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| 1 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 2 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 3 | Efficient synthesis of hydroxyl functioned polyesters from natural polyols and sebacic acid显示文摘Amphiphilic 氢氧根工作了聚酯(HFP ) 能为淀粉和树脂的混合被用作 compatibilizers。我们为 HFP 的有效准备开发了一个合成方法。水被高流动率 N2 而非高真空面对 dehydrative 冷凝作用催化剂与木糖醇,山梨糖醇,或甘露糖醇在癸二酸酸的 polycondensation 期间移开,产品与[] 27.2 mL/g, 1903 的 Mn, 167,693 的 Mw, 30.5 的 Tg ? 牵橹湡捩湩吗? | Zhuo Yuan Ning Qing Shan Zhang Qin Pei Wu Yun Zheng Li Dong Xia Ma Jia Zhe Chen | 2011 | Chinese Chemical Letters2011，22，6： | 5 |
| 4 | m6A RNA methylation-mediated HNF3γreduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 6 | Broad area quantum cascade lasers operating in pulsed mode above 100℃ at λ ~ 4.7 μm显示文摘We demonstrate a broad area(400 μm) high power quantum cascade laser(QCL). A total peak power of 62 W operating at room temperature is achieved at λ~ 4.7 μm. The temperature dependence of the peak power characteristic is given in the experiment, and also the temperature of the active zone is simulated by a finite-elementmethod(FEM). We find that the interface roughness of the active core has a great effect on the temperature of the active zone and can be enormously improved using the solid source molecular beam epitaxy(MBE) growth system. | Yue Zhao Fangliang Yan Jinchuan Zhang Fengqi Liu Ning Zhuo Junqi Liu Lijun Wang Zhanguo Wang | 2017 | Journal of Semiconductors2017，38，7： | 3 |
| 7 | Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing in vitro Fertilization-Embryo Transfer:A Randomized Clinical Trial显示文摘Objective:To observe the effect of acupuncture on endometrium and pregnancy outcomes in patients with polycystic ovary syndrome(PCOS)infertility undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods:Eighty-three patients were randomly assigned to observation group(40 cases)and control group(43 cases)according to the random numbers generated by SPSS software.The patients of the two groups received GnRH agonist long protocol as a routine treatment.In the observation group,acupuncture was given at two acupoint groups for 30 min once every other day.Group 1 included Guanyuan(CV 4),Qihai(CV 6),Zhongji(CV 3),bilateral acupoints Zigong(EX-CA1).Group 2 included Mingmen(GV 4),Yaoyangguan(GV 3),bilateral Shenshu(BL 23)and Ciliao(BL 32).The two groups of acupoints were used alternately.The whole needling process was performed at the time of ovulation induction until the transplantation day and consisted of3 courses,while the control group did not receive acupuncture interventions.The Gn dosage and Gn stimulation time,endometrial thickness and type(A,B,and C),serum oestradiol(E2)and progesterone(P)levels on the day of injection of human chorionic gonadotropin(hCG),clinical pregnancy rate,as well as live birth rate were observed.Adverse reactions were also be recorded.All patients were followed up for the pregnant rate 14 days after IVF-ET and live birth rate after pregnancy.All adverse reactions(AEs)of acupuncture were recorded during the trial.Ressults:The Gn dosage and Gn stimulation time in the observation group were lower in the observation group than in the control group(P<0.01).The proportion of type A endometrium in the observation group were higher than that in the control group(P<0.05).The serum E2 and P levels on the day of hCG injection was lower and the clinical pregnancy rate was higher in the observation group compared to those in the control group(P<0.05).There was no serious AEs during this trial.Conclusion:Acupuncture can improve the proportion of type A endometrium,regulate the levelse of serum Eand P on the day of hCG injection,and improve the pregnancy rate in patients with PCOS infertility undergoing IVF-ET. | WU Jia-man NING Yan YE Yang-yang LIU Yu-lei TANG Meng HU Shan ZHUO Yuan-yuan | 2022 | Chinese Journal of Integrative Medicine2022，28，8： | 3 |
| 8 | Numerical study on dynamic mechanism of brain volume and shear deformation under blast loading显示文摘Blast-induced traumatic brain injury(b-TBI)is a kind of significant injury to soldiers in the current military conflicts.However,the mechanism of b-TBI has not been well understood,and even there are some contradictory conclusions.It is crucial to reveal the dynamic mechanism of brain volume and shear deformations under blast loading for better understanding of b-TBI.In this paper,the numerical simulation method is adopted to carry out comprehensive and in-depth researches on this issue for the first time.Based on the coupled Eulerian-Lagrangian method,the fluid-structure coupling model of the blast wave and human head is developed to simulate two situations,namely the head subjected to the frontal and lateral impacts.The simulation results are analyzed to obtain the underlying dynamic mechanisms of brain deformation.The brain volume deformation is dominated by the local bending vibration of the skull,and the corresponding frequency for the forehead skull under the frontal impact and the lateral skull faced to the lateral impact is as high as 8 kHz and 5 kHz,respectively.This leads to the high-frequency fluctuation of brain pressure and the large pressure gradient along the skull,totally different from the dynamic response of brain under head collisions.While the brain shear deformation mainly depends on the relative tangential displacement between the skull and brain and the anatomical structure of inner skull,being not related to the brain pressure and its gradient.By further comparing the medical statistics,it is inferred that diffuse axonal injury and brain contusion,the two most common types of b-TBI,are mainly attributed to brain shear deformations.And the von Mises stress can be adopted as the indicator for these two brain injuries.This study can provide theoretical guidance for the diagnosis of b-TBI and the development of protective equipment. | Zhijie Li Zhibo Du Xiaochuan You Zhanli Liu Jian Cheng Chengcheng Luo Dongyang Chu Shaowu Ning Yue Kang Ce Yang Zhuo Zhuang | 2019 | Acta Mechanica Sinica2019，35，5： | 3 |
| 9 | High powerλ~8.5μm quantum cascade laser grown by MOCVD operating continuous-wave up to 408 K显示文摘Robust quantum cascade laser(QCL)enduring high temperature continuous-wave(CW)operation is of critical importance for some applications.We report on the realization of lattice-matched InGaAs/InAlAs/InP QCL materials grown by metal-organic chemical vapor deposition(MOCVD).High interface quality structures designed for light emission at 8.5μm are achieved by optimizing and precise controlling of growth conditions.A CW output power of 1.04 W at 288 K was obtained from a 4 mm-long and 10μm-wide coated laser.Corresponding maximum wall-plug efficiency and threshold current density were 7.1%and 1.18 kA/cm2,respectively.The device can operate in CW mode up to 408 K with an output power of 160 mW. | Teng Fei Shenqiang Zhai Jinchuan Zhang Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Zhiwei Jia Kun Li Yongqiang Sun Kai Guo Fengqi Liu Zhanguo Wang | 2021 | Journal of Semiconductors2021，42，11： | 3 |
| 10 | Recursive adaptive filter using current innovation for celestial navigation during the Mars approach phase显示文摘Celestial navigation is a commonly used autonomous navigation technique for deep space navigation.A nonlinear filter such as the unscented Kalman filter(UKF) is typically applied in a celestial navigation system(CNS). However, on account of being subject to a number of factors, such as ephemeris errors and centroid determination, the measurement model error of a CNS cannot be accurately determined. The analysis conducted in this study also shows that the measurement model error is time-variant during the Mars approach phase.This implies that covariance matrix of the measurement error R is usually inaccurate, which may induce large estimation errors that even result in filter divergence. Some adaptive methods are able to address this issue.However, traditional adaptive filters, for scaling R, usually require a sequence of innovation and are affected by the statistic window size. A new recursive adaptive UKF(RAUKF) is proposed in this paper, which only uses current innovation to scale R. The navigation performance of the proposed RAUKF method is compared with some traditional adaptive filters through simulations. The results show that this method is better than traditional adaptive filters in a CNS during the Mars approach phase. | Xiaolin NING Zhuo LI Weiren WU Yuqing YANG Jiancheng FANG Gang LIU | 2017 | Science China(Information Sciences)2017，60，3： | 3 |
| 11 | InAs-based interband cascade lasers at 4.0 μm operating at room temperature显示文摘InAs-based interband cascade lasers(ICLs) with InAs plasmon waveguides or InAs/AlSb superlattice(SL) waveguides were demonstrated at emission wavelengths below 4.1 μm. The threshold current densities of the lasers with SL waveguides were 37 A/cm^2 at 77 K in continuous wave mode. The operation temperature of these lasers reached room temperature in pulsed mode. Compared with the thick InAs n++ plasmon cladding layer, the InAs/AlSb superlattice cladding layers have greater advantages for ICLs with wavelengths less than 4 μm even in InAs based ICLs because in the short-wavelength region they have a higher confinement factor than InAs plasmon waveguides. | Tian Yu Shuman Liu Jinchuan Zhang Bo Xu Lijun Wang Junqi Liu Ning Zhuo Shenqiang Zhai Xiaoling Ye Yonghai Chen Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018，39，11： | 3 |
| 12 | Application research of enhanced in-situ micro-ecological remediation of petroleum contaminated soil显示文摘Experimental study of enhanced in-situ micro-ecological remediation of petroleum contaminated loess soil was carried out in Zhongyuan oil production areas, and the enhanced in-situ micro-ecological remediation technique includes optimistic in-situ microbial communities, physical chemistry methods, alfalfa planting and regulation of soil environmental elements. Experiments showed that the oil content in the contaminated soil with oil content about 2 898.25 mg/kg can be reduced about 98.61% after in-situ micro-ecological remediation for 99 days, which demonstrated the effectiveness of in-situ micro-ecological remediation methods for petroleum contaminated soil in central plains of China, and explored the practical and feasible application of these methods. | ZHANG Sheng ZHANG Cui-yun HE Ze CHEN Li ZHANG Fa-wang YIN Mi-ying NING Zhuo SUN Zhen-hua ZHEN Shi-jun | 2016 | Journal of Groundwater Science and Engineering2016，4，3： | 2 |
| 13 | Quantum cascade lasers: from sketch to mainstream in the mid and far infrared显示文摘Electrically-pumped semiconductor lasers based on monolithic chip configuration possess plenty of advantages such as small volume,light weight,long lifetime and stable performance.Nevertheless this type of lasers rely on the interband transition,which sets the bounds for emission wavelength typically below 4μm,and state of the art performance has been attained below 3μm.Attempts to employ small bandgap meterials like antimonide or lead salts ended with poor performance mainly due to imperfect crystal quality and severe Auger recombination.In view of the broad application prospects of infrared spectral range above 3μm,more attention was casted again on the low-dimensional quantum structure materials,such as quantum wells and quantum dots,which have been applied in the near infrared successfully decades ago. | Ning Zhuo Fengqi Liu Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，1： | 1 |
| 14 | Room temperature continuous wave operation of quantum cascade laser atλ~9.4μm显示文摘Continuous wave(CW) operation of long wave infrared(LWIR) quantum cascade lasers(QCLs) is achieved up to a temperature of 303 K. For room temperature CW operation, the wafer with 35 stages was processed into buried heterostructure lasers. For a 2-mm-long and 10-μm-wide laser with high-reflectivity(HR) coating on the rear facet, CW output power of 45 m W at 283 K and 9 m W at 303 K is obtained. The lasing wavelength is around 9.4 μm locating in the LWIR spectrum range. | Chuncai Hou Yue Zhao Jinchuan Zhang Shenqiang Zhai Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018，39，3： | 1 |
| 15 | Quantum cascade superluminescent light emitters with high power and compact structure显示文摘Quantum cascade(QC)superluminescent light emitters(SLEs)have emerged as desirable broadband mid-infrared(MIR)light sources for growing number of applications in areas like medical imaging,gas sensing and national defense.However,it is challenging to obtain a practical high-power device due to the very low efficiency of spontaneous emission in the intersubband transitions in QC structures.Herein a design of^5μm SLEs is demonstrated with a two-phonon resonancebased QC active structure coupled with a compact combinatorial waveguide structure which comprises a short straight part adjacent to a tilted stripe and to a J-shaped waveguide.The as-fabricated SLEs achieve a high output power of 1.8 mW,exhibiting the potential to be integrated into array devices without taking up too much chip space.These results may facilitate the realization of SLE arrays to attain larger output power and pave the pathway towards the practical applications of broadband MIR light sources. | Jialin Sun Chuncai Hou Hongmei Chen Jinchuan Zhang Ning Zhuo Jiqiang Ning Changcheng Zheng Zhanguo Wang Fengqi Liu Ziyang Zhang | 2020 | Journal of Semiconductors2020，41，1： | 1 |
| 16 | Chirped coupled ridge waveguide quantum cascade laser arrays with stable single-lobe far-field patterns显示文摘Power scaling in a broad area quantum cascade laser(QCL) tends to deteriorate beam quality with the emission of a multiple-lobe far-field pattern. In this paper, we demonstrate a coupled ridge waveguide QCL array consisting of five elements with chirped geometry. In-phase mode operation is secured by managing supermode loss with properly designed geometries of ridges. A single-lobe lateral far-field with a near diffraction limited beam pattern was obtained in the whole current dynamic range. The devices were fabricated with the wet and dry etching method. The regrowth technique of the In P:Fe insulation layer and In P:Si waveguide layer was employed.Such a structure has the potential to optimize the beam quality of the recently reported high-power broad-area QCL with a reduced cascade number. | YUE ZHAO JIN-CHUAN ZHANG CHUAN-WEI LIU NING ZHUO SHEN-QIANG ZHAI LI-JuN WANG JuN-QI LIU SHU-MAN LIU FENG-QI LIU ZHAN-GUO WANG | 2018 | Photonics Research2018，6，8： | 1 |
| 17 | Coupled-ridge waveguide quantum cascade laser array lasing at λ~5μm显示文摘In this work,we demonstrated high-power quantum cascade laser(QCL)arrays lasing at λ~5μm by employing an optimized coupled-ridge waveguide(CRW)structure.Five-element QCL arrays were simulated and fabricated through a two-step etching method to extend the CRW structure to a mid-wave infrared regime.A lateral far-field with the main peak near a diffraction-limited intensity curve of about 10°was observed by properly designing a geometric shape of the ridges and interspaces.By introducing a buried 2nd-order distributed feedback(DFB)grating,substrate emission with a radiation power above 1 W at 25℃ is achieved.Single longitudinal mode operation is obtained by changing the temperature of the heatsink with a good linear wavelength tuning coefficient of -0.2 cm^(-1)/K. | Pengchang Yang Jinchuan Zhang Zenghui Gu Chuanwei Liu Yue Zhao Fengmin Cheng Shenqiang Zhai Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Fengqi Liu | 2021 | Journal of Semiconductors2021，42，9： | 1 |
| 18 | A Comparative Study on Endoscopy Treatment in Rectal Carcinoid Tumors显示文摘 | Zhi-Feng Zhao Ning Zhang Shu-Ren Ma Zhuo Yang Xiao Han Yun-Feng Zhao Fei Gao Zhao-Jie Gong Lin Yang | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，3： | 1 |
| 19 | A Comparative Study on Endoscopy Treatment in Rectal Carcinoid Tumors显示文摘 | Zhi-Feng Zhao Ning Zhang Shu-Ren Ma Zhuo Yang Xiao Han Yun-Feng Zhao Fei Gao Zhao-Jie Gong Lin Yang | 2012 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2012，，3： | 1 |
| 20 | Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage 显示文摘 | Ning YC Cai GY Zhuo L eta1 | 2013 | Mech Ageing Dev2013，134，1112： | 1 |
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