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| 1 | Synthetic hexaploid wheat and its utilization for wheat genetic improvement in China显示文摘Synthetic hexaploid wheat (Triticum turgidum × Aegilops tauschii) was created to explore for novel genes from T. turgidum and Ae. tauschii that can be used for common wheat improvement. In the present paper, research advances on the utilization of synthetic hexaploid wheat for wheat genetic improvement in China are reviewed. Over 200 synthetic hexaploid wheat (SHW) accessions from the International Maize and Wheat Improvement Centre (CIMMYT) were introduced into China since 1995. Four cultivars derived from these, Chuanmai 38, Chuanmai 42, Chuanmai 43 and Chuanmai 47, have been released in China. Of these, Chuanmai 42, with large kernels and resistance to stripe rust, had the highest average yield (> 6 t/ha) among all cultivars over two years in Sichuan provincial yield trials, outyielding the commercial check cultivar Chuanmai 107 by 22.7%. Meanwhile, by either artificial chromosome doubling via colchicine treatment or spontaneous chromosome doubling via a union of unreduced gametes (2n) from T. turgidum-Ae. tauschii hybrids, new SHW lines were produced in China. Mitotic-like meiosis might be the cytological mechanism of spontaneous chromosome doubling. SHW lines with genes for spontaneous chromosome doubling may be useful for producing new SHW-alien amphidiploids and double haploid in wheat genetic improvement. | Wuyun Yang Dengcai Liu Jun Li Lianquan Zhang Huiting Wei Xiaorong Hu Youliang Zheng Zhouhu He Yuchun Zou | 2009 | Journal of Genetics and Genomics2009，36，9： | 18 |
| 2 | Standardization of CPUE for Chilean Jack Mackerel (Trachurus murphyi) from Chinese Trawl Fleets in the High Seas of the Southeast Pacific Ocean显示文摘The generalized linear model(GLM) and generalized additive model(GAM) were applied to the standardization of catch per unit effort(CPUE) for Chilean jack mackerel from Chinese factory trawl fishing fleets in the Southeast Pacific Ocean from 2001 to 2010 by removing the operational,environmental,spatial and temporal impacts.A total of 9 factors were selected to build the GLM and GAM,i.e.,Year,Month,Vessel,La Ni a and El Ni o events(ELE),Latitude,Longitude,Sea surface temperature(SST),SST anomaly(SSTA),Nino3.4 index and an interaction term between Longitude and Latitude.The first 5 factors were significant components in the GLM,which in combination explained 27.34% of the total variance in nominal CPUE.In the stepwise GAM,all factors explained 30.78% of the total variance,with Month,Year and Vessel as the main factors influencing CPUE.The higher CPUE occurred during the period April to July at a SST range of 12-15℃ and a SSTA range of 0.2-1.0℃.The CPUE was significantly higher in normal years compared with that in La Ni a and El Ni o years.The abundance of Chilean jack mackerel declined during 2001 and 2010,with an increase in 2007.This work provided the relative abundance index of Chilean jack mackerel for stock assessment by standardizing catch and effort data of Chinese trawl fisheries and examined the influence of temporal,spatial,environmental and fisheries operational factors on Chilean jack mackerel CPUE. | LI Gang ZOU Xiaorong CHEN Xinjun ZHOU Yinqi ZHANG Min | 2013 | Journal of Ocean University of China2013，12，3： | 9 |
| 3 | The application of event-tree based approach in long-term crude oil scheduling显示文摘This paper addresses the problem of optimal operation in long-term crude oil scheduling,which involves unloading crude oil from vessels,transferring it to charging tanks and feeding it to the distillation units.The application of a new approach for modeling and optimization of long-term crude oil scheduling is presented and the event-tree based modeling method that is very different from mathematical programming is employed.This approach is developed on the basis of natural language modeling and continuous time representation.Event triggered rules,decomposition strategy,depth-first search algorithm and pruning strategy are adopted to improve the efficiency of searching the optimum solution.This approach is successfully applied to an industrial-size problem over a horizon of 4 weeks,involving 7 vessels,6 storage tanks,6 charging tanks,2 crude oil distillation units,and 6 crude oil types.The CPU (AMD 3000+,2.0GHz) solving time is less than 70 seconds. | ZOU LaiXi,LI ChuFu,ZHANG Ming & HE XiaoRong Department of Chemical Engineering,Tsinghua University,Beijing 100084,China | 2010 | Science China Chemistry2010，53，6： | 3 |
| 4 | High Expression of Calcitonin Gene-Related Peptide and Substance P in Esophageal Mucosa of Patients with Non-Erosive Reflux Disease显示文摘 | Xiaorong Xu Zhaoshen Li Duowu Zou Min Yang Zhanju Liu Xingpeng Wang | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 5 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 6 | Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy显示文摘Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68/PD-L1 co-expression,the positive groups had a significantly higher proportion of TP53/KRAS co-mutations than the negative groups(both 13.0%vs.0.0%,P=0.023).Notably,enriched PI3K(P=0.012)and cell cycle pathway(P=0.021)were found in the CD8/PD-L1 co-expression group.Conclusion:Tumor immune microenvironmental marker expression,especially CD8/PD-L1 or CD68/PD-L1 co-expression,was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC. | Fengying Wu Tao Jiang Gongyan Chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying Cheng Jianhua Chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang Qun Chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou | 2022 | Cancer Communications2022，42，12： | 1 |
| 7 | Kinetics of oil group-type generation and expulsion: An integrated application to Dongying Depression, Bohai Bay Basin, China显示文摘 | Wei Zhifu Zou Yanrong Cai Yulan Wang Lei Luo Xiaorong Peng Pingan | 2012 | Org Geochem2012，52，： | 1 |
| 8 | Recent Progress in Structural Modification and Activities on Panax notoginseng Saponins显示文摘This paper reviews recent progress in the structural modification and activities on Panax notoginseng saponins(PNS).PNS can not only improve the function of cardio-cerebral system,central nervous system and immune system,but also reveal anticancer,anti-aging and anti-oxidation activities.In order to solve the problem of low bioavailability and poor absorbability of PNS in vivo,usually,the researchers modified the structure of PNS with three methods:glycoside cleavage(including acid hydrolysis,sulfation,etc.),biotransformation method(including enzyme hydrolysis,microbial transformation)and combinatorial chemical method.It was found that the structural modification sites of PNS were single,mainly aimed at C-3,C-6 and C-20,which provided a new perspective for the structural modification of PNS.Therefore,structural modification on PNS with high yield and ready availability are significant in the discovery of new active ingredients and industrialization.Derivatives of PNS are applied to research of structure-activity relationship,which is beneficial to the development of new medicines. | Jinna ZHOU Xiaorong ZHOU Cheng ZOU Mu WANG Hong YU | 2022 | Medicinal Plant2022，13，4： | 0 |
| 9 | Identification of the hydrogen utilization pathway for the electrocatalytic hydrogenation of phenol显示文摘Electrochemical hydrogenation(ECH)of biomass-derived platform molecules is a burgeoning route for the sustainable utilization of hydrogen.However,the noble-metal-catalyzed ECH of phenolic compounds suffers from intense competition with hydrogen evolution reaction.We prepared Pt Rh bimetallic nanoparticles dispersed on highly ordered mesoporous carbon nanospheres,which improves the utilization efficiency of adsorbed hydrogen(H_(ad))to ECH in H-UPD region(>0 V vs.RHE).Further analysis reveals(i)the strong overlapping between the d-orbitals of Pt and Rh enhances specific adsorption of phenol;(ii)incorporation of Rh devotes an electronic effect on weakening the alloy-H_(ad)interaction to increase the FE of ECH.DFT calculations confirm the selectivity difference and the ECH parallel pathways:cyclohexanol and cyclohexanone are formed via hydrogenation/dehydrogenation of the intermediate ^(*)C_(6)H_(10) OH.These findings deepen our fundamental understanding of the ECH process,and cast new light on exploration of highly efficient electrocatalysts for biomass upgrading. | Ling Zhou Xiaorong Zhu Hui Su Hongzhen Lin Yanhong Lyu Xu Zhao Chen Chen Nana Zhang Chao Xie Yingying Li Yuxuan Lu Jianyun Zheng Benrt Johannessen San Ping Jiang Qinghua Liu Yafei Li Yuqin Zou Shuangyin Wang | 2021 | Science China Chemistry2021，64，9： | 0 |
| 10 | Value of TCD foaming Test in Screening Patent Foramen Ovale in Migraine Patients and Efficacy of PFO Occlusion显示文摘Objective:To explore the effect of TCD foaming test in screening patent foramen ovale in migraine patients,as well as in the treatment effect.Methods:From September 2019 to August 2020,236 patients with migraine and 362 patients with normal physical examination were treated in our hospital.According to the random number table method,60 patients with migraine were selected as the observation group,and 60 patients with normal physical examination were selected as the control group.48 cases of PFO were confirmed by TCD foaming test Among the patients with migraine,36 patients received interventional occlusion therapy.The therapeutic effect and VAS score of the two groups were analyzed.Results:Through TCD foaming test,the proportion of PFO in the observation group was 80%,and that in the control group was 13.33%.The proportion of PFO in the observation group was significantly higher than that in the control group,and the difference was statistically significant(χ^(2)=53.5714,P<0.01);The symptoms disappeared in 30 patients and improved in 4 patients;Among the 36 patients who received interventional occlusion therapy,the VAS score of patients before and after the operation was significantly changed,and the proportion of patients whose pain disappeared after the operation was 83.33%,which was significantly lower than that before the operation,and the difference was comparable(χ^(2)=51.4286,P<0.01).Conclusion:TCD foaming test for PFO screening has strong applicability,not only safe and convenient,will not cause trauma to patients,and through interventional occlusion treatment,can significantly improve the clinical symptoms of migraine patients and cure patients. | Lilan Du Xiaorong Guo Honglin Zhang Min Zhang Guangli Zou | 2021 | Proceedings of Anticancer Research2021，5，2： | 0 |
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