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| 1 | Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats显示文摘AIM: To investigate the effect of pinaverium bromide, a Ltype calcium channel blocker with selectivity for the gastrointestinal tract on contractile activity of colonic circular smooth muscle in normal or cold-restraint stressed rats and its possible mechanism.METHODS: Cold-restraint stress was conducted on rats to increase fecal pellets output. Each isolated colonic circular muscle strip was suspended in a tissue chamber containing warm oxygenated Tyrode-Ringer solution. The contractile response to ACh or KCl was measured isometrically on inkwriting recorder. Incubated muscle in different concentrations of pinaverium and the effects of pinaverium were investigated on ACh or KCl-induced contraction. Colon smooth muscle cells were cultured from rats and [Ca2+]i was measured in cell suspension using the Ca2+ fluorescent dye fura-2/AlMl.RESULTS: During stress, rats fecal pellet output increased 61% (P<0.01). Stimulated with ACh or KCl, the muscle contractility was higher in stress than that in control. Pinaverium inhibited the increment of [Ca2+]i and the muscle contraction in response to ACh or KCl in a dose dependent manner. A significant inhibition of pinaverium to ACh or KCl induced [Ca2+]i increment was observed at 10-6 mol/L. The IC50 values for inhibition of ACh induced contraction for the stress and control group were 1.66×10-6 mol/L and 0.91×10-6mol/L, respectively. The ICs0 values for inhibition of KCl induced contraction for the stress and control group were 8.13×10-7 mol/L and 3.80×10-7 mol/L, respectively.CONCLUSION: Increase in [Ca2+]i of smooth muscle cells is directly related to the generation of contraction force in colon. L-type Ca2+ channels represent the main route of Ca2+ entry.Pinaverium inhibits the calcium influx through L-type channels;decreases the contractile response to many kinds of agonists and regulates the stress-induced colon hypermotility. | YunDai Jian-XiangLiu Jun-XiaLi Yun-FengXu | 2003 | World Journal of Gastroenterology2003，9，3： | 21 |
| 2 | 2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed. | Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge | 2019 | Science Bulletin2019，64，3： | 12 |
| 3 | Clinical,Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau显示文摘Objective To analyze characteristics of high altitude pulmonary edema(HAPE)in Chinese patients.Methods We performed a retrospective study of 98 patients with HAPE.We reviewed the medical records and summarized the clinical,laboratory and imaging characteristics of these cases,and compared the results on admission with those determined before discharge.Results Forty-eight(49.0%)patients developed HAPE at the altitude of 2800 m to 3000 m.Ninty-five(96.9%)patients were man.Moist rales were audible from the both lungs,and moist rales over the right lung were clearer than those over the left lung in fourteen patients.The white blood cells[(12.83±5.55)versus(8.95±3.23)×109/L,P=0.001)]as well as neutrophil counts[(11.34±3.81)versus(7.49±2.83)×109/L,P=0.001)]were higher,whereas the counts of other subsets of white blood cells were lower on admission than those after recovery(all P<0.05).Serum levels of alkaline phosphatase(115.8±37.6 versus 85.7±32.4 mmol/L,P=0.020),cholinesterase(7226.2±1631.8 versus 6285.3±1693.3 mmol/L,P=0.040),creatinine(85.2±17.1 versus 75.1±12.8 mmol/L,P=0.021),uric acid(401.9±114.2 versus 326.0±154.3 mmol/L,P=0.041),and uric glucose(7.20±1.10 versus 5.51±1.11 mmol/L,P=0.001)were higher,but carbondioxide combining power(CO2CP,26.7±4.4 versus 28.9±4.5 mmol/L,P=0.042)and serous calcium(2.32±0.13 versus 2.41±0.10 mmol/L,P=0.006)were lower on admission.Arterial blood gas results showed hypoxemia and respiratory alkalosis on admission.Conclusions In the present research,men were more susceptible to HAPE than women,and in the process of HAPE,the lesions of the right lung were more serious than those of the left lung.Some indicators of routine blood test and blood biochemistry of HAPE patients changed. | Zongbin Li Hongyan Chen Jiayue Li Gaoyuan Li Chunwei Liu Yundai Chen | 2018 | Chinese Medical Sciences Journal2018，33，3： | 9 |
| 4 | Early Warning of Acute Altitude Sickness by Physiological Variables and Noninvasive Cardiovascular Indicators显示文摘Objective To examine if the variations at sea level would be able to predict subsequent susceptibility to acute altitude sickness in subjects upon a rapid ascent to high altitude.Methods One hundred and six Han nationality male individuals were recruited to this research.Dynamic electrocardiogram,treadmill exercise test,echocardiography,routine blood examination and biochemical analysis were performed when subjects at sea level and entering the plateau respectively.Then multiple regression analysis was performed to construct a multiple linear regression equation using the Lake Louise Score as dependent variable to predict the risk factors at sea level related to acute mountain sickness(AMS).Results Approximately 49.05%of the individuals developed AMS.The tricuspid annular plane systolic excursion(22.0+2.66 vs.23.2+3.19 mm,t=l.998,P=0.048)was significantly lower in the AMS group at sea level,while count of eosinophil[(0.264+0.393)×109/L vs.(0.126+0.084)×109/L,t=-2.040,P—0.045],percentage of diflerences exceeding 50 ms between adjacent normal number of intervals(PNN50,9.66%±5.40%vs.6.98%±5.66%,t=-2.229,P=0.028)and heart rate variability triangle index(57.1+16.1 vs.50.6+12.7,t=-2.271,P=0.025)were significantly higher.After acute exposure to high altitude,C-reactive protein(0.098+0.103 vs.0.062+0.045 g/L,t=-2.132,P=0.037),aspartate aminotransferase(19.7+6.7275.17,3±3.95 U/L,t=-2.231,P=0.028)and creatinine(85.1±12.9 vs.77.7±11.2 mmol/L,t=3.162,P=0.002)were significantly higher in the AMS group,while alkaline phosphatase(71.7+18.2 vs.80.6+20.2 U/L,t=2.389,P=0.019),standard deviation of normal-to-normal RR intervals(126.5+35.9 vs.143.3+36.4 ms,t—2.320,P—0.022),ejection time(276.9+50.8 vs.313.8+48.9 ms,t—3.641,P—0.001)and heart rate variability triangle index(37.1+12.9 vs.41.9+11.1,t=2.O2O,P=0.047)were significantly lower.Using the Lake Louise Score as the dependent variable,prediction equation were established to estimate AMS:Lake Louise Score=3.783+0.281Xeosinophil-0.219Xalkaline phosphatase+O.O32XPNN50.Conclusions We elucidated the differences of pl^siological variables as well as noninvasive cardiovascular indicators for subjects after high altitude exposure compared with those at sea level.We also created an acute high altitude reaction early warning equation based on the physiological variables and noninvasive cardiovascular indicators at sea level. | Zongbin Li Chunwei Liu Jun Guo Yajun Shi Yang Li Jinli Wang Jing Wang Yundai Chen | 2020 | Chinese Medical Sciences Journal2020，35，1： | 8 |
| 5 | Intein-mediated Rapid Purification of Recombinant Human Pituitary Adenylate Cyclase Activating Polypeptide显示文摘Abstract In order to obtain the recombinant human PACAP efficiently by intein-mediated single column purification, a gene encoding human PACAP was synthesized and cloned into Escherichia coli expression vector pKYB. The recombinant vector pKY-PAC was transferred into E. coli ER2566 cells and the target protein was over-expressed as a fusion to the N-terminus of a self-cleavable affinity tag. After the PACAPintein-CBD fusion protein was purified by chitin-affinity chromatography, the self-cleavage activity of the intein was induced by DTT and the rhPACAP was released from the chitin-bound intein tag. The activity of the rhPACAP to stimulate cyclic AMP accumulation was detected using the human pancreas carcinoma cells SW1990. Twenty-two milligrams of rhPACAP with the purity over 98% was obtained by single column purification from 1 liter of induced culture. The preliminary biological assay indicated that the rhPACAP,which has an extra Met at its N-terminus compared with the native human PACAP, had the similar activity of stimulating cAMP accumulation with the standard PACAP38 in the SW 1990 cells. A new efficient production procedure of the active recombinant human PACAP was established. | Rong-jieYU AnHONG YunDAI YuanGAO | 2004 | Acta Biochimica et Biophysica Sinica2004，36，11： | 3 |
| 6 | Efficacy and safety of single-bolus tenecteplase compared with front-loaded alteplase in Chinese patients with acute myocardial infarction显示文摘Background and Objective Previous study showed tenecteplase and alteplaxe were equovalent for 30-day mortality in the treatment of acute myocardial infarction. The purpose of this open-label,randomized,multi-center,angiographic trial was to assess the efficacy and safety of tenecteplase compared with alteplase in Chinese patients with acute myocardial infarction. Methods We recruited patients with acute ST-elevation myocardial infarction presenting within 6 hours of symptom onset from October,2002 to March,2004,in 5 hospitals in Beijing. After giving informed consent,patients were randomly assigned a single-bolus injection of tenecteplase(30-50 mg according to body weight) or front loaded alteplase(100 mg) ,and underwent coronary angiography at 90 min after starting the study drug. All patients received aspirin and heparin(target activated partial thromboplastin time 50-70 s) . The primary efficacy end point was the rate of TIMI grade 3 flow at 90 minutes. Other efficacy end points included TIMI grade 2/3 flow at 90 minutes. Safety end points included all stroke,intracranial hemorrhage(ICH) ,moderate/severe hemorrhage(except for ICH) ,all-cause mortality at 30-days,and major non-fatal cardiac events at 30 days. Results Overall 110 patients were eligible for statistical analysis,with 58 patients assigned to receive tenecteplase and 52 patients to alteplase. Tenecteplase produced a rate of TIMI grade 3 flow at 90 minutes after the start of thrombolysis(68.4%) similar to that of alteplase(66.7%,P=1.0) ;the rates of TIMI grade 2 or 3 were similar for patients treated with tenecteplase versus alteplase(89.5% versus 80.4%,respectively,P=0.278) . At 30 days,rates for all strokes were similar for the two groups(5.17% for tenecteplase and 1.92% for alteplase,P=0.62) ;rates of ICH were 3.45% and 1.92%(tenecteplase and rt-PA,P=1.00) respectively. The rate of moderate/severe hemorrhage was 8.62% with tenecteplase and 5.77% with alteplase(P=0.72) ;total mortality was almost identical in the two groups(13.8% versus 9.6%,respectively,P=0.565) while the rates of non-fatal cardiac complications were 10.35% and 11.54%(tenecteplase and alteplase,P=1.0) . Conclusions The efficacy of a single-bolus,weight-adjusted tenecteplase fibrinolytic regimen is equivalent to front-loaded alteplase in terms of the rates of TIMI grade 3 flow,and TIMI 2 or 3 flow,but the 30-day mortality and ICH in both groups was so high that the use of tenecteplase is not permitted in China. These negative safety results might be due to the high rate of percutaneous coronary intervention(PCI) and high dose of bolus heparin and suboptimal concomitant medical therapy during hospitalization,so further studies are needed to confirm the safety for tenecteplase in Chinese patients. | Feng Liang Dayi Hu Xubo Shi Mingshu Gao Jiaping Wei Hong Zhao Lei Wang Sanqing Jia Hongyu Wang Ruhuai Liu Yundai Chen Yanling Lu | 2007 | Journal of Geriatric Cardiology2007，4，3： | 1 |
| 7 | Potential Assessment of Spatial Correlation to Improve Maximum Distributed PV Hosting Capacity of Distribution Networks显示文摘Successful distributed photovoltaic (PV) planning now requires a hosting capacity assessment process that accounts for an appropriate model of PV output and its uncertainty. This paper explores how the PV hosting capacity of distribution networks can be increased by means of spatial correlation among distributed PV outputs. To achieve this, a novel PV hosting capacity assessment method is proposed to account for arbitrary geographically dispersed distributed PVs. In this method, the empirical relation between the spatial correlation coefficient and distance is fitted by historical data in one place and then applied to model the joint probability distribution of PV outputs at a neighboring location. To derive the PV hosting capacity at candidate locations, a stochastic PV hosting capacity assessment model that aims to maximize the PV hosting capacity under thermal and voltage constraints is proposed. Benders decomposition algorithm is also employed to reduce the computational cost associated with the numerous sampling scenarios. Finally, a rural 59-bus distribution network in Suzhou, China, is used to demonstrate the effectiveness of the proposed PV hosting capacity assessment methodology and the significant benefits obtained by increasing geographical distance. | Han Wu Yue Yuan Junpeng Zhu Kejun Qian Yundai Xu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 1 |
| 8 | Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina peetoris显示文摘 | Feng T Yundai C Lian C | 2010 | Atherosclerosis2010，213，2： | 1 |
| 9 | Obstructive sleep ap-nea syndrome increases serum angiotensin II and inci- dence of non-dipping circadian blood pressure in patients with essentialhypertension显示文摘 | Hailing W?Ying Z Yundai C | 2012 | Sleep and Biological Rhythms2012，10，3： | 1 |
| 10 | Exendin-4 enhances the migration of adipose-derived stem cells to neonatalrat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromalcell-derived factor-1α/CXC chemokine receptor 4 pathway显示文摘 | Hao Zhou Junjie Yang Ting Xin Tao Zhang Shunyin Hu Shanshan Zhou Guanghui Chen Yundai Chen | 2015 | Molecular Medicine Reports2015，，6： | 1 |
| 11 | Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus:a prospective cohort study显示文摘Objective:This study evaluated the prognostic power of serum uric acid(UA)in predicting adverse events in elderly acute coronary syndrome(ACS)patients with diabetes mellitus(DM).Methods:The analysis involved 718 ACS patients>80 years old whose general clinical data and baseline blood biochemical indicators were collected prospectively from January 2006 to December 2012.These patients were classified into two groups based on DM status,and then followed up after discharge.The Kaplan-Meier method was used for major adverse cardiac event(MACE)rates and all-cause mortality.Multivariate Cox regression was performed to analyze the relationship between UA level and long-term clinical prognosis.Receiver operating characteristic(ROC)curves were analyzed to predict the cutoff value of UA in elderly ACS patients with DM.There were 242 and 476 patients in the DM and non-DM(NDM)groups,respectively,and the follow-up time after discharge was 40‒120 months(median,63 months;interquartile range,51‒74 months).Results:The all-cause mortality,cardiac mortality,and MACE rates in both DM and NDM patients were higher than those in the control group(P=0.001).All-cause mortalities,cardiac mortalities,and MACE rates in DM patients with moderate and high UA levels were significantly higher than those in the NDM group(P=0.001).Long-term survival rates decreased significantly with increased UA levels in the ACS groups(P=0.001).UA(odds ratio(OR)=2.106,95%confidence interval(CI)=1.244‒3.568,P=0.006)was found to be an independent risk factor for all-cause mortality and MACE in elderly ACS patients with DM.The cutoff value of UA was 353.6μmol/L(sensitivity,67.4%;specificity,65.7%).Conclusions:Serum UA level is a strong independent predictor of long-term all-cause death and MACE in elderly ACS patients with DM. | Yang JIAO Jihang WANG Xia YANG Mingzhi SHEN Hao XUE Jun GUO Wei DONG Yundai CHEN Qing XI Zhenhong FU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 1 |
| 12 | Assessment Model for Distributed Wind Generation Hosting Capacity Considering Complex Spatial Correlations显示文摘To facilitate the large-scale integration of distributed wind generation(DWG), the uncertainty of DWG outputs needs to be quantified, and the maximum DWG hosting capacity(DWGHC) of distribution systems must be assessed. However, the structure of the high-dimensional nonlinear dependencies and the abnormal marginal distributions observed in geographically dispersed DWG outputs lead to the increase of the complexity of the uncertainty analysis. To address this issue,this paper proposes a novel assessment model for DWGHC that considers the spatial correlations between distributed generation(DG) outputs. In our method, an advanced dependence modeling approach called vine copula is applied to capture the high-dimensional correlation between geographically dispersed DWG outputs and generate a sufficient number of correlated scenarios. To avoid an overly conservative hosting capacity in some extreme scenarios, a novel chance-constrained assessment model for DWGHC is developed to determine the optimal sizes and locations of DWG for a given DWG curtailment probability. To handle the computational challenges associated with large-scale scenarios, a bilinear variant of Benders decomposition(BD) is employed to solve the chance-constrained problem.The effectiveness of the proposed method is demonstrated using a typical 38-bus distribution system in eastern China. | Han Wu Yue Yuan Junpeng Zhu Yundai Xu | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 1 |
| 13 | Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina pectoris显示文摘 | FENG T YUNDAI C LIAN C | 2010 | Atherosclerosis2010，213，2： | 1 |
| 14 | Complex shaped silicon carbide ceramic heat exchanger for application in high-temperature recuperative burner显示文摘 | GUANG Liangliu PEI Yundai YAN Zhongwang | 2011 | Journal of the European Ceramic Society2011，31，： | 1 |
| 15 | Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants显示文摘The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang | 2022 | Genes & Diseases2022，9，2： | 1 |
| 16 | Characterization of culprit lesions in acute coronary syndromes compared with stable angina pectoris by dual-source computed tomography显示文摘 | Xia Yang Luyue Gai Wei Dong Hongbin Liu Zhijun Sun Feng Tian Yundai Chen | 2013 | The International Journal of Cardiovascular Imaging2013，，4： | 1 |
| 17 | Comparing the biological charac-teristics of adipose tissue-derived stem cells of different persons 显示文摘 | Shu W Shu YT Yundai C | 2012 | J Cell Biochem2012，23，： | 1 |
| 18 | Independent no-reflow predictors in female patients with St-elevation acute myocardial infarction treated with primary percutaneous coronary intervention显示文摘 | Yundai Chen Changhua Wang Xinchun Yang | 2012 | Heart and Vessels2012，27，3： | 1 |
| 19 | Case Fatality Rate of Patients with Acute Myocardial Infarction in 253 Chest Pain Centers--China,2019-2020显示文摘Summary What is already known about this topic?Acute myocardial infarction(AMI)is the most serious form of cardiovascular diseases.The case fatality rate(CFR)of AMI patients is an important index to reflect the prognosis of AMI.What is added by this report?During the study period,the overall 30-day,60-day,and 90-day CFR of AMI was 5.9%,6.9%,and 7.6%,respectively.The CFRs in gradeⅢhospitals were lower than in gradeⅡhospitals,and the in-hospital CFR was significantly lower than that in post-discharge out-of-hospital. | Zheng Long Wei Liu Zhenping Zhao Suijun Tong Lijun Wang Maigeng Zhou Dingcheng Xiang Yundai Chen Jianan Wang Xiaoshu Cheng Bao Li Lang Li Wei Li Bei Shi Hong Shi Peng Yin Kai Huang Yong Huo | 2022 | China CDC weekly2022，4，24： | 1 |
| 20 | Assessment of coronary plaque cha- racteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina pectoris显示文摘 | Feng T Yundai C Lian C | 2010 | Atherosclerosis2010，213，2： | 1 |
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