|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone physiological microenvironment and healing mechanism:Basis for future bone-tissue engineering scaffolds显示文摘Bone-tissue defects affect millions of people worldwide.Despite being common treatment approaches,autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect.This has prompted researchers to explore novel bone-regeneration methods.In recent decades,the development of bone tissue engineering(BTE)scaffolds has been leading the forefront of this field.As researchers have provided deep insights into bone physiology and the bone-healing mechanism,various biomimicking and bioinspired BTE scaffolds have been reported.Now it is necessary to review the progress of natural bone physiology and bone healing mechanism,which will provide more valuable enlightenments for researchers in this field.This work details the physiological microenvironment of the natural bone tissue,bone-healing process,and various biomolecules involved therein.Next,according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism,it elaborates the biomimetic design of a scaffold,highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration. | Guanyin Zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao | 2021 | Bioactive Materials2021，6，11： | 11 |
| 2 | Mechanisms underlying attenuation of apoptosis of cortical neurons in the hypoxic brain by flavonoids from the stems and leaves of Scutellaria baicalensis Georgi显示文摘Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi, an antioxidant, markedly improve memory impairments and neuronal injuries. In the present study, primary cortical neurons of rats were exposed to potassium cyanide to establish a model of in vitro neural cell apoptosis. Inhibition of apoptosis by flavonoids from the stems and leaves of Scutellaria baicalensis Georgi at concentrations of 18.98, 37.36, and 75.92 μg/mL was detected using this model. These flavonoids dramatically increased cell survival, inhibited cell apoptosis and excessive production of malondialdehyde, and increased the activities of superoxide dismutase, glutathione peroxidase, and Na+-K+-ATPase in primary cortical neurons exposed to potassium cyanide. The flavonoids from the stems and leaves of Scutellaria baicalensis Georgi were originally found to have a polyhydric structure and to protect against cerebral hypoxia in in vitro and in vivo models, including hypoxia induced by potassium cyanide or cerebral ischemia. The present study suggests that flavonoids from the stems and leaves of Scutellaria baicalensis Georgi exert neuroprotective effects via modulation of oxidative stress, such as malondialdehyde, superoxide dismutase, glutathione peroxidase and Na+-K+-ATPase disorders induced by potassium cyanide. | Guangxin Miao Hongxiang Zhao Ke Guo Jianjun Cheng Shufeng Zhang Xiaofeng Zhang Zhenling Cai Hong Miao Yazhen Shang | 2014 | Neural Regeneration Research2014，9，17： | 8 |
| 3 | Expression and clinical significance of HIF-1α,VEGF and Survivin in esophageal squamous cell carcinoma显示文摘Objective:To evaluate the expression and correlation of hypoxia inducible factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF)and Survivin proteins in biopsy specimens of esophageal squamous cell carcinoma(ESCC), and then determine whether the levels of expression of these proteins could predict the clinical effectiveness of radiotherapy in individual cancers.Methods:The expressions of HIF-1α,VEGF and Survivin were shown by S-P immunohistochemical stainingmethodinbiopsyspecimensofESCC,whichwereobtainedendoscopicallyfrom50patientsbeforeradiotherapy,and 10 cases of normal esophageal tissue.Results:The positive expression rates of HIF-1α,VEGF and Survivin were 68%,74% and72%inESCCrespectively.However,thethreetumormarkershadnegativeexpressionsinnormalesophagealtissue.The positive rate of HIF-1αwas positively correlated with VEGF and Survivin proteins.The positive rates of HIF-1αand Survivin were closely related to the clinical stage,radiotherapy effectiveness and survival,otherwise,the expression of HIF-1αwas closely related to distant metastasis;both of them were no correlation with the differentiation degree of tumor.The effective rates of radiotherapy and mean survival periods of those cases with positive and negative expressions of HIF-1αwere 8.8%, 10 months and 81.25%,25 months,respectively.The one,two,and three years survival rates of patients with positive and negative expressions of HIF-1αwere 38.2%,5.9%,2.9%,and 81.3%,54.2%,15.8%,respectively(P=0.001).Patients with HIF-1αpositive expression obviously survived less than those with negative expression and the difference was significant. The expression of VEGF was only related to the distant metastasis.Conclusion:Over expressions of HIF-1α,VEGF and Survivin were found in ESCC.The positive rate of HIF-1αwas positively correlated with VEGF and Survivin proteins.The expression of HIF-1αmay serve as an important parameter in evaluating response for radiotherapy and prognosis of ESCC. It may play an important role by up-regulating the transcription of VEGF and Survivin genes. | Hongzhen Zhang Yazhen Wang Ning Xu Shuchai Zhu Bin Liu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 7 |
| 4 | Biomechanical analysis of optic nerve injury treated by compound light granules and ciliary neurotrophic factor显示文摘In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone. | Yuying Jiang Haitao Xu Jingxiang Liu Peng Li Yazhen Wu | 2012 | Neural Regeneration Research2012，7，36： | 6 |
| 5 | Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose- polymerase-mediated apoptosis under high-glucose stimulation显示文摘Proliferative 糖尿病的 retinopathy,在成年人的视觉损失的主要原因,严肃的 microvascular 复杂并发症之一被糖尿病引起。poly-ADP-ribose-polymerase (PARP ) 和原子因素(NF ) 发信号的 -B 涉及损害过程。损害激活 PARP,它接着加强 NF-B 激活和原因房间 apoptosis。象 NF-B 小径一样,发信号的 Notch1 在房间增长,区别,和 apoptosis 的规定起一个关键作用。然而,在这些发信号的小径之间的连接很好没被理解。在这研究,我们使用了导致的两 streptozotocin (STZ ) 糖尿病的老鼠和人的网膜的脉管的 endothelial 房间(HRVEC ) 在高葡萄糖到有教养检测这些关系。我们发现 apoptosis 在导致 STZ 的糖尿病的老鼠和 high-glucose-treated HRVEC 被增加,它由于 Notch1 和 p-Akt 的 PARP,劈开的 caspase3,和减少的表示的增加的激活。Notch1 overexpression 的结果并且击倒显示发信号的 Notch1 参予了 PARP 和 p50 的相互作用,并且直接禁止了调停 PARP 、调停 p50 的 apoptosis。这些现象能被预告的处理经由减少 p-Akt 层次与 PI3K 禁止者 wortmannin 堵住。因此,我们的学习证明发信号的 Notch1 通过 Akt 的激活在高葡萄糖下面保护房间免受 PARP-B-induced 和 NF-B-induced apoptosis 的伤害。 | Xiuhong Qin Zhenzhen Zhang Haitao XLI Yazhen Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 4 |
| 6 | Hybrid speciation via inheritance of alternate alleles of parental isolating genes显示文摘It is increasingly realized that homoploid hybrid speciation(HHS),which involves no change in chromosome number,is an important mechanism of speciation.HHS will likely increase in frequency as ecological and geographical barriers between species are continuing to be disrupted by human activities.HHS requires the establishment of reproductive isolation between a hybrid and its parents,but the underlying genes and genetic mechanisms remain largely unknown.In this study,we reveal by integrated approaches that reproductive isolation originates in one homoploid hybrid plant species through the inheritance of altemate alleles at genes that determine parental premating isolation.The parent species of this hybrid species are reproductively isolated by differences in flowering time and survivorship on soils containing high concentrations of iron.We found that the hybrid species inherits alleles of parental isolating major genes related to flowering time from one parent and alleles of major genes related to iron tolerance from the other parent.In this way,it became reproductively isolated from one parent by the difference in flowering time and from the other by habitat adaptation(iron tolerance).These findings and further modeling results suggest that HHS may occur relatively easily via the inheritance of alternate parental premating isolating genes and barriers. | Zefu Wang Yuanzhong Jiang Hao Bi Zhiqiang Lu Yazhen Ma Xiaoyue Yang Ningning Chen Bin Tian Bingbing Liu Xingxing Mao Tao Ma Stephen P.DiFazio Quanjun Hu Richard J.Abbott Jianquan Liu | 2021 | Molecular Plant2021，14，2： | 4 |
| 7 | Bortezomib improves progression-free survival in multiple myeloma patients overexpressing preferentially expressed antigen of melanoma显示文摘 | Qin Yazhen Lu Jin Bao Li Zhu Honghu Li Jinlan Li Lingdi Lai Yueyun Shi Hongxia Wang Yazhe Liu Yanrong Jiang Bin Huang Xiaojun | 2014 | Chinese Medical Journal2014，，9： | 4 |
| 8 | Carbon Dynamics in Woody Biomass of Forest Ecosystem in China with Forest Management Practices under Future Climate Change and Rising CO_2 Concentration显示文摘It is critical to study how different forest management practices affect forest carbon sequestration under global climate change regime.Previous researches focused on the stand-level forest carbon sequestration with rare investigation of forest carbon stocks influenced by forest management practices and climate change at regional scale.In this study,a general integrative approach was used to simulate spatial and temporal variations of woody biomass and harvested biomass of forest in China during the 21st century under different scenarios of climate and CO2 concentration changes and management tasks by coupling Integrated Terrestrial Ecosystem Carbon budget(InTEC) model with Global Forest Model(G4M).The results showed that forest management practices have more predominant effects on forest stem stocking biomass than climate and CO2 concentration change.Meanwhile,the concurrent future changes in climate and CO2 concentration will enhance the amounts of stem stocking biomass in forests of China by 12%–23% during 2001–2100 relative to that with climate change only.The task for maximizing stem stocking biomass will dramatically enhance the stem stocking biomass from 2001–2100,while the task for maximum average increment will result in an increment of stem stocking biomass before 2050 then decline.The difference of woody biomass responding to forest management tasks was owing to the current age structure of forests in China.Meanwhile,the sensitivity of long-term woody biomass to management practices for different forest types(coniferous forest,mixed forest and deciduous forest) under changing climate and CO2 concentration was also analyzed.In addition,longer rotation length under future climate change and rising CO2 concentration scenario will dramatically increase the woody biomass of China during 2001–2100.Therefore,our estimation indicated that taking the role of forest management in the carbon cycle into the consideration at regional or national level is very important to project the forest carbon sequestration under future climate change and rising atmospheric CO2 concentration. | ZHOU Lei WANG Shaoqiang Georg KINDERMANN YU Guirui HUANG Mei Robert MICKLER Florian KRAXNER SHI Hao GONG Yazhen | 2013 | Chinese Geographical Science2013，23，5： | 3 |
| 9 | Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection显示文摘The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of drugs.Therefore,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in AD.RAGE is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal brain.Meanwhile,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of ROS.As a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was decreased.Neurotoxicity was also alleviated with structural regeneration and functional recovery of neurons.Besides,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the brain.Overall,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD lesion.Thus it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection. | Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 10 | Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury显示文摘Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cells were transplanted into a hypoxic-ischemic neonatal rat model via the tail vein. BrdU-positive cells at day 7 post-transplantation, as well as nestin- and neuron specific enolase-positive cells at day 14 were increased compared with those of the single neural stem cell transplantation group. In addition, the proportion of neuronal differentiation was enhanced. The genetically modified cell-transplanted rats exhibited enhanced performance in correctly crossing a Y-maze and climbing an angled slope compared with those of the single neural stem cell transplantation group. These results showed that human insulin-like growth factor 1-transfected neural stem cell transplantation promotes the recovery of the learning, memory and motor functions in hypoxic-ischemic rats. | Dengna Zhu Yanjie Jia Jun Wang Boai Zhang Guohui Niu Yazhen Fan | 2011 | Neural Regeneration Research2011，6，19： | 3 |
| 11 | Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes显示文摘Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge.Here,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanoparticle(PHA)-incorporated conductive alginate/gelatin(AG)scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory microenvironment.PHA confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the scaffold.The conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+channels.Moreover,the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species(ROS)-scavenging ability and anti-inflammatory activity.It also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in macrophages.The scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive,ROS-scavenging,anti-inflammatory,and immunomodulatory abilities.This study provides fundamental insights into the synergistical effects of conductivity,osteoinductivity,and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration. | Yazhen Li Lu Yang Yue Hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao Chaoming Xie Xiong Lu | 2022 | Bioactive Materials2022，7，12： | 3 |
| 12 | A three-dimensional diffusion equation of suspended sediment by waves and currents显示文摘Based on the law of mass conservation, a general three-dimensional diffusion equation of suspended sediment due to waves and currents, adaptable to estuarial and coastal areas, is derived by decomposing the instantaneous velocities and concentrations into three-dif-ferent-time-scale components respectively. A three-dimensional suspended sediment | Pingxing Ding Fengyan Shi Yazhen Kong | 1999 | Chinese Science Bulletin1999，44，19： | 2 |
| 13 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 14 | In Situ Measurement of Ammonia Concentration in Soil Headspace Using Fourier Transform Mid-Infrared Photoacoustic Spectroscopy显示文摘Ammonia(NH3) volatilization is one of the important pathways of nitrogen loss in alkaline soil, and the NH3 concentration in soil headspace is directly linked with the NH3 volatilization. Ammonia was characterized by Fourier transform mid-infrared photoacoustic spectroscopy(FTIR-PAS) and two typical absorption bands in the region of 850–1 200 cm-1were observed, which could be used for the prediction of NH3 concentration in the soil headspace. An alkaline soil from North China was involved in the soil incubation, pot and field experiments under three fertilization treatments(control without N input(CK), urea and coated urea). Ammonia concentrations in the soil headspace were determined in each experiment. In the soil incubation experiment, the NH3 emissions were initiated by the N input, reached the highest concentration on day 2, and decreased to the level as measured in CK after 8 d, with significantly higher NH3 emissions in the urea treatment compared to coated urea treatment, especially during the first 4 d. The NH3 concentration in soil headspace of the pot experiment showed the similar dynamics as that in the incubation experiment; however, the NH3 concentration in the soil headspace in the field experiment demonstrated a significantly different emission pattern with those of the incubation and pot experiments, and there was a 4-d delay for the NH3 concentration. Therefore, the NH3 concentration in the incubation and pot experiments could not be directly used to model the real NH3 emission in the field due to the differences in fertilization method and application rate as well as soil temperature and soil disturbance. It was recommended that light irrigation in the second week after fertilization and involvement of controlled release coated urea could be used to significantly decrease N loss from the perspective of NH3 volatilization. | DU Changwen WANG Jiao ZHOU Zijun SHEN Yazhen ZHOU Jianmin | 2015 | Pedosphere2015，25，4： | 2 |
| 15 | Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H_2O_2-induced oxidative damage to rat cortical neurons显示文摘Primary cultures of rat cortical neurons were treated with H2O2 in an in vitro model of free radical neurotoxicity. Flavonoids extracted from the stems and leaves of Scutellaria baicalensis Georgi, known as SSF, at concentrations of 18.98, 37.36 and 75.92 μg/mL, protected neurons against H2O2 injury in a dose-dependent manner. SSF increased cell survival, reduced lactate dehydrogenase release and inhibited malondialdehyde production. SSF also inhibited reductions in superoxide dismutase, glutathione peroxidase and Na+-K+-ATPase activities. These results in-dicate that SSF can protect rat cortical neurons against H2O2-induced oxidative injury. | Yongping Liu Kai Cao Hong Miao Jianjun Cheng Yazhen Shang | 2011 | Neural Regeneration Research2011，6，27： | 2 |
| 16 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 17 | i4Ocean: transfer function-based interactive visualization of ocean temperature and salinity volume data显示文摘In this paper,we present a novel ocean visualization framework,which focuses on analyzing multidimensional and spatiotemporal ocean data.GPU-based visualization methods are explored to effectively visualize ocean data.An improved ray casting algorithm for heterogeneous multisection ocean volume data is presented.A two-layer spherical shell is taken as the ocean data proxy geometry,which enables oceanographers to obtain a real geographic background based on global terrain.An efficient ray sampling technique including an adaptive sampling technique and a preintegrated transfer function is proposed to achieve high-effectiveness and high-efficiency rendering.Moreover,an interactive transfer function is also designed to analyze the 3D structure of ocean temperature and salinity anomaly phenomena.Based on the framework,an integrated visualization system called i4Ocean is created.The visualization of ocean temperature and salinity anomalies extracted interactively by the transfer function is demonstrated. | Fenglin Tian Qing Mao Yazhen Zhang Ge Chen | 2021 | International Journal of Digital Earth2021，14，6： | 2 |
| 18 | Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion显示文摘Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile,D-galactose,aging in vivo model,as well as an in vitro model of oxidative/hypoxic injury,we established a cerebral ischemia/reperfusion model in rats by middle cerebral artery occlusion.The light/electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury.Moreover,the activities of lactate dehydrogenase,Na+-K+-ATPase,Ca2+-ATPase and superoxide dismutase were significantly lowered,and the levels of malonaldehyde increased.In addition,the memory of rats worsened.However,treatment with flavonoids from Scutellaria baicalensis Georgi (35,70 and 140 mg/kg) for 13 days dramatically improved the above abnormal changes.These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and morphological consequences after cerebral ischemia/reperfusion may be beneficial for the treatment of ischemic brain disease. | Yazhen Shang Hong Zhang Jianjun Cheng Hong Miao Yongping Liu Kai Cao Hui Wang | 2013 | Neural Regeneration Research2013，8，6： | 2 |
| 19 | Preparation and thermal energy properties of paraffin/halloysite nanotube composite as form-stable phase change material显示文摘 | Zhang Jiangshan Zhang Xiang Wan Yazhen | 2012 | Solar Ener gy2012，86，5： | 1 |
| 20 | Treatment of Textile Dye Plant Effluent by Nanofiltration Membrane 显示文摘 | Xu Yazhen Remre | 1999 | Separation Science and Tectmology1999，34，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员