenming Zhao Mingkun Li Yiming Bao Yongbiao Xue Hua Chen | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 1 |
| 12 | The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males显示文摘 | Yan Han Yankai Xia Jiayuan Han Jinping Zhou Shoulin Wang Pengfei Zhu Rencheng Zhao Nianzu Jin Ling Song Xinru Wang | 2008 | Chemosphere2008，，5： | 1 |
| 13 | Ten tandem repeats of beta-hCG 109-118 enhance immunogenicity and anti-tumor effects of beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65显示文摘 | Yankai Z Rong Y Yi H | 2006 | Biochem Biophys Res Commun2006，345，： | 1 |
| 14 | Changes of mesenteric lymph microcirculation and intestinal lymph circulation during shock in rat 显示文摘 | Zhang Jing Liu Yankai | 1994 | Lymphology1994，，： | 1 |
| 15 | Improved efficacy of DNA vaccina-tion against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacte heat-shock protein HSP65显示文摘 | Yi H Rong Y Yankai Z | 2006 | Vaccine2006，24，14： | 1 |
| 16 | Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis显示文摘 | Juan Wen Jie Jiang Chenyue Ding Juncheng Dai Yao Liu Yankai Xia Jiayin Liu Zhibin Hu | 2012 | Fertility and Sterility2012，，： | 1 |
| 17 | Freeway Slope Stability E- valuation Based on Multi -Level Fuzzy Neural Network 显示文摘 | Wu Yankai Sang Xiansong Niu Bin | 2012 | Advanced Materials Research2012，430，： | 1 |
| 18 | Experimental study on filtering mixed solid-liquid dust with a sliding granular bed filter显示文摘The filtration of mixed dust that included a small number of melted(liquid)particles was studied in an experimental granular bed filter(GBF).Results show that the collection efficiency of dust containing melted particles is higher than that of dust composed of solid particles but the pressure drop from the former is higher than that of the latter.The collection efficiency and pressure drop increase as the concentration of melted particles increases.A surface sliding GBF exhibits good comprehensive performance when filtering dust,especially dust containing a mix of solid and liquid particles.The effects of the gas temperature,gas velocity,sliding filter bed thickness,and sliding collector flux on filter performance were also examined.Based on the experimental results,correlations for the collection efficiency and pressure drop for mixed dust are presented. | Yankai Peng Chuanping Liu Li Wang Shaowu Yin Lige Tong Zeyi Jiang | 2021 | Particuology2021，19，5： | 1 |
| 19 | The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma显示文摘 | Hu Xiangbing Zhang Yankai Lin Ming Lu Yong Zhang Yu Zhang Huiyong Chen Yingying Hou Jing Xing Yun Jin Liang Cao Rongyue Liu Jingjing | 2009 | International Immunopharmacology2009，，： | 1 |
| 20 | Vaccination with the repeat β-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects显示文摘 | Jie Yang Yankai Zhang Huaqian Wang Zhenqiu Gao Zeyu Wang Bin Liu Xiuhua Zhang Mingzhu Du Xiao Huang Maolei Xu Jie Wu Taiming Li Jingjing Liu Rongyue Cao | 2012 | Tumor Biology2012，，： | 1 |
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