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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer显示文摘 | Shuanqyan Tan Qiheng Gou Wenchen Pu Chenglin Guo Yun Yang Ke Wu Yaxin Liu Lunxu Liu Yu-Quan Wei Yong Peng | 2018 | Cell Research2018，28，6： | 24 |
| 3 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 4 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 5 | miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer显示文摘Non-small-cell 肺癌症(NSCLC ) 是最普通的肺癌症之一,并且 microRNAs (miRNAs ) 被报导了在 NSCLC 起必要作用。最近的研究显示了那 miR-330-3p 表情在 NSCLC 样品并且在 NSCLC 大脑转移的纸巾是起来调整的。在这研究, miR-330-3p 表示的起来规定在 NSCLC 和 20 件 NSCLC 耐心的样品被证实。而且, miR-330-3p 在 NSCLC 房间线 A549 和 H23 是过去表示的,并且 miR-330-3p 的提升功能在调整 NSCLC 房间增长和房间周期分发被调查。为了识别潜力,在 NSCLC 指向 miR-330-3p 的基因, miRNA 目标预言数据库被使用。酶活动试金和即时 RT-PCR 分析证实 miR-330-3p 否定地与早生长反应 2 的表示(EGR2 ) 被相关。而且, EGR2 mRNA 为 miR-330-3p 包含二个潜在的有约束力的地点,这也被发现。有 siRNA 的 EGR2 击倒被表明在 NSCLC 房间线作为 miR-330-3p 的在表示上有类似的效果。一起拿,我们的结果证明 EGR2 是 miR-330-3p 的一个目标。 | Xuzhi Liu Hanbing Shi Bo Liu Jianing Li Yaxin Liu Baiquan Yu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 8 |
| 6 | Design and Experimental Research on Seedling Pick-Up Mechanism of Planetary Gear Train with Combined Non-circular Gear Transmission显示文摘Currently, transplanting mechanisms for dryland plug seedlings in China are mainly semiautomatic and have low efficiency. The rotary seedling pick-up mechanism with a planetary gear train for non-uniform intermittent transmission, and a concave and convex locking arc device, has a large rigid impact. To solve these problems, according to the design requirements for a dryland plug seedling transplanting mechanism, a rotary seedling pick-up mechanism of a planetary gear train with combined non-circular gear transmission of incomplete eccentric circular and noncircular gears was proposed. This has the characteristics of two-times greater fluctuation of the transmission ratio in a cycle, and can achieve a non-uniform continuous drive. Through analysis of the working principle of the seedling pick-up mechanism, its kinematics model was established. The human–computer interaction optimization method and self-developed computer-aided analysis and optimization software were used to obtain a set of parameters that satisfy the operation requirements of the seedling pick-up mechanism. According to the optimized parameters, the structure of the seedling pick-up mechanism was designed, a virtual prototype of the mechanism was created, and a physical prototype was manufactured. A virtual motion simulation of the mechanism was performed, high-speed photographic kinematics tests were conducted, and the kinematic properties of the physical prototype were investigated, whereby the correctness of the theoretical model and the optimized design of the mechanism were verified. Further, laboratory seedling pick-up tests were conducted. The success ratio of seedling pick-up was 93.8% when the seedling pick-up efficiency of the mechanism was 60 plants per minute per row, indicating that the mechanism has a high efficiency and success ratio for seedling pick-up and can be applied to a dryland plug seedling transplanter. | Yaxin Yu Jikun Liu Bingliang Ye Gaohong Yu Xuejun Jin Liang Sun Junhua Tong | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 7 |
| 7 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 8 | Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis显示文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment. | Huiping Li Cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing Wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 9 | Assessment of effects of best management practices on agricultural non-point source pollution in Xiangxi River watershed显示文摘 | Ruimin Liu Peipei Zhang Xiujuan Wang Yaxin Chen Zhenyao Shen | 2013 | Agricultural Water Management2013，，： | 3 |
| 10 | Identifi cation of egg protein-derived peptides as xanthine oxidase inhibitors:virtual hydrolysis,molecular docking,and in vitro activity evaluation显示文摘The purpose of this study was to screen the xanthine oxidase(XO)inhibitory peptides from egg white proteins through virtual hydrolysis,in vitro activity validation,and molecular docking.The results demonstrated that tripeptide EEK from ovalbumin exhibited potent XO inhibitory activity with an IC50 value of 141μmol/L.The molecular docking results showed that tripeptide EEK bound with the active center of XO via 3 carbon hydrogen bond interactions,2 salt bridges,5 conventional hydrogen bond interactions,and 4 attractive charge interactions.The residues Glu802,Phe1009,and Arg880 may play key roles in the XO catalytic reaction.Especially,the key intermolecular forces of inhibiting XO activity may be special type of hydrogen bonds including carbon hydrogen bond interactions and attraction charge interactions.The novel tripeptide EEK is potential candidates for controlling hyperuricemia. | Zhipeng Yu Yaxin Cao Ruotong Kan Huizhuo Ji Wenzhu Zhao Sijia Wu Jingbo Liu David Shiuan | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 11 | Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene显示文摘在癌症的 multidrug 抵抗 1 的 Overexpression (MDR1 ) 为化疗的失败仍然是主要原因之一。在现在的学习,我们发现 MyoD 和 PEA3 能激活 P-glycoprotein (P-gp ) 在 SGC7901 房间的表示。MyoD 和 PEA3 击倒稀释了 MDR1 表示并且增加了 multidrug 的敏感抵抗癌症房间到被 P-gp 在 SGC7901/VCR 房间搬运的细胞毒素的药。MyoD 或 PEA3 能在 MDR1 倡导者上绑在电子盒子和 PEA3 地点并且激活它的抄写。由 MyoD 和 PEA3 的 MDR1 表示的规定可以提供潜在的方法在癌症治疗克服 MDR。 | Yaxin Zhao Jiefan Liu Qi Hong Chen Yang Li Chen Ying Chen Qiaoqiao Wang Kuaile Zhao Wei Jin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 3 |
| 12 | Solitary beam propagation in periodic layered Kerr media enables high-efficiency pulse compression and mode self-cleaning显示文摘Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed media.With both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for stability.Space-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond pulses.Taking advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic generation.We also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology. | Sheng Zhang Zongyuan Fu Bingbing Zhu Guangyu Fan Yudong Chen Shunjia Wang Yaxin Liu Andrius Baltuska Cheng Jin Chuanshan Tian Zhensheng Tao | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 13 | Pt-Re/rGO bimetallic catalyst for highly selective hydrogenation of cinnamaldehyde to cinnamylalcohol显示文摘In the present work, a series of Pt-based catalysts, alloyed with a second metal, i.e., Re, Sn, Er, La, and Y, and supported on activated carbon, ordered mesoporous carbon, N-doped mesoporous carbon or reduced graphene oxide(rGO), have been developed for selective hydrogenation of cinnamaldehyde to cinnamylalcohol. Re and rGO were proved to be the most favorable metal dopant and catalyst support, respectively. Pt_(50) Re_(50)/rGO showed the highest cinnamylalcohol selectivity of 89% with 94% conversion of cinnamaldehyde at the reaction conditions of 120 °C, 2.0 MPaH_2 and 4 h. | Zuojun Wei Xinmiao Zhu Xiaoshuang Liu Haiqin Xu Xinghua Li Yaxin Hou Yingxin Liu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 14 | Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation显示文摘We established a rat model of cardiac arrest by clamping the endotracheal tube of adult rats at expiration. Twenty-four hours after cardiopulmonary resuscitation, nerve cell injury and expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase content were increased. Rats injected with Xuebijing, a Chinese herb compound preparation, exhibited normal cellular structure and morphology, dense neuronal cytoplasm, and decreased tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase expression at 24 hours following cardiopulmonary resuscitation. These data suggest that Xuebijing can attenuate neuronal injury induced by hypoxia and reperfusion during cardiopulmonary resuscitation. | Haifeng Li Mingli Sun Yaxin Yu Xiaoliang Liu | 2011 | Neural Regeneration Research2011，6，33： | 2 |
| 15 | The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: A meta-analysis of randomized controlled trials显示文摘 | Yaxin Liu Tao Tian Huijun Zhang Linggen Gao Xianliang Zhou | 2014 | Atherosclerosis2014，，1： | 2 |
| 16 | Stimuli-responsive photofunctional materials for green and security printing显示文摘Information recording on paper has always been the most important approach to keep records of human activity and to spread civilization.With the progress of science and technology,paper with different functions should be exploited to conform to the increasing demands in various scenarios.In one aspect,traditional paper can only be used once,and using large amounts of paper causes deforestation,additional solid waste treatment,environmental pollution,and high energy consumption.Consequently,the development of rewritable paper that is environment-friendly,low cost,and can save resources is significant for green printing.In the other aspect,information leakage brings security issues,which may lead to severe consequences,such as war outbreak,economic loss,social problems,and so on.Therefore,the development of security printing has also attracted wide interests.Stimuli-responsive photofunctional materials that have reversible variations in absorption or emission in response to changes in the external environmental have a great potential for the achievement of green and security printing.To date,much progress has been made in these research areas.This paper lists different smart materials that respond to various external stimuli,such as light,water,pH,heat,and metal ions,and summarizes the recent advances towards green and security printing.Also,we discuss the current challenges and future directions in this rapidly growing research field.It is expected that this review article will stimulate and guide future studies for the advanced green and security printing. | Yun Ma Yaxin Yu Jiangang Li Shujuan Liu Wei Huang Qiang Zhao | 2021 | InfoMat2021，3，1： | 2 |
| 17 | Annual Report of CARR in 2018显示文摘China Advanced Research Reactor(CARR)successfully completed its annual operation plan in 2018 with annual cumulative power operation period of 81 d,maximum stable operation power of about 30 MW,and total released energy of about 1 524MW·d.Especially,it operated for continuous 14dfrom July 25to August 7,which created a new record of continuous stable high power operation since the construction. | LIU Jinpo QIAO Yaxin | 2018 | 中国原子能科学研究院年报2018，，1： | 2 |
| 18 | Simulation and experiment research of non-contact micro-liquid re- agent dispensing 显示文摘 | YAO Vufeng LU Shizhou LIU Yaxin | 2013 | Advance Journal of Food Science and Technology2013，5，5： | 1 |
| 19 | Bond- graph model of a piezostack driven jetting dispenser 显示文摘 | LU Shizhou LIU Yaxin YAO Yufeng | 2014 | Simulation Modelling Practice and Theory2014，49，： | 1 |
| 20 | Enhanced photo catalytic activity in anatase/TiOffB) core-shell nanofiber 显示文摘 | Li Wei Liu Chang Zhou Yaxin Bai Yang Feng Xin Yang Zhuhong Lu Linghong Lu Xiaohua Chan Kwong-Yu | 2008 | Journal of Physical Chemistry C2008，112，20： | 1 |
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