|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationships Between Evacuation Population Size, Earthquake Emergency Shelter Capacity, and Evacuation Time显示文摘Determining the location of earthquake emergency shelters and the allocation of affected population to them are key issues that face shelter planning and emergency management. To solve this emergency shelter location–allocation problem, evacuation time and the construction cost of shelters—both influenced by the evacuation population size and its spatial distribution—are two important considerations. In this article, a mathematical model with two objectives—to minimize total weighted evacuation time(TWET) and total shelter area(TSA)—is allied with a modified particle swarm optimization algorithm to address the problem. The relationships between evacuation population size, evacuation time, and total shelter area are examined using Jinzhan Town in Chaoyang District of Beijing, China, as a case study. The results show that TWET has a power function relationship with TSA under different population size scenarios, and a linear function applies between evacuation population and TWET under different TSAs. The joint relationships of TSA, TWET, and population size show that TWET increases with population increase and TSA decrease, and compared with TSA, population influences TWET more strongly. Given a reliable projection of population change and spatial planning of a study area, this method can be useful for government decision making on the location of earthquake emergency shelters and on the allocation of evacuees to those shelters. | Xiujuan Zhao Wei Xu Yunjia Ma Lianije Qin Junlin Zhang Ying Wang | 2017 | International Journal of Disaster Risk Science2017，8，4： | 5 |
| 2 | Transformation of sulfamethazine during the chlorination disinfection process: Transformation,kinetics, and toxicology assessment显示文摘Various disinfection byproducts(DBPs) form during the process of chlorination disinfection,posing potential threats to drinking water safety and human health. Sulfamethazine(SMT),the most commonly used and frequently detected veterinary antibiotic, was investigated in detail with regard to its transformation and kinetics in reactions with free available chlorine(FAC). Using liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry, several DBPs were identified based on different confidence levels, and a variety of reaction types, including desulfonation, S–N cleavage, hydroxylation, and chlorine substitution, were proposed. The kinetic experiments indicated that the reaction rate was FAC-and pH-dependent, and SMT exhibits low reactivity toward FAC in alkaline conditions. The DBPs exhibited a much higher acute toxicity than SMT, as estimated by quantitative structure activity relationship models. More importantly, we observed that the FAC-treated SMT reaction solution might increase the genotoxic potential due to the generation of DBPs. This investigation provides substantial new details related to the transformation of SMT in the chlorination disinfection process. | Yunjia Yang Jiachen Shi Yi Yang Jie Yin Jing Zhang Bing Shao | 2019 | Journal of Environmental Sciences2019，31，2： | 4 |
| 3 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 4 | Urinary analysis reveals high Alternaria mycotoxins exposure in the general population from Beijing, China显示文摘Alternaria mycotoxins are of concern due to its adverse health effect, they affect various cereal crops and grain-based food along with modified forms that contribute to overall exposure. This study aimed to determine the frequency and level of exposure to Alternaria mycotoxins(tenuazonic acid, TeA;alternariol, AOH;alternariol monomethyl ether, AME;tentoxin, TEN;and altenuene, ALT) in human urine from Beijing adults. A total of 2212 urine samples were collected and analyzed for five mycotoxins using LC–ESI–MS/MS. More than98% of the samples had at least one Alternaria mycotoxin detected. Among the mycotoxins,AME had the highest detection rate(96.0%), followed by TeA(70.5%). The calculated average daily intake values of AME(12.5 ng/kg b.w.) was 5 times the TTC value(2.5 ng/kg b.w.) set by the EFSA, indicating the potential health risks associated with mycotoxins. Immediate attention and subsequent actions should be taken to identify the sources of mycotoxins and the corresponding exposure pathways to humans in the investigated regions. | Xiaoting Qiao Gang Li Jing Zhang Jing Du Yunjia Yang Jie Yin Hui Li Jie Xie You Jiang Xiang Fang Xinhua Dai Bing Shao | 2022 | Journal of Environmental Sciences2022，34，8： | 3 |
| 5 | Novel application of red mud as disposal catalyst for pyrolysis and gasification of coal显示文摘Red mud(RM)with the high alkalinity as a catalyst was evaluated for coal pyrolysis in a fixed bed as well as CO_(2) gasification of its resultant char in a thermogravimetric analyzer(TGA).The addition of RM into coal could improve the quality of tar during pyrolysis and enhance the reactivity of char during gasification.For catalytic pyrolysis with 12 wt%RM at 600℃,the light fraction in tar was 72.0 wt%,which increased by 20.0%,compared with coal pyrolysis alone.The role of metal oxides in RM on coal pyrolysis was further clarified as well.After catalytic pyrolysis with RM,the specific surface area of resultant char increased,especially for mesoporous surface area,and meanwhile the sodium in RM was proved to migrate to the char surface.These positive factors contributed to the CO_(2) gasification activity of char.RM with the high alkalinity showed a promising catalyst candidate for coal pyrolysis and gasification in terms of its catalytic effects and low cost. | Zhaohui Chen Deliang Wang Hang Yang Yusheng Zhang Yunjia Li Changming Li Jian Yu Shiqiu Gao | 2021 | Carbon Resources Conversion2021，4，1： | 2 |
| 6 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 7 | Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response显示文摘Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains elusive.Here,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic arteries.Typically,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and infammation.In contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process.Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation.Mechanistically,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation.Especially,compared to macrophages,endothelial STING activation plays a more pronounced role in atherosclerosis.We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction. | Xuesong Li Xiang Chen Longbin Zheng Minghong Chen Yunjia Zhang Ruigong Zhu Jiajing Chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao Hongshan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 8 | MiR-130a regulates and dendritic spine MeCP2 neurite outgrowth density by targeting显示文摘 | Yunjia Zhang Mengmeng Chen Zilong Qiu Keping Hu Warren McGee Xiaoping Chen Jianghong Liu Li Zhu Jane Y. Wu | 2016 | Protein & Cell2016，7，7： | 1 |
| 9 | Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry 显示文摘 | YANG Yunjia LU Libin ZHANG Jing | 2014 | Journal of Chromatography A2014，1328，： | 1 |
| 10 | Determination of seven bisphenol analogues in reed and Callitrichaceae by ultra performance 'tiquid chromatography-tandemmass spectrometry 显示文摘 | LU Libin YANG Yunjia ZHANG Jing | 2014 | Journal Chromatography B2014，95，： | 1 |
| 11 | Single-Crystalline Hydrogen-Bonded Crosslinked Organic Frameworks and Their Dynamic Guest Sorption显示文摘CONSPECTUS:Porous organic framework materials constructed by periodically aligned molecular entities offer chemically tailored microenvironments to absorb molecules and ions for various applications.Fundamentally understanding the microenvironments of these porous organic materialsfrom pore size,shape,and dynamics to potential substrate binding sitesis critical for the rational design of porous organic materials.The solid-state structures of these porous organic materials,such as covalent organic frameworks(COFs),can provide unambiguous atomic-level structural details. | Jayanta Samanta Yunjia Zhang Mingshi Zhang Albert D.Chen Chenfeng Ke | 2022 | Accounts of Materials Research2022，3，11： | 0 |
| 12 | Method for Solving Non-specific Amplification Interference of Fluorescence Quantitative PCR in Gene Detection显示文摘Objective:To explore a method to solve the issue of interference in fluorescence quantitative PCR non-specific amplification for gene detection.Method:A three-step method was used for amplification,and the quantitative fluorescence signal collection process was set in the extension stage.Results:Three-step amplification has the advantages of wide application range;improved accuracy;and reduced primer design requirements.Conclusion:The interference of non-specific amplification signals was effectively avoided,the melting curve plotting process was omitted,the reaction time was shortened,and the detection accuracy was improved. | Jinku Zhang Jirui Sun Haizhi Qiao Lu Han Yunjia Liu | 2021 | Proceedings of Anticancer Research2021，5，1： | 0 |
| 13 | A button switch inspired duplex hydrogel sensor based on both triboelectric and piezoresistive effects for detecting dynamic and static pressure显示文摘The capability to sense complex pressure variations comprehensively is vital for wearable electronics and flexible human–machine interfaces.In this paper,inspired by button switches,a duplex tactile sensor based on the combination of triboelectric and piezoresistive effects is designed and fabricated.Because of its excellent mechanical strength and electrical stability,a double-networked ionic hydrogel is used as both the conductive electrode and elastic current regulator.In addition,micro-pyramidal patterned polydimethylsiloxane(PDMS)acts as both the friction layer and the encapsulation elastomer,thereby boosting the triboelectric output performance significantly.The duplex hydrogel sensor demonstrates comprehensive sensing ability in detecting the whole stimulation process including the dynamic and static pressures.The dynamic stress intensity(10–300 Pa),the action time,and the static variations(increase and decrease)of the pressure can be identified precisely from the dual-channel signals.Combined with a signal processing module,an intelligent visible door lamp is achieved for monitoring the entire“contact–hold–release–separation”state of the external stimulation,which shows great application potential for future smart robot e-skin and flexible electronics. | Zhensheng Chen Jiahao Yu Xiaoxi Zhang Haozhe Zeng Yunjia Li Jin Wu Kai Tao | 2022 | Nanotechnology and Precision Engineering2022，5，2： | 0 |
| 14 | Signal space transform and multidimensional information joint processing for moving target显示文摘A signal space transform method for detection of line spectrum signals radiated by moving target is proposed.With time-frequency analysis and beamforming processing,a three-dimensional(3D)time-frequency-azimuth signal space is obtained in the array coordinate system.Given certain target course angle,this 3D signal space is transformed to the time-frequency-relative bearing spectrum signal space in the target coordinate system.Related theoretical derivation,simulation,and experimental data processing are performed.The findings demonstrate that the method is capable of converting the target line spectrum signal 3D trajectory to a 2D trajectory on the corresponding slice in the transformed signal space and signal processing gain of multi-dimensional information joint processing is obtained easier than in 3D signal space. | SHI Yunjia PIAO Shengchun GUO Junyuan ZHANG Liu | 2024 | Chinese Journal of Acoustics2024，43，1： | 0 |
| 15 | Numerical analysis for permafrost temperature field in the short term of permafrost subgrade filling显示文摘Purpose-It is of great significance to study the influence of subgrade filling on permafrost temperature field in permafrost area for the smooth construction and safe operation of railway.Design/methodology/approach-The paper builds up the model for the hydrothermal coupling calculation of permafrost using finite element software COMSOL to study how permafrost temperature field changes in the short term after subgrade filling,on which basis it proposes the method of calculation for the concave distortion of freezing front in the subgrade-covered area.Findings-The results show that the freezing front below the subgrade center sinks due to the thermal effect of subgrade filling,which will trigger hydrothermal erosion in case of sufficient moisture inflows,leading to the thawing settlement or the cracking of the subgrade,etc.The heat output of soil will be hindered the most in case of July filling,in which case the sinking and the distortion of the freezing front is found to be the most severe,which the recovery of the permafrost temperature field,the slowest,constituting the most unfavorable working condition.The concave distortion of the freezing front in the subgrade area increases with the increase in temperature difference between the filler and ground surface,the subgrade height,the subgrade width and the volumetric thermal capacity of filler,while decreases with the increase of the thermal conductivity of filler.Therefore,the filler chose for engineering project shall be of small volumetric thermal capacity,low initial temperature and high thermal conductivity whenever possible.Originality/value-The concave distortion of the freezing front under different working conditions at different times after filling can be calculated using the method proposed. | Yunjia Wang Qianli Zhang | 2023 | Railway Sciences2023，2，2： | 0 |
| 16 | Fe saponite, a layered silicate for reversible lithium-ions storage with large diffusion coefficient显示文摘A kind of layered Li;MSiO;material,Fe saponite with Na;pillaring (Na^(+)-FSAP) was developed as a lowcost and environment-friendly lithium-ion storage material.The Na^(+)-FSAP follows the insertion/deinsertion working mechanism accompanied by valence change of Fe from Fe^(1.86+) to Fe^(2.71+) (average value) after stabilization,and displays a specific capacity of 125 m Ah g^(-1) at 50 m A g^(-1) with retention ratio of 80.8%after 75 cycles.The Na^(+)-pillaring effect and abundant structural water in the gallery urge Li^(+) migrate rapidly,resulting in a large Li^(+) diffusion coefficient within a range of 10^(-6.5)–10^(-7.5) cm^(2)s^(-1).Thus,the Na^(+)-FSAP provides a model material to design electrode materials with rapid lithium-ion migration and has great potential to take place of polyanionic-type Li_(2)MSiO_(4)(M=Mn,Fe,Co) cathode materials. | Jian Zhang Qing Yin Yunjia Wu Shuoxiao Zhang Kai-Jie Wang Jingbin Han | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 17 | The spatial transcriptomic landscape of human gingiva in health and periodontitis显示文摘The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells. | Zongshan Shen Ran Zhang Yunjia Huang Jiayao Chen Mengjun Yu Chunhua Li Yong Zhang Lingling Chen Xin Huang Jichen Yang Zhengmei Lin Songlin Wang Bin Cheng | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 18 | Genome-wide development and utilization of Simple Sequence Repeats in Chinese cabbage(Brassica rapa L.ssp.pekinensis)显示文摘With the complementation of whole-genome sequencing of Chinese cabbage,it is necessary to develop genome-wide Simple Sequence Repeat(SSR)markers and analyse their characteristics,which will bring a revolution in the molecular marker-assisted breeding of Chinese cabbage.In this study distribution and characteristics of SSR loci in the genome of Chinese cabbage'Chiifu'was analyzed.Finally,a total of 173,892 SSR markers that occurred in 10 chromosomes were identified,and Perfect Repeat Motifs(P type)which is a main form of SSR loci with a mean distance of 1.89 kb/SSR was identified.Among them,mono-,di-,and tri-nucleotide repeat motifs were equally distributed across chromosomes compared with tetra-,penta-,and hexa-nucleotide repeat motifs.The largest proportion of SSR loci consisted of mono-and dinucleotide repeat motifs,which accounted for 93.04%of the total SSR loci.A/T and AT/TA were the most abundant motifs,accounting for 97.61%and 64.05%of the mono-and dinucleotide repeats,respectively.Furthermore,200 SSR markers were used for the amplification of 12 Chinese cabbage germplasm,in which 30 were highly polymorphic.These SSR markers were further used for the association analyses of flowering time of 190 Chinese cabbage accessions.The results revealed that 9 and 10 alleles were associated with bolting and flowering time,respectivley.The results show that development of SSR markers is feasible and useful in marker assisted selection of Chinese cabbage. | Ying Gao Na Li Xiaoguang Li Yin Lu Daling Feng Xiaomeng Zhang Aixia Gu Yunjia Ge Javaria Tabusam Mengyang Liu Yanhua Wang Xueping Chen Shuxing Shen Shuangxia Luo Jianjun Zhao | 2022 | Vegetable Research2022，2，1： | 0 |
| 19 | Efficient capture of C_(2)H_(2)from CO_(2)and C_(n)H_(4)by a novel fluorinated anion pillared MOF with flexible molecular sieving effect显示文摘The efficient separation of acetylene(C_(2)H_(2))from carbon dioxide(CO_(2))and CnH_(4)(n=1 and 2)to manufacture high purity C_(2)H_(2)and recover other light hydrocarbons is technologically important,while posing significant challenges.Herein,we reported a new TiF62−anion(TIFSIX)pillared metal-organic framework(MOF)ZNU-5(ZNU=Zhejiang Normal University)with ultramicropores for highly selective C_(2)H_(2)capture with low adsorption heat through gate opening based molecular sieving effect.ZNU-5 takes up a large amount of C_(2)H_(2)(128.6 cm^(3)/g)at 1.0 bar and 298 K but excludes CO_(2),CH_(4),and C_(2)H_(4).Such high capacity has never been realized in MOFs with molecular sieving.The breakthrough experiments further confirmed the highly selective C_(2)H_(2)separation performance from multi-component gas mixtures.3.3,2.8,and 2.2 mmol/g of C_(2)H_(2)is captured at ZNU-5 from equimolar C_(2)H_(2)/CO_(2),C_(2)H_(2)/CO_(2)/CH_(4),and C_(2)H_(2)/CO_(2)/CH_(4)/C_(2)H_(4)mixtures,respectively.Furthermore,2.6,2.0,and 1.5 mmol/g of>98%purity C_(2)H_(2)can be recycled from the desorption process.Combining high working capacity,low adsorption heat,as well as good recyclability,ZNU-5 is promising for C_(2)H_(2)purification. | Lingyao Wang Nuo Xu Yongqi Hu Wanqi Sun Rajamani Krishna Jiahao Li Yunjia Jiang Simon Duttwyler Yuanbin Zhang | 2023 | Nano Research2023，16，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员