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| 1 | bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis显示文摘Iron(Fe)deficiency is prevalent in plants grown in neutral or alkaline soil.Plants have evolved sophisticated mechanisms that regulate Fe homeostasis,ensuring survival.In Arabidopsis,FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR(FIT)is a crucial regulator of Fe-deficiency response.FIT is activated indirectly by basic helix-loop-helix(bHLH)IVc transcription factors(TFs)under Fed eficiency;how ever,it remains unclear which protein(s)act as the linker to mediate the activation of FIT by bHLH IVc TFs.In this study,we characterize the functions of bHLH121 and demonstrate that it directly associates with the FIT promoter.We found that loss-of-function mutations of bHLH121 cause severe Fedeficiency symptoms,reduced Feaccum ulation,and disrupted expression of genes associated with Fehomeostasis.Genetic analysis showed that FIT is epistatic to bHLH121 and FIT overexpression partially rescues the bhlh121 mutant.Further investigations revealed that bHLH IVc TFs interact with and promote nuclear accumulation of bHLH121.We demonstrated that bHLH121 has DNA-binding activity and can bind the prom oters of the FIT and bHLHlb genes,but we did not find that it has either direct transcriptional activation or repression activity tow ard these genes.Meanw hile,we found that bHLH121 functions downstream of and is a direct target of bHLH IVc TFs,and its expression is induced by Fe deficiency in a bHLH IV c-dependent manner.Taken together,these results establish that bHLH121 functions together with bHLH IVc TFs to positively regulate the expression of FIT and thus plays a pivotal role in maintaining Fe homeostasis in Arabidopsis. | Rihua Lei Yang Li Yuerong Cai Chenyang Li Mengna Pu Chengkai Lu Yujie Yang Gang Liang | 2020 | Molecular Plant2020，13，4： | 14 |
| 2 | Correlation between platelet gelsolin levels and different types of coronary heart disease显示文摘Gelsolin is an important cytoskeletal protein of platelets and studies have shown a close relationship between gelsolin and cardiovascular disease.However,the role of gelsolin in the development of coronary heart disease(CHD) is unclear.In this study,we record the distribution of gelsolin in human platelets and plasma and its association with different types of CHD.This study included 114 cases,with 33 stable angina pectoris(SAP) cases,81 acute coronary syndrome(ACS) cases—composed of 39 unstable angina pectoris(UAP) and 42 acute myocardial infarction(AMI) cases,and 31 healthy control participants.Gelsolin concentration in platelet rich plasma(PRP) and platelet poor plasma(PPP),actin filament(F-actin) and Gc-globulin of PPP were determined by enzyme-linked immunoadsorbent assay(ELISA).The fluorescence intensity of CD62p and cytoplasmic calcium([Ca2+] i) in human platelets measured by flow cytometry.We also used turbidimetry to detect the platelet aggregation rate(PAR).We analyzed the correlation between platelet gelsolin concentration and CD62p or plasma F-actin levels among each different patient group.Compared with the control group,the gelsolin level in PRP of UAP and AMI groups increased significantly(P<0.01),while the gelsolin level in PPP of all the three patient groups decreased markedly(P<0.01),and the CD62p,PAR,[Ca2+] i of platelets,F-actin and Gc-globulin of the UAP and AMI groups increased significantly(P<0.01).Compared with the SAP group,the gelsolin level in PRP,the PAR,[Ca2+] i of platelets and CD62p of other two groups increased significantly(P<0.01),F-actin of the AMI group increased markedly(P<0.01).Platelet cytoskeleton protein dynamics vary among the different types of CHD.Platelet gelsolin levels are markedly increased and accompanied by increased platelet activity,F-actin and [Ca2+] i of ACS patients,while gelsolin levels in PPP are markedly lower.Abnormally increased platelet gelsolin levels show high positive correlation with the level of platelet activity.Therefore,platelet gelsolin might be a novel molecular marker and/or a new potential therapeutic target of anti-platelet therapy of ACS. | LIU Yue YIN HuiJun JIANG YueRong XUE Mei CHEN KeJi | 2012 | Chinese Science Bulletin2012，57，6： | 8 |
| 3 | Integrative Chinese and western medicine on atherosclerosis of coronary heart disease: what are the new control strategies?显示文摘How to control and prevent atherosclerosis(AS) remains a global issue that needs to be deeply discussed. The innovation concept of AS and coronary heart disease(CHD) in western medicine provides a good opportunity to develop the traditional Chinese medicine etiology and new control strategies accordingly. This article reviewed and refined the updated control strategies of AS of CHD integrated Chinese and western medicine based on the innovation concept and therapeutic guideline of AS and CHD during the last 10 years. | Yue Liu Yuerong Jiang Jingchun Zhang Dazhuo Shi | 2014 | Chinese Science Bulletin2014，59，11： | 4 |
| 4 | bHLH104 confers tolerance to cadmium stress in Arabidopsis thaliana显示文摘Cd is a non-essential heavy metal that is toxic to both plants and animals. Here, we reveal that the transcription factor bHLH104 positively regulates Cd tolerance in Arabidopsis thaliana. We show that Fe deficiency-responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss-of-function mutants, but enhanced upon overexpression of bHLH104. Correspondingly, the bhlh104 mutants displayed sensitivity to Cd stress, whereas plants overexpressing bHLH104 exhibited enhanced Cd tolerance.Further analysis suggested that bHLH104 positively regulates four heavy metal detoxification-associated genes, IREG2, MTP3, HMA3 and NAS4, which play roles in Cd sequestration and tolerance. The bHLH104 overexpression plants accumulated high levels of Cd in the root but low levels of Cd in the shoot, which might contribute to the Cd tolerance in those lines. The present study thus points to bHLH104 as a potentially useful tool for genetic engineering of plants with enhanced Cd tolerance. | Xiani Yao Yuerong Cai Diqiu Yu Gang Liang | 2018 | Journal of Integrative Plant Biology2018，60，8： | 4 |
| 5 | Simulation and Experiment on Workability for Cold Pressure Forming of Sheet Metal Part with Step Cross-section显示文摘In modern manufacturing,a new type of sheet metal part with step cross-section in both inner hole and outer edge is proposed.The traditional stamping separating processes can only produce sheet metal part with vertical cross-section.According to the latest developing theory and potential of cold pressure forming:combination of pressure and cold forging,a new flow control forming of sheet metal(FCF) is excogitated based on blanking process of general stamping and combined with cold forging processes such as extrusion and coining,etc,which is aiming at the above-mentioned new type of sheet metal part.With utilization of this new process,the new type of sheet metal parts can be manufactured.In order to shorten the testing period,the numerical simulation was carried out by using DEFORM-3D software,and both deformation and mechanics rules were analyzed.Based on the simulation,both punching part and blanked parts of this new type were successfully developed.Then a new conception of optimal distance between the step walls of inner hole and outside edge was proposed and the design principle for its numerical value was inferred.Furthermore,a mold set for combination of stamping & cold forging was designed and manufactured,by which the technologic experiments were taken for validation with Aluminum plate of thickness 2.35 mm for power battery cover board,which verified the principle of the distance between the step walls.The research of cold pressure forming of thin sheet metal with step cross-section is significant,not only to the development of modern mechanical manufacture,but also to metal plastic forming science. | LU Xianfeng LI Hufeng ZHANG Yuerong ZHOU Yong | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 3 |
| 6 | Estimation of black tea quality by analysis of chemical composition and colour difference of tea infusions显示文摘 | Yuerong Liang Jianliang Lu Lingyun Zhang Shan Wu Ying Wu | 2002 | Food Chemistry2002，，2： | 3 |
| 7 | Investigation of gene expression profiles in coronary heart disease and functional analysis of target gene显示文摘The research outlined here includes constitution of the differential gene expression profile by means of oligonucleotide gene microarray and functional analysis of the target gene for coronary heart disease (CHD). In a microarray screening experiment, the predominance of inflammation- and immune-related genes is presented in the expression profile of 107 differential genes based on the analysis of gene ontology and gene pathway. IL-8, an inflammatory factor, is identified as one of the genes that were markedly up-regulated in CHD. The plasma level of IL-8 is significantly raised in patients with CHD (n = 30) compared with healthy controls (n = 40), which underscores the clinical relevance of the in vitro finding. The further functional analysis shows that IL-8 affects platelet aggregation percentage, ex-pression of CD62p and platelet aggregation morphology in 12 healthy volunteers to some extent. These findings suggest the relevance of inflammation and immune responses to CHD at the DNA level. Moreover, IL-8 may be involved in the pathogenesis of CHD through the pathway of platelet activation. | YIN HuiJun MA XiaoJuan JIANG YueRong SHI DaZhuo CHEN KeJi | 2009 | Chinese Science Bulletin2009，54，5： | 3 |
| 8 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 9 | Differential gene expression profile in ischemic myo-cardium of Wistar rats with acute myocardial infarction显示文摘To determine the differential genes in ischemic myocardium of Wistar rats with acute myocardial in- farction (AMI), we constructed two differential gene expression profiles. AMI model was generated by ligation of the left anterior descending coronary artery in Wistar rats. Total RNA was extracted from the normal and the ischemic heart tissues under the ligation point at the 8th day after the operation. Dif- ferential gene expression profiles of the two samples were constructed by using long serial analysis of gene expression (LongSAGE). Real time fluorescence quantitative PCR (Q-PCR) was used to confirm the expression changes of partial target genes. The main results were as follows: a total of 15966 tags were screened from the normal and the ischemic LongSAGE maps, and 9646 tags in the normal tissue and 9563 tags in the ischemic tissue were obtained. Among them, 7665 novel tags were identified by NCBI BLAST search. In the ischemic tissue, 142 genes significantly changed compared to those in the normal tissue (P<0.05). These differentially expressed genes may play important roles in the pathways of oxidation and phosphorylation, ATP synthesis and glycolysis and so on. Partial genes identified by the LongSAGE were confirmed by Q-PCR. The results show that AMI causes a series of gene expres- sion changes in the regulation of the pathways related to energy metabolism. | GUO ChunYu YIN HuiJun JIANG YueRong XUE Mei SHI DaZhuo | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 10 | Effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits显示文摘In this study, the effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits was observed. Thirty New Zealand rabbits were randomly divided into the normal control group, the model control group and the simvastatin group, 10 in each group. Rabbits in the normal control group were fed with normal forage, while rabbits in the rest two groups were fed with high fat forage. The balloon injury was performed two weeks later to establish an abdominal aortic atherosclerosis model, and then high fat forage was successively fed to them. Meanwhile, simvastatin at the daily dose of 2.5 mg/kg body weight was administered to rabbits in the simvastatin group. After 6 weeks of successive administration, levels of blood lipids were measured after blood sampling, and the serum high sensitivity C-reactive protein (hsCRP) and matrix metalloproteinase-3,-9 (MMP-3,-9) were detected using enzyme-linked immunosorbent assay. The macroscopically pathological indices of the plaque tissue were observed using hematoxylin and eosin (HE) staining of abdominal aorta specimens under a light microscope, and the plaque area (PA), cross-sectional vascular area (CVA) and correcting plaque area (PA/CVA) were determined quantitatively using imaging software. The protein expressions of the vascular endothelial growth factor (VEGF), factor VIII related antigen (FVIIIRAg), MMP-3 and cluster of differentiation antigen 40 ligand (CD40L) in the plaque were detected with the immunohistochemical method. Compared with the model control group, the levels of VEGF, FVIIIRAg, MMP-3, CD40L protein expression and the serum expression levels of hsCRP, MMP-3, MMP-9 in the simvastatin group were significantly reduced (P<0.05, P<0.01). The ratio PA/CVA in the simvastatin group was more significantly reduced when compared with that in the model control group (P<0.01). The levels of serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL) were significantly reduced in the simvastatin group when compared with those in the model control group (P<0.05, P<0.01). Simvastatin plays a certain role in stabilizing the atherosclerotic plaque, and inhibiting the angiogenesis in the atherosclerotic plaque may be one of possible mechanisms. | ZHANG Lu JIANG YueRong XUE Mei WU CaiFeng WANG JingShang YIN HuiJun | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 11 | Evaluation and Overview of Progress in Farmland Protection Researches显示文摘With rapid advance of urbanization in China,both quantity and quality of farmland are gravely threatened,human-land conflict is growing,and the issue of grain security becomes more serious.Accordingly,practical and feasible protection of farmland has become one of core problems in China's land resource management.From theory,system,effective factors and measures and methods of farmland protection, this paper comprehensively analyzes research achievement and progress in farmland protection,in the hope of providing basis for further indepth research of farmland protection in China. | Lan LUO Guo ZHANG Yuerong ZHENG Xiang NING | 2013 | Asian Agricultural Research2013，5，8： | 2 |
| 12 | A study on chemical estimation of pu-erh tea quality显示文摘 | Yuerong Liang Lingyun Zhang Jianliang Lu | 2005 | Sci Food Agric2005，85，： | 1 |
| 13 | Es- timation of black tea quality by analysis of chemical composition and colour difference of tea infusions 显示文摘 | Liang Yuerong Lu Jianliang Zhang Lingyun | 2003 | Food Chemistry2003，80，2： | 1 |
| 14 | A study on chemical estimation of pu-erh tea quality 显示文摘 | Liang Yuerong Zhang Lingyun Lu Jianliang | 2005 | Jour- nal of the Science of Food and Agriculture2005，85，3： | 1 |
| 15 | Gradient V2O5 surface-coated LiMn2O4 cathode towards enhanced performance in Li-ion battery applications显示文摘 | MING Hai YAN Yuerong MING Jun | 2014 | Electrochimica Acta2014，120，： | 1 |
| 16 | Expression of basic genes involved in tea polyphenol synthesis in relation to accumulation of catechins and total tea polyphenols显示文摘 | George Edward Mamati Yuerong Liang Jianliang Lu | 2006 | Journal of the Science of Food and Agriculture J Sci Food Agric2006，86，： | 1 |
| 17 | Molecular-based Integrated Identification of Bacterial Blight(Xanthomonas axonopodis pv. dieffenbachiae) in Anthurium and Detection of Latent Infection显示文摘Bacterial blight,caused by Xanthomonas axonopodis pv. dieffenbachiae( Xad),is the most destructive disease of anthurium worldwide,and no effective control technique has been developed currently. The comprehensive survey and precise detection of the pathogen is essential for evaluating disease progress and strengthening management to avoid a serious epidemic. In this study,a total of 253 blight-suspected samples of anthurum and other Araceae species were collected across the country,and 166 potential pathogenic bacteria strains were isolated and purified,after combined analysis on the characteristics of morphology,pathogenicity,16 S r DNA sequences and amplicons of Xad-specific SCAR markers. Finally,93 of which were considered as X. axonopodis pv. dieffenbachiae. In addition,by using a nested-PCR in repeated detections,17 out of 21 prevalent anthurium cultivars without blight symptom exhibited latent infection even in young leaves. The results indicated that the anthurium bacterial blight distributed commonly in growing areas in China,and most of the commercial cultivars had no strong resistance.The identification of Xad infection( latent) would be beneficial for the disease forecasting and management improving in anthurium production. | Niu Junhai Gao Yuerong Leng Qingyun Yang Guangsui Lin Xinge Zhang Zhiqun Yin Junmei | 2014 | Plant Diseases and Pests2014，5，5： | 1 |
| 18 | Fine Mapping of QTLs for Stigma Exsertion Rate from Oryza glaberrima by Chromosome Segment Substitution显示文摘Stigma exsertion is an important trait for outcrossing ability in rice.Stigma exsertion rate(SER)of male sterile lines(MSLs)is a key factor affecting F1-seed production in hybrid rice.In this study,seven QTLs for SER were detected on five chromosomes using a set of single-segment substitution lines(SSSLs)derived from O.glaberrima.Three of the QTLs were mapped in the estimated intervals of 92.5–333.0 kb.qSER-5 was located in a substitution segment of 92.5 kb.qS ER-1 b and qS ER-8 b were respectively limited to 333.0 kb and 107.5 kb by secondary substitution mapping.qSER-1 b and qSER-3 had bigger additive effects of 11.5%and 11.9%,respectively,while the other five QTLs had smaller additive effects from 5.7%to 8.6%.Open reading frames were identified in the regions of qS ER-5 and qSER-8 b in O.sativa and O.glaberrima genomes.Fine mapping of the QTLs laid a foundation for the cloning of genes,and QTLs for SER will be used to develop MSLs with strong ability of outcrossing. | TAN Quanya ZHU Haitao LIU Hui NI Yuerong WU Shengze LUAN Xin LIU Junwei YANG Weifeng YANG Zifeng ZENG Ruizhen LIU Guifu WANG Shaokui ZHANG Guiquan | 2022 | Rice science2022，29，1： | 1 |
| 19 | Estimation of black tea quality by analysis of chemical composition and colour difference of tea infusions显示文摘 | LIANG Yuerong LU Jianliang ZHANG Lingyun | 2003 | Food Chemistry2003，80，2： | 1 |
| 20 | A study on chemical estimation of pu-erh tea quality 显示文摘 | Liang Yuerong Zhang Lingyun Lu Jianliang | 2005 | Sci Food Agric2005，85，： | 1 |
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