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| 1 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 2 | Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression显示文摘Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose(150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain. | Jinhua Fu Yingjin Zhang Renrong Wu Yingjun Zheng Xianghui Zhang Mei Yang Jingping Zhao Yong Liu | 2014 | Neural Regeneration Research2014，9，5： | 10 |
| 3 | Protist Interactions and Seasonal Dynamics in the Coast of Yantai, Northern Yellow Sea of China as Revealed by Metabarcoding显示文摘Facilitated by the high-throughput sequencing(HTS)technique,the importance of protists to aquatic systems has been widely acknowledged in the last decade.However,information of protistan biotic interactions and seasonal dynamics is much less known in the coast ecosystem with intensive anthropic disturbance.In this study,year-round changes of protist community composition and diversity in the coastal water of Yantai,a city along the northern Yellow Sea in China,were investigated using HTS for the V4 region of 18S rDNA.The interactions among protist groups were also analyzed using the co-occurrence network.Data analyses showed that Alveolata,Chlorophyta,and Stramenopiles are the most dominant phytoplanktonic protists in the investigated coastal area.The community composition displayed strong seasonal variation.The abundant families Dino-Group-I-Clade-1 and Ulotrichales_X had higher proportions in spring and summer,while Bathycoccaceae exhibited higher ratios in autumn and winter.Alpha diversities(Shannon and Simpson)were the highest in autumn and the lowest in spring(ANOVA test,P<0.05).Nutrients(SiO42−,PO43−),total organic carbon(TOC),and pH seemed to drive the variation of alpha diversity,while temperature,PO43−and TON were the most significant factors influencing the whole protist community.Co-variance network analyses reveal frequent co-occurrence events among ciliates,chlorophytes and dinoflagellate,suggesting biotic interactions have been induced by predation,parasitism and mixotrophy. | FU Yingjun ZHENG Pengfei ZHANG Xiaoli ZHANG Qianqian JI Daode | 2020 | Journal of Ocean University of China2020，19，4： | 3 |
| 4 | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances显示文摘Background Working memory(WM)deficit is considered a core feature and cognitive biomarker in patients with schizophrenia.Several studies have reported prominent object WM deficits in patients with schizophrenia,suggesting that visual WM in these patients extends to non-spatial domains.However,whether non-spatial WM is similarly affected remains unclear.Aim This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.Methods The study included 36 patients with first-episode schizophrenia and 35 healthy controls.Visual object WM capacity,including face and house WM capacity,was assessed by means of delayed matching-to sample visual WM tasks,in which participants must distribute memory so that they can discriminate a target sample.We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale.Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results Both face and house WM capacity was significantly impaired in patients with schizophrenia.For both tasks,the performance of all the subjects was worse under the high-load condition than under the low-load condition.We found that WM capacity was highly positively correlated with the performance on RBANS total scores(r=−0.528,p=0.005),RBANS delayed memory scores(r=−0.470,p=0.013),RBANS attention scores(r=−0.584,p=0.001),RBANS language scores(r=−0.448,p=0.019),Trail-Making Test:Part A raw scores(r=0.465,p=0.015)and simple IQ total scores(r=−0.538,p=0.005),and correlated with scores of the vocabulary test(r=−0.490,p=0.011)and scores of the Block Diagram Test(r=−0.426,p=0.027)in schizophrenia.No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.Conclusions Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition,suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. | Yi Liu Taiyong Bi Bei Zhang Qijie Kuang Haijing Li Kunlun Zong Jingping Zhao Yuping Ning Shenglin She Yingjun Zheng | 2021 | General Psychiatry2021，34，1： | 2 |
| 5 | Study of hot electrons generated from intense laser-plasma interaction employing Image Plate显示文摘Image Plate (IP) is convenient to be used and very suitable for radiation detection because of its advantages such as wide dynamic range, high detective quantum efficiency, ultrahigh sensitivity and superior linearity. The function mechanism and characteristics of IP are introduced in this paper. IP was employed in the study of hot electrons generated from intense laser-plasma interaction. The angular distri- bution and energy spectrum of hot electrons were measured with IP in the experi- ments. The results demonstrate that IP is an effective radiation detector for the study of laser-plasma interaction. | LIANG WenXi LI YuTong XU MiaoHua YUAN XiaoHui ZHENG ZhiYuan ZHANG Yi LIU Feng WANG ZhaoHua LI HanMing JIN Zhan WEI ZhiYi ZHAO Wei LI YingJun ZHANG Jie | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 2 |
| 6 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 7 | Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: Occurrence, distribution and ecological risks显示文摘 | Ruijie Zhang Jianhui Tang Jun Li Qian Zheng Di Liu Yingjun Chen Yongde Zou Xiaoxiang Chen Chunling Luo Gan Zhang | 2013 | Environmental Pollution2013，，： | 1 |
| 8 | Study on the synthetic process of calcium borate 显示文摘 | Cao Chune Wang Yingjun Zheng Naizhang | 2005 | Key Engineering Materials2005，，280283： | 1 |
| 9 | Application performance and surface morphologies of amino polysiloxanes with different amino values and amino types 显示文摘 | XU Yingjun YIN Hong ZHENG Haifeng | 2011 | Journal of Applied Polymer Science2011，119，： | 1 |
| 10 | Experimental investigation of a novel multi-effect solar desalination system based on humidification- dehumidification process 显示文摘 | Chang Zehui Zheng Hongfei Yang Yingjun | 2014 | Renewalbe Energy2014，，： | 1 |
| 11 | In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen–hydroxyapatite layered scaffolds显示文摘 | Jiaan Zhou Caixia Xu Gang Wu Xiaodong Cao Liangming Zhang Zhichen Zhai Zhiwen Zheng Xiaofeng Chen Yingjun Wang | 2011 | Acta Biomaterialia2011，，11： | 1 |
| 12 | High expression level of TMPRSS4 predicts adverse outcomes of colorectal cancer patients显示文摘 | Ao Huang Houmin Zhou Hongchao Zhao Yingjun Quan Bo Feng Minhua Zheng | 2013 | Medical Oncology2013，，： | 1 |
| 13 | HIF-1αand HDAC1 mediated regulation of FAM99AmiR92a signaling contributes to hypoxia induced HCC metastasis显示文摘Dear Editor,Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers.Previous studies have shown that many protein-coding genes and microRNAs are regulated upon hypoxia and involved in the progression of cancer.However,the roles of lncRNAs in the hypoxia-responsive gene networks and how lncRNA-related signaling network regulates hypoxia induced tumor metastasis is still not clear. | Bixing Zhao Kun Ke Yingchao Wang Fei Wang Yingjun Shi Xiaoyuan Zheng Xiaoyu Yang Xiaolong Liu Jingfeng Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 14 | How Does Muhiple-Packet Reception Capability Scale the Performance of Wireless Local Area Networks?显示文摘 | Zhang Yingjun Zheng Pengxuan Liew Soungchang | 2009 | IEEE Trans on Mobile Computing2009，8，7： | 1 |
| 15 | Pr- eparation and characterization of polyvinyl alcohol )/hydroxyla- pafite hybrid hydrogels显示文摘 | ZHENG Yudong WANG Yingjun CHEN Xiaofeng | 2007 | Journal of Composite Materials2007，41，17： | 1 |
| 16 | Efficacy and safety of thermal ablation in patients with liver metastases显示文摘 | Yingjun Liu Shengping Li Xiangbin Wan Yi Li Binkui Li Yaqi Zhang Yunfei Yuan Yun Zheng | 2013 | European Journal of Gastroenterology & Hepatology2013，，4： | 1 |
| 17 | Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: Occurrence, distribution and ecological risks显示文摘 | Ruijie Zhang Jianhui Tang Jun Li Qian Zheng Di Liu Yingjun Chen Yongde Zou Xiaoxiang Chen Chunling Luo Gan Zhang | 2013 | Environmental Pollution2013，，： | 1 |
| 18 | Occurrence and risks of antibiotics in the Laizhou Bay, China: Impacts of river discharge显示文摘 | Ruijie Zhang Gan Zhang Qian Zheng Jianhui Tang Yingjun Chen Weihai Xu Yongde Zou Xiaoxiang Chen | 2012 | Ecotoxicology and Environmental Safety2012，，： | 1 |
| 19 | Application of GIS in Oilfield Power System显示文摘This paper discusses the use of GIS in oilfield power system,combined with the basic concept and advantages of GIS,combined with the characteristics of the oilfield power system,put forward the overall design system of the oilfield power system,ensure the stability of the power system operation,give full play to the role of GIS. | Yingjun Hao Bin Tan Xiaoli Zheng Long Zhai Yun Sun Sichao Gao | 2020 | Journal of Electronic Research and Application2020，4，2： | 0 |
| 20 | Lifetime of 2+ State in 106Cd显示文摘Several nuclei including 106Cd in Aabout 100mass region have been predicted to exhibit E(5)critical point symmetry[1].However,the E(5)symmetry in 106Cd is still hard to be identified.One of difficulties is that the B(E2)information,or the mean lifetime,of 2+ state in 106Cd deter- | ZHONG Jian MA Yingjun WU Xiaoguang ZHENG Yun LI Guangsheng LI Congbo ZHU Baoji CHEN Qiming DENG Litao ZHOU Wenkui | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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