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| 1 | Testicular sperm extraction and intracytoplasmic sperm injection in non obstructive azoospermia显示文摘Objective To report the experience in sperm extraction from testicular biopsies (TESE) performed from March 1996 to July 1998 in men with non obstructive azoospermia (NOA) Methods Comparisons of age, volume of both testes, serum FSH and testosterone in men, and histology of testicular samples in the first cycles between cycles with spermatozoa found and those without spermatozoa found were performed Comparisons of fertilization, cleavage and pregnancy rates between cycles with spermatozoa injected and those with spermatids injected were performed Results Spermatozoa were found in only 12 out of 26 first TESE cycles (46 2%) and other cycles had spermatids (round cells) only Age of men, history of mumps orchitis/oligozoospermia, volume of both testes and serum FSH/testosterone levels in men were not significantly different between cycles with and without spermatozoa The fertilization rate was significantly higher in cycles with spermatozoa injected than those with round cell injections (63 3% vs 23 2%, P <0 0001, Chi squared test) The pregnancy rate was 14 3% per cycle when spermatozoa were injected Conclusions TESE followed by Intracytoplasmic sperm injection (ICSI) is an effective treatment in patients with NOA Less than half of the patients undergoing TESE had spermatozoa recovered Age of men, volume of both testes and serum FSH/ testosterone levels in men were not useful in predicting successful recovery Compared to using ejaculated and epididymal spermatozoa, fertilization and pregnancy rates were achieved when testicular spermatozoa were used for | Ng Hung Yu Ernest, Lau Yee Lan, Yeung Shu Biu, So Wai Ki, Tam Po Chor and Ho Pak Chung | 2000 | Chinese Medical Journal2000，，3： | 7 |
| 2 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 3 | Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong显示文摘 | Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong Siu Wai Tang | 2016 | Journal of Geriatric Cardiology2016，13，5： | 5 |
| 4 | Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells显示文摘Monosialoganglioside 1(GM1) is the main ganglioside subtype and has neuroprotective properties in the central nervous system. In this study, we aimed to determine whether GM1 alleviates neurotoxicity induced by moderate and high concentrations of propofol combined with remifentanil in the immature central nervous system. Hippocampal neural stem cells were isolated from newborn Sprague-Dawley rats and treated with remifentanil(5, 10, 20 ng/m L) and propofol(1.0, 2.5, 5.0 μg/m L), and/or GM1(12.5, 25, 50 μg/m L). GM1 reversed combined propofol and remifentanil-induced decreases in the percentage of 5-bromodeoxyuridine(+) cells and also reversed the increase in apoptotic cell percentage during neural stem cell proliferation and differentiation. However, GM1 with combined propofol and remifentanil did not affect β-tubulin(+) or glial fibrillary acidic protein(+) cell percentage during neural stem cell differentiation. In conclusion, we show that GM1 alleviates the damaging effects of propofol combined with remifentanil at moderate and high exposure concentrations in neural stem cells in vitro, and exerts protective effects on the immature central nervous system. | Jiang Lu Xue-qin Yao Xin Luo Yu Wang Sookja Kim Chung He-xin Tang Chi Wai Cheung Xian-yu Wang Chen Meng Qing Li | 2017 | Neural Regeneration Research2017，12，6： | 4 |
| 5 | Is it safe to perform operation for colorectal malignancy in Chinese patients without DVT prophylaxis? An 8-year experience from a regional hospital in Hong Kong显示文摘背景 Colorectal 外科为手术后的深静脉血栓(DVT ) 和肺的栓塞被认为是高风险外科之一。在为 malignancy.Methods 数据的 colorectal 外科从从 2000 ~ 2008 的 colorectal 恶意的未来的数据库是镇定的以后,这研究瞄准了调查静脉的 thromboembolism (VTE ) 的发生。1421 colorectal 的一个总数(开并且 laparoscopic ) 没有 DVT prophylaxis.Results,手术仅仅为 colorectal 恶意被动七个病人(0.5%) 开发了征兆的 DVT,没有死亡,他们之一有肺的栓塞的复杂并发症。然而,为 colorectal 恶意的开的操作作为 DVT 的可能的风险因素被识别风险因素喜欢起作用的时间,低前面的切除术,性,在 colorectal 操作用我们的地区的汉语是低的,没有 DVT 预防,为恶意动 colorectal 手术可能是安全的以后,年龄等等不是静脉的 thromboembolism 的 identified.Conclusion 风险。 | Day Weida Lau Ying Yu Patrick Yip Wai Chun Andrew | 2010 | Chinese Medical Journal2010，，15： | 3 |
| 6 | Magnetism in Carbon Nanoscrolls: Quasi-Half-Metals and Half-Metals in Pristine Hydrocarbons显示文摘A magnetic ground state is revealed for the first time in zigzag-edged carbon nanoscrolls(ZCNSs)from spin-unrestricted density functional theory calculations.Unlike their flat counterpart-zigzag-edged carbon nanoribbons,which are semiconductors with spin-degenerate electronic structure-ZCNSs show a variety of magnetic configurations,namely spin-selective semiconductors,metals,semimetals,quasi-half-metals,and half-metals.To the best of our knowledge,this is the first discovery of quasi-half-metals and half-metals in a pure hydrocarbon without resort to an external electric field.In addition,we calculated the spin-dependent transportation of the semiconducting ZCNSs with 12 and 20 zigzag chains,and found that they are 13% and 17% at the Fermi level,respectively,suggesting that ZCNS can be an effective spin filter. | Lin Lai Jing Lu Lu Wang Guangfu Luo Jing Zhou Rui Qin Yu Chen Hong Li Zhengxiang Gao Guangping Li Wai Ning Mei Yutaka Maeda Takeshi Akasaka and Stefano Sanvito | 2009 | Nano Research2009，2，11： | 3 |
| 7 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 8 | Liver fibrosis progression in chronic hepatitis B patients positive for hepatitis B e antigen: A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，11： | 2 |
| 9 | Room temperature Ⅲ–Ⅴ nanolasers with distributed Bragg reflectors epitaxially grown on(001) silicon-on-insulators显示文摘Efficient, scalable, bufferless, and compact Ⅲ–V lasers directly grown on(001)-oriented silicon-on-insulators(SOIs) are preferred light sources in Si-photonics. In this article, we present the design and operation of Ⅲ–V telecom nanolaser arrays with integrated distributed Bragg reflectors(DBRs) epitaxially grown on industry-standard(001) SOI wafers. We simulated the mirror reflectance of different guided modes under various mirror architectures, and accordingly devised nanoscale DBR gratings to support high reflectivity around1500 nm for the doughnut-shaped TE01 mode. Building from InP/InGaAs nanoridges grown on SOI, we fabricated subwavelength DBR mirrors at both ends of the nanoridge laser cavities and thus demonstrated room-temperature low-threshold InP/InGaAs nanolasers with a 0.28 μm^2 cross-section and a 20 μm effective cavity length. The direct growth of these bufferless nanoscale Ⅲ–V light emitters on Si-photonics standard(001) SOI wafers opens future options of fully integrated Si-based nanophotonic integrated circuits in the telecom wavelength regime. | YU HAN WAI KIT NG YING XUE KAM SING WONG KEI MAY LAU | 2019 | Photonics Research2019，7，9： | 2 |
| 10 | Macrophage Migration Inhibitory Factor Is an Important Mediator in the Pathogenesis of Gastric Inflammation in Rats显示文摘 | Xiao Ru Huang Connie Wun Chun Hui Yong-Xiong Chen Benjamin Chun Yu Wong Peter C.W. Fung Christine Metz Chi Hin Cho Wai Mo Hui Richard Bucala Shiu-Kum Lam Hui Y. Lan | 2001 | Gastroenterology2001，，3： | 2 |
| 11 | Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress显示文摘 | Sin Bond Leung Huina Zhang Chi Wai Lau Yu Huang Zhixiu Lin Wagner Vilegas | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 12 | Liver fibrosis progression is uncommon in patients with inactive chronic hepatitis B : A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，12： | 2 |
| 13 | Aldose Reductase–Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets显示文摘 | Wai Ho Tang Jeremiah Stitham Yu Jin Renjing Liu Seung Hee Lee Jing Du Gourg Atteya Scott Gleim Geralyn Spollett Kathleen Martin John Hwa | 2014 | Circulation2014，，15： | 1 |
| 14 | Assessment of visual function in chronic progressive external ohthalmoplegia 显示文摘 | Yu Wai Man CY Smith T | 2006 | Eye2006，20，5： | 1 |
| 15 | Effect of age on ovarian stromal flow measured by three - dimensional ultrasound with power Doppler in Chinese women with proven fertility 显示文摘 | Ernest Hung Yu Ng Carina Chi Wai Chart William Shu Biu Yeung | 2004 | Hum Reprod2004，19，： | 1 |
| 16 | Shipping emissions associated with increased cardiovascular hospitalizations显示文摘 | Linwei Tian Kin-fai Ho Peter K.K. Louie Hong Qiu Vivian C. Pun Haidong Kan Ignatius T.S. Yu Tze Wai Wong | 2013 | Atmospheric Environment2013，，： | 1 |
| 17 | On some models for value-at-risk 显示文摘 | Yu P L Li Wai Keung Jin Shusong | 2010 | Econometric Reviews2010，29，： | 1 |
| 18 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 19 | Effects of a Laser Acupuncture Therapy on Treating Pain显示文摘 | WONG Wai XIAO Shao-jun YU Wing | 2001 | SPIE Int Soc Opt Eng2001，4606，： | 1 |
| 20 | A random- ized placebo - controlled trial of idebenone in Lebers hereditary op- tic neuropathy 显示文摘 | Klopstock T Yu -Wai -Man P Dimitriadis K | 2011 | Brain2011，134，9： | 1 |
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