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| 1 | Mechanical property of artificial methane hydrate under triaxial compression显示文摘Methane production from hydrate reservoir may induce seabed slide and deformation of the hydrate-bearing strata.The research on mechanical properties of methane hydrate is considered to be important for developing an efficient methane exploitation technology.In this paper,a triaxial test system containing a pressure crystal device was developed with the conditions to stabilize the hydrate.A series of triaxial shear tests were carried out on artificial methane hydrate specimen.In addition,mechanical characteristics of methane hydrate were studied with the strain rates of 0.1 and 1.0 mm/min,respectively,under the conditions of different temperatures(T =-5,-10,and-20 ℃) and confining pressures(P = 0,5,10,15,and 20 MPa).The preliminary results show that when the confining pressure was less than 10 MPa,the increase of confining pressure leaded to the enhancement of shear strength.Furthermore,the decreasing temperature and the increasing strain rate both caused the increase in shear strength. | Yongchen Song Feng Yu Yanghui Li Weiguo Liu Jiafei Zhao | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 28 |
| 2 | Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction显示文摘 | PengXia JinhuaZhou Xiaoyu Song BingWu XingLiu Di Li Shuyuan Zhang Zhikai Wang H uijuan Yu Tarsha Ward Jiancun Zhang Yinmei Li Xiaoning Wang YongChen Zhen Guo Xuebiao Yao | 2014 | Journal of Molecular Cell Biology2014，8，3： | 9 |
| 3 | Identification of Regulatory DNA Elements Using Genome-wide Mapping of DNase I Hypersensitive Sites during Tomato Fruit Development显示文摘开发并且西红柿水果成熟被 transcriptional 规定精确控制,它取决于规章的蛋白质的安排可接近性到倡导者和另外的 cis 规章的 DNA 元素。基因表示上的这可接近性和它的效果在定义发展进程起一个主要作用。为了理解规章的机制和词法、解剖的功能的元素 modulating,在水果开发期间变化,我们产生了 DNase 的染色体宽的高分辨率的地图我从西红柿栽培变种 “Moneymaker” 的水果纸巾的过分敏感的地点(DHS )在 20 点,天张贴开花期以及裂缝舞台。由越过水果发展阶段探索 DHS 的变化,我们指出了与发展特定的基因有关的最可能的过分敏感的地点。由在维生素酸 biosynthetic 小径在这些发展特定的基因或基因的 DHS 上检测有约束力的主题,我们揭示了贡献协调植物成熟的基因抄写的普通规章的元素并且专业化新陈代谢的小径。我们的结果贡献一更好涉及西红柿水果开发的基因的规章的动力学理解并且成熟。 | Zhengkun Qiu Ren Li Shuaibin Zhang Ketao Wang Meng Xu Jiayang Li Yongchen Du Hong YU Xia Cui | 2016 | Molecular Plant2016，9，8： | 6 |
| 4 | Numerical studies of hydrate dissociation and gas production behavior in porous media during depressurization process显示文摘In this study,a numerical model is developed to investigate the hydrate dissociation and gas production in porous media by depressurization.A series of simulation runs are conducted to study the impacts of permeability characteristics,including permeability reduction exponent,absolute permeability,hydrate accumulation habits and hydrate saturation,sand average grain size and irreducible water saturation.The effects of the distribution of hydrate in porous media are examined by adapting conceptual models of hydrate accumulation habits into simulations to govern the evolution of permeability with hydrate decomposition,which is also compared with the conventional reservoir permeability model,i.e.Corey model.The simulations show that the hydrate dissociation rate increases with the decrease of permeability reduction exponent,hydrate saturation and the sand average grain size.Compared with the conceptual models of hydrate accumulation habits,our simulations indicate that Corey model overpredicts the gas production and the performance of hydrate coating models is superior to that of hydrate filling models in gas production,which behavior does follow by the order of capillary coating>pore coating>pore filling>capillary filling.From the analysis of t1/2,some interesting results are suggested as follows:(1) there is a 'switch' value(the'switch'absolute permeability) for laboratory-scale hydrate dissociation in porous media,the absolute permeability has almost no influence on the gas production behavior when the permeability exceeds the 'switch' value.In this study,the 'switch' value of absolute permeability can be estimated to be between 10 and 50 md.(2) An optimum value of initial effective water saturation Sw,e exists where hydrate dissociation rate reaches the maximum and the optimum value largely coincides with the value of irreducible water saturation S wr,e.For the case of Sw,Swr,e,there are different control mechanisms dominating the process of hydrate dissociation and gas production. | Xuke Ruan Mingjun Yang Yongchen Song Haifeng Liang Yanghui Li | 2012 | Journal of Natural Gas Chemistry2012，21，4： | 3 |
| 5 | Water permeability in MXene membranes: Process matters显示文摘Recent studies have shown impressive transport behaviors of water and ions within lamellar MXene membranes,which endows great promise in developing advanced separation application based high performance MXene membranes.However,most of the researches focused on modification of MXene nanoflakes and optimizing interlayer distance,leaving the impact of membrane fabrication process marginal.In this work,we studied the water flux of membranes made by vacuum filtration using delaminated MXene nanoflakes as the building-blocks.Our results show that the water permeability is extremely sensitive to the process,especially at the drying process,loading and deposit rate of nanoflakes(the feeding concentration).We find that the voids from less ordered stack rather than in-plane defects and interlayer galleries contribute to the large water permeability.The voids can be effectively avoided via deposition of MXene nanoflakes at a slow rate.Manipulating the stack of MXene nanoflakes during vacuum filtration and drying are critical for development of MXene membranes with desired performance for water permeation. | Hang Zhou Yuwei Wang Fuqiang Wang Hao Deng Yongchen Song Changping Li Zheng Ling | 2020 | Chinese Chemical Letters2020，31，6： | 3 |
| 6 | A putative bHLH transcription factor is a candidate gene for male sterile 32,a locus affecting pollen and tapetum development in tomato显示文摘The tomato(Solanum lycopersicum)male sterile 32(ms32)mutant has been used in hybrid seed breeding programs largely because it produces no pollen and has exserted stigmas.In this study,histological examination of anthers revealed dysfunctional pollen and tapetum development in the ms32 mutant.The ms32 locus was fine mapped to a 28.5 kb interval that encoded four putative genes.Solyc01g081100,a homolog of Arabidopsis bHLH10/89/90 and rice EAT1,was proposed to be the candidate gene of MS32 because it contained a single nucleotide polymorphism(SNP)that led to the formation of a premature stop codon.A codominant derived cleaved amplified polymorphic sequence(dCAPS)marker,MS32D,was developed based on the SNP.Real-time quantitative reverse-transcription PCR showed that most of the genes,which were proposed to be involved in pollen and tapetum development in tomato,were downregulated in the ms32 mutant.These findings may aid in marker-assisted selection of ms32 in hybrid breeding programs and facilitate studies on the regulatory mechanisms of pollen and tapetum development in tomato. | Xiaoyan Liu Mengxia Yang Xiaolin Liu Kai Wei Xue Cao Xiaotian Wang Xiaoxuan Wang Yanmei Guo Yongchen Du Junming Li Lei Liu Jinshuai Shu Yong Qin Zejun Huang | 2019 | Horticulture Research2019，6，1： | 3 |
| 7 | Adsorption isotherms and kinetic characteristics of methane on block anthracite over a wide pressure range显示文摘It is important to quantitatively understand the methane adsorption and transport mechanism in coal for an evaluation of the reserves and for its production forecast. In this work, a block coal sample was chosen to perform the CH4 adsorption experiments using the gravimetric method at temperatures of 293.60 K, 311.26 K, 332.98 K and 352.55 K and pressures up to 19 MPa. The excess adsorption capacity of CH4 in dry block anthracite increased, followed by a sequence decrease with the increasing pressure. High temperature restrained the growth of the excess adsorption due to that the adsorption is an intrinsically physical and exothermic process. The excess adsorption peak decreased slowly with the increase of temperature and intersected at a pressure of more than 18 MPa; meanwhile, the pressure at the excess adsorption peak increased.The existing correlations were examined in terms of density rather than pressure. The DR+k correlation, with an average relative deviation of ±0.51%, fitted our data better than the others, with an average relative deviation of up to 2.29%. The transportation characteristics of CH4 adsorption was also investigated in this study, including the adsorption rate and diffusion in block coal. The kinetic data could be described by a modified unipore model. The adsorption rates were found to exhibit dependence on pressure and temperature at low pressures, while the calculated diffusivities exhibited little temperature dependence. In addition, the kinetic characteristics were compared between CH4 and CO2 adsorption on the block coal. The excess adsorption ratios of CO2 to CH4obtained from the DR+k model decreased with the increasing pressure. | Wanli Xing Yongchen Song Yi Zhang Weiguo Liu Lanlan Jiang Yanghui Li Yuechao Zhao | 2015 | Journal of Energy Chemistry2015，24，2： | 2 |
| 8 | The detection of tetrahydrofuran hydrate formation and saturation using magnetic resonance imaging technique显示文摘Tetrahydrofuran(THF) hydrate was formed in bulk as well as in glass beads pack with a mean diameter of 3.0 mm by controlling the temperature under ambient pressure.Images of THF hydrate formation procedure were obtained using the magnetic resonance imaging(MRI) technique.The experiment results showed that MRI is an effective method for the detection of hydrate formation.Saturation of hydrate formed both in bulk and glass beads can be confirmed by intensity integration of MRI images. | Yu Liu Yongchen Song Yongjun Chen Lei Yao Qingping Li | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 2 |
| 9 | The status of natural gas hydrate research in China: A review显示文摘 | Song Yongchen Yang Lei Zhao Jiafei Liu Weiguo Yang Mingjun Li Yanghui | 2014 | Renewable and Sustainable Energy Reviews2014，31，： | 1 |
| 10 | Age-related Resistance and the Defense Signaling Pathway of Ph-3 Gene Against Phytophthora infestans in Tomatoes显示文摘Resistance(R) genes against plant pathogens often have age-related resistance(ARR) effects. However, the mechanism involved in this phenomenon remains unknown. In this paper, Solanum lycopersicum ‘CLN2037B' and S. pimpinellifolium ‘L3708' harboring the Ph-3 gene, as well as S. habrochaites ‘LA2099', ‘LA1777' and ‘LA1033' harboring quantitative trait loci(QTLs), were tested to investigate age-related resistance against late blight(LB; caused by Phytophthora infestans) in the three-leaf stage of the plants. The results demonstrated that the QTL-related LB resistance showed the same age-related resistance as the Ph-3-mediated resistance at the six- and nine-leaf stages compared with the three-leaf stage. This indicated that there is a common defense mechanism in tomatoes against P. infestans via ARR. In addition, we combined ethylene(ET), salicylic acid(SA) and jasmonic acid(JA) mutants with virus-induced gene silencing(VIGS) to study the Ph-3-dependent resistance signaling pathway. The results showed that ethylene and salicylic acid, but not jasmonic acid, are involved in the LB resistance mediated by the Ph-3 gene. | Sayed Rashad Ali Shah LI Tao CHI Haijuan LIU Lei ZHENG Zheng LI Junming DU Yongchen | 2015 | Horticultural Plant Journal2015，1，2： | 1 |
| 11 | OBV(obscure vein),a C_(2)H_(2)zinc finger transcription factor,positively regulates chloroplast development and bundle sheath extension formation in tomato(Solanum lycopersicum)leaf veins显示文摘Leaf veins play an important role in plant growth and development,and the bundle sheath(BS)is believed to greatly improve the photosynthetic efficiency of C_(4) plants.The OBV mutation in tomato(Solanum lycopersicum)results in dark veins and has been used widely in processing tomato varieties.However,physiological performance has difficulty explaining fitness in production.In this study,we confirmed that this mutation was caused by both the increased chlorophyll content and the absence of bundle sheath extension(BSE)in the veins.Using genome-wide association analysis and map-based cloning,we revealed that OBV encoded a C_(2)H_(2) L domain class transcription factor.It was localized in the nucleus and presented cell type-specific gene expression in the leaf veins.Furthermore,we verified the gene function by generating CRISPR/Cas9 knockout and overexpression mutants of the tomato gene.RNA sequencing analysis revealed that OBV was involved in regulating chloroplast development and photosynthesis,which greatly supported the change in chlorophyll content by mutation.Taken together,these findings demonstrated that OBV affected the growth and development of tomato by regulating chloroplast development in leaf veins.This study also provides a solid foundation to further decipher the mechanism of BSEs and to understand the evolution of photosynthesis in land plants. | Jinghua Lu Chunyang Pan Xin Li Zejun Huang Jinshuai Shu Xiaoxuan Wang Xiaoxiao Lu Feng Pan Junling Hu Hui Zhang Wenyue Su Min Zhang Yongchen Du Lei Liu Yanmei Guo Junming Li | 2021 | Horticulture Research2021，8，1： | 1 |
| 12 | Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction显示文摘 | Muhammad Khan Ting Li Muhammad Khalil Ahmad Khan Azhar Rasul Faisal Nawaz Meiyan Sun Yongchen Zheng Tonghui Ma D. M. Clarke | 2012 | BioMed Research International2012，，： | 1 |
| 13 | Characteristics of microbial communities in water from CBM wells and biogas production potential in eastern Yunnan and western Guizhou, China显示文摘The study of microbial communities in the produced water of coalbed methane(CBM)wells is an important aspect of microbial-enhanced methane production.Water produced from 15 CBM wells in four synclines in eastern Yunnan and western Guizhou was collected.Through the use of 16S ribosomal RNA(16S rRNA)amplicon sequencing and realtime fluorescence quantitative polymerase chain reaction(PCR),the characteristics of bacterial and archaeal communities before and after enrichment culture were studied.The methanogenic pathways of secondary biogas were discussed,and potential microbial-enhanced methane production was preliminarily evaluated.The results showed that the bacterial DNA content in uncultured produced water was low,so it is difficult to detect.After enrichment,the dominant bacteria phyla were Proteobacteria,Bacteroidetes,and Firmicutes.A total of seven phyla were detected in the uncultured produced water,and the dominant archaeal phylum was Euyarchaeota.Methanogens were the main component of archaea.The dominant archaeal genera were Methanobacterium,Methanoculleus and Methanobrevibacter.The community structure of the archaea changed noticeably after four days of enrichment culture.The relative abundance of Euryarchaeota increased to 99%in most samples after enrichment culture.It was found that there was a transition from Methanoregula to Methanobacterium within genera.The relative abundance of Methanobacterium increased,which can produce hydrogenotrophic methane.Combined with the isotopic composition of the produced water and gas,it is considered that the CBM in the Tucheng and Enhong synlines consists of a mixture of thermogenic gas and biogas.The proportion of secondary biogas in the Tucheng and Enhong synlines are estimated to range from 10.89% to 49.62%.There are mainly hydrogentrophic methanogens in the study area,and CO_(2) reduction is the main way of microbial gas production.After enrichment culture of produced water in the study area,the hydrogenotrophic methanogens were enriched.These two areas have strong potential for microbial-enhanced methane production. | Wenguang TIAN Zhaobiao YANG Zonghao QIN Yong QIN Cunlei LI Benju LU Yongchen LI | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
| 14 | Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients显示文摘Dear Editor,Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and its subvariants BA.1,BA.2,and BA.3 emerged and circulated almost simultaneously(Desingu et al.,2022).BA.2 was more efficient in transmission and quickly overtook BA.1 to become the variant most frequently detected worldwide(Yamasoba et al.,2022a).Compared to the prototype SARS-CoV-2 spike protein(S),the BA.1 and BA.2 spike proteins harbor more than 30 mutations,of which 21 are identical between the two subvariants,while the BA.3 spike differs from BA.1 and BA.2 by 3 mutations in the receptor binding domain(RBD)(Fig.1A).More recently,BA.4 and BA.5(hereafter BA.4/5)emerged,sharing the same spike sequence and containing four additional mutations,Del69–70,L452R,F486V,and R493Q,compared with BA.2.BA.4/5 were detected first in South Africa and evolved independently of BA.2;they have spread widely and replaced BA.2 as the predominant VOC(Gruell et al.,2022b;Tegally et al.,2022).In addition,BA.2.75,derived from the BA.2 subvariant,harbors nine additional mutations in the spike protein compared with BA.2(Fig.1A).BA.4/5 and BA.2.75 have led to the continuous emergence of novel Omicron subvariants,including BF.7 and BQ.1.These new subvariants may be driving waves of pandemics. | Jun Chen Jing Yang Fangfang Chang Yabin Hu Qian Wu Shishan Teng Yongchen Liu Jian Zhang Rongzhang He Bo Liu Xingyu Zheng Ze Liu Yanxi Peng Zhenhua Xie Yuanfang Zhang Rui Lu Dong Pan You Wang Liting Peng Wenpei Liu Yi-Ping Li Xiaowang Qu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 15 | SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals显示文摘Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. However, the longevity and functional role of T_(FH) cellsubsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection andinactivated vaccine elicited both spike-specific CXCR3^(+) T_(FH) cell and CXCR3^(-) T_(FH) cell responses, which showed distinct responsepatterns. Spike- specific CXCR3^(+) T_(FH) cells exhibit a dominant and more durable response than CXCR3^(-) T_(FH) cells that positivelycorrelated with antibody responses. A third booster dose preferentially expands the spike-specific CXCR3^(+) T_(FH) cell subset inducedby two doses of inactivated vaccine, contributing to antibody maturation and potency. Functionally, spike-specific CXCR3^(+) T_(FH) cellshave a greater ability to induce spike-specific antibody secreting cells (ASCs) differentiation compared to spike-specific CXCR3^(-) T_(FH)cells. In conclusion, the persistent and functional role of spike-specific CXCR3^(+) T_(FH) cells following SARS-CoV-2 infection andvaccination may play an important role in antibody maintenance and recall response, thereby conferring long-term protection. Thefindings from this study will inform the development of SARS-CoV-2 vaccines aiming to induce long-term protective immunememory. | Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 16 | Target decomposition and recognition from wide-angle SAR imaging based on a Gaussian amplitude-phase model显示文摘Wide-angle synthetic aperture radar(W-SAR) imaging accounts for multi-azimuthal scattering and is feasible for retrieving more comprehensive features of complex targets. Because a typical target is seen as composed of its components(typically, some simple geometric objects), a Gaussian amplitude-phase(GAP)model has been developed for the analysis of multi-azimuthal scattering from these objects. Based on the timefrequency analysis of wide-angle scattering, the parameters of the GAP model were estimated, including the Gaussian variance, the surface curvature, and the number of objects in all imaged pixels. Numerical simulations and real measurements demonstrate the capability of the GAP model for decomposing and recognizing complex electric-large targets. | Yongchen LI Ya-Qiu JIN | 2017 | Science China(Information Sciences)2017，60，6： | 0 |
| 17 | Imaging and structural feature decomposition of a complex target using multi-aspect polarimetric scattering显示文摘Based on the Huynen parametric decomposition of target scattering matrix, the polarimetric ellipse parameters are transformed and applied to decomposition of scattering mechanisms of a complex target in VHR POL-SAR images(very high resolution, polarimetric synthetic aperture radar). Making use of multi-aspect(or circle-aspect) and wideband VHR POL-SAR images, scattering mechanisms of a volumetric target and its structural components are recognized over image pixels. Utilizing the layover features, the target height profile is also estimated from two-dimensional image. As example, polarimetric scattering data of some vehicles on ground, including multi-aspect simulated data and experimental measurements, are applied to validations of scattering mechanism decompositions and target structural feature recognition. | Yongchen LI Ya-Qiu JIN | 2016 | Science China(Information Sciences)2016，59，8： | 0 |
| 18 | Realtime prediction of hard rock TBM advance rate using temporal convolutional network(TCN)with tunnel construction big data显示文摘Real-time dynamic adjustment of the tunnel bore machine(TBM)advance rate according to the rockmachine interaction parameters is of great significance to the adaptability of TBM and its efficiency in construction.This paper proposes a real-time predictive model of TBM advance rate using the temporal convolutional network(TCN),based on TBM construction big data.The prediction model was built using an experimental database,containing 235 data sets,established from the construction data from the Jilin Water-Diversion Tunnel Project in China.The TBM operating parameters,including total thrust,cutterhead rotation,cutterhead torque and penetration rate,are selected as the input parameters of the model.The TCN model is found outperforming the recurrent neural network(RNN)and long short-term memory(LSTM)model in predicting the TBM advance rate with much smaller values of mean absolute percentage error than the latter two.The penetration rate and cutterhead torque of the current moment have significant influence on the TBM advance rate of the next moment.On the contrary,the influence of the cutterhead rotation and total thrust is moderate.The work provides a new concept of real-time prediction of the TBM performance for highly efficient tunnel construction. | Zaobao LIU Yongchen WANG Long LI Xingli FANG Junze WANG | 2022 | Frontiers of Structural and Civil Engineering2022，16，4： | 0 |
| 19 | An improved model for predicting hydrate phase equilibrium in marine sediment environment显示文摘Based on the models of hydrate phase equilibrium in bulk water and porous media,an improved model was proposed to predict the methane hydrate equilibrium in marine sediment environment.In the suggested model,mechanical equilibrium of force between the interfaces in hydrate-liquid-vapor system was considered.When electrolyte was present in pore water,interfacial energy between hydrate and liquid was corrected by an equation that is expressed as the function of temperature and electrolyte concentration.The activity of water is calculated based on the Pitzer model and the interfacial energy between liquid and gas is solved using the Li method.The prediction results show good agreement with the experimental data.By comparison with other models,it is proved that this model can improve the accuracy for predicting hydrate phase equilibrium in marine sediment environment. | Yongchen Song Mingjun Yang Yongjun Chen Qingping Li | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 0 |
| 20 | A large-scale experimental simulator for natural gas hydrate recovery and its experimental applications显示文摘To facilitate the recovery of natural gas hydrate(NGH)deposits in the South China Sea,we have designed and developed the world's largest publicly reported experimental simulator for NGH recovery.This system can also be used to perform CO_(2) capture and sequestration experiments and to simulate NGH recovery using CH_(4)/CO_(2) replacement.This system was used to prepare a shallow gas and hydrate reservoir,to simulate NGH recovery via depressurization with a horizontal well.A set of experimental procedures and data analysis methods were prepared for this system.By analyzing the measurements taken by each probe,we determined the temperature,pressure,and acoustic parameter trends that accompany NGH recovery.The results demonstrate that the temperature fields,pressure fields,acoustic characteristics,and electrical impedances of an NGH recovery experiment can be precisely monitored in real time using the aforementioned experimental system.Furthermore,fluid production rates can be calculated at a high level of precision.It was concluded that(1)the optimal production pressure differential ranges from 0.8 to 1.0 MPa,and the wellbore will clog if the pressure differential reaches 1.2 MPa;and(2)during NGH decomposition,strong heterogeneities will arise in the surrounding temperature and pressure fields,which will affect the shallow gas stratum. | Yang Ge Qingping Li Xin Lv Mingqiang Chen Bo Yang Benjian Song Jiafei Zhao Yongchen Song | 2023 | Petroleum2023，9，4： | 0 |
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