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| 1 | Developing disease-resistant thermosensitive male sterile rice by multiplex gene editing显示文摘High-quality and disease-resistant male sterile lines have great potential for applications in hybrid rice breeding.We introduced specific mutations into the TMS5,Pi21,and Xa13 genes in Pinzhan intermediate breeding material using the CRISPR/Cas9 multiplex genome editing system.We found that the transgenefree homozygous triple tms5/pi21/xa13 mutants obtained in the T1 generation displayed characteristics of thermosensitive genic male sterility(TGMS)with enhancedresistance to rice blast and bacterial blight.Our study provides a convenient and effective way of converting breeding intermediate material into TGMS lines through multiplex gene editing,which could significantly accelerate the breeding of sterile lines. | Sanfeng Li Lan Shen Ping Hu Qing Liu Xudong Zhu Qian Qian Kejian Wang Yuexing Wang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 11 |
| 2 | Degree of Brine Evaporation and Origin of the Mengyejing Potash Deposit:Evidence from Fluid Inclusions in Halite显示文摘The Mengyejing potash deposit is located in the southern port of the Simao Basin, Yunnan Province, and is hosted in mid-Cretaceous strata. The chemical compositions of fluid inclusions in halite crystals, collected from the level-610 adit in the deposit, were analysed by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS). The results show that the brine is of the Na-K-Mg-Ca-Cl type and has K concentrations that are distinctly higher than those of Mg and Ca, unlike normal brines associated with Cretaceous halite. The high K concentrations indicate that the degree of evaporation of the ancient Mengyejing saline lake was very high, reaching the sylvite deposition stage but rarely reaching the carnallite deposition stage. The trajectory of the H and O isotopic compositions of the brines in the halite-hosted fluid inclusions corresponds to intense evaporation, indicating that the net evaporation exceeded the net inflow of brines. These brine compositions in halite-hosted fluid inclusions were likely formed by the dissolution of previously deposited K-bearing minerals by fresh continental and/or seawater, forming a type of modified seawater, with deep hydrothermal fluids potentially supplying additional potassium. The basin likely experienced multiple seawater incursion, dissolution and redeposition events in a high-temperature environment with high evaporation rates. | SHEN Lijian LIU Chenglin WANG Licheng HU Yufei HU Mingyue FENG Yuexing | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 9 |
| 3 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 4 | LA-ICPMS in-situ U-Pb Geochronology of Low-Uranium Carbonate Minerals and Its Application to Reservoir Diagenetic Evolution Studies显示文摘Reconstruction of the diagenetic evolution of reservoirs is one of the most significant tasks in oil and gas exploration and development.Assessing the accurate timing of diagenetic events is critical to better understand the process of reservoir evolution,but the isotope dating of diagenetic events is technically challenging.This paper uses three case studies in the sedimentary basins in China to demonstrate the promising application of recently developed LA-(MC)-ICPMS in-situ U-Pb geochronology.Our results show that the new U-Pb dating method provides a reliable and efficient chronological approach to determine the absolute ages of diagenetic events.For example,the U-Pb age data of the Cambrian carbonate reservoir in the Tarim Basin reveals three diagenetic events at 526±14,515±21,and 481±4.6 Ma,respectively.It is worth noting that microscopic observations are particularly important for improving the success rate of U-Pb dating.In addition,the recent progress and future prospects in the in-situ U-Pb dating method are also discussed in this study,suggesting that this method is currently hindered by the lack of international carbonate standards for data correction. | Entao Liu Jian-Xin Zhao Hua Wang Songqi Pan Yuexing Feng Qianglu Chen Faye Liu Jiasheng Xu | 2021 | Journal of Earth Science2021，32，4： | 3 |
| 5 | MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice显示文摘Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, multi-tillering dwarf1(mtd1), a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtd1 mutant exhibited pleiotropic phenotypes, including dwarfism, more tillers, brittle culms and delayed heading date.By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOC_Os09g02650(BC12) in mtd1 mutant had a single nucleotide substitution(G to A), which generated a premature translation stop. Over-expressing MTD1/BC12 coding sequence rescued all the phenotypes of mtd1 mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtd1 mutant.Quantitative reverse transcription-PCR analysis showed that MTD1/BC12 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remarkably, a-amylase activity analysis and gibberellic acid(GA)treatment showed that the dwarf phenotype of mtd1 mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice. | Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang Zhenyuan Shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao | 2016 | Science Bulletin2016，61，23： | 3 |
| 6 | Stress Relaxation and Sensitivity Weight for Bi-Directional Evolutionary Structural Optimization to Improve the Computational Efficiency and Stabilization on Stress-Based Topology Optimization显示文摘Stress-based topology optimization is one of the most concerns of structural optimization and receives much attention in a wide range of engineering designs.To solve the inherent issues of stress-based topology optimization,many schemes are added to the conventional bi-directional evolutionary structural optimization(BESO)method in the previous studies.However,these schemes degrade the generality of BESO and increase the computational cost.This study proposes an improved topology optimization method for the continuum structures considering stress minimization in the framework of the conventional BESO method.A global stress measure constructed by p-norm function is treated as the objective function.To stabilize the optimization process,both qp-relaxation and sensitivity weight scheme are introduced.Design variables are updated by the conventional BESO method.Several 2D and 3D examples are used to demonstrate the validity of the proposed method.The results show that the optimization process can be stabilized by qp-relaxation.The value of q and p are crucial to reasonable solutions.The proposed sensitivity weight scheme further stabilizes the optimization process and evenly distributes the stress field.The computational efficiency of the proposed method is higher than the previous methods because it keeps the generality of BESO and does not need additional schemes. | Chao Ma Yunkai Gao Yuexing Duan Zhe Liu | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 2 |
| 7 | Characterization of heavy-chain antibody gene repertoires in Bactrian camels显示文摘Camelids are the only mammals that can produce functional heavy-chain antibodies(HCAbs).Although HCAbs were discovered over 30 years ago,the antibody gene repertoire of Bactrian camels remains largely underexplored.To characterize the diversity of variable genes of HCAbs(VHHs),germline and rearranged VHH repertoires are constructed.Phylogenetics analysis shows that all camelid VHH genes are derived from a common ancestor and the nucleotide diversity of VHHs is similar across all camelid species.While species-specific hallmark sites are identified,the non-canonical cysteines specific to VHHs are distinct in Bactrian camels and dromedaries compared with alpacas.Though low divergence at the germline repertoire between wild and domestic Bactrian camels,higher expression of VHHs is observed in some wild Bactrian camels than that of domestic ones.This study not only adds our understanding of VHH repertoire diversity across camelids,but also provides useful resources for HCAb engineering. | Yuexing Liu Li Yi Yixue Li Zhen Wang Jirimutu | 2023 | Journal of Genetics and Genomics2023，50，1： | 2 |
| 8 | Effects of Different Selenium Application Methods on Wheat (Triticum aestivum L.) Biofortification and Nutritional Quality显示文摘Mineral nutrient malnutrition,especially deficiency in selenium(Se),affects the health of approximately 1 billion people worldwide.Wheat,a staple food crop,plays an important role in producing Se-enriched foodstuffs to increase the Se intake of humans.This study aimed to evaluate the effects of different Se application methods on grain yield and nutritional quality,grain Se absorption and accumulation,as well as 14 other trace elements concentrations in wheat grains.A sand culture experiment was conducted via a completely randomized 3×2×1 factorial scheme(three Se levels×two methods of Se application,foliar or soil×one Se sources,selenite),with two wheat cultivars(Guizi No.1,Chinese Spring).The results showed that both foliar Se and soil Se application methods had effects on wheat pollination.Foliar Se application resulted in early flowering of wheat,while soil Se application caused early flowering of wheat at low Se levels(5 mg kg^(−1))and delayed wheat flowering at high selenium levels(10 mg kg^(−1)),respectively.For trace elements,human essential trace elements(Fe,Zn,Mn,Cu,Cr,Mo,Co and Ni)concentrations in wheat grains were dependent of Se applica-tion methods and wheat cultivars.However,toxic trace elements(Cd,Pb,Hg,As,Li and Al)concentrations can be decreased by both methods,indicating a possible antagonistic effect.Moreover,both methods increased Se concentrations,and improved grain yield and nutritional quality,while the foliar application was better than soil.Accordingly,this study provided useful information concerning nutritional biofortification of wheat,indicating that it is feasible to apply Se to conduct Se biofortification,inhibit the heavy metal elements concentrations and improve yield and quality in crops,which caused human health benefits. | Yong Liang Yuexing Chen Dong Liu Jianping Cheng Gang Zhao Tzion Fahima Jun Yan | 2020 | Phyton-International Journal of Experimental Botany2020，89，2： | 1 |
| 9 | Development of Inner Mould Direct-Pressure Tire Vulcanization Technology Equipment 显示文摘 | Jinyun Zhang Wei Jiao Yuexing Liu | 2013 | Key Engineering Materials2013，，561： | 1 |
| 10 | Finite element analysis for mechanical properties of a new section contour tire显示文摘 | JIAO Zhiwei ZHAO Peng LIU Yuexing | 2013 | Key Engineering Materials2013，561，6： | 1 |
| 11 | Association between C-reactive protein and depression: modulated by gender and mediated by body weight显示文摘 | Yuexing Liu Hasan Al-Sayegh Rajai Jabrah Wei Wang Fei Yan Jian Zhang | 2014 | Psychiatry Research2014，，： | 1 |
| 12 | Effectiveness of quality of care for patients with type 2 diabetes in China:findings from the Shanghai Integration Model(SIM)显示文摘This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai,China.A total of 173235 patients with type 2 diabetes in 2017 were included in the analysis.Profiles of risk factors and intermediate outcomes were determined.The patients had a mean age of 66.43±8.12(standard deviation(SD))years and a mean diabetes duration of 7.95±5.53(SD)years.The percentage of patients who achieved the target level for HbA_(1c)(<7.0%)was 48.6%.Patients who achieved the target levels for blood pressure(BP)<130/80 mmHg and low-density lipoprotein-cholesterol(LDL-c)<2.6 mmol/L reached 17.5%and 34.0%,respectively.A total of 3.8%achieved all three target levels,and the value increased to 6.8%with an adaptation of the BP target level(<140/90 mmHg)for those over 65 years.Multivariable analysis identified the factors associated with a great likelihood of achieving all three target levels:male,young age,short diabetes duration,low body mass index,macrovascular complications,no microvascular complications,prescribed with lipid-lowering medication,and no prescription of antihypertensive medication.In conclusion,nearly 50%and one-third of the patients with diabetes met the target levels for HbA_(1c)and LDL-c,respectively,with a low percentage achieving the BP target level.The percentage of patients who achieved all three target levels needs significant improvement. | Chun Cai Yuexing Liu Yanyun Li Yan Shi Haidong Zou Yuqian Bao Yun Shen Xin Cui Chen Fu Weiping Jia the SIM Study Group | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 13 | Cell-cell communication analysis for single-cell RNA sequencing and its applications in carcinogenesis and COVID-19显示文摘Cell-cell communication is the basis of physiological processes and cell signals.The disease occurs when the cells do not adequately communicate and the messages are blocked.With ligand-receptor interaction databases and single-cell RNA sequencing(scRNA-seq)databases,we can detect intercellular signaling and reconstruct the cell-cell communications among different cell types.This review summarized the computational approaches for analyzing the cell-cell communication based on scRNA-seq data and discussed its applications in carcinogenesis and COVID-19.We believe that this review will accelerate the scRNA-seq data deciphering and facilitate the cell-cell communication studies for complex physiological processes,such as carcinogenesis and SARS-CoV-2 infection. | Md Wahiduzzaman Yuexing Liu Tao Huang Wu Wei Yixue Li | 2022 | Biosafety and Health2022，4，4： | 0 |
| 14 | Dynamics of Exciton Transport in Two-Dimensional Materials显示文摘In recent years,two-dimensional(2D)materials have attracted extensive interests due to the large exciton binding energy different from bulk materials.Many peculiar properties have been discovered that have farreaching perspectives in the next generation of optoelectronic devices.In this review,we introduce the forms of exciton existence in 2D materials and several promising 2D materials with good applications at first.Then,we summarize relevant contemporary tools for probing exciton dynamics and methods of regulating 2D exciton transport,for instance,electrical regulation,stress/surface wave regulation and moirépotential regulation,etc.Finally,we conclude the general development of regulation in 2D materials and propose several possible opportunities of application prospect. | Xia Yuexing Zhang Shuai Wu Keming Gong Yiyang Yue Shuai Liu Xinfeng | 2023 | 中国激光2023，50，1： | 0 |
| 15 | Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grown on Cd/Pb-contaminated farmland显示文摘Substitute planting with rapeseed offers promise for safely using large areas of Cd/Pb-contaminated farmland.Cd/Pb distributions during rapeseed oil production were investigated and health risks posed by the oil were assessed.Tests were performed using three cultivars(Brassica rapa SYH and ZS100 and Brassica napus QY-1)and four oil extraction techniques(mechanical and low-temperature pressing and n-hexane and subcritical low-temperature butane extraction).The amounts of Cd and Pb in oil were 0.73%-8.44%and 3.14%-11.76%,respectively,of the amounts in rapeseed and were strongly affected by the cultivar and oil extraction technique.The heavy metal(HM)concentrations were lower in solvent-extracted oil(particularly subcritical low-temperature butane extracted oil,in which HMs were not detected)than mechanically pressed oil.The Cd and Pb transfer indices were lower(meaning larger proportions of HMs were retained by the rapeseed meal)for B.rapa than B.napus.This was attributed to a high HM binding protein content of B.rapa seed.Health risks to humans were assessed using a probabilistic risk assessment model.The carcinogenic risk was mainly(97.1%-99.9%)caused by Cd and poses more concern than non-carcinogenic risk.Stronger health risks are posed by mechanically pressed than solvent-extracted oil,and higher carcinogenic risks are posed to people living in rural areas than urban areas.Substitute planting with B.rapa and extracting oil with organic solvent(preferably subcritical low-temperature butane)are optimal for safely utilizing Cd/Pb-contaminated soil.Attention should be paid to the health risks posed by Cd in oil to rural populations. | Junmei Guo Yuexing Wei Junxing Yang Tongbin Chen Guodi Zheng Tianwei Qian Xiaona Liu Xiaofei Meng Mengke He | 2023 | Frontiers of Environmental Science & Engineering2023，17，7： | 0 |
| 16 | Photoinduced Terminal Fluorine and Ti^(3+)in TiOF_(2)/TiO_(2)Heterostructure for Enhanced Charge Transfer显示文摘As an effective way to enhance the photo/electrocatalytic performance of titanium dioxide(TiO_(2))is to explore the positive roles of doped fluorine sites in the fluorinated TiO_(2)systems,which,currently still lacks the direct experimental evidence due to the complexity of the species involved.Herein,we have fabricated TiOF_(2)/TiO_(2)with interfacial bridging fluorine(Ti2-F)via a coherent phase transition through hydrothermal synthesis.Nuclear magnetic resonance and electron paramagnetic resonance characterization have provided strong evidence of the transformation of the doped fluorine from Ti2-F to Ti1-F and the subsequent generation of Ti^(3+)at the interface of the TiOF_(2)and TiO_(2)under UV-visible(UV-vis)light irradiation.Density functional theory(DFT)calculations and photo/electrochemical measurements further confirmed the electron donor behavior of the Ti^(3+).The benefit is a significantly enhanced charge transfer efficiency in TiOF_(2)/TiO_(2),which not only resulted in improved performances for the photodegradation of acetone being 5.5 times higher than the commercial TiO_(2)but also supported high capacity for sodium-ion storage.Thus,the TiOF_(2)/TiO_(2)with Ti2-F provided a perfect structure to investigate the roles of fluorine sites in fluorinated TiO_(2)systems and their interaction with material properties. | Jie Hu Yi Lu Xiao-Long Liu Christoph Janiak Wei Geng Si-Ming Wu Xiao-Fang Zhao Li-Ying Wang Ge Tian Yuexing Zhang Bao-Lian Su Xiao-Yu Yang | 2020 | CCS Chemistry2020，2，6： | 0 |
| 17 | “Substituents optimization”and“push effect”dual strategy for design of cobalt phthalocyanine catalyst on oxygen reduction reaction显示文摘Molecular metallocycle electrocatalysts like metalloporphyrins and metallophthalocyanines were found to be effective for oxygen reduction reaction(ORR)due to their M-N_(4) active sites and large conjugated elec-tronic molecular structures.Herein,the“substituents optimization”strategy combined with“push effect”modification was innovatively employed to target a single Co-N_(4) active site in three substituted phthalo-cyaninato cobalt complexes:tetranitrophthalocyaninato cobalt(CoTNPc),tetra(4-nitrophenoxy)phthalo-cyaninato cobalt(CoTPNPc),and tetraphenoxy phthalocyaninato cobalt(CoTPPc)electrocatalyst,also with 4-phenylpyridine axial coordination on Co-N_(4) unit.Through substituents screening,the half-wave poten-tial(E_(1/2))for ORR increases in the order of CoTPNPc(0.75 V) | Wenjuan Li Wenmiao Chen Hongyan Zhuo JinShi Yu Xue Liu Yuexing Zhang Yanli Chen | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 18 | Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia显示文摘2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参与评选,会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判,评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图标奖共11名。从2013年第6期开始,《生理通讯》将陆续转载获奖者的参评论文各一篇,以飨读者。 | Yajing Wang Jianli Zhao Yanqing Zhang Wayne Bond Lau Li-Yuan Jiao Baojiang Liu Yuexing Yuan Xiaoliang Wang Ling Tao Erhe Gao Walter J. Koch Xin-Liang Ma | 2013 | 生理通讯2013，32，6： | 0 |
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