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| 1 | Emerging in-plane anisotropic two-dimensional materials显示文摘Black phosphorus(BP)is a rapidly up and coming star in two-dimensional(2D)materials.The unique characteristic of BP is its in-plane anisotropy.This characteristic of BP ignites a new type of 2D materials that have low-symmetry structures and in-plane anisotropic properties.On this basis,they offer richer and more unique low-dimensional physics compared to isotropic 2D materials,thus providing a fertile ground for novel applications including electronics,optoelectronics,molecular detection,thermoelectric,piezoelectric,and ferroelectric with respect to in-plane anisotropy.This article reviews the recent advance in characterization and applications of in-plane anisotropic 2D materials. | Liang Li Wei Han Lejing Pi Ping Niu Junbo Han Chengliang Wang Bin Su Huiqiao Li Jie Xiong Yoshio Bando Tianyou Zhai | 2019 | InfoMat2019，1，1： | 16 |
| 2 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 3 | Identification of an AFLP marker linked to the stripe rust resistance gene Yr10 in wheat显示文摘AFLP analysis of near-isogenic lines of the stripe rust resistance gene Yr10 was carried out with 6 Pst I -primers and 10 Taq I -primers with the donor parent of Yr1O gene as the check. A total of about 4200 distinguishable bands were amplified, of which 5 were stable. The genetic linkage of the 5 polymorphic DNA fragments with the target gene were tested preliminarily on a segregating F2 population derived from a cross between the gene donor parent 'Moro' and susceptible cultivar 'Mingxian 169'. The DNA fragment PT0502 was found closely linked to the Yr10 gene and cloned and sequenced. Based on the sequence specific primers for PCR were designed and synthesized. Genetic linkage analysis with 195 segregating F2 plants indicated that the genetic distance was 0.5 cM between the main product SC200 fragment produced by PCR with the primers and the Yr10 gene. The primers can be used to detect the Yr10 gene quickly, effectively and exactly. | SHAO Ymgtian NIU Yongchun ZHU Lihuang ZHAI Wenxue XU Shichang WU Liren | 2001 | Chinese Science Bulletin2001，46，17： | 9 |
| 4 | STUDY ON DIFFUSION WELDING OF ALUMINIUN MATRIX COMPOSITE显示文摘Effects of diffusion welding parameters on strength of welded joint based on particle reinforced alumini- um matrix composite Al2O3p/6061Al were studied by comparing with aluminium matrix alloy,Mecha- nism for the loss of joint strength was analyzed.It was pointed out that the key processing parameters affecting the strength of joint was the welding temperature.The high quality joint can be successfully obtained with appropriate diffusion welding parameters. | J. T. Niu L. M. Liu J. P. Zhai J. Yu X. M. Zhang (National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 750001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 4 |
| 5 | Multi-wavelength colloidal quantum dot lasers in distributed feedback cavities显示文摘Lasers with multi-wavelength colloidal quantum dots(CQDs)can be achieved using complex grating structures and flexible substrate.The structure contains graduated periods and rectangular cavity fabricated through interference lithography,which acts as the distributed feedback cavity.A layer of densely packed CQD film is deposited on the cavity via spin coating technique.The performance of CQD lasers based on different distributed feedback cavities is investigated.Multi-wavelength lasing is achieved based on a flexible rectangular cavity. | Anwer HAYAT Junhua TONG Chao CHEN Lianze NIU Gohar AZIZ Tianrui ZHAI Xinping ZHANG | 2020 | Science China(Information Sciences)2020，63，8： | 3 |
| 6 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 7 | Specific photoacoustic cavitation through nucleus targeted nanoparticles for high-efficiency tumor therapy显示文摘As a new type of cancer treatment,photoacoustic(PA)therapy is based on PA shockwave for rapid,selective and effective killing of cancer cells.The nucleus has been widely used as a target for tumor therapy,which has obtained a very considerable therapeutic effect.In situ destruction of tumor cell nucleus by photoacoustic therapy has not been studied.In this paper,a highly efficient nucleus-targeted photoacoustic theranostic polymer was developed for fluorescence and photoacoustic dual-mode imaging-guided PA therapy.The prepared polymer consists of nucleus targeting TAT peptide(TAT:YGRKKRRQRRR),hydrophilic chain poly(N,N-dimethylacrylamide)(PDMA),and near-infrared(NIR)light absorbing agent(hCyR),which can self-assemble to form nanoparticles of approximately 28 nm(denoted as TAT-PDMA-hCyR NPs).The designed nanoparticles show excellent nucleus targeting and tumor cell death(up to 80%)caused by DNA damage under pulsed laser irradiation compared to non-nucleus target counterpart PDMA-hCyR NPs without TAT peptide in vitro.As expected,the fluorescence and PA dual-mode imaging observed that TAT-PDMA-hCyR NPs were able to passively target and enrich in tumors,providing an experimental basis for in vivo treatment and thus ensuring a significant tumor inhibition rate(about 92%).In conclusion,this study provides a new and practicable method for the development of nucleus-targeting nanoparticles as potential theranostic agent for in vivo cancer imaging and therapy. | Yuan Wang Guangle Niu Shaodong Zhai Wenjia Zhang Da Xing | 2020 | Nano Research2020，13，3： | 3 |
| 8 | RGB WGM lasing woven in fiber braiding cavity显示文摘It is critical to realize woven and wearable red-green-blue(RGB) whispering gallery mode(WGM)lasing that is tunable and flexible in the fiber braiding cavity. However, it is still a challenge to achieve tunable full-color lasing with the large color gamut by a facile approach. Here, we design the braiding cavity to realize RGB WGM lasing with high performance. The braiding cavity consists of three optical fibers coated with dye-doped polymer. Each fiber therein serves as a resonant cavity to support multiple lasing modes. There is no interference owing to the air gap between them;therefore, we can achieve full-color WGM lasing. The lasing emission in our fiber braiding cavity covers a color gamut of 86.7% larger than standard RGB space.Our work may provide a platform for potential applications in white laser and integrated optoelectronic devices. | Kun GE Zhiyang XU Dan GUO Ben NIU Jun RUAN Libin CUI Tianrui ZHAI | 2022 | Science China(Information Sciences)2022，65，8： | 2 |
| 9 | Structural characterization of coatomer in its cytosolic state显示文摘上衣蛋白质上的研究(COPI ) 我贡献了上衣蛋白质怎么产生泡开始细胞内部的运输的基本理解。COPI 建筑群的核心部件是 coatomer,它是需要从 cytosol 被招募到膜以便在膜弯曲并且货物排序工作的 multimeric 建筑群。clathrin 适配器上的以前的结构的研究发现了膜招募在在货物排序支持他们的角色导致一个大 conformational 变化。这里,追求否定污点的电子显微镜学结合了单个粒子的分析,和也表现的 CXMS (化学 cross-linking 结合了集体 spectrometry ) 为确认,我们重建了在它的可溶的形式的 coatomer 的结构。当与在它的膜界限形式的 coatomer 的以前阐明的结构相比我们不观察一个大 conformational 变化时。因此,结果揭开 COPI 对 clathrin 怎么覆盖的关键差别被膜招募调整。 | Shengliu Wang Yujia Zhai Xiaoyun Pang Tongxin Niu Yue-He Ding Meng-Qiu Dong Victor W. Hsu Zhe Sun Fei Sun | 2016 | Protein & Cell2016，7，8： | 2 |
| 10 | Clinical application of free/total PSA ratio in the diagnosis of prostate cancer in men over 50 years of age with total PSA levels of 2.0-25.0 ng ml^(−1) in Western China显示文摘The goal of this study was to investigate the clinical application of free/total prostate-specific antigen(F/T PSA)ratio,considering the new broad serum total PSA(T-PSA)“gray zone”of 2.0–25.0 ng ml^(−1)in differential diagnosis of prostate cancer(PCa)and benign prostate diseases(BPD)in men over 50 years in Western China.A total of 1655 patients were included,528 with PCa and 1127 with BPD.Serum T-PSA,free PSA(F-PSA),and F/T PSA ratio were analyzed.Receiver operating characteristic curves were used to assess the efficiency of PSA and F/T PSA ratio.There were 47.4%of cancer patients with T-PSA of 2.0–25.0 ng ml^(−1).When T-PSA was 2.0–4.0 ng ml^(−1),4.0–10.0 ng ml^(−1),and 10.0–25.0 ng ml^(−1),the area under the curve(AUC)of F/T PSA ratio was 0.749,0.769,and 0.761,respectively.The best AUC of F/T PSA ratio was 0.811 when T-PSA was 2.0–25.0 ng ml^(−1),with a specificity of 0.732,a sensitivity of 0.788,and an optimal cutoff value of 15.5%.The AUC of F/T PSA ratio in different age groups(50–59 years,60–69 years,70–79 years,and≥80 years)was 0.767,0.806,0.815,and 0.833,respectively,and the best sensitivity(0.857)and specificity(0.802)were observed in patients over 80 years.The T-PSA trend was in accordance with the Gleason score,tumor node metastasis(TNM)stage,and American Joint Committee on Cancer prognosis group.Therefore,the F/T PSA ratio can facilitate the differential diagnosis of PCa and BPD in the broad T-PSA“gray zone”.Serum T-PSA can be a Gleason score and prognostic indicator. | Xue-Dan Gao Qiang Miao Jun-Long Zhang Jian-Zhao Zhai Xue-Mei Gui Yi-Han Cai Qian Niu Bei Cai | 2022 | Asian Journal of Andrology2022，24，2： | 2 |
| 11 | Isolation and characterization of 49 polymorphic microsatellite loci for Decapterus maruadsi using SLAF-seq, and cross-amplifi cation to related species显示文摘Decapterus maruadsi is a commercially important species in China, but has been heavily exploited in some areas. There is a growing need to develop microsatellites promoting its genetic research for the adequate management of this ?shery resources. The recently developed speci?c-locus ampli?ed fragment sequencing(SLAF-seq) is an effcient and high-resolution method for genome-wide microsatellite markers discovery. In this study, 28 905 microsatellites(mono-to hexa-nucleotide repeats) were identi?ed using SLAF-seq technology, of which di-nucleotide was the most frequent(13 590, 47.02%), followed by mono-nucleotide(8 138, 28.15%), tri-nucleotide(5 727, 19.81%), tetra-nucleotide(1 104, 3.82%), pentanucleotide(234, 0.81%), and hexa-nucleotide(112, 0.39%). One hundred and thirty-two microsatellite loci(di-and tri-nucleotide) were randomly selected for ampli?cation and polymorphism, of which 49 were highly polymorphic and well-resolved. The average number of alleles per locus was 13.63, ranging from 4 to 25, and allele sizes varied between 110 bp and 309 bp. The observed heterozygosity( Ho) and expected heterozygosity( He) ranged from 0.233 to 1.000 and from 0.374 to 0.959, with mean values of 0.738 and0.836, respectively. The polymorphism information content(PIC) ranged from 0.341 to 0.941(mean=0.806).However, 12 loci deviated from Hardy-Weinberg equilibrium. Furthermore, transferability tests were also successful in validating the utility of the developed markers in ?ve phylogenetically related species of family Carangidae. A total of 48 microsatellite markers were successfully cross-ampli?ed in Decapterus macarellus, Decapterus macrosoma, Decapterus kurroides, Trachurus japonicus, and Selaroides leptolepis.The present microsatellites provided the ?rst known set of microsatellite DNA markers for D. maruadsi,D. macarellus, D. kurroides, and D. macrosoma, and would be useful for further population genetic and molecular phylogeny studies as well as help with the ?sheries management formulation and implementation of the understudied species. | NIU Sufang ZHAI Yun WU Renxie ZHANG Haoran TIAN Letian DENG Jiaxin XIAO Yao | 2019 | Journal of Oceanology and Limnology2019，37，1： | 2 |
| 12 | Postconditioning of stellate ganglion block improves intestinal barrier function by inhibiting autophagy in conscious rats following hemorrhagic shock and resuscitation显示文摘To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfunction is a critical link of distant organ injury caused by hemorrhagic shock.Prophylactic treatment with stellate ganglion block(SGB)significantly reduces hemorrhagic shock-induced intestinal barrier damage. | Zhonghua Li Wendi Wang Qi Sun Tingjiao Suo Jiayi Zhai Huibo Du Zhen’ao Zhao Fulong Li Chunyu Niu Zigang Zhao | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | An Assessment of the Predictability of the East Asian Subtropical Westerly Jet Based on TIGGE Data显示文摘The predictability of the position, spatial coverage and intensity of the East Asian subtropical westerly jet(EASWJ) in the summers of 2010 to 2012 was examined for ensemble prediction systems(EPSs) from four representative TIGGE centers,including the ECMWF, the NCEP, the CMA, and the JMA. Results showed that each EPS predicted all EASWJ properties well, while the levels of skill of all EPSs declined as the lead time extended. Overall, improvements from the control to the ensemble mean forecasts for predicting the EASWJ were apparent. For the deterministic forecasts of all EPSs, the prediction of the average axis was better than the prediction of the spatial coverage and intensity of the EASWJ. ECMWF performed best, with a lead of approximately 0.5–1 day in predictability over the second-best EPS for all EASWJ properties throughout the forecast range. For probabilistic forecasts, differences in skills among the different EPSs were more evident in the earlier part of the forecast for the EASWJ axis and spatial coverage, while they departed obviously throughout the forecast range for the intensity. ECMWF led JMA by about 0.5–1 day for the EASWJ axis, and by about 1–2 days for the spatial coverage and intensity at almost all lead times. The largest lead of ECMWF over the relatively worse EPSs, such as NCEP and CMA, was approximately 3–4 days for all EASWJ properties. In summary, ECMWF showed the highest level of skill for predicting the EASWJ, followed by JMA. | ZHOU Baiquan NIU Ruoyun ZHAI Panmao | 2015 | Advances in Atmospheric Sciences2015，32，3： | 2 |
| 14 | In-situ hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA damage显示文摘Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,such as genetic diseases and cancers.Therefore,the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biological recognition.Herein,we constructed an in situ hydrophobic environment-triggering reactive fluorescence probe named MBI-CN.The fluorophore was 2-styrene-1H-benzo[d]imidazole,and malononitrile was introduced as a core into a molecule to initiate the hydrolysis reaction in the specific environment containing damaged mitochondrial DNA.In this design,MBI-CN conjugates to mitochondrial DNA without causing additional damages.Thus,MBI-CN can be hydrolyzed to generate MBI-CHO in an in situ hydrophobic environment with mitochondrial DNA damage.Meanwhile,MBI-CHO immediately emitted a significative fluorescence signal changes at 437 and 553 nm within 25 s for the damaged mitochondria DNA.Give that the specific and rapid response of MBI-CN does not cause additional damages to mitochondrial DNA,it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA damage during cell apoptosis and initial assessment of cell apoptosis. | Beidou Feng Huiyu Niu Hongchen Zhai Congcong Shen Hua Zhang | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 2 |
| 15 | EFFECTS OF DIFFUSION WELDING PARAMETERS ON JOINT STRENGTH OF SiCw/6061AI COMPOSITE显示文摘Diffusion welding was used to join SiCw/6061AI composites. The effects of welding pammeters on strength Of welded joint were investigated. JOint Of high quality for SiCw/6061Al composites can be obtained with aPPropriate diffesion welding parameters. | L.M. Liu J.T. Niu Z.H. Lai Y.L. Guo and J.P. Zhai (National Key Laboratory of Advanced Welding Production Technologyt HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 1 |
| 16 | Retrospective series of subtotal colonic bypass and antiperistaltic cecoproctostomy for the treatment of slow-transit constipation显示文摘 | Wang Y Zhai C Niu L | 2010 | Int J Colorectal Dis2010，25，5： | 1 |
| 17 | Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells显示文摘 | Wei Zhang Minghui Niu Kunfeng Yan Xuguang Zhai Qian Zhou Li Zhang Yajun Zhou | 2013 | International Journal of Biochemistry and Cell Biology2013，，3： | 1 |
| 18 | Photocatalytic degradation of SA-loaded Ru-doped TiO2 to dye wastewater in the sunlight显示文摘 | NIU M G CHEN L C ZHAI Q G | | 0，，： | 1 |
| 19 | 14 μm quantum cascade lasers based on diagonal transition and nonresonant extraction显示文摘We report In P-based room-temperature high-average-power quantum cascade lasers emitting at 14 μm. Using a novel active region design, a diagonal bound-to-bound lasing transition is guaranteed by efficient electron injection into the upper laser level and fast nonresonant electron extraction through a miniband from the lower laser level. For a 4 mm long and 40 μm wide double channel ridge waveguide laser with 55 stages of the active region, the threshold current density is only 3.13 k A∕cm^2 at room temperature. At 293 K, the maximum singlefacet peak power and average power are up to 830 m W and 75 m W, respectively. The laser exhibits a characteristic temperature T0 of 395 K over a temperature range from 293 to 353 K. | Shouzhu Niu Junqi Liu Fengmin Cheng Huan Wang Jinchuan Zhang Ning Zhuo Shenqiang Zhai Lijun Wang Shuman Liu Fengqi Liu Zhanguo Wang Xiaohua Wang Zhipeng Wei | 2019 | Photonics Research2019，7，11： | 1 |
| 20 | Application of an Improved Analog-Based Heavy Precipitation Forecast Model to the Yangtze–Huai River Valley and Its Performance in June–July 2020显示文摘Precipitation extremes,such as the record-breaking Meiyu characterized by frequent occurrences of rainstorms that resulted in severe flooding over the Yangtze-Huai River valley(YHRV)in June-July 2020,are always attracting considerable interest,highlighting the importance of improving the forecast accuracy at the medium-to-long range.To elevate the skill in forecasting heavy precipitation events(HPEs)with both long and short durations,the Key Influential Systems Based Analog Model(KISAM)was further improved and brought into operational application in 2020.Verification and comparison of this newly adapted analog model and ensemble mean forecasts from the ECMWF at lead times of up to 15 days were carried out for the identified 16 HPEs over the YHRV in June-July 2020.The results demonstrate that KISAM is advantageous over ECMWF ensemble mean for forecasts of heavy precipitation≥25 mm day-1 at the medium-to-long(6-15-day)lead times,based on the traditional dichotomous metrics.At short lead times,ECMWF ensemble mean outperforms KISAM due largely to the low false alarm rates(FARs)benefited from an underestimation of the frequency of heavy precipitation.However,at the medium-to-long forecast range,the large fraction of misses induced by the high degree of underforecasting overwhelms the fairly good FARs in the ECMWF ensemble mean,which partly explains its inferiority to KISAM in terms of the threat score.Further assessment on forecasts of the latitudinal location of accumulated heavy precipitation indicates that smaller displacement errors also account for a part of the better performance of KISAM at lead times of 8-12 days. | Baiquan ZHOU Panmao ZHAI Ruoyun NIU | 2021 | Journal of Meteorological Research2021，35，6： | 1 |
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