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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 3 | Morphological and functional changes of mitochondria in apoptotic esophageal carcinoma cells induced by arsenic trioxide显示文摘AIM:To demonstrate that mitochondrial morphological andfunctional changes are an important intermediate link in thecourse of apoptosis in esophageal carcinoma calls inducedby As_2O_3.METHODS:The esophageal carcinoma call line SHEEC1,established in our laboratory,was cultured in 199 growthmedium,supplemented with 100mL·L^(-1)calf serum and3 mol·L^(-1)As_2O_3(the same below).After 2,4,6,12,24 hof drug adding,the SHEECl calls were collected for light-and electron-microscopic examination.The mitochondriawere labeled by Rhodamine fluorescence probe and thefluorescence intensity of the mitochondria was measured byflow cytorneter and cytofluorimetric analysis.Further,themitochondrial transmembrane potential(MTP,ΔΨm)change was also calculated.RESULTS:The mitochondrial morphological change afteradding As_2O_3 could be divided into three stages.In theearly-stage(2-6h)after adding As203,an adaptiveproliferation of mitochondria appeared;in the mid-stage(6-12 h)a degenerative change was observed;and in the late-stage(12-24 h)the mitochondria swelled with outermembrane broken down and then calls death with apoptoticchanges of nucleus.The functional change of themitochondria indicated by fluorescent intensity,whichreflected the MTP status of mitochondria,was in accordancewith morphological change of the mitochondria.Thefluorescent intensity increased at early-stage,decUned inmid-stage and decreased to the lowest in the late-stage.24h after As_2O_3 adding,the cell nucleus showed typicalapoptotic changes.CONCLUSION:Under the inducement of As_2O_3,the earlyapoptotic changes of SHEEC1 cells ware the apparentmorphological and functional changes of mitochondria,afterwards the nucleus changes followed.It is consideredthat changes of mitochondria are an important intermediatelink in the course of apoptosis of esophageal carcinoma cells induced by As_2O_3. | Zhong-Ying Shen Jian Shen Qiao-Shan Li Department of Pathology,Medical College of Shantou University,Shantou 515031,Guandong Province,China Cai-Yun Chen Central Lab.Medical College of Shantou University Jiong-Yu Chen Central Lab.of Tumor Hospital,Medical College of Shantou University Yi Zeng Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2002 | World Journal of Gastroenterology2002，8，1： | 35 |
| 4 | Characteristics of land surface thermal-hydrologic processes for different regions over North China during prevailing summer monsoon period显示文摘The observation stations of Northern China are divided into three regions:the arid Northwest China,the Loess Plateau,and the cool Northeast China.The consistencies,differences,and associated mechanisms of land surface thermal-hydrologic processes among the three regions were studied based on the normalization of major variables of land surface thermal-hydrologic processes,using data collected during prevailing summer monsoon period(July and August,2008).It is shown that differences of surface thermal-hydrologic processes are remarkable among the three regions because of different impacts of summer monsoon.Especially their soil wet layers occur at different depths,and the average albedo and its diurnal variations are distinctly different.Surface net short-wave radiation in the Loess Plateau is close to that in the cool Northeast China,but its surface net long-wave radiation is close to that in the arid Northwest China.And the ratio of net radiation to global solar radiation in the cool Northeast China is higher than the other two regions,though its temperature is lower.There are obvious regional differences in the ratios of surface sensible and latent heat fluxes to net radiation for the three regions because of distinct contribution of sensible and latent heat fluxesto land surface energy balance.The three regions are markedly different in the ratio of water vapor flux to pan evaporation,but they are consistent in the ratio of water vapor flux to precipitation.These results not only indicate different influences of climate and environmental factors on land surface thermal-hydrologic processes in the three regions,but also show that summer monsoon is important in the formation and variation of the pattern of land surface thermal-hydrologic processes. | ZHANG Qiang ZENG Jian ZHANG LiYang | 2012 | Science China Earth Sciences2012，55，11： | 28 |
| 5 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 6 | Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China显示文摘Background: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.Methods: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan–Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.Results: The most common tumor location was the rectum(37.4%), followed by the pancreas(28.1%), stomach(20.7%), small intestine(7.2%), appendix(3.4%), and colon(3.3%). After initial definitive diagnosis, 1016(85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival(OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively(P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively(P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not(P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor(P y, M category, and sur= 0.031) or neuroendocrine carcinoma(P gery were found to be independent prog= 0.046). In multivariate analysis, age, grade, N categornostic factors.Conclusions: Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery. | Cheng Fang Wei Wang Yu Zhang Xingyu Feng Jian Sun Yujie Zeng Ye Chen Yong Li Minhu Chen Zhiwei Zhou Jie Chen | 2017 | Chinese Journal of Cancer2017，36，10： | 23 |
| 7 | Telomere and telomerase in the initial stage of immortalization of esophageal epithelial cell显示文摘AIM: To search for the biomarker of cellular immortalization,the telomere length, telomerase activity and its subunits incultured epithelial cells of human fetal esophagus in theprocess of immortalization.METHODS: The transgenic cell line of human fetalesophageal epithelium (SHEE) was established with E6 E7genes of bt man papillomavirus (HPV) type 18 in ourlaboratory. Morphological phenotype of cultured SHEE cellsfrom the 6th to 30th passages, was examined by phasecontrast microscopy, the telomere length was assayed bySouthern blot method, and the activity of telomerase wasanalyzed by telomeric repeat amplification protocol (TRAP).Expressions of subunits of telomerase, hTR and hTERT,were assessed by RT-PCR. DNA content in cell cycle wasdetected by flow cytometry. The cell apoptosis wasexamined by electron microscopy (EM) and TUNEL label.RESULTS: SHEE cells from the 6 th to 10 th passagesshowed cellular proliferation with a good differentiation.From the 12 th to the 16 th passages, many senescent andapoptotic cells appeared, and the telomere length sharplyshortened from 23 kb to 17 kb without expression of hTERTand telornerase activity. At the 20 th passage, SHEE cellsovercame the senescence and apoptosis and restored theirproliferative activity with expression of telomerase andhTERT at low levels, but the telomere length shortenedcontinuously to the lowest of 3 kb. After the 30 th passagecells proliferation was restored by increment of cells at S andG2M phase in the cell cycle end telomerase activity expressedat high levels and with maintenance of telomere length.CONCLUSION: At the early stage of SHEE cells, telomeresare shortened without expression of telomerase and hTERTcausing cellular senescence and cell death. From the 20 thto the 30 th passages, the activation of telomerase andmaintenance of telomere length show a progressive processfor immortalization of esophageal epithelial cells. Theexpression of telomerase may constitute a biomarker fordetection of immortalization of cells. | Zhong-Ying Shen Li-Yan Xu Wei-Jia Cai Min-Hua Chen Jian Shen,Department of Tumor Pathology,Medical College of Shantou University,Shantou 515031,Guangdong Province,China En-Min Li,Department of Biochemistry and Molecular Biology,Medical College of Shantou University,Shantou 515031,Guangdong Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2002 | World Journal of Gastroenterology2002，8，2： | 21 |
| 8 | Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department: A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing显示文摘 | Guo-Gan Wang Si-Jia Wang Jian Qin Chun-Sheng Li Xue-Zhong Yu Hong Shen Li-Pei Yang Yan Fu Ya-An Zheng Bin Zhao Dong-Min Yu Fu-Jun Qin De-Gui Zhou Ying Li Fu-Jun Liu Wei Li Wei Zhao Xin Gao Zheng Wang Ming Jin Hong Zeng Yi Li Guo-Xing Wang Hong Zhou Xiao-Lu Sun Peng-Bo Wang Kam-Sang Woo | 2017 | Chinese Medical Journal2017，，16： | 21 |
| 9 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 10 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 11 | Sparse SAR imaging based on L_(1/2) regularization显示文摘In this paper,a novel method for synthetic aperture radar(SAR)imaging is proposed.The approach is based on L1/2 regularization to reconstruct the scattering field,which optimizes a quadratic error term of the SAR observation process subject to the interested scene sparsity.Compared to the conventional SAR imaging technique,the new method implements SAR imaging effectively at much lower sampling rate than the Nyquist rate,and produces high-quality images with reduced sidelobes and increased resolution.Also,over the prevalent greedy pursuit and L1 regularization based SAR imaging methods,there are remarkable performance improvements of the new method.On one hand,the new method significantly reduces the number of measurements needed for reconstruction,as supported by a phase transition diagram study.On the other hand,the new method is more robust to the observation noise.These fundamental properties of the new method are supported and demonstrated both by simulations and real SAR data experiments. | ZENG JinShan FANG Jian XU ZongBen | 2012 | Science China(Information Sciences)2012，55，8： | 18 |
| 12 | Quality of life after three kinds of esophagectomy for cancer显示文摘AIM:To evaluate quality of life(QOL) following Ivor Lewis,left transthoracic,and combined thoracoscopic/laparoscopic esophagectomy in patients with esophageal cancer.METHODS:Ninety patients with esophageal cancer were assigned to Ivor Lewis(n = 30),combined thoracoscopic/laparoscopic(n = 30),and left transthoracic(n = 30) esophagectomy groups.The QOL-core 30 questionnaire and the supplemental QOL-esophageal module 18 questionnaire for patients with esophageal cancer,both developed by the European Organization for Research and Treatment of Cancer,were used to evaluate patients' QOL from 1 wk before to 24 wk after surgery.RESULTS:A total of 324 questionnaires were collected from 90 patients;36 postoperative questionnaires were not completed because patients could not be contacted for follow-up visits.QOL declined markedly in all patients at 1 wk postoperatively:preoperative and 1-wk postoperative global QOL scores in the Ivor Lewis,combined thoracoscopic/laparoscopic,and left transthoracic groups were 80.8 ± 9.3 vs 32.0 ± 16.1(P < 0.001),81.1 ± 9.0 vs 53.3 ± 11.5(P < 0.001),and 83.6 ± 11.2 vs 46.4 ± 11.3(P < 0.001),respectively.Thereafter,QOL recovered gradually in all patients.Patients who underwent Ivor Lewis esophagectomy showed the most pronounced decline in QOL;global scores were lower in this group than in the combined thoracoscopic/laparoscopic(P < 0.001) and left transthoracic(P < 0.001) groups at 1 wk postoperatively and was not restored to the preoperative level at 24 wk postoperatively.QOL declined least in patients undergoing combined thoracoscopic/laparoscopic esophagectomy,and most indices had recovered to preoperative levels at 24 wk postoperatively.In the Ivor Lewis and combined thoracoscopic/laparoscopic groups,pain and physical function scores were 78.9 ± 18.5 vs 57.8 ± 19.9(P < 0.001) and 59.3 ± 16.1 vs 70.2 ± 19.2(P = 0.02),respectively,at 1 wk postoperatively and 26.1 ± 28.6 vs 9.5 ± 15.6(P = 0.007) and 88.4 ± 10.5 vs 95.8 ± 7.3(P = 0.003),respectively,at 24 wk postoperatively.Scores in the left transthoracic esophagectomy group fell between those of the other two groups.CONCLUSION:Compared with Ivor Lewis and left transthoracic esophagectomies,combined thoracoscopic/laparoscopic esophagectomy enables higher postoperative QOL,making it a preferable surgical approach for esophageal cancer. | Jian Zeng Jin-Shi Liu | 2012 | World Journal of Gastroenterology2012，18，36： | 18 |
| 13 | Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells显示文摘Aim: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3,-8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results: GA inhibited cell growth in a time-and dose-dependent manner. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. Conclusions: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. | Jingyan Xu Min Zhou Jian Ouyang Jing Wang Qiguo Zhang Yong Xu Yueyi Xu Qian Zhang Xihui Xu Hui Zeng | 2013 | Chinese Journal of Cancer Research2013，25，2： | 18 |
| 14 | Effect of lipid on proliferation and activation of rat hepatic stellate cells(Ⅰ)显示文摘INTRODUCTIONDespitetheearlycontroversyovertheprimarycelularsourceofextracelularmatrixproteinsinliverfibrosis,compelinginvitro... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao, FAN Zhu Ping and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 18 |
| 15 | Fuzzy Control of LED Tunnel Lighting and Energy Conservation显示文摘Current highway tunnel lighting control systems are often manually controlled,resulting in significant energy waste.This article designs a fuzzy control algorithm for tunnel lighting energy control systems.The system uses LED (Light Emitting Diode) lighting,so the fuzzy control algorithm is designed for LED lights.The traffic and the natural illumination level are used as parameters in the intelligent lighting control algorithm.This system has been deployed in the Lengshui tunnel on the 49th provincial highway of Zhejiang province and operated for more than six months.The performance results show that the energy conservation system provides sufficient lighting levels for traffic safety with significant energy conservation. | Hong Zeng Jian Qiu Xingfa Shen Guojun Dai Peng Liu Shuping Le | 2011 | Tsinghua Science and Technology2011，16，6： | 17 |
| 16 | 前列腺癌骨转移患者的临床特征和预后因素显示文摘本文为了研究前列腺癌骨转移患者的临床特征及相关预后因素。研究搜集1997--2009年间诊治的115例前列腺癌骨转移患者进行回顾性分析。对患者年龄、诊断原发灶时Gleason评分、诊断原发灶时临床分期、是否内分泌治疗、是否行去势术、原发灶是否放疗、骨转移灶数目、骨转移时PSA和ALP水平、有无周围器官侵犯、有无区域和非区域淋巴结转移、是否伴骨旁软组织侵犯及其他脏器转移进行单因素和多因素预后分析。生存率计算运用Kaplan.Meier法,单因素分析采用Logrank法,多因素分析采用Cox回归模型。结果发现随访率为100%,1、3、5年随访例数分别为103、79、55例。1、3、5年生存率分别为89.1%、60.9%、49.8%,中位生存期为48.5个月。单因素分析结果显示患者年龄(Z2=7.18,P=0.028)、诊断原发灶时Gleason评分(x2=8.58,P=0.014)、诊断原发灶时临床分期(x2=10.62,P=0.014)、骨转移灶数目(x2=6.87,P=0.009)、骨转移时ALP水平(2=8.95,P=0.011)、有无周围器官侵犯(x2=9.03,P=0.003)和有无非区域淋巴结转移(Z2=12.45,P=0.000)的生存率有差异,余各项无差异。Cox模型多因素分析显示骨转移时ALP水平(x2=4.077,P=0.020)、诊断原发灶时Gleason评分(x2=4.573,P=0.044)和是否有非区域淋巴结转移(x2=3.934,P=0.030)是影响预后的因素。骨转移时碱性磷酸酶水平、诊断原发灶时Glason评分和非区域淋巴结转移是独立预测因素,这些预后因素将有助于我们确定适当的放射治疗分割方式和治疗剂量。 | Jian He Zhao-Chong Zeng Ping Yang Bing Chen We Jiang Shi-Suo Du | 2012 | Asian Journal of Andrology2012，14，3： | 16 |
| 17 | Survivin mRNA expression in urine as a biomarker for patients with transitional cell carcinoma of bladder显示文摘膀胱的过渡房间癌(TCC ) 是在 uropoiesis 系统的最普通的恶意的肿瘤。最新,除了 CT 和 MRI 成像和 cystoscopy,仍然有为诊断 ofTCC 的一个理想的标记的缺乏。Cystoscopy 是侵略考试,它增加尿道感染的可能性。尿细胞学有低敏感(21%—40%) 在膀胱癌症的诊断,特别为那些与中等或高的区别。Thespecificity 被象标本收集那样的因素经常影响,尿道感染,等等。由真实 time-PCR 在尿检测 survivin mRNA 的表示在标本收集简单并且敏感、相对特定,它为 TCC 提供一个简单、非侵略的诊断方法。而且它允许比较,基因表示在不同阶段和等级 ofTCC 铺平,它能帮助定义 TCC 的恶意度。 | HOU Jian-quan HE Jun WEN Duan-gai CHEN Zi-xing ZENG Jian | 2006 | Chinese Medical Journal2006，，13： | 15 |
| 18 | Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection显示文摘 | Hui-Chuan Sun Lu Xie Xin-Rong Yang Wei Li Jian Yu Xiao-Dong Zhu Yong Xia Ti Zhang Yang Xu Bo Hu Li-Ping Du Ling-Yao Zeng Jian Ouyang Wei Zhang Tian-Qiang Song Qiang Li Ying-Hong Shi Jian Zhou Shuang-Jian Qiu Qian Liu Yi-Xue Li Zhao-You Tang Yu Shyr Feng Shen Jia Fan | 2017 | Chinese Medical Journal2017，，22： | 15 |
| 19 | Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector显示文摘瞄准:调查在人的肝细胞在肿瘤生长和 apoptosis 上表示 MDA-7/IL-24 的复制无能的侵入人体气管粘膜的病菌向量的效果癌(HCC ) 房间线 HepG2 和正常的肝房间衬里 L02。方法:我们构造了 recombinant 复制无能的 Ad.mda-7 病毒向量并且感染了它进人的 HCC 房间线 HepG2 和正常的肝房间线 L02。RT-PCR 被执行检测在房间表示的 mRNA。被 ELISA 用来在文化上层清液检测 MDA-7/IL-24 蛋白质表示。Ad.mda-7 导致的 apoptosis 的效果被 Hoechst 与染色的 Annexin-V 和 PI 染色和流动血细胞计数试金证实。MTT 试金被用来决定 HepG2 细胞的生长抑制,并且房间周期和 hypodiploidy 分析被流动血细胞计数执行。结果:Recombinant 复制有缺陷者病毒表示 MDA-7/IL-24 成功地被构造。RT-PCR 证明 Ad.mda-7 能调停进 HepG2 和 L02 的外长的基因 MDA-7/IL-24 的表示。在上层清液的 MDA-7/IL-24 蛋白质的集中分别地在 Ad.mda-7-infected L02 和 HepG2 房间是 130 pg/mL 和 110 pg/mL。 Ad.mda-7 感染显然导致了 apoptosis (从2.60%+/-0.72%到33.6%+/-13.2%, P=0.00012 )并且在 HepG2 (抑制比率IR=68%)的生长抑制和在房间的 G2/M 阶段的特定的癌症房间类型的百分比的增加骑车(从6.44%~32.29%, P<0.01 ),然而并非在 L02 房间。结论:这些结果有选择地在人的肝细胞癌细胞线 HepG2 与复制无能的侵入人体气管粘膜的病菌向量由 mda-7/IL-24 基因证实 apoptosis 和生长抑制的正式就职。 | Cong-Jun Wang Xin-Bo Xue Ji-Lin Yi Kun Chen Jian-WeiZheng Jian Wang Jian-Ping Zeng Rong-Hua Xu | 2006 | World Journal of Gastroenterology2006，12，11： | 15 |
| 20 | Time-depth conversion of transient electromagnetic method used in coal mines显示文摘Accuracy of time-depth conversion in data processing of transient electromagnetic prospecting always affects the accu- rate positioning of water bodies in coal mines. In order to improve the accuracy of time-depth conversion, we established a mathe- matical model of time-depth conversion for a transient electromagnetic method based on the theory of 'double smoke ring effect' of full space transient electromagnetic field transmission. Using a 3-layer as well as a 4-layer geo-electric model for roadway floors, we performed the time-depth conversion of theoretical curves of apparent resistance varying over time. In these curves, the depth corresponding to extreme value points is nearly the same as the depth of a geo-electric model. The position of water body deter- mined by our time-depth conversion method agrees well with the result of borehole drilling, indicating that the established time-depth conversion model can clearly improve the accuracy of spatial positioning of water bodies in coal mines. | YU Jing-cun WANG Yang-zhou LIU Jian ZENG Xiao-bo | 2008 | Journal of China University of Mining and Technology2008，18，4： | 15 |
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