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| 1 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 2 | Physical Location of the Rice Pi-5(t), Glh and RTSV Genes by ISH of BAC Clones显示文摘Mapplng of low of slngle-copy sequences on plant chromosomes has proven dirricult because ofvery low frequency or slgnal detectlon. Rlce BAC Ilbrary ls belng used wldely ln rlce genome research due tolts distlnctlve advantages over other llbrary systems. In tkls study, two blotln-Iabeled rice BAC clones closelylinked to a rlce blast reslstance, green Ieaf hopper reslstance and tungro spherlcal virus resistance gene,Pi-5(t),Glh, RTSV, were in situ hybrldlred to rlce ckromosomes. They were located on the long arm andshort arm of ckromosome 4 with FL value of 40% and 100% respectively-The rrequency of signal detectionreacked 46. 8% and 59- 2%- The slgnal location were conslstent wltk the selectlve marker on rice saturatedm0Iecular map. The results demonstrated the advautages to Iocate BAC cIones to ckromosomes by in sho hybrldization and will racilitate tke rlce low of slngle-copy gene Iocation by using the BAC library. | Yan Huimin, Song Yunchun, Li Lijia, Bi Xuezhi, Fu Binying(College of Life Sciences, Wuhan University, Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 24 |
| 3 | Monitoring lake changes of Qinghai-Tibetan Plateau over the past 30 years using satellite remote sensing data显示文摘During the years 2006–2009,lakes in the Qinghai-Tibetan Plateau(QTP)were investigated using satellite remote sensing strategies.We report the results of this investigation as well as follow-up research and expanded work.For the investigation,we mainly focused on lakes whose areas are more than 1 km2.The remote sensing data that we used included 408 scenes of CBERS CCD images and 5 scenes of Landsat ETM?images in Qinghai Province and Tibet Autonomous Region.All these data were acquired around years 2005–2006.Besides remote sensing images,we also collected 1,259 topographic maps.Numbers and areas of lakes were analyzed statistically,which were then compared with those coming from the first lake investigation(implemented between the1960s and 1980s).According to our investigation,up to and around year 2005–2006,the total number of lakes in the QTP was 1,055(222 in Qinghai and 833 in Tibet),accounting for more than 30%of that of China.Thirty newborn lakes with area[1 km2were found,and 5 dead lakes with initial area[1 km2were also found.Among those 13 big lakes([500 km2),Yamzhog Yumco had seriously shrunk,and it has continued to shrink in recent years;Qinghai Lake had shrunk during the period,but some new researches indicated that it has been expanding since the year 2004;Siling Co,Nam Co,and Chibuzhang Co had expanded in the period.We divided the newborn lakes into six categories according to their forming reasons,including river expansion,wetland conversion,etc.The changes of natural conditions led to the death of four lakes,and human exploitation was the main reason for the death of Dalianhai Lake in Qinghai.We picked out three regions which were sensitive to the change of climate and ecological environment:Nagqu Region,Kekexili Region,and the source area of the Yellow River(SAYR).Lakes in both Nagqu and Kekexili have been expanded;meanwhile,most lakes in the SAYR have obviously been shrunk.These regional patterns of lake changes were highly related to variations of temperature,glacier,precipitation,and evaporation.Our investigation and analysis will provide references for researches related to lake changes in the QTP and the response to climate fluctuations. | Wei Wan Pengfeng Xiao Xuezhi Feng Hui Li Ronghua Ma Hongtao Duan Limin Zhao | 2014 | Chinese Science Bulletin2014，59，10： | 22 |
| 4 | Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa显示文摘To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the control of the promoter for the erythromycin resistance gene by splicing using overlapping extension PCR. This was cloned into the integrating vector pSET152, yielding the Vitreoscilla hemoglobin gene expression plasmid pSET152EVHB. This was then introduced into S. spinosa SP06081 by conjugal transfer, and integrated into the chromosome by site-specific recombination at the integration site ΦC31 on pSET152EVHB. The resultant conjugant, S. spinosa S078-1101, was genetically stable. The integration was further confirmed by PCR and Southern blotting analysis. A carbon monoxide differential spectrum assay showed that active Vitreoscilla hemoglobin was successfully expressed in S. spinosa S078-1101. Fermentation results revealed that expression of the Vitreoscilla hemoglobin gene significantly promoted spinosad biosynthesis under normal oxygen and moderately oxygen-limiting conditions (P<0.01). These findings demonstrate that integrating expression of the Vitreoscilla hemoglobin gene improves oxygen uptake and is an effective means for the genetic improvement of S. spinosa fermentation. | LUO YuShuang KOU XiaoXiao DING XueZhi HU ShengBiao TANG Ying LI WenPing HUANG Fan YANG Qi CHEN HanNa XIA LiQiu | 2012 | Science China(Life Sciences)2012，55，2： | 14 |
| 5 | Optimal planning of energy storage system in active distribution system based on fuzzy multi-objective bi-level optimization显示文摘A fuzzy multi-objective bi-level optimization problem is proposed to model the planning of energy storage system(ESS) in active distribution systems(ADS). The proposed model enables us to take into account how optimal operation strategy of ESS in the lower level can affect and be affected by the optimal allocation of ESS in the upper level. The power characteristic model of micro-grid(MG)and typical daily scenarios are established to take full consideration of time-variable nature of renewable energy generations(REGs) and load demand while easing the burden of computation. To solve the bi-level mixed integer problem, a multi-subgroup hierarchical chaos hybrid algorithm is introduced based on differential evolution(DE) and particle swarm optimization(PSO). The modified IEEE-33 bus benchmark distribution system is utilized to investigate the availability and effectiveness of the proposed model and the hybrid algorithm. Results indicate that the planningmodel gives an adequate consideration to the optimal operation and different roles of ESS, and has the advantages of objectiveness and reasonableness. | Rui LI Wei WANG Zhe CHEN Xuezhi WU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，2： | 9 |
| 6 | Sequential therapy according to distinct disease progression patterns in advanced ALK-positive non-small-cell lung cancer after crizotinib treatment显示文摘Objective: Crizotinib is recommended as the first-line therapy for advanced anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC). Despite its initial efficacy, patients ultimately acquire resistance to crizotinib within 1 year. In such patients, the optimal sequential therapy after crizotinib treatment remains unknown. This study explored which sequential therapy option confers the greatest benefit.Methods: A total of 138 patients with advanced ALK-positive NSCLC resistant to crizotinib were studied. Based on patterns of disease progression of metastases, patients were divided into 3 groups: brain progression, non-liver progression, and liver progression. Sequential therapies included crizotinib continuation plus local therapy, nextgeneration ALK inhibitors(ALKi's), and chemotherapy. The primary endpoint was overall survival(OS) from the time of crizotinib resistance to death or last follow-up.Results: The 138 patients included 64 cases with progression in brain, 57 cases in non-liver sites and 17 cases in liver. A significant difference in OS was observed among the distinct progression pattern(median OS, 25.4 months in brain, 15.8 months in non-liver, and 10.8 months in liver, respectively, P=0.020). The difference in OS among sequential therapies was statistically significant in the non-liver progression group(median OS, 27.6 months with next-generation ALKi's, 13.3 months with crizotinib continuation, and 10.8 months with chemotherapy,respectively, P=0.019). However, crizotinib continuation plus local therapy seems to provide non-inferior median OS compared with next-generation ALKi's for patients with brain progression(median OS, 28.9 months vs.32.8 months, P=0.204). And no significant differences in OS were found in patients with progression in liver(P=0.061).Conclusions: Crizotinib continuation together with local therapy might be a feasible strategy for patients with progression in brain beyond crizotinib resistance, as well as next-generation ALKi's. Next-generation ALKi's tended to provide a survival benefit in patients with non-liver progression. | Haiyan Xu Di Ma Guangjian Yang Junling Li Xuezhi Hao Puyuan Xing Lu Yang Fei Xu Yan Wang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 6 |
| 7 | Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather显示文摘Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power system.This paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi Zhuang Autonomous Region of China during 2011–2014.The result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe weather.Based on the results, an estimation method is proposed in this paper.Split and aggregation is used to smooth the outage and weather data.The poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage events.Regression analysis is applied to obtain the correlation between the weather intensity and history failure rate.Furthermore the method proposed is validated against the empirical outage data. | Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG Lisha YE Xuezhi XIA Han LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 5 |
| 8 | Global Stability for a Heroin Model with Age-Dependent Susceptibility显示文摘This paper considers global asymptotic properties for an age-structured model of heroin use based on the principles of mathematical epidemiology where the incidence rate depends on the age of susceptible individuals. The basic reproduction number of the heroin spread is obtained. It completely determines the stability of equilibria. By using the direct Lyapunov method with Volterra type Lyapunov function, the authors show that the drug-free equilibrium is globally asymptotically stable if the basic reproduction number is less than one, and the unique drug spread equilibrium is globally asymptotically stable if the basic reproduction number is greater than one. | FANG Bin LI Xuezhi MARTCHEVA Maia CAI Liming | 2015 | Journal of Systems Science & Complexity2015，28，6： | 5 |
| 9 | Polyoxometalates-engineered hydrogen generation rate and durability of Pt/CNT catalysts from ammonia borane显示文摘Heterogeneously catalyzed hydrolytic dehydrogenation of ammonia borane is a remarkable structure sensitive reaction. In this work, a strategy by using polyoxometalates(POMs) as the ligands is proposed to engineer the surface and electronic properties of Pt/CNT catalysts toward the enhanced hydrogen generation rate and durability. Three kinds of POMs, i.e., silicotungstic acid(STA), phosphotungstic acid(PTA)and molybdophosphoric acid(PMA), are comparatively studied, among which the STA shows positive effects on the catalytic activity and durability. A catalyst structure-performance relationship is established by a combination of kinetic and isotopic analyses with multiple characterization techniques, such as HAADF-STEM, EDS, Raman spectroscopy and XPS. It is shown that the STA compared to the other two POMs can increase the Pt binding energy and thus promote the reaction. The insights demonstrated here could open a new avenue for boosting the reaction by employing the POMs as the ligands to engineer the catalyst electronic properties. | Wenzhao Fu Chen Han Dali Li Wenyao Chen Jian Ji Gang Qian Weikang Yuan Xuezhi Duan Xinggui Zhou | 2020 | Journal of Energy Chemistry2020，29，2： | 5 |
| 10 | Cytotoxicity of the soluble and insoluble fractions of atmospheric fine particulate matter显示文摘Inhaled atmospheric fine particulate matter(PM2.5)includes soluble and insoluble fractions,and each fraction can interact with cells and cause adverse effects.PM2.5 samples were collected in Jinan,China,and the soluble and insoluble fractions were separated.According to physiochemical characterization,the soluble fraction mainly contains watersoluble ions and organic acids,and the insoluble fraction mainly contains kaolinite,calcium carbonate and some organic carbon.The interaction between PM2.5 and model cell membranes was examined with a quartz crystal microbalance with dissipation(QCM-D)to quantify PM2.5 attachment on membranes and membrane disruption.The cytotoxicity of the total PM2.5 and the soluble and insoluble fractions,was investigated.Negatively charged PM2.5 can adhere to the positively charged membranes and disrupt them.PM2.5also adheres to negatively charged membranes but does not cause membrane rupture.Therefore,electrostatic repulsion does not prevent PM2.5 attachment,but electrostatic attraction induces remarkable membrane rupture.The human lung epithelial cell line A549 was used for cytotoxicity assessment.The detected membrane leakage,cellular swelling and blebbing indicated a cell necrosis process.Moreover,the insoluble PM2.5 fraction caused a higher cell mortality and more serious cell membrane damage than the soluble fraction.The levels of reactive oxygen species(ROS)enhanced by the two fractions were not significantly different.The findings provide more information to better understand the mechanism of PM2.5 cytotoxicity and the effect of PM2.5 solubility on cytotoxicity. | Ling Liu Qiuhua Zhou Xuezhi Yang Gang Li Jingzhu Zhang Xuehua Zhou Wei Jiang | 2020 | Journal of Environmental Sciences2020，32，5： | 4 |
| 11 | Effects of Rubber Shock Absorber on the Flywheel Micro Vibration in the Satellite Imaging System显示文摘当一颗卫星在轨道时,它的飞轮将产生微颤动并且影响照相机的成像质量。以便减少这效果,一个橡胶减震器被使用,并且一个数字模型和试验性的安装被开发在学习在微颤动上调查它的效果。一个综合模型为系统被开发,并且跟踪方法的一条光线在建模被使用。图象飞机的点坐标和排水量被获得,并且系统的 modulate 转移函数(MTF ) 是计算的。包括一个橡胶减震器的一颗卫星被设计,并且实验被执行。模拟和实验结果证明 MTF 增加几乎 10 % ,建议橡胶减震器是有用的减少飞轮颤动。 | Changcheng DENG Deqiang MU Xuezhi JIA Zongxuan LI | 2016 | Photonic Sensors2016，6，4： | 4 |
| 12 | Low Complexity Multiuser Detection with Recursively Successive Zero-Forcing and SIC Based on Nullspace for Multiuser MIMO-OFDM System显示文摘To improve the spectrum efficiency, this paper considers the multiuser detection with the MU-MIMO technology for multiuser MIMO-OFDM system uplink with the same subcarrier shared by multiple users. A low complexity multiuser detection algorithm with recursively successive zero-forcing and successive interference cancellation(RSZF-SIC) based on nullspace is proposed. The RSZF process based on the block diagonalization(BD) technique eliminates the co-channel interference(CCI) by a recursive method based on the nullspace orthogonal theorem. The SIC process detects the user signals respectively with the reasonable user detection sequence based on the results of the RSZF process. The computational complexity of the proposed algorithm is effectively reduced by reducing the total number of singular value decomposition(SVD) operations and the dimension of the SVD matrix in the recursive procedure. The performance of the proposed algorithm is improved in terms of bit error rate and sum capacity of the system, especially in the highSNR regime. | Zhang Chengwen Wang Bin Li Danli Tan Xuezhi | 2015 | China Communications2015，12，9： | 3 |
| 13 | Jinghua Weikang capsule protects against Helicobacter pylori-induced inflammatory responses via the nuclear factor-kappa B signaling pathway显示文摘OBJECTIVE: To investigate the inhibitory effect of Jinghua Weikang capsule(JWC) on gastric inflammation induced by Helicobacter pylori(H. pylori)via the nuclear factor-kappa B(NF-κB) signaling pathway in Kunming mice.METHODS: We investigated the anti-inflammation potential of JWC extract in vivo in a H. pylori-induced gastritis mouse model. The expression of inflammation-related molecules was evaluated by Western blotting, and the concentrations of in vivo inflammatory markers were measured by enzyme-linked immunosorbent assay. Inflammatory cell infiltration was evaluated by histopathological examination, and m RNA levels of related genes were evaluated by quantitative reverse transcription polymerase chain reaction.RESULTS: JWC had a dose-dependent protective effect against H. pylori-induced gastritis by protecting gastric epithelial cells and inhibiting inflammatory cell infiltration. Mechanistically, JWC decreased the protein levels of phosphorylated IκBαand NF-κB p65, m RNA levels of NF-κB pathway molecules, and plasma levels of tumor necrosis factor-α and interleukin 1 beta.CONCLUSION: An important finding of our study is that JWC attenuated gastrointestinal inflammation and ulceration and exerted a protective effect against gastric injury via inhibition of inflammation reactions and regulating the canonical NF-κB signaling pathway in vivo. | Shi Zongming Ye Hui Yu Jing Cheng Hong Li Jiang Zhang Xuezhi | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 3 |
| 14 | Uncertainty analysis of cross-calibration for HJ-1 CCD camera显示文摘Radiometric calibration of sensor is the basis of quantitative remote sensing,and uncertainty analysis is critical to ensure the accuracy of cross-calibration.Therefore,firstly,cross-calibration formulas were improved by redefining calibration coefficient and spectral band matching factor.In these formulas,cci was redefined as the calibration coefficient of normalized apparent reflectance,and spectral band matching factor as the ratio of normalized apparent reflectance.Secondly,based on the contrast of ideal and actual conditions in cross-calibration,8 sources of cross-calibration uncertainty were proposed:calibration uncertainty of standard sensor;pixel matching uncertainty;spectral band matching factor uncertainty caused by site altitude setting error,atmospheric parameters setting error,surface spectrum source,surface bidirectional reflectance characteristic,and error of atmospheric radiative transfer model;and uncertainty caused by other factors which were not considered.Finally,the contribution of each uncertainty was further analyzed and discussed for the HJ-1 CCD camera.The results provide many valuable references for evaluating the feasibility of alternative cross-calibration measurements. | WANG Zuo XIAO PengFeng GU XingFa FENG XueZhi LI XiaoYing GAO HaiLiang LI Hui LIN JinTang ZHANG XueLiang | 2013 | Chinese Science Bulletin2013，58，7： | 3 |
| 15 | The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal. | Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma | 2018 | Journal of Integrative Plant Biology2018，60，7： | 3 |
| 16 | Biotreatment of Wastewater from Soda-pretreatment Process of Corn Stover Using White-rot Fungus Z-6显示文摘Alkaline pretreatment of straw materials prior to enzyme hydrolysis is a key step for bioconversion of lignocellulose to bioethanol and chemicals.Wastewater from the alkaline pretreatment process must be treated before discharge to minimize its environmental impact.In this study,biotreatment of the wastewater from soda-pretreatment process of corn stover was investigated using fungus Z-6,and some indexes such as color,chemical oxygen demand(COD),and lignin content of wastewater before and after biotreatment were determined to assess the effect of the biotreatment.Results showed that fungus treatment could remove color up to approximately 72%after 2 d,and decrease COD and lignin content by about 63%and 60%,respectively after 3 d.The wastewater was fractionated using dynamic ultrafiltration method,and the changes in lignin contents of the effluent fractions with different molecular weights before and after biotreatment were analyzed.Some compounds produced by the fungus during treatment were identified using gas chromatography-mass(GC-MS)spectrometer,which revealed that depolymerization of lignin occurred during the biotreatment process. | Xuezhi Li Jian Zhao | 2020 | Paper And Biomaterials2020，5，4： | 2 |
| 17 | Analysis of the origin of peak aerosol optical depth in springtime over the Gulf of Tonkin显示文摘By aggregating MODIS(moderate-resolution imaging spectroradiometer) AOD(aerosol optical depth) and OMI(ozone monitoring instrument) UVAI(ultra violet aerosol index)datasets over 2010–2014, it was found that peak aerosol loading in seasonal variation occurred annually in spring over the Gulf of Tonkin(17–23°N, 105–110°E). The vertical structure of the aerosol extinction coefficient retrieved from the spaceborne lidar CALIOP(cloud-aerosol lidar with orthogonal polarization) showed that the springtime peak AOD could be attributed to an abrupt increase in aerosol loading between altitudes of 2 and 5 km.In contrast, aerosol loading in the low atmosphere(below 1 km) was only half of that in winter. Wind fields in the low and high atmosphere exhibited opposite transportation patterns in spring over the Gulf of Tonkin, implying different sources for each level. By comparing the emission inventory of anthropogenic sources with biomass burning, and analyzing the seasonal variation of the vertical structure of aerosols over the Northern Indo-China Peninsula(NIC), it was concluded that biomass burning emissions contributed to high aerosol loading in spring. The relatively high topography and the high surface temperature in spring made planetary boundary layer height greater than 3 km over NIC. In addition, small-scale cumulus convection frequently occurred, facilitating pollutant rising to over 3 km, which was a height favoring long-range transport. Thus, pollutants emitted from biomass burning over NIC in spring were raised to the high atmosphere, then experienced long-range transport, leading to the increase in aerosol loading at high altitudes over the Gulf of Tonkin during spring. | Xiaoli Shan Jun Xu Yixue Li Feng Han Xiaohui Du Jingying Mao Yunbo Chen Youjiang He Fan Meng Xuezhi Dai | 2016 | Journal of Environmental Sciences2016，28，2： | 2 |
| 18 | Tissue Culture and Rapid Propagation of Spathiphyllum kochii Engl. et Krause显示文摘[Objectives] This study was conducted on tissue-culture rapid propagation techniques of Spathiphyllum kochii Engl. et Krause. [Methods] With lateral buds of S. kochii as explants, the effects of such four basic media as MS, B5, Nitsch and Wpm and the ratio of two hormones(1, 2, 3 mg/L 6-BA and 0.1, 0.3, 0.5 mg/L NAA) on bud proliferation of S. kochii were studied by the complete test method, and the effect of the ratio of the two hormones(0.25, 0.50, 1.00 mg/L NAA and 1.0, 1.5 mg/L IBA) on rooting of S. kochii as well as the effect of substrate ratio(perlite and peat soil at 1∶9, 2∶8, 3∶7, 4∶6 and 5∶5) on its transplanting survival rate were also studied. [Results] The best basic medium for the rapid propagation of S. kochii was MS. The best hormone ratio suitable for bud proliferation was 2 mg/L6-BA+0.1 mg/L NAA, and the average number of buds proliferated at 45 d was 3.04. The average bud height was 2.05 cm; the most suitable medium for rooting was 1/2 MS+1 mg/L IBA+0.25 mg/L NAA, and its rooting rate was 100%; and the best transplanting substrate was 5∶5 perlite and peat. The soil ratio had a survival rate of 94%. [Conclusions] This study provides a theoretical basis for the improvement of the transplanting survival rate of test-tube S. kochii plantlets. | Shufang FAN Furong MAO Bin LIU Dawei JIAN Xiaoqin LI Xuezhi ZUO | 2019 | Agricultural Biotechnology2019，8，2： | 2 |
| 19 | Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus-Eluting Stents in “Real-World” Practice显示文摘 | Yaling Han Quanmin Jing Bo Xu Lixia Yang Huiliang Liu Xiaoming Shang Tieming Jiang Zhanquan Li Hua Zhang Hui Li Jian Qiu Yingfeng Liu Yi Li Xuezhi Chen Runlin Gao | 2009 | JACC: Cardiovascular Interventions2009，，4： | 2 |
| 20 | Impact of crizotinib on long-term survival of ALK-positive advanced non-small-cell lung cancer: A Chinese multicenter cohort study显示文摘Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib. | Puyuan Xing Di Ma Qiang Wang Xuezhi Hao Mengzhao Wang Yan Wang Li Shan Tao Xin Li Liang Hongge Liang Yang Du Zhaohui Zhang Junling Li | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
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