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| 1 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 2 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 3 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 4 | Gradient Effect on Farmers' Income in the Mountain Areas and its Implication for Poverty Alleviation Strategies:Empirical Analysis from the Upper Reach of Minjiang River,China显示文摘Using four types of settlements in the upper reach of Minjiang River as case,we establish structural models in farmers' income of different settlement patterns based on rural household panel data to reveal the gradient effect on farmers' income and determinants.The results indicate that:(1) except the resettlement area,the incomes for farmers living in river valley,semi-mountain,and high-mountain settlements present a decreasing trend with the elevation increasing;on the contrary,their nonfarm earnings show an increasing trend with the elevation decreasing;(2) from the effect on farmers' income,there is a common feature that the nonfarm earnings and farming incomes have significant positive effects,and family size and productive expenditure have significant negative effects.One exception to this is the productive expenditure,which becomes insignificant in the model of resettlement area;(3) from the way of increasing farmers' income and alleviating poverty,there are great differences for four types of settlements in mountain areas,however,the improvement of agricultural product sales,agricultural production subsidies,the expansion for nonfarm employment,and the control of the family's size are the most effective approaches for poverty alleviation. | FANG Yiping FAN Jie SHEN Maoying SONG Mengqiang | 2012 | Journal of Mountain Science2012，9，6： | 7 |
| 5 | Concentration profile of jet gas in the feed injection zone of a FCC riser显示文摘喷气气体的集中侧面被使用一种氢踪迹技术在一个冷模型的 FCC 起床人的 feed 注射地区调查。试验性的结果表明喷气气体集中侧面的四种类型能被用来描述在喷气气体之间混合并且预先提起在 feed 注射地区的气体。四种类型是为弱混合,为完整的混合的为中等混合的模糊塑造 M 的侧面,为强壮的混合的锋利的侧面,和抛物线的侧面的不同塑造 M 的侧面。为起始、完整的混合还原剂的区域的高度当减少时喷气气体速度或增加预先提起气体速度。而且,动量比率, Mj/Mr,(在 Mj 是喷气气体的动量的地方,先生是混合动量预先提起煤气、稳固的粒子) 被介绍在喷气气体集中分发上描述煤气的稳固的物理性质,操作条件,和设备配置的效果。为区域的高度起始、完整在喷气气体之间混合并且预先提起气体被发现当时,是 0 0.375 和 0.375 0.675 m Mj/Mr <
0.29 , 0.375 0.675 和 1.075 1.375 m 什么时候 Mj/Mr >
0.54 ,和 0 0.375 和 0.675 1.075 m 什么时候在 0.29 和 0.54 之间的 Mj/Mr ,分别地。 | Chenglin E Yiping Fan Kai Zhang Hu Zhang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 6 | High-order mode lasing in all-FMF laser cavities显示文摘We experimentally demonstrate two kinds of all few-mode fiber(FMF) ring lasers with high-order mode(HOM)oscillation in the laser cavity. One kind is a switchable-wavelength all-FMF HOM laser with an output of tunable optical vortex beams(OVBs); the other is a Q-switched all-FMF HOM laser with an output of pulsed cylindrical vector beams(CVBs). The lasers are composed of all-FMF components and few-mode erbium-doped fiber. A Sagnac interferometer made of a 3 dB FMF coupler functions as the wavelength selector, and switchable multiwavelength tunable OVBs are experimentally realized. Carbon nanotube-based saturable absorbers and the nonlinear polarization rotation technique are used to achieve Q-switched CVB lasers. This is the first report, to our knowledge, on the generation of switchable-wavelength and Q-switched HOM beams in all-FMF laser cavities. | TENG WANG AO YANG FAN SHI YIPING HUANG JIANXIANG WEN XIANGLONG ZENG | 2019 | Photonics Research2019，7，1： | 4 |
| 7 | Senp2 regulates adipose lipid storage by de-SUMOylation of Setdbl显示文摘 | Quan Zheng Ying Cao Yalan Chen Jiqiu Wang Qiuju Fan Xian Huang Yiping Wang Tianshi Wang Xiuzhi Wang Jiao Ma Jinke Cheng | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 8 | Experiments and simulations of gas-solid flow in an airlift loop reactor显示文摘The hydrodynamics in a gas-solid airlift loop reactor was investigated systematically using experimental measurements and CFD simulation.In the experiments,the time averaged parameters,such as solid fraction and particle velocity,were measured by optical fiber probe.In the simulation,the modified Gidaspow drag model accounting for the interparticles clustering was incorporated into the Eulerian-Eulerian CFD model with particulate-phase kinetic theory.Predicted values of solid fraction and particle velocity were compared with experimental results,validating the drag model and the simulation.The results show that the profiles of particle velocity and solid fraction are uniform in annulus.However,the core-annulus structure appears in other three regions (draft tube region,bottom region and particle diffluence region),which presents the similar heterogeneous feature of aggregative fluidization usually occurred in normal fluidized beds.Simulated profiles of particle residence time distribution indicate that the airlift loop reactor should be characterized by near perfect mixing. | Chaoyu Yan Chunxi Lu Yiping Fan Rui Cao Yansheng Liu | 2011 | Particuology2011，9，2： | 2 |
| 9 | Experimental study on filtration performance of the moving bed granular filter with axial flow显示文摘The filtration performance of the moving bed granular filter with axial flow (MBGF-AF) is investigated through a large cold experiment. The effect of different operation parameters on the filtration performance (collection efficiency, pressure drop) of the axial-flow moving bed filter is investigated in combination with the dust deposition effect and the mechanism of trapping dust by the capturing particles. The results show that the collection efficiency of MBGF-AF is enhanced by decreasing the superficial gas velocity, increasing the inlet dust concentration properly, or decreasing the moving velocity of the capturing particles. A model covering the above operation parameters is established to calculate the collection efficiency of the moving bed granular filter. It is used in a wide range of operating parameters for the MBGFs. | Han Lv Yuxue Liu Yingying Dong Yiping Fan Chunxi Lu | 2023 | Particuology2023，，1： | 2 |
| 10 | Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis显示文摘RNF20,an E3 ligase critical for monoubiquitination of histone H2B at lysine 120(H2Bub),has been implicated in the regulation of various cellar processes;however,its physiological roles in adipocytes remain poorly characterized.Here,we report that the adipocyte-specific knockout of Rnf20(ASKO)in mice led to progressive fat toss,organomegaly and hyperinsulinemia.Despite signs of hyperinsulinemia,normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice.In addition,high-fat diet-fed ASKO mice developed severe liver steatosis.Moreover,we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue(BAT)selective genes,including uncoupling protein 1(l/cpf),and impaired mitochondrial functions.Significantly decreased levels of peroxisome proliterator-activated receptor gamma(Ppary)were observed in the gonadal white adipose tissues(gWAT)from the ASKO mice,suggesting that Rnf20 regulates adipogenesis,at least in part,through Ppary.Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice.Collectively,our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function. | Xiaojuan Liang Cong Tao Jianfei Pan Lilan Zhang Lulu Liu Ying Zhao Yiping Fan Chunwei Cao Jiali Liu Jin Zhang Sin Man Lam Guanghou Shui Wanzhu Jin Wei Li Jianguo Zhao Kui Li Yanfang Wang | 2021 | Protein & Cell2021，12，6： | 1 |
| 11 | 显示文摘 | Wang Yiping Thakur R Fan Qiuxi | 2005 | European Journal of Pharmaceutics and Biopharmaceutics2005，60，： | 1 |
| 12 | The temporal features of self-referential processing evoked by national flag显示文摘 | Wei Fan Youxue Zhang Xia Wang Xiaoyan Wang Xiaoyi Zhang Yiping Zhong | 2011 | Neuroscience Letters2011，，3： | 1 |
| 13 | Intraregional Cross-holding of Reserve Currencies:A Proposal for Asia to Deal with the Global Reserve Risks显示文摘Economists have put forward various proposals to deal with the growing risks of the global reserve currency system.In this paper we recommend that Asian economies hold each other's currencies as part of their foreign reserves.Different from crisis-fighting currency swap arrangements or crisis-rescuing fund mechanisms,this mechanism means that reserves would be held,with a regular arrangement in place and on an ongoing basis.We propose that the global reserve system should be pushed in the direction of diversification,which could be a transitional step toward a new single reserve system.This mechanism would not necessitate any currency being a globally accepted reserve currency but would mean that every currency carried some weight in the reserve system.Establishment of such a system would require significant development of regional bond markets and facilitation of macroeconomic surveillance among the economies. | Gang Fan Bijun Wang Yiping Huang | 2013 | China & World Economy2013，21，4： | 1 |
| 14 | Effects of early enteral nutrition supplemented with arginine on intestinal mucosal immunity in severely burned mice显示文摘 | Jun Fan Qingyan Meng Guanghua Guo Yong Xie Xuedong Li Yiping Xiu Tairan Li Liang Ma | 2009 | Clinical Nutrition2009，，： | 1 |
| 15 | Event-related potential correlates of the collective self-relevant effect显示文摘 | Ke Zhao Jiajin Yuan Yiping Zhong Yunshi Peng Jie Chen Luping Zhou Wei Fan Daoqun Ding | 2009 | Neuroscience Letters2009，，1： | 1 |
| 16 | The preparation and application of crude cellulase for cellulose-hydrogen production by anaerobic fermentation 显示文摘 | GUO Yiping FAN Shaoqun FAN Yaoting | 2010 | Int J Hydrogen Energy2010，35，： | 1 |
| 17 | Unexpected de-twinning of strongly-textured Ti mediated by local stress显示文摘As one of the heterostructures,the layered structure has attracted extensive research interests as it could regulate the deformation mechanisms[1-3].A remarkable combination of strength and ductility has been achieved in layered metals,including CuCu[4-6],Cu-Ni[7],Cu-Al[8,9],Cu-Ti[10],Ti-Ti[11,12],and Ti-Al[13-15].During deformation,mechanical mismatch(discrepancies of yield strength,work hardening,etc.)between component layers leads to mutual constraints,which generates local stress and local strain that deviate from the applied counterparts[16-18].As a result,the activation of additional deformation mechanisms is promoted in layered metals,such as slip systems with low Schmid factor or high critical resolved shear stress[19,20]. | Kesong Miao Meng Huang Yiping Xia Hao Wu Qing Liu Guohua Fan | 2022 | Journal of Materials Science & Technology2022，，30： | 1 |
| 18 | Effects of protein oxidation, cathepsins, and various freezing temperatures on the quality of superchilled sturgeon fillets显示文摘Many aquatic products have been stored using superchilling technology, but rarely used for the storage of sturgeon fillets. In this study, we investigated the effects of protein oxidation, cathepsin, and various freezing temperatures on the quality of superchilled sturgeon fillets. Sensory evaluation results showed that the sensory attributes of superchilled (−3 °C) sturgeon fillets were acceptable three times longer (18 days) than samples stored at refrigeration temperatures (4 °C). The sarcoplasmic protein, carbonyl, myofibrillar protein, total sulfhydryl content and the surface hydrophobicity were determined using fluorescence spectrophotometry and SDS-PAGE. Results showed that superchilling might protect myofibrillar proteins from oxidation compared to refrigeration temperatures. The activity of the three cathepsins (B, L, and H) in terms of myofibrillar, mitochondria, lysosomes, and sarcoplasm demonstrated that superchilling can inhibit cathepsins activity in sturgeon and protect its muscle structure. Microscopic observations showed that as the temperature decreased, the gap area of the muscle fibers decreased, and the deformation of cross-sectional slices was gradually reduced. In addition, the freezing rate of ice crystals produced during the freezing process influenced the muscle structure, texture, and sensory attributes. Superchilled sturgeon fillets showed good hardness, chewiness, and water retention. In conclusion, superchilling technology shows promise for its ability to extend the shelf life while maintaining the texture and sensory attributes of fresh sturgeon fillets. | Nana Zhao Xianqing Yang Yujin Li Haohao Wu Yiping Chen Ruichang Gao Feng Xiao Fan Bai Jinlin Wang Zunying Liu Xin Gao Yuanhui Zhao | 2022 | Marine Life Science & Technology2022，4，1： | 1 |
| 19 | Solids mixing in a fluidized bed riser 显示文摘 | Yan Chaoyu Fan Yiping Lu Chunxi | 2009 | Powder Technology2009，193，1： | 1 |
| 20 | Visual simulation of heat shimmerirg and mirage 显示文摘 | ZHAO Ye HAN Yiping FAN Zhe el al | 2007 | IEEE Tran actions on Visualiza tion and Computer Graphics2007，13，1： | 1 |
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