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| 1 | Study on the functional changes of BK_(Ca) channels in human vascular smooth muscle cells from Han Chinese patients with hypertension显示文摘Chronic hypertension is associated with an impaired vascular relaxation due to an increased vascular tone.However,the underlying mechanisms are not fully understood in human patients.The present study was to inves-tigate whether large conductance Ca2+-and voltage-activated K+(BKCa)channels are involved in | Yang Yan Li Pengyun Cheng Jun Mao Liang Wen Jing Tan Xiaoqiu Liu Zhifei Zeng Xiaorong | 2013 | 泸州医学院学报2013，36，3： | 31 |
| 2 | Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases显示文摘Altered micro RNA(mi RNA) associated with gastric cancer(GC) development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease(BGD) and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD(10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps) and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction(q RT-PCR) analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic(ROC) area under the curve(AUC) of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression. | Qinghai Zeng Cuihong Jin Wenhang Chen Fang Xia Qi Wang Fan Fan Juan Du Yihang Guo Changwei Lin Kaiyan Yang Jingjing Li Xiaowei Peng Xiaorong Li Ke Cao | 2014 | Chinese Journal of Cancer Research2014，26，6： | 12 |
| 3 | iRGD decorated liposomes:A novel actively penetrating topical ocular drug delivery strategy显示文摘Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular drug administration,topical administration results in a drug bioavailability of less than 1%.iRGD modified drug delivery strategies have been developed for cancer therapy,however active targeting iRGD platforms for ocular drug delivery have yet to be explored.Herein,an iRGD modified liposomes was developed for ocular drug delivery via topical administration.The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner.These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases. | Hai Huang Xiaorong Yang Huili Li Hansi Lu James Oswald Yongmei Liu Jun Zeng Chaohui Jin Xingchen Peng Jiyan Liu Xiangrong Song | 2020 | Nano Research2020，13，11： | 2 |
| 4 | Role of calcium mobilization in the regulation of spontaneous transient outward currents in porcine coronary artery myocytes显示文摘The purpose of the present study was to further study the characteristics and regulation of spontaneous transient outward currents (STOCs) in freshly isolated porcine coronary artery smooth muscle cells (ASMCs). STOCs were recorded using the perforated whole-cell patch-clamp configuration. STOCs were voltage-dependent and superimposed stochastically onto whole-cell Ca2+-activated-K+ (BKCa) currents. Charybdotoxin (ChTX, 200 nmol/L), a selective blocker of BKCa channels, completely inhibited STOCs within 10 min. STOCs activity was greatly suppressed when extracellular Ca2+ concentration decreased from 1.8 mmol/L to 200 nmol/L, further removal of Ca2+ abolished STOCs activity. Ca2+ ionophore A23187 (10 μmol/L) increased STOCs activity significantly. Verapamil (20 μmol/L) and CdCl2 (200 μmol/L), two kinds of organic L-type voltage-dependent Ca2+ channels (L-VDCCs) antagonists, had little effect on STOCs. In addition, the ryanodine receptors (RyRs) agonist caffeine (5 mmol/L) significantly activated STOCs. Application of ryanodine (50 μmol/L) to block RyRs abolished STOCs, subsequent washout of ryanodine or application of caffeine failed to reproduce STOCs activity. Inhibition of inositol 1,4,5-trisphosphate receptors (IP3Rs) by 2APB (40 μmol/L) greatly suppressed the activity of STOCs, application of caffeine (5 mmol/L) in the presence of 2APB caused a burst of outward currents followed by inhibition of STOCs. These results suggest that STOCs in porcine coronary ASMCs are mediated by BKCa channels. Extracellular Ca2+ is essential for STOCs activity, while Ca2+ entry through L-VDCCs has little effect on STOCs. Intracellular Ca2+ release induced by RyRs is responsible for the regulation of STOCs, whereas IP3Rs might also be involved. | LI PengYun ZENG XiaoRong YANG Yan CAI Fang LIU ZhiFei LI MiaoLing PEI Jie ZHOU Wen | 2007 | Science China(Life Sciences)2007，50，5： | 1 |
| 5 | Weak centers and bifurcation of critical periods in reversible cubic systems显示文摘 | ZHANG Weinian HUO Xiaorong ZENG Zhenbing | 2000 | Computers&Mathematics with Applications2000，40，6： | 1 |
| 6 | Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel显示文摘Dear Editor,Small conductance Ca2+-activated potassium (SK) channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2+ levels and membrane potential (Adelman et al., 2012). Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes (Xu et al., 2003). This suggests that the | Tao Li Xuehui Fan Yiyan Yu Linlin Chen Wenjun Huang Yan Yang Jimin Cao Xiaorong Zeng Xiaoqiu Tan | 2018 | Science China(Life Sciences)2018，61，5： | 1 |
| 7 | A complete discrimination system for polynomials显示文摘 | Yang Lu Hou Xiaorong Zeng Zhenbing | 1996 | Science in China1996，39，6： | 1 |
| 8 | Weak cen- ters and bifurcation of critical periods in reversible cubicsystems显示文摘 | Zb:ang Weinian Hou Xiaorong Zeng Zhenbing | 2000 | Computers and Mathematics with Applica- tions2000，40，： | 1 |
| 9 | An Intelligent Retrieval Platform for Distributional Agri- culture Science and Technology Data显示文摘 | Xiaorong Yang Wensheng Wang Qingtian Zeng and Nengfu Xie | 2011 | IFIP International Federation for Information Processing2011，，344： | 1 |
| 10 | Weak centers and bifurcation of critical periods in revertible cubic system显示文摘 | Zhang Weinian Hou Xiaorong Zeng Zhenbing | 2000 | Computers & Mathematics with Ap- plications2000，40，： | 1 |
| 11 | A complete discrimination system for polynomials显示文摘 | Hou Xiaorong Zeng Z B | 1996 | Science in China SerE1996，39，6： | 1 |
| 12 | Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non-small cell lung cancer patients with brain metastasis显示文摘Dear editor,The scarcity of routinemetastatic biopsies or resection limits the finding of biomarkers of diagnosis and prognosis in patients with brain metastases.Derived from necrosis,apoptosis,and secretion of tumor cells,circulating tumor DNA(ctDNA)is widely distributed in various body fluids,including peripheral blood and cerebrospinal fluid(CSF),as an alternative biomarker for tumor-associated analysis[1].Fortunately,genomic alterations of blood ctDNA and CSF ctDNA have been proven as prognostic markers in non-small cell lung cancer(NSCLC)patients with brain metastasis[2,3]. | Ling Peng Yawen Bin Peng Ding Lingjuan Chen Hao Zeng Zelong Xu Liyan Ji Xuan Gao Pian Liu Ye Wang Sheng Zhang Zhongxing Liao Xuefeng Xia Ruiguang Zhang Fan Tong Xiaorong Dong | 2023 | Cancer Communications2023，43，5： | 0 |
| 13 | Stress-Activated Protein Kinase OsSAPK7 Regulates Salt- Stress Tolerance by Modulating Diverse Stress-Defensive Responses in Rice显示文摘Soil salinity is an environmental threat limiting rice productivity.Identification of salinity tolerance genes and exploitation of their mechanisms in plants are vital for crop breeding.In this study,the function of stress-activated protein kinase 7(OsSAPK7),a SnRK2 family member,was characterized in response to salt stress in rice.Compared with variety 9804,OsSAPK7-overexpression plants had a greater survival rate,increased chlorophyll and proline contents,and superoxide dismutase and catalase activities at the seedling stage under salt-stress conditio ns,as well as decreased sodium potassium ratio(Na+/K+)and malondialdehyde contents.After salt stress,the OsSAPK7 knockout plants had lower survival rates,in creased Na^K*ratios and malomdiadehyde contents,and decreased physiological parameters compared with 9804.These changes in transgenic lines suggested that OsSAPK7 increased the salt tolerance of rice by modulating ion homeostasis,redox reactions and photosynthesis.The results of RNA-Seq indicated that genes involved in redox-dependent signaling pathway,photosynthesis and zeatin synthesis pathways were significantly down-regulated in the OsSAPK7 knockout line compared with 9804 un der salt-stress conditio n,which con firmed that OsSAPK7 positively regulated salt tolera nee by modulating diverse stress-defe nsive resp on ses in rice.These findings provided novel in sights for the genetic improvement of rice and for understanding the regulatory mechanisms of salt-stress toleranee. | ZENG Dan WANG Chunchao XIE Junpin ZHANG Fan LU Jialing SHI Xiaorong SHI Yingyao ZHOU Yongli | 2021 | Rice science2021，28，6： | 0 |
| 14 | PI4Kb, PIPs and BK_(Ca) channel function显示文摘Large conductance calcium-activated potassium(BKCa)channels are broadly expressed in vascular smooth muscle cells(VSMCs)and play a crucial role in the regulation of vascular tone[1].Activation of BKCachannel by elevation of the[Ca^(2+)]idue to membrane depolarization increases the K^+ conductance of the membrane,and drives the VSMC membrane potential to hyperpolarization,which | Xiuli Cheng Xiaoqiu Tan Weixia Liu Hui Li Li Yan Yan Yang Xiaorong Zeng Jimin Cao | 2016 | Science Bulletin2016，61，23： | 0 |
| 15 | THE METHOD OF SEPARATING HARMONIC SIGNALS FROM MULTIPLICATIVE AND ADDITIVE NOISES显示文摘This paper focuses on the extraction of a harmonic signal from multiplicative and additive noises. A method is proposed in two stages: (1) to square the original discrete time series, which in- cludes both signals and noises, and form a new time series. By this means, the multiplicative noise is converted to additive noise; and (2) to filter out the noise by using existing noise removal schemes. With a large amount of simulation, experimental results demonstrated the efficiency and effective- ness of this newly developed method in terms of Signal-to-Noise Ratio (SNR) and other criteria. From the experiment, it is also found that: the two kinds of noises affect the SNR differently. In gen- eral, the SNR is not influenced by multiplicative Gaussian noise regardless of its variance. However, if both kinds of noise exist, the SNR decreases with the incensement of the Variance of Additive Noise to Multiplicative Noise Ratio (VAMNR). This analysis is also supported by simulation work. | Fan Yangyu Zhang Zhengwei Wei Xiaorong Zeng Li Wei Wei | 2007 | Journal of Electronics(China)2007，24，6： | 0 |
| 16 | Self-sufficient nanoparticles with dual-enzyme activity trigger radical storms and activate cascade-amplified antitumor immunologic responses显示文摘Radiotherapy(RT) can potentially induce systemic immune responses by initiating immunogenic cell death(ICD) of tumor cells.However,RT-induced antitumor immunologic responses are sporadic and insufficient against cancer metastases.Herein,we construct multifunctional self-sufficient nanoparticles(MARS) with dual-enzyme activity(GOx and peroxidase-like) to trigger radical storms and activate the cascade-amplified systemic immune responses to suppress both local tumors and metastatic relapse.In addition to limiting the Warburg effect to actualize starvation therapy,MARS catalyzes glucose to produce hydrogen peroxide(H_(2)O_(2)),which is then used in the Cu^(+)-mediated Fenton-like reaction and RT sensitization.RT and chemodynamic therapy produce reactive oxygen species in the form of radical storms,which have a robust ICD impact on mobilizing the immune system.Thus,when MARS is combined with RT,potent systemic antitumor immunity can be generated by activating antigen-presenting cells,promoting dendritic cells maturation,increasing the infiltration of cytotoxic T lymphocytes,and reprogramming the immuno suppre ssive tumor microenvironment.Furthermore,the synergistic therapy of RT and MARS effectively suppresses local tumor growth,increases mouse longevity,and results in a 90% reduction in lung metastasis and postoperative recurrence.Overall,we provide a viable approach to treating cancer by inducing radical storms and activating cascade-amplified systemic immunity. | Liping Bai Jin Yang Siting Yu Zhongzheng Xiang Yuanyuan Zeng Meiling Shen Xiaorong Kou Qinjie Wu Changyang Gong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 17 | High-entropy alloy catalysts:From bulk to nano toward highly efficient carbon and nitrogen catalysis显示文摘High-entropy alloys(HEAs)have attracted widespread attention as both structural and functional materials owing to their huge multielement composition space and unique high-entropy mixing structure.Recently,emerging HEAs,either in nano or highly porous bulk forms,are developed and utilized for various catalytic and clean energy applications with superior activity and remarkable durability.Being catalysts,HEAs possess some unique advantages,including(1)a multielement composition space for the discovery of new catalysts and fine-tuning of surface adsorption(i.e.,activity and selectivity),(2)diverse active sites derived from the random multielement mixing that are especially suitable for multistep catalysis,and(3)a high-entropy stabilized structure that improves the structural durability in harsh catalytic environments.Benefited from these inherent advantages,HEA catalysts have demonstrated superior catalytic performances and are promising for complex carbon(C)and nitrogen(N)cycle reactions featuring multistep reaction pathways and many different intermediates.However,the design,synthesis,characterization,and understanding of HEA catalysts for C-and N-involved reactions are extremely challenging because of both complex high-entropy materials and complex reactions.In this review,we present the recent development of HEA catalysts,particularly on their innovative and extensive syntheses,advanced(in situ)characterizations,and applications in complex C and N looping reactions,aiming to provide a focused view on how to utilize intrinsically complex catalysts for these important and complex reactions.In the end,remaining challenges and future directions are proposed to guide the development and application of HEA catalysts for highly efficient energy storage and chemical conversion toward carbon neutrality. | Lanlan Yu Kaizhu Zeng Chenghang Li Xiaorong Lin Hanwen Liu Wenhui Shi Hua-Jun Qiu Yifei Yuan Yonggang Yao | 2022 | Carbon Energy2022，4，5： | 0 |
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