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| 1 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 2 | Combination of ribavirin and reduning protects mice against severe pneumonia induced by H1N1 influenza a virus显示文摘OBJECTIVE:To investigate the effects of ribavirin administration combined with Reduning in a mouse model of influenza A(H1N1)-induced severe pneumonia.METHODS:Influenza A/Beijing/501/2009(H1N1)-infected C57BL/6 mice were randomly divided into four experimental groups treated with either a mock injection of phosphate-buffered saline(PBS),ribavirin(66.6 mg/kg daily)or Reduning(86.6 mg/kg daily),or a combination of both,for 7 days.Mice were monitored for clinical signs and survival,and body weight was measured daily for 14 days.Virus titer,lung wet-to-dry ratios,pathology and cytokines including interleukin(IL)-6,IL-10,and interferon(IFN)-γwere assayed on different days.RESULTS:In the untreated group injected with phosphate buffer saline,all the mice died of the infection.The survival rate of mice treated with Reduning was only 10%,whereas 100%of the ribavirin-and the combination-treated mice survived.Low lung viral loads indicated that ribavirin significantly inhibited virus replication,whereas Reduning did not.Lung wet-to-dry ratios demonstrated that both ribavirin and Reduning,administered together or separately,reduced acute lung edema compared with results in the untreated group.Pathology analyses also showed that treatment with a combination of both drugs relieved pathological lesions,whereas the single drug treatment did not.Levels of IL-6,IL-10 and IFN-γin mice treated with ribavirin or the combination of both ribavirin and Reduning were all significantly lower than in the untreated group,especially in the combination-treated group.In addition,Reduning administration significantly decreased both IL-6 and IL-10production but had no effect on IFN-γ.CONCLUSION:Due to the synergistic effect of antiviral and antiinflammation,the combination of ribavirin and Reduning could be an effective treatment for severe H1N1 which was considered to be significant to delayed antiviral and drug resistant. | Ma Yuexia Zhang Wei Zhao Zhongpeng Li Min Liu Jian Wang Yuguang | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 13 |
| 3 | Analyses of circRNA profiling during the development from pre-receptive to receptive phases in the goat endometrium显示文摘Background: Recent studies have revealed that noncoding RNAs play important regulatory roles in the formation of endometrial receptivity.Circular RNAs(circRNAs) are a universally expressed noncoding RNA species that have been recently proposed to act as miRNA sponges that directly regulate expression of target genes or parental genes.Results: We used Illumina Solexa technology to analyze the expression profiles of circRNAs in the endometrium from three goats at gestational day 5(pre-receptive endometrium,PE) and three goats at gestational day 15(receptive endometrium,RE).Overall,21,813 circRNAs were identified,of which 5,925 circRNAs were specific to the RE and 9,078 were specific to the PE,which suggested high stage-specificity.Further analysis found 334 differentially expressed circRNAs in the RE compared with PE(P < 0.05).The analysis of the circRNA-miRNA interaction network further supported the idea that circRNAs act as miRNA sponges to regulate gene expression.Moreover,some circRNAs were regulated by estrogen(E2)/progesterone(P4) in endometrial epithelium cell lines(EECs) and endometrial stromal cell line(ESCs),and each circRNA molecule exhibited unique regulation characteristics with respect to E2 and P4.Conclusions: These data provide an endometrium circRNA expression atlas corresponding to the biology of the goat receptive endometrium during embryo implantation. | Yuxuan Song Lei Zhang Xiaorui Liu Mengxiao Niu Jiuzeng Cui Sicheng Che Yuexia Liu Xiaopeng An Binyun Cao | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 8 |
| 4 | Two-Layer Coupled Network Model for Topic Derivation in Public Opinion Propagation显示文摘In view of the fact that news can generate derivative topics when it spreads through micro-blogs,a two-layer coupled SEIR public opinion propagation model is proposed in this paper.The model divides the process of public opinion propagation into two layers:the original topic layer and the derived topic layer.Messages are transmitted separately by the SEIR model in the two topic layers,which are independent and interactive.The influence of the topic derivation rate on the propagation trend is established by solving for the equilibrium point and propagation threshold.Further,we establish the relationship between the original topic and the derived topic by simulation.This paper uses the Baidu index to demonstrate the correctness of the model.The relationship between the derived topic and the original topic is verified by adjusting the parameters by the control variable method.The results show that the proposed model is consistent with the propagation of actual public opinion. | Yuexia Zhang Yixuan Feng | 2020 | China Communications2020，17，3： | 5 |
| 5 | Indoor environmental quality and the prevalence of childhood asthma and rhinitis in Wuhan area of China显示文摘Indoor environmental quality is suspected to be at least part of the cause of the increasing prevalence of childhood asthma and allergy.This study is part of the China,Children,Homes,Health(CCHH)project,which was designed to identify the risk factors indoors that are associated with prevalence of asthma and allergy among children in China.A cross-sectional questionnaire study was carried out in Wuhan in 2011.The questionnaire was a modified(to Chinese building characteristics)version of a questionnaire used first in Sweden.The parents of 2193 children,aged 1–8 years,replied,a response rate of 91.4%(2193/2400).Prevalences of asthma and allergic symptoms were calculated,and a Chi-square test and multiple logistic regression were used to identify risk factors.Prevalences of health outcomes are'wheezing last 12 months'18.5%,'cough at night last 12 months'15.4%,'doctor-diagnosed asthma'6.0%,'rhinitis last 12 months'48.7%,'doctor-diagnosed allergic rhinitis'17.5%.Factors associated with increased risk for asthma,allergy and related symptoms include living in an urban area,dampness(significant),use of gas for cooking,new dwelling decoration(paint and furniture obtained during pregnancy),keeping pets and breast feeding less than 3months.Factors associated with reduced risk as installing an exhaust fan in the bathroom.Home environmental factors are significantly associated with the prevalence of childhood asthma and rhinitis in Wuhan.Urbanization and dampness problems at home are significant risk factors for doctor diagnosed asthma and allergic rhinitis among children in Wuhan. | ZHANG Ming ZHOU ESheng YE Xin SUN YueXia SUNDELL Jan YANG Xu | 2013 | Chinese Science Bulletin2013，58，34： | 4 |
| 6 | Effects of intermedinl-53 on myocardial fibrosis显示文摘Intermedin (IMD ) 是 calcitonin/calcitonin 的一个成员基因相关的肽(CGRP ) 家庭并且类似或更多的有势力心血管的行动比 adrenomedullin (ADM ) 和任何另外的 CGRP。现在的工作的目的是在 vivo 并且在 vitro 在心脏的成纤维细胞纤维变性上学习 IMD1-53 的效果。心肌的梗塞模型被绑扎准备老鼠左前面的下降冠的动脉。在左室的间充质的骨胶原内容被天狼星红污点存取。心功能被血液动力学的变化探索。表示我和 III 打骨胶原, IMD1-53,受体修改活动的蛋白质(斜面) 1/2/3,和 calcitonin 在左室的像受体的受体(CRLR ) 被西方的污点分析检测。心脏的成纤维细胞(CFbs ) 纤维变性被与醛固酮(ALD ) 对待房间导致。在上层清液的 CFbs 增长和 hydroxyproline 内容被 3- 决定[4,5-dimehyl-2-thiazolyl ]-2,5-diphenyl-2H-tetrazolium 溴化物试金和连接酶的 immunosorbent 试金。心功能在心肌的梗塞模型老鼠被减少。类型的表示我和在在心肌的老鼠的 infarcted 地区的类型 III 骨胶原是比在假冒操作组的那些高级的。在左室的 IMD1-53,斜面,和 CRLR 也是起来调整的。在 vitro,实验证明 ALD 是 CFbs 激活的一个强大的激发器。IMD1-53 减少了以一种剂量依赖者方式的导致 ALD 的 CFbs 增长。而且, CGRP8-37 和 ADM22-52 显著地在导致 ALD 的心肌的房间纤维变性上堵住了 IMD1-53 的效果。IMD 能涉及心脏的纤维变性的发作。象 ADM 一样, IMD1-53 在 CFbs 上施加 antifibrotic 效果,它可能被 CRLR/RAMP 建筑群和 ADM 受体调停。 | Xiaoling Yang Huiping Zhang Yuexia Jia Lan Ni Guizhong Li Lihua Xue Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 4 |
| 7 | Variations of Summer Phytoplankton Community Related to Environmental Factors in a Macro-Tidal Estuarine Embayment, Hangzhou Bay, China显示文摘To explore the distribution and composition of phytoplankton community and their responses to environmental changes, summer net-collected phytoplankton and physicochemical parameters in the Hangzhou Bay during 2004–2010 were investigated. A total of four phyla and 84 species were identified, including 67 diatom and 12 dinoflagellate species. The dominant species con- stantly consisted of the diatoms, although the dominance of dinoflagellate and cyanobacteria increased recently. Due to great spa- tio-temporal variations in environmental factors(salinity, suspended solids, and nutrient concentration), significant heterogeneities in community compositions among different years and subregions(inner and middle sections, and bay mouth) were found based on the analyses of multidimensional scaling and similarity. Canonical correspondence analysis showed that salinity and Si/N were the main variables associated with algal assemblage. Compared with the historical data since the 1980 s, eutrophication(N, P, and N/P increased with decreasing Si/N) was exacerbated drastically. Moreover, climatic forcing and human activities resulted in a series of physical alterations, including sediment retention, temperature increase, and salinity decrease as well as reduction in water exchanges. All these changes induced obvious increases in cell density and Chl-a while decreases in species diversity and diatom-dinoflagellate ratio as well as the shifting of dominant species. Therefore, the long-term phytoplankton variations were closely related to anthropogenic and climatic perturbations in the Hangzhou Bay. | ZHANG Yuexia YU Jun JIANG Zhibing WANG Qin WANG Hui | 2015 | Journal of Ocean University of China2015，14，6： | 4 |
| 8 | Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China显示文摘Atopic eczema is a common health problem in children.The prevalence has increased in the past decades.Besides a genetic predisposition,lifestyle factors,dietary habits and indoor environments are thought to be related to its high prevalence.A cross-sectional questionnaire study was carried out in 2011 in the Wuhan area to study associations between home environments and children’s health.The questionnaires were replied to by parents of 2193 children 1 8 years old and the response rate was91.4%(2193/2400).The results show:(1)The prevalence of'eczema symptom ever that lasted for 6 months'was 23.2%;'eczema symptom in the last 12 months'7.4%and'awake at night due to itchy rash'3.4%.(2)Risk factors:Closer to business area(AOR 1.4),moisture related problems(AOR 1.3 2.2),moldy and stuffy odor perception(AOR 1.5),mice observed(AOR 1.8),pet keeping(AOR 1.3),exposure to environmental tobacco smoke(AOR 1.3)and incense(AOR 1.8)were significant risk factors for atopic eczema symptoms ever.Living in an apartment,compared to single family house,was related to more eczema symptom in the last 12 months.Damp clothing/bed sheets and perception of stuffy odor were risk factors for both'eczema symptom in the last 12 months'and'awake due to itchy rash(severe eczema)'.The odds ratio of mice observed for severe eczema was 3.1(95%CI:1.4 6.7).It suggests that urbanization,life style and dampness problems at home were significant risk factors for eczema symptoms among children in Wuhan,China. | ZHANG Ming WU Yang YUAN Ye ZHOU ESheng SUNDELL Jan SUN YueXia YANG Xu | 2013 | Chinese Science Bulletin2013，58，34： | 3 |
| 9 | Time Series Analysis on the Ratio for Pixels with Abnormal Brightness Temperature Increase and Its Variation Before Some Earthquakes with M_S≥5.0 in the Taiwan Region显示文摘In the study of the application of MODIS satellite remote sensing data to earthquake prediction, the paper puts forward for the first time a quantitative method to estimate the ratio for the pixels with abnormal brightness temperature (BT) increase and a preliminary scheme for cloud removal. The principle is that, firstly, the cloudless data observed by the same satellite at the same period of time but in different days (usually 1 day to 3 days) are mosaiced to get high ratio of clear sky, and then the BT variation curve and mean square difference (MSD) of each pixel are calculated with the data from the covered area to determine daily whether the BT data of the day is normal or not at a certain pixel by using double the MSD as the criterion. The ratio for the pixels with abnormal BT increase can be calculated by dividing the total number of abnormal pixels with the total pixels of the whole area. Analysis on a series of recent earthquakes in the Taiwan Region shows that the ratio for pixels with abnormal BT increase, which normally undulates around zero, has a sudden enhancement 1 day to 20 days before medium-strong earthquakes. It is expected that a new method for identifying earthquake auspice could be found through special studies in regions with frequent seismic activity by analyzing the change of the ratio for the pixels with abnormal BT increase from MODIS satellite remote sensing infrared (IR) information from which the effect of clouds has been removed to a certain extent. | Liu Fang Xin Hua Zhang Tiebao Lu Qian Ren Yuexia | 2007 | Earthquake Research in China2007，21，4： | 3 |
| 10 | Dynamic Systems of Petroleum Accumulation in the Nanpu Depression,Bohai Bay Basin,China显示文摘为石油累积和分发的理解区分石油累积(DSPA ) 的动态系统是重要的。根据形成压力框架,石油的基因类型和水管系统的特征,石油累积的三个动态系统在 Nanpu 消沉在垂直侧面被识别, Bohai 海湾盆。更深的 DSPA (到 Es2 的包括的形成 Es3 ) 是有高过压、高度成熟的自我采购的油的一个封上的系统。大多数在系统的原油近来在时期积累了渐新世(23.5 妈) 和迟了的上新世(2.4 妈) 。中间的 DSPA (到 Ed1 的包括的形成 Es1 ) 是 overpressured 有成熟或降低成熟的自我采购的油的封上一半的系统。在系统的油的累积也发生在迟了的渐新世(23.5 妈) 和迟了的上新世(2.4 妈) 。更浅的 DSPA (到 Q 的包括的形成 Ed2 ) 是有从中间的系统的降低成熟的采购侨民的油的一个静水力学的系统。在这个系统以内的油仅仅在迟了的上新世时期积累了。在更浅的系统的油沿着 sandbodies 由侧面的移植在中间的系统从先前积累的油沿着差错垂直地移居了,而在更深的系统的石油累积主要从由沿着 sandbodies 并且很少的侧面的移植的本身从系统移植了的系统被导出。在这种情况中,看起来更深的系统是除了另外的二个证明有利系统的更潜在的探索前景。 | LIU Guangdi SUN Mingliang ZHANG Zhihuan DONG Yuexia | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 3 |
| 11 | Molecular characterization of root exudates using Fourier transform ion cyclotron resonance mass spectrometry显示文摘The release of root exudates(REs) provides an important source of soil organic carbon. This work revealed the molecular composition of REs of different plant species including alfalfa( Medicago sativa L.), bean( Phaseolus vulgaris L.), barley( Hordeum vulgare L.), maize( Zea mays), wheat( Triticum aestivum L.), ryegrass( Lolium perenne L.) and pumpkin( Cucurbita maxima) using electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS). The combination of positive ion mode( + ESI) and negative ion mode(-ESI) increased the number of the molecules detected by ESI FT-ICR MS, and a total of 8758 molecules were identified across all the samples. In detail, lipids and proteins and unsaturated hydrocarbons were more easily detected in + ESI mode, while aromatic compounds with high O/C were readily ionized in-ESI mode, and only 38% of the total assigned formulas were shared by -ESI and + ESI modes. Multivariate statistical analysis of the formulas indicated that the close related plants species secreted REs with similar molecular components. Moreover, the unsaturation degree and nitrogen content were the two key parameters able to distinguish the similarities and differences of molecular components of REs between plant species. The results provided a feasible analysis method for characterization of the molecular components of REs and for the first time characterized the molecular components of REs of a variety of plant species using ESI FT-ICR MS. | Yuexia Miao Jitao Lv Honglin Huang Dong Cao Shuzhen Zhang | 2020 | Journal of Environmental Sciences2020，32，12： | 2 |
| 12 | Phosphatase activity and culture conditions of the yeast Candida mycoderma sp. and analysis of organic phosphorus hydrolysis ability显示文摘Orthophosphate is an essential but limiting macronutrient for plant growth. About 67%cropland in China lacks sufficient phosphorus, especially that with red soil. Extensive soil phosphorus reserves exist in the form of organic phosphorus, which is unavailable for root uptake unless hydrolyzed by secretory acid phosphatases. Thus, many microorganisms with the ability to produce phosphatase have been exploited. In this work, the activity of an extracellular acid phosphatase and yeast biomass from Candida mycoderma was measured under different culture conditions, such as p H, temperature, and carbon source. A maximal phosphatase activity of 8.47 × 105± 0.11 × 105U/g was achieved by C. Mycoderma in 36 hr under the optimal conditions. The extracellular acid phosphatase has high activity over a wide p H tolerance range from 2.5 to 5.0(optimum p H 3.5). The effects of different phosphorus compounds on the acid phosphatase production were also studied. The presence of phytin, lecithin or calcium phosphate reduced the phosphatase activity and biomass yield significantly. In addition, the p H of the culture medium was reduced significantly by lecithin. The efficiency of the strain in releasing orthophosphate from organic phosphorus was studied in red soil(used in planting trees) and rice soil(originating as red soil). The available phosphorus content was increased by 230% after inoculating20 days in rice soil and decreased by 50% after inoculating 10 days in red soil. This work indicates that the yeast strain C. mycoderma has potential application for enhancing phosphorus utilization in plants that grow in rice soil. | Mang Yan Liufang Yu Liang Zhang Yuexia Guo Kewei Dai Yuru Chen | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 13 | Gap Junctions Enhance the Antiproliferative Effect of MicroRNA‐124‐3p in Glioblastoma Cells显示文摘 | Zhang Suzhi Tao Liang Peng Yuexia Liu Lucy Hong Xiaoting Zhang Yuan Wang Qin | 2015 | Physiol2015，，10： | 1 |
| 14 | Discussion on evaluating the vulnerability of storm surge hazard bearing bodies in the coastal areas of Wenzhou显示文摘Wenzhou 是暴风雨巨浪经常、严肃以社会,经济,陆地利用,和反灾难能力开始的中国的海岸上的一个区域,在 Wenzhou 的沿海的区域的每个县的危险被评估县然后被划分成温和,中等,重,并且由选择 15 个因素建立评估的极其重的易碎的区域索引系统,用主要部件分析,结果出现设置每个因素的重量所有除了 Pingyang 县适合进重、极其重的易碎的区域的范畴县,它是温和的在在在 Wenzhou 沿海的区域的所有县之中的暴风雨巨浪危险没有重要差别,它高度在浙江沿海的区域和这研究提供的政府政策的取向与社会经济的开发的一般平衡被联系为评估危险袭击巨浪评估结果的一个方法能提供基础因为袭击的回答澎湃,贡献灾难预防并且缓解计划,并且地区性的持续开发计划。 | Yuexia ZHANG Jing GUO Zhumei CHE | 2015 | Frontiers of Earth Science2015，9，2： | 1 |
| 15 | Geology and development of geothermal field in Neogene Guantao Formation in northern Bohai Bay Basin: A case of the Caofeidian geothermal heating project in Tangshan, China显示文摘Taking the Gaoshangpu-Liuzan geothermal field in the Nanpu sag of the Bohai Bay Basin as the research object, this paper discusses the geological conditions and potential of the geothermal resources of the Guantao Formation in the study area, and introduces the development practice of geothermal energy heating in Caofeidian. The average buried depth of the Guantao Formation is 1500–2500 m, the lithology is dominated by sandy conglomerate, and the average thickness of thermal reservoir is 120–300 m. The average porosity of thermal reservoir is 28%–35%, the permeability is(600–2000)×10^(-3) μm^(2), and the temperature of thermal reservoir is 70–110 ℃. The formation has total geothermal resources of 13.79×10^(18) J, equivalent to 4.70×10^(8) t of standard coal. Based on a large amount of seismic and drilling data from oil and gas exploration, this study carried out high quality target area selection, simulation of sandstone thermal reservoir, and production and injection in the same layer. The geothermal heating project with distributed production and injection well pattern covering an area of 230×10^(4) m^(2) was completed in the new district of Caofeidian in 2018. The project has been running steadily for two heating seasons, with an average annual saving of 6.06×10^(4) t of standard coal and a reduction of 15.87×10^(4) t of carbon dioxide, achieving good economic and social benefits. This project has proved that the Neogene sandstone geothermal reservoir in eastern China can achieve sustainable large-scale development by using the technology of 'balanced production and injection in the same layer'. It provides effective reference for the exploration and development of geothermal resource in oil and gas-bearing basins in eastern China. | DONG Yuexia HUANG Hongxiang REN Lu LI Hongda DU Zhiqiang E Junjie WANG Qi ZHANG Xiaoming | 2021 | Petroleum Exploration and Development2021，48，3： | 1 |
| 16 | Remote monitoring contributes to preventing overwork-related events in health workers on the COVID-19 frontlines显示文摘Fighting on the frontlines against the coronavirus disease 2019(COVID-19)pandemic,health workers are at high risk of virus infection and overwork-related sudden death and disorders including cardiovascular diseases and stress.When we noted the increase of overwork-related sudden deaths in physicians and nurses in the first 2 weeks after lockdown of Wuhan,we organized the‘Touching Your Heart’program by remote monitoring,aiming to protect health workers from overwork-related disorders through integrated volunteer work by physicians and medical engineering researchers from Wuhan Huoshenshan Hospital,Nanjing Medical University,and Tiangong University.By remotely monitoring the health conditions of the medical aid team working atWuhan Huoshenshan Hospital,the programsuccessfully helped in avoiding severe overwork-related events.The results from our program should be used to remind frontline health workers around the world to take precautions against overworked-related severe events,and showthat precision monitoring is effective in improving work efficiency and maintaining a sustainable workforce during emergency situations like a pandemic. | Faming Zhang Huiquan Wang Ruijuan Chen Wenzhi Hu Yuexia Zhong Xin Wang | 2020 | Precision Clinical Medicine2020，3，2： | 1 |
| 17 | Surface-enhanced Raman scattering of uracil and uracil dimer on silver by density functional method显示文摘 | Simin Gao Hongyan Wang Baomei Zhang Yuexia Lin | 2013 | Journal of Molecular Structure2013，，： | 1 |
| 18 | Validity of building characteristics and dorm dampness obtained in a self- administrated questionnaire 显示文摘 | Sun Yuexia Jan Sundell Zhang Yufeng | 2007 | Science of the Total Environment2007，387，3： | 1 |
| 19 | circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways显示文摘The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats. | Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui Ba Langda Suo Yuxuan Song Lei Zhang | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 20 | 5G Ultra-Dense Network Fingerprint Positioning Method Based on Matrix Completion显示文摘The problem of high-precision indoor positioning in the 5G era has attracted more and more attention.A fingerprint location method based on matrix completion(MC-FPL)is proposed for 5G ultradense networks to overcome the high costs of traditional fingerprint database construction and matching algorithms.First,a partial fingerprint database constructed and the accelerated proximal gradient algorithm is used to fill the partial fingerprint database to construct a full fingerprint database.Second,a fingerprint database division method based on the strongest received signal strength indicator is proposed,which divides the original fingerprint database into several sub-fingerprint databases.Finally,a classification weighted K-nearest neighbor fingerprint matching algorithm is proposed.The estimated coordinates of the point to be located can be obtained by fingerprint matching in a sub-fingerprint database.The simulation results show that the MC-FPL algorithm can reduce the complexity of database construction and fingerprint matching and has higher positioning accuracy compared with the traditional fingerprint algorithm. | Yuexia Zhang Chong Liu | 2023 | China Communications2023，20，3： | 0 |
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