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| 1 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro显示文摘心脏的间充质的干细胞(C-MSCs ) 是在损害以后在心修理起一个作用的内长的心脏的 stromal 房间。C-MSC-derived exosomes (Exo ) 对尖锐心肌的 ischemia/reperfusion 导致的 apoptosis 显示出保护的效果。Suxiao Jiuxin 药片(SJP ) 是为尖锐心肌的局部缺血的处理在中国使用的一个繁体中文药(TCM ) 公式,它作为主要部件包含 tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。在这研究,我们调查了 SJP 处理是否在 vitro 从 C-MSCs 影响了 exosome 版本。从老鼠准备的 C-MSCs 与 SJP (62.5 g/mL ) 被对待, TMP (25 g/mL ) 或 BOR (15 g/mL ) 。用 acetylcholinesterase 活动试金,我们发现 SJP 和 TMP 处理显著地与控制乙醇处理相比增加了 exosome 分泌物。中立 sphingomyelinase 2 (nSMase2 ) 小径在 exosome 形成是重要的并且包装。但是 nSMase2 mRNA 的既不水平也不蛋白质的水平改变了后面的 SJP, TMP 或 BOR 处理,建议那 SJP 经由一条 nSMase2 独立的小径刺激了 exosome 版本。Rab27a 和 Rab27b GTPases 控制了 exosome 分泌物小径的不同步骤。我们证明 SJP 处理显著地与控制处理相比增加了 Rab27a, SYTL4 (Rab27a 受动器) 和 Rab27b 的蛋白质层次。SJP 处理另外显著地 upregulated Rab27b 的 mRNA 水平,而非 Rab27a。而且, C-MSC-exosome 版本的导致 SJP 的增加被 Rab27b 禁止击倒,建议那 SJP 经由一条 GTPase 依赖的小径从 C-MSCs 支持 exosome 分泌物。这研究在 modulating 为 SJP 揭示新奇机制心脏的动态平衡。 | Xiao-fen RUAN Cheng-wei JU Yan SHEN Yu-tao LIU II-man KIM Hong YU Neal WEINTRAUB Xiao-long WANG Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 19 |
| 4 | Relative pollen productivities of typical steppe species in northern China and their potential in past vegetation reconstruction显示文摘The Relative Pollen Productivities(RPPs)of common steppe species are estimated using Extended R-value(ERV)model based on pollen analysis and vegetation survey of 30 surface soil samples from typical steppe area of northern China.Artemisia,Chenopodiaceae,Poaceae,Cyperaceae,and Asteraceae are the dominant pollen types in pollen assemblages,reflecting the typical steppe communities well.The five dominant pollen types and six common types(Thalictrum,Iridaceae,Potentilla,Ephedra,Brassicaceae,and Ulmus)have strong wind transport abilities;the estimated Relevant Source Area of Pollen(RSAP)is ca.1000 m when the sediment basin radius is set at 0.5 m.Ulmus,Artemisia,Brassicaceae,Chenopodiaceae,and Thalictrum have relative high RPPs;Poaceae,Cyperaceae,Potentilla,and Ephedra pollen have moderate RPPs;Asteraceae and Iridaceae have low RPPs.The reliability test of RPPs revealed that most of the RPPs are reliable in past vegetation reconstruction.However,the RPPs of Asteraceae and Iridaceae are obviously underestimated,and those of Poaceae,Chenopodiaceae,and Ephedra are either slightly underestimated or slightly overestimated,suggesting that those RPPs should be considered with caution.These RPPs were applied to estimating plant abundances for two fossil pollen spectra(from the Lake Bayanchagan and Lake Haoluku)covering the Holocene in typical steppe area,using the'Regional Estimates of Vegetation Abundance from Large Sites'(REVEALS)model.The RPPs-based vegetation reconstruction revealed that meadow-steppe dominated by Poaceae,Cyperaceae,and Artemisia plants flourished in this area before 6500–5600 cal yr BP,and then was replaced by present typical steppe. | XU QingHai CAO XianYong TIAN Fang ZHANG ShengRui LI YueCong LI ManYue LI Jie LIU YaoLiang LIANG Jian | 2014 | Science China Earth Sciences2014，57，6： | 13 |
| 5 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 6 | DESC: enabling secure data exchange based on smart contracts显示文摘Dear editor,As data are one of the most important factors of today’s intelligent systems but are relatively scarce,people try exchanging data with other organizations or public marketplaces.However,data exchange is now lack of a secure execution mecha- | Jiao LIANG Weili HAN Zeqing GUO Yaoliang CHEN Chang CAO Xiaoyang Sean WANG Fenghua LI | 2018 | Science China(Information Sciences)2018，61，4： | 5 |
| 7 | Modeling grassland net primary productivity and water-use efficiency along an elevational gradient of the Northern Tianshan Mountains显示文摘Mountainous ecosystems are considered highly sensitive and vulnerable to natural disasters and climatic changes.Therefore,quantifying the effects of elevation on grassland productivity to understand ecosystem-climate interactions is vital for mountainous ecosystems.Water-use efficiency(WUE)provides a useful index for understanding the metabolism of terrestrial ecosystems as well as for evaluating the degradation of grasslands.This paper explored net primary productivity(NPP)and WUE in grasslands along an elevational gradient ranging from 400 to 3,400 m asl in the northern Tianshan Mountains-southern Junggar Basin(TMJB),Xinjiang of China,using the Biome-BGC model.The results showed that:1)the NPP increased by 0.05 g C/(m2·a)with every increase of 1-m elevation,reached the maximum at the mid-high elevation(1,600 m asl),and then decreased by 0.06 g C/(m2·a)per 1-m increase in elevation;2)the grassland NPP was positively correlated with temperature in alpine meadow(AM,2,700-3,500 m asl),mid-mountain forest meadow(MMFM,1,650-2,700 m asl)and low-mountain dry grassland(LMDG,650-1,650 m asl),while positive correlations were found between NPP and annual precipitation in plain desert grassland(PDG,lower than 650 m asl);3)an increase(from 0.08 to 1.09 g C/(m2·a))in mean NPP for the grassland in TMJB under a real climate change scenario was observed from 1959 to 2009;and 4)remarkable differences in WUE were found among different elevations.In general,WUE increased with decreasing elevation,because water availability is lower at lower elevations;however,at elevations lower than 540 m asl,we did observe a decreasing trend of WUE with decreasing elevation,which may be due to the sharp changes in canopy cover over this gradient.Our research suggests that the NPP simulated by Biome-BGC is consistent with field data,and the modeling provides an opportunity to further evaluate interactions between environmental factors and ecosystem productivity. | QiFei HAN GePing LUO ChaoFan LI Hui YE YaoLiang CHEN | 2013 | Journal of Arid Land2013，5，3： | 5 |
| 8 | Abrupt vegetation shifts caused by gradual climate changes in central Asia during the Holocene显示文摘Understanding the response of ecosystems to past climate is critical for evaluating the impacts of future climate changes.A large-scale abrupt shift of vegetation in response to the Holocene gradual climate changes has been well documented for the Sahara-Sahel ecosystem. Whether such a non-linear response is of universal significance remains to be further addressed. Here,we examine the vegetation-climate relationships in central Asia based on a compilation of 38 high-quality pollen records. The results show that the Holocene vegetation experienced two major abrupt shifts, one in the early Holocene(Shift I, establishing shift) and another in the late Holocene(Shift II, collapsing shift), while the mid-Holocene vegetation remained rather stable. The timings of these shifts in different regions are asynchronous, which are not readily linkable with any known abrupt climate shifts,but are highly correlated with the local rainfalls. These new findings suggest that the observed vegetation shifts are attributable to the threshold effects of the orbital-induced gradual climate changes. During the early Holocene, the orbital-induced precipitation increase would have first reached the threshold for vegetation 'establishment' for moister areas, but significantly later for drier areas. In contrast, the orbital-induced precipitation decrease during the late Holocene would have first reached the threshold, and led to the vegetation 'collapse' for drier areas, but delayed for moister areas. The well-known 4.2 kyr BP drought event and human intervention would have also helped the vegetation collapses at some sites. These interpretations are strongly supported by our surface pollen-climate analyses and ecosystem simulations. These results also imply that future climate changes may cause abrupt changes in the dry ecosystem once the threshold is reached. | ZHAO Yan LIU YaoLiang GUO ZhengTang FANG KeYan LI Quan CAO XianYong | 2017 | Science China Earth Sciences2017，60，7： | 4 |
| 9 | High-resolution digital beamforming of UWB signals based on Carathéodory representation for delay compensation and array extrapolation显示文摘To realize high-resolution digital beamforming(DBF)of ultra-wideband(UWB) signals, we propose a DBF method based on Carath ′eodory representation for delay compensation and array extrapolation. Delay compensation by Carath ′eodory representation could achieve high interpolation accuracy while using the single channel sampling technique. Array extrapolation by Carath ′eodory representation reformulates and extends each snapshot, consequently extends the aperture of the original uniform linear array(ULA) by several times and provides a better realtime performance than the existing aperture extrapolation utilizing vector extrapolation based on the two dimensional autoregressive(2-D AR) model. The UWB linear frequency modulated(LFM) signal is used for simulation analysis. Simulation results demonstrate that the proposed method is featured by a much higher spatial resolution than traditional DBF methods and lower sidelobes than using Lagrange fractional filters. | DU Qiang SONG Yaoliang JI Chenhe AHMAD Zeeshan | 2018 | Journal of Systems Engineering and Electronics2018，29，5： | 2 |
| 10 | A Novel Least-Entanglement-Assisted Asymmetric Quantum Codes Based on Sliding Grill显示文摘We propose new methods for constructing novel entanglement-assisted asymmetric quantum codes based on combinatorial designs and sliding grill. Based on a special case of combinatorial designs, our proposed method can construct a type of parity check matrix with greater column weight and better decoding performance. Combined with the characteristic of asymmetric quantum channel, we propose new method of sliding grill. Mother matrix and submatrix can be constructed. The null space of the parity-check matrix gives entanglement-assisted asymmetric quantum code. Tanner graph of the code has a girth of at least 6. Our proposed quantum code has higher code rate with the same error correction capability. These families of entanglement-assisted asymmetric quantum codes consume only one copy of maximally entangled state(ebit),and outperform other quantum codes based on similar construction method according to our numerical computation. | CAO Dong SONG Yaoliang ZHU Cheng | 2014 | Chinese Journal of Electronics2014，23，3： | 2 |
| 11 | Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction 显示文摘 | Tang YaoLiang Zhao Qiang Qin Xinyu | 2005 | Ann Thorac Surg2005，80，1： | 1 |
| 12 | Full-scale experiment for segmental linings of deep-buried shield tunnels bearing high inner water pressure:Comparison of mechanical behaviors of continuous-and stagger-jointed structures显示文摘Full-scale loading tests were performed on shield segmental linings bearing a high earth pressure and high inner water pressure,focus-ing on the effects of the inner water load and assembly manner on the mechanical properties of the segmental linings.The test results indicate that the deep-buried segmental linings without inner pressure have a high safety reserve.After the action of high inner water pressure,the lining deformation will increase with the reduction of the safety reserve,caused by the significant decrease in the axial force in the linings.Because the bending moment at the segmental joints is transferred to the segment sections in the adjacent ling rings,the convergence deformation,openings of segmental joints,and bolt strains are smaller for the stagger-jointed lining than those for the continuous-jointed lining;however,dislocations appear in the circumferential joints owing to the stagger-jointed assembly.Although it significantly improves the mechanical performance of the segmental lining,stagger-jointed assembly results in compromising the water-proofing safety of circumferential joints.The stagger-jointed assembly manner can be considered to improve the service performance of shield tunnels bearing high inner water pressure on the premise that circumferential joint waterproofing is satisfied. | Long Zhou Yi Shen Linxing Guan Zhiguo Yan Wei Sun Yaoliang Li | 2023 | Underground Space2023，，1： | 1 |
| 13 | Exploring Tree Species Classification in Subtropical Regions with a Modified Hierarchy-Based Classifier Using High Spatial Resolution Multisensor Data显示文摘Tree species distribution is valuable for forest resource management.However,it is a challenge to classify tree species in subtropical regions due to complex landscapes and limitations of remote sensing data.The objective of this study was to propose a modified hierarchy-based classifier(MHBC)by optimizing the classification tree structures and variable selection method.Major steps to create an MHBC include automatic determination of classification tree structures based on the Z-score algorithm,selection and optimization of variables for each node,and classification using the optimized model.Experiments based on the fusion of Gaofen-1/Ziyuan-3 panchromatic(GF-1/ZY-3 PAN)and Sentinel-2 multispectral(MS)data indicated that(1)the MHBC provided overall classification accuracies of 85.19%for Gaofeng Forest Farm in China’s southern subtropical region and 94.4%for Huashi Township in China’s northern subtropical region,which had higher accuracies than random forest(RF)and classification and regression tree(CART);(2)critical variables for each class can be identified using the MHBC,and optimal variables of most nodes are spectral bands and vegetation indices;(3)compared to results from RF and CART,MHBC mainly improved the accuracies of the lower levels of classification tree structures(difficult classes to separate).The novelty in using MHBC is its simple and practical operation,easy-to-understand,and visualized variables that were selected in each node of the automatically constructed hierarchical trees.The robust performance of MHBC implies the potential to apply this approach to other sites for accurate classification of forest types. | Xiandie Jiang Shuai Zhao Yaoliang Chen Dengsheng Lu | 2022 | Journal of Remote Sensing2022，，1： | 1 |
| 14 | Nutrient removal performance and microbial community analysis of a combined ABR–MBR (CAMBR) process显示文摘 | Peng Wu Xiaoming Ji Xiaokang Song Yaoliang Shen | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 15 | Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases显示文摘 | Yanfang CHEN Yaoliang TANG Guo-Chang FAN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 1 |
| 16 | Adaptive Joint Synchronization and Decryption Chaotic Secure Communication Receivers显示文摘 | XU Maoge SONG Yaoliang LIU Liwei | 2008 | Chinese Journal of Electronics2008，17，1： | 1 |
| 17 | Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation显示文摘Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the renal interstitium,causing nephrocalcinosis.1 Although CaOx nephrocalcinosis is usually asymptomatic. | Haoran Liu Chen Duan Xiaoqi Yang Jianhe Liu Yaoliang Deng Hans-Göran Tiselius Zhangqun Ye Tao Wang Jinchun Xing Hua Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 1 |
| 18 | A class of check matrices constructed from Euclidean geometry and their appli- cation to quantum LDPC codes显示文摘 | Cao Dong Song Yaoliang | 2013 | Communications and Networks2013，15，1： | 1 |
| 19 | Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction 显示文摘 | Tang Yaoliang Zhao Qiang Qin Xinyu | 2005 | Ann Thorac Surg2005，80，1： | 1 |
| 20 | Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium显示文摘 | Tang Yaoliang Zhao Qiang Zhang YC | 2004 | Regulatory Peptides2004，117，1： | 1 |
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