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| 1 | Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis显示文摘AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection.METHODS: From January 2000 to December 2011,195 patients underwent pancreatic resection in our hospital.The prognostic factors after pancreatic resection were analyzed in all 195 patients.After excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were compared.For this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 years.For statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two groups.The CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate analysis.RESULTS: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 d.With the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic factors.The multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic factors.Among the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after operation.Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(35% vs 8%,P = 0.008),R0 resection(95% vs 61%,P = 0.004),and absence of lymph nodemetastases(60% vs 18%,P = 0.036) were significantly associated with the 5-year survival.CONCLUSION: Negative surgical margins and a tumor size ≤ 20 mm were independent favorable prognostic factors.Histologically curative resection and early tumor detection are important factors in achieving long-term survival. | Takehito Yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada Kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani | 2015 | World Journal of Gastroenterology2015，21，1： | 18 |
| 2 | Phase I/II study of S-1 plus cisplatin combined with peptide vaccinesfor human vascular endothelial growth factor receptor 1 and 2 in patients withadvanced gastric cancer显示文摘 | Toru Masuzawa Yoshiyuki Fujiwara Kaoru Okada Ayumu Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Ryuji Osawa Kazuyoshi Takeda Koji Yoshida Takuya Tsunoda Yusuke Nakamura Masaki Mori Yuichiro Doki | 2012 | International Journal of Oncology2012，，4： | 2 |
| 3 | Radical Cation Diels-Alder Reactions of Non-Conjugated Alkenes as Dienophiles by Electrocatalysis显示文摘Radical cation Diels-Alder reactions provide a powerful method for the construction of six-membered ring systems between both electron-rich dienes and dienophiles. However, the most recent examples of this class have been limited to β-methylstyrenes as dienophiles;the use of non-conjugated alkenes remains challenging. The present study describes the serendipitous development of novel radical cation Diels-Alder reactions by electrocatalysis that use non-conjugated alkenes as dienophiles. The key to successful transformation involves highly substituted cyclohexenyl radical cations that are stable enough to be reduced by intermolecular single electron transfer. | Atsushi Ozaki Yusuke Yamaguchi Yohei Okada Kazuhiro Chiba | 2019 | Chinese Journal of Chemistry2019，37，6： | 1 |
| 4 | A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy显示文摘 | Ryo Suzuki Yusuke Oda Naoki Utoguchi Eisuke Namai Yuichiro Taira Naoki Okada Norimitsu Kadowaki Tetsuya Kodama Katsuro Tachibana Kazuo Maruyama | 2008 | Journal of Controlled Release2008，，3： | 1 |
| 5 | HLA-Cw*1202-B*5201-DRB1*1502 Haplotype Increases Risk for Ulcerative Colitis but Reduces Risk for Crohn’s Disease显示文摘 | Yukinori Okada Keiko Yamazaki Junji Umeno Atsushi Takahashi Natsuhiko Kumasaka Kyota Ashikawa Tomomi Aoi Masakazu Takazoe Toshiyuki Matsui Atsushi Hirano Takayuki Matsumoto Naoyuki Kamatani Yusuke Nakamura Kazuhiko Yamamoto Michiaki Kubo | 2011 | Gastroenterology2011，，3： | 1 |
| 6 | Hypomagnesemia in Type 2 Diabetic Nephropathy显示文摘 | Yusuke Sakaguchi Tatsuya Shoji Terumasa Hayashi Akira Suzuki Morihiro Shimizu Kensuke Mitsumoto Hiroaki Kawabata Kakuya Niihata Noriyuki Okada Yoshitaka Isaka Hiromi Rakugi Yoshiharu Tsubakihara | 2012 | Diabetes Care2012，，7： | 1 |
| 7 | Transgene-derived hepatocyte growth factor attenuates reactive renalfibrosis in aristolochic acid nephrotoxicity显示文摘 | Hirokazu Okada Yusuke Watanabe Tsutomu Inoue | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
| 8 | Effects of stress management program for teachers in Japan: a pilot study显示文摘 | Akihito Shimazu Yusuke Okada Mitsumi Sakamoto | 2003 | J Occup Heal2003，45，： | 1 |
| 9 | A Transcranial Doppler Ultrasonography Study of Cerebrovascular CO sub 2 Reactivity in Mitochondrial Encephalomyopathy显示文摘 | Ryuhei Kodaka Yusuke Itagaki Masayasu Matsumoto Toshisaburo Nagai Shintaro Okada | 1996 | Stroke A Journal of Cerebral Circulation1996，，： | 1 |
| 10 | Polymorphisms of GSTP1, ERCC2 and TS?3’UTR are associated with the clinicaloutcome of mFOLFOX6 in colorectal cancer patients显示文摘 | Kensuke Kumamoto Keiichiro Ishibashi Norimichi Okada Yusuke Tajima Kouki Kuwabara Yoichi Kumagai Hiroyuki Baba Norihiro Haga Hideyuki Ishida | 2013 | Oncology Letters2013，，3： | 1 |
| 11 | Antennal motor activ- ity induced by pilocarpine in the American cockroach 显示文摘 | Jiro Okada Yusuke Morimoto Yoshihiro Toh | 2009 | Journal of Comparative Physiology2009，195，4： | 1 |
| 12 | Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model显示文摘 | Kiyoshi Okada Hiroyuki Tanaka Ko Temporin Michio Okamoto Yusuke Kuroda Hisao Moritomo Tsuyoshi Murase Hideki Yoshikawa | 2009 | Experimental Neurology2009，，2： | 1 |
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