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| 1 | Aftershock sequence relocation of the 2021 M_(S)7.4 Maduo Earthquake, Qinghai, China显示文摘The 2021 Qinghai Maduo M_(S)7.4 earthquake was one of the strongest earthquakes that occurred in the Bayan Har block of the Tibetan Plateau during the past 30 years,which spatially filled in the gap of strong earthquake in the eastern section of the northern block boundary.In this study,the aftershock sequence within 8 days after the mainshock was relocated by double difference algorithm.The results show that the total length of the aftershock zone is approximately 170 km;the mainshock epicenter is located in the center of the aftershock zone,indicating a bilateral rupture.The aftershocks are mainly distributed along NWW direction with an overall strike of 285°.The focal depth profiles indicate that the seismogenic fault is nearly vertical and dips to southwest or northeast in different sections,indicating a complex geometry.There is an aftershock gap located to the southeast of the mainshock epicenter with a scale of approximately 20 km.At the eastern end of the aftershock zone,horsetaillike branch faults show the terminal effect of a large strike-slip fault.There is a NW-trending aftershock zone on the north side of the western section,which may be a branch fault triggered by the mainshock.The location of the aftershock sequence is close to the eastern section of the Kunlun Mountain Pass-Jiangcuo(KMPJ)fault.The sequence overlaps well with surface trace of the KMPJ fault.We speculate that the KMPJ fault is the main seismogenic fault of the M_(S)7.4 Maduo earthquake. | Weilai WANG Lihua FANG Jianping WU Hongwei TU Liyi CHEN Guijuan LAI Long ZHANG | 2021 | Science China Earth Sciences2021，64，8： | 11 |
| 2 | JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients显示文摘以前的研究揭示了那根骨头从病人们早展出了的全身的豺狼座 erythematosus (SLE ) 的髓间充质的干细胞(BM-MSCs ) 老朽签名,它可以参予 SLE 的发展。然而,关于这现象的分子的机制充分没被阐明。在当前的学习,我们试图调查表明发信号的抄写(STAT ) 的变换器和使活跃之物的 Janus kinase (JAK ) 是否调停了从 SLE 病人的 BM-MSCs 的老朽。12 个女 SLE 病人和健康题目在学习被注册。所有 BM-MSCs 被密度坡度 centrifugation 孤立。西方的污点分析被用来测试表明分子的 JAK-STAT 的表示。我们由流动 cytometry 观察了房间,由染色的 F 肌动朊的细胞骨架结构的变化,和房间周期的分发的女郎的活动。从 SLE 病人的 BM-MSCs 显示出表明 transduction, phosphorylated JAK2 的高水平,和 STAT3 的 JAK-STAT 的老朽,和反常激活的突出的特征。在在正常 MSC 的 IFN- 的刺激以后,发信号的 JAK-STAT 被激活。房间体积和联系老朽的牛乳糖的数字(SA -- 女郎) 在 SLE BM-MSCs 积极被增加。细胞骨架的组织是将近混乱的。房间增长的率被减少。AG490, JAK2 的禁止者,并且在 BM-MSCs 的 STAT3 击倒,能显著地颠倒老朽。在摘要,我们的学习显示 JAK-STAT 发信号小径可以在 SLE BM-MSCs 的老朽起一个关键作用。 | Juan Ji Yeqing Wu Yan Meng Lijuan Zhang Guijuan Feng Yunfei Xia Wenrong Xue Shuyang Zhao Zhifeng Gu Xiaoyi Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 8 |
| 3 | A survey of autoencoder-based recommender systems显示文摘In the past decade,recommender systems have been widely used to provide users with personalized products and services.However,most traditional recommender systems are still facing a challenge in dealing with the huge volume,complexity,and dynamics of information.To tackle this challenge,many studies have been conducted to improve recommender system by integrating deep learning techniques.As an unsupervised deep learning method,autoencoder has been widely used for its excellent performance in data dimensionality reduction,feature extraction,and data reconstruction.Meanwhile,recent researches have shown the high efficiency of autoencoder in information retrieval and recommendation tasks.Applying autoencoder on recommender systems would improve the quality of recommendations due to its better understanding of users,demands and characteristics of items.This paper reviews the recent researches on autoencoder-based recommender systems.The differences between autoencoder-based recommender systems and traditional recommender systems are presented in this paper.At last,some potential research directions of autoencoder-based recommender systems are discussed. | Guijuan ZHANG Yang LIU Xiaoning JIN | 2020 | Frontiers of Computer Science2020，14，2： | 6 |
| 4 | Modulation of expression of P16 and Her2 in rat breast tissues of mammary hyperplasia model by external use of Rupifang Extract显示文摘OBJECTIVE:To observe the effect of Rupifang Extract in external use on expression of proto-oncogenes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model.To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia.METHODS:Thirty virginal female Wistar rats were randomized into 5 groups,6 in each,A:blank control group;B:model group;C:the low dose group of Rupifang;D:the middle dose group of Rupifang;and E:The high dose group of Rupifang.The mammary hyperplasia rat models were produced by injecting estradiol benzoate and progesterone and irritating by tail nipping.Drug intervention was also launched during the model formation.After 30 days,the expression of her2 and p16 in breast tissues of rats in each group were detected by the SP immunohistochemical method.RESULTS:Compared with Blank control group,the expression of her2 in breast tissues in Model group was higher,and the expression of p16 was lower(P<0.05 or P<0.01).After intervention with Rupifang Extract,compared with Model group,the expression of her2 in breast tissues in Rupifang groups was lower,and the expression of p16 higher(P<0.05 or P<0.01).CONCLUSION:The mechanisms of Rupifang Extract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and increasing the expression of tumor suppression genes p16. | Guijuan Zhang Dehui Li Hui Guo Rui Liao Bizhu Tan Suyi Zhang Yubin Liu Min Ma Xiaoting Zeng Zhuolong Peng Si Huang Yinghui Zheng Yi Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 5 | Reaearch on Skempton’s coefficient B based on the observation of groundwater of Changping station显示文摘Based on isotropic linear poroelastic theory and under the undrained condition,we summarize three equations connecting the Skempton’s coefficient B with the groundwater level.After analysis,we propose a method to calculate the Skempton’s coefficient B according to the relationship between water level and tidal strain.With this method we can get the value of B without the earthquake occurrence,which can provide the high frequency waves for research.Besides,we can also get the in-suit Skempton’s coefficient B without the experiment of rock physics.In addition,we analyze the observed data of Changping station recorded in groundwater monitoring network(abv.,GMN)before and after the Wenchuan MS8.0 with this method,and find out there’s a slight change of the value of B after the seismic waves passed by,which implies that the propagation of seismic waves may have brought some variations to the poroelastic medium of the well. | Yan Zhang Fuqiong Huang Guijuan Lai | 2009 | Earthquake Science2009，22，6： | 6 |
| 6 | External use of Ruyanneixiao cream efficiently blocks precancerous mammary lesions by interfering with glycolysis induced by inhibition of hypoxia inducible factor-1α, hexokinase 2, phosphofructokinase, and pyruvate kinase M2 expression显示文摘OBJECTIVE:To investigate the effect of Ruyanneixiao cream(RYNX) on the expression of hypoxia inducible factor-1α(HIF-1α), hexokinase 2(HK2),phosphofructokinase(PFK), and pyruvate kinase M2(PKM2) mRNA and protein in MCF-10 AT cells and in an animal model of precancerous mammary lesions.METHODS:Following treatment of MCF-10 AT cells with RYNX, tamoxifen(TAM) and YC-1 for 48 h,HIF-1α, HK2, PFK, PKM2 mRNA and protein expression was analyzed.Fifty female SD rats were randomly divided into control, model, TAM, and highand low-dose RYNX groups, with 10 rats in each group.A precancerous mammary lesion model was established for all groups except the control group.High-and low-dose RYNX cream containing TAM was coated on the breasts of animals in the corresponding groups.The rat mammary tissue was removed in the 10 th week and HIF-1α, HK2, PFK,PKM2 mRNA and protein was analyzed.RESULTS:In vitro analyses demonstrated that, compared with the matrix group, HIF-1α, HK2, PFK,PKM2 mRNA and protein expression was significantly decreased in the RYNX group(P < 0.05).Compared with the YC-1 + RYNX group, HK2, PFK,and PKM2 protein expression was significantly reduced in the RYNX group.HIF-1α, HK2, PFK, and PKM2 protein expression was increased significantly in the model group(P < 0.05) compared with the control group, while HIF-1α, HK2, PFK, and PKM2 mRNA and protein expression was significantly decreased in both the high-and low-dose RYNX groups(P < 0.05), with the effect being greater in the high-dose group.CONCLUSION:RYNX can block precancerous breast lesions by decreasing the expression of HK2,PFK, and PKM2 mRNA and protein via inhibition of HIF-1α mRNA and protein overexpression in a dose-dependent manner. | Li Xiaobo Ma Min Zhang Guijuan Ma Yi Liao Rui Chen Ruixue Yan Xianxin Bie Fengjie Huang Maojie Liang Shijie | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 5 |
| 7 | YIELD SURFACES AND PLASTIC FLOW OF 45 STEEL UNDER TENSION-TORSION LOADING PATHS显示文摘An experimental analysis on the subsequent yield-surfaces evolution using multiple specimens is presented for a 45 steel after a prescribed pre-strain loading in three different directions respectively, and the yielding is defined by a designated offsetting strain. The size of the subsequent yield surface is found smaller than the initial yield surface; the negative cross effects are observed in the normal loading direction, its shape is not a Mises circle but has a rather blunt nose in loading direction and flat in the opposite. These results strongly depend on the loading path and the prescribed offset plastic strain. The plastic flow direction to the subsequent yield surface is investigated, and it is found that the plastic flow direction deviates from the normal flow rule. The deviation differs from preloading case to preloading case. And the plastic flow direction would have a larger deviation from the normal of the yield surface, if the subsequent yield was defined by a smaller offset strain. Furthermore, the experiments are simulated using the Chaboche model, and the results show that it can rationally predict yield-surface only when yield is defined by a fairly large offset strain. | Guijuan Hu Keshi Zhang Shihong Huang Jiann-Wen Woody Ju | 2012 | Acta Mechanica Solida Sinica2012，25，4： | 5 |
| 8 | HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas显示文摘Hepatocellular carcinoma(HCC) is highly heterogeneous in nature and has been one of the most common cancer types worldwide. To ensure repeatability of identified gene expression patterns and comprehensively annotate the transcriptomes of HCC, we carefully curated 15 public HCC expression datasets that cover around 4000 clinical samples and developed the database HCCDB to serve as a one-stop online resource for exploring HCC gene expression with userfriendly interfaces. The global differential gene expression landscape of HCC was established by analyzing the consistently differentially expressed genes across multiple datasets. Moreover, a 4 D metric was proposed to fully characterize the expression pattern of each gene by integrating data from The Cancer Genome Atlas(TCGA) and Genotype-Tissue Expression(GTEx). To facilitate a comprehensive understanding of gene expression patterns in HCC, HCCDB also provides links to third-party databases on drug, proteomics, and literatures, and graphically displays the resultsfrom computational analyses, including differential expression analysis, tissue-specific and tumorspecific expression analysis, survival analysis, and co-expression analysis. HCCDB is freely accessible at http://lifeome.net/database/hccdb. | Qiuyu Lian Shicheng Wang Guchao Zhang Dongfang Wang Guijuan Luo Jing Tang Lei Chen Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 5 |
| 9 | Diffusion and Regeneration Mechanism of Waste Composite Oils Rejuvenator in Aged Asphalt显示文摘The physical performance of recycled asphalt was used as the main evaluation index to study the optimal range of a self-made rejuvenator.Through the penetration,viscosity and gel permeation chromatography(GPC)tests,the diffusion degree of the rejuvenator under different temperatures and time process was analyzed,and the diffusion efficiency of the rejuvenator was evaluated from the macro and micro perspective.The regeneration mechanism of the rejuvenator in the aged asphalt was also analyzed using the Fourier transform infrared spectroscopy(FTIR),scanning electron microscope(SEM)and chemical composition tests.The research results showed that the optimum rejuvenator content was about 3%.Higher temperature and longer time were beneficial to improving the permeability and diffusion of the rejuvenator.During the aging process,the light components were reduced,and more macromolecular asphaltenes were generated as well as a large number of carbonyl and sulfoxide.After diffusion and regeneration,the light components in the asphalt were supplemented,the wrinkles and gullies of the aged asphalt were almost improved to the surface state of the matrix asphalt. | 李海滨 YANG Fayong ZHANG Fan ZOU Xiaolong ZHAO Guijuan | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，5： | 3 |
| 10 | Constitutive Modeling of Slip, Twinning and Detwinning for Mg Alloy and Inhomogeneous Evolution of Microstructure显示文摘 | Yuan Chen Guijuan Hu Yongting Lan Keshi Zhang Ganwei Cai | 2018 | Acta Mechanica Solida Sinica2018，31，4： | 3 |
| 11 | Systemic Vasculitis:An Important and Underestimated Cause of Malignant Hypertension显示文摘Objectives:Malignant hypertension(MHT)is defi ned as severe hypertension accompanied by ischemic failure of one or more organs.The aims of this study were to evaluate the current clinical and etiologic profi les of MHT.Methods:As a retrospective study,we selected all patients admitted to our center from January 2013 to December 2016.Seventy patients with MHT were included.Results:The average age of the patients was 40 years,and more than half of the patients were male(78.57%).There were 24 patients with essential hypertension,accounting for 34.29%of the patients,and 46 with secondary hypertension,accounting for 65.71%of the patients.For secondary MHT,systemic vasculitis(25.57%)was the most common cause,followed by severe obstructive sleep apnea syndrome(15.71%),primary renal parenchymal hypertension(11.43%),primary aldosteronism(7.14%),and Cushing syndrome(1.43%)and nutcracker phenomenon(1.43%).Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing severity.The levels of white blood cells,hypersensitive C-reactive protein,serum creatinine,and 24-hour urinary protein were above their normal range.Conclusion:Systemic vasculitis may be one of the main causes of MHT,and has been underestimated in the past.In future clinical work,clinicians need to pay more attention to patients with systemic vasculitis. | Qing Zhu Shasha Liu Mulalibieke Heizhati Xiaoguang Yao Menghui Wang Qin Luo Lei Wang Delian Zhang Guijuan Chang Nanfang Li | 2019 | Cardiovascular Innovations and Applications2019，，B07： | 2 |
| 12 | Highly Oxygenated Dimeric Grayanane Diterpenoids as Analgesics:TRPV1 and TRPA1 Dual Antagonists from Rhododendron molle显示文摘Six highly oxygenated dimeric grayanane diterpenoids(1—6)including three new ones,bismollethers A—C(1—3),were isolated from the flowers of Rhododendron molle collected at Qichun,Hubei,China.The structures and relative configurations of 1—6 were determined by comprehensive spectroscopic data analysis and 13C NMR calculation with DP4+analysis.The absolute configurations of bismollethers A—C(1—3)and birhodomollein B(5)were indubitably assigned by single-crystal X-ray diffraction analysis,revealing the head-to-tail linking manner of diterpenoid monomers.Bismollether A(1)is a caged dimeric grayanane diterpenoid linked through two oxygen-bridges of C-2−O−C-14′and C-14−O−C-2′,featuring a unique 1,8-dioxacyclotetradecane motif.The plausible biosynthesis pathways of 1—6 are proposed.All the isolates displayed significant analgesic activities and their structure-activity relationships were discussed.Grayanane diterpenoid dimers were found to be TRPV1 and TRPA1 dual antagonists,and docking studies provide a structural basis to design potent analgesics. | Lang Huang Guijuan Zheng Yuanyuan Feng Pengfei Jin Biao Gao Hanqi Zhang Xiaomin Ma Junfei Zhou Guangmin Yao | 2022 | Chinese Journal of Chemistry2022，40，19： | 2 |
| 13 | Off-axis three-mirror reflective zoom system based on freeform surface显示文摘 | Guijuan XIE Jull CHANG Ke ZHANG Jide ZHOU Yajun NIU | 2016 | Frontiers of Optoelectronics2016，9，4： | 1 |
| 14 | Rhodauricanol A, an analgesic diterpenoid with an unprecedented5/6/5/7 tetracyclic system featuring a unique16-oxa-tetracyclo[11.2.1.0^(1,5).0^(7,13)]hexadecane core from Rhododendron dauricum显示文摘A novel diterpenoid with an unprecedented 5/6/5/7 tetracyclic system, rhodauricanol A(1), five new grayanane-derived diterpenoids, dauricanols A-E(2-6), and five known ones(7-11) were isolated from the flowers of Rhododendron dauricum. Rhodauricanol A(1) possesses a unique 5/6/5/7 tetracyclic ring system featuring a 16-oxa-tetracyclo[11.2.1.0^(1,5).0^(7,13)]hexadecane core. Dauricanols A-C(2-4) are the first1,3-dioxolane conjugates of grayanane diterpenoids and 5-hydroxymethylfurfural and vanillin, respectively, and dauricanols D(5) and E(6) represent the first examples of 6-deoxy-1,5-seco-grayanane diterpenoids. Their structures were determined by spectroscopic methods, quantum chemical calculation including ^(13)C NMR-DP4+ analysis and ECD calculation, and single-crystal X-ray diffraction analysis. Plausible biosynthetic pathways for 1-4 were proposed. All the isolates showed significant analgesic activities,and dauricanols B(3) and C(4) showed more potent analgesic activities than the positive control, morphine. | Yuanyuan Feng Suqin Zha Hanqi Zhang Biao Gao Guijuan Zheng Pengfei Jin Yingyi Chen Guangmin Yao | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 15 | Programmed 6-Step Approach of Improved Liposuction-Curettage for Axillary Bromhidrosis显示文摘Background Liposuction-curettage is a long-standing and effective treatment for axillary bromhidrosis.However,residual malodor and skin necrosis typically occur following this treatment.Therefore,we improved this method to ensure fewer complications and better outcomes.Here,we have presented our programmed 6-step approach of improved liposuction-curettage.Methods The programmed 6-step approach of improved liposuction-curettage was used to remove the axillary apocrine glands.We used pointed and obtuse cannulas designed for liposuction-curettage.Results Patients treated using the programmed 6-step approach of improved liposuctioncurettage did not experience any serious complications or residual malodor.Conclusion The programmed 6-step approach of improved liposuction-curettage was more effective than traditional surgery with respect to the treatment of axillary bromhidrosis. | Yanqi LIU Yanmeng PAN Minxia ZHANG Li CHEN Fawei XU Hongfang MA Xing HE Ying HU Guijuan HE Jiaqin CAI Weiqiang TAN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，3： | 1 |
| 16 | Relationship between Mikania micrantha invasion and soil microbial biomass, respiration and functional diversity显示文摘 | LI Weihua ZHANG Chongbang GAO Guijuan | 2007 | Plant and Soil2007，296，： | 1 |
| 17 | Research status of earthquake forecasting in hydraulicfracturing induced earthquakes显示文摘In the new types of industrial activities including unconventional energy extraction associated with shale gas and hot dry rock,gas reservoir operations,CO2 geological storage,undergoing research on induced earthquake forecasting has become one of the forward positions of current seismology.As for the intense actual demand,the immature research on induced earthquake forecasting has already been applied in pre-assessment of site safety and seismic hazard and risk management.This work will review systematically recent advances in earthquake forecasting induced by hydraulic fracturing during industrial production from four aspects:earthquake occurrence probability,maximum expected magnitude forecasting,seismic risk analysis for engineering and social applications and key scientific problems.In terms of earthquake occurrence probability,we introduce statistical forecasting models such as an improved ETAS and non-stationary ETAS and physical forecasting models such as Seismogenic Index(SI)and hydro-mechanism nucleation.Research on maximum expected magnitude forecasting has experienced four stages of linear relationship with net injection volume of fluid,power exponential relationship and physical forecasting regarding fault parameters.For seismic risk analysis,we focus on probabilistic seismic hazard assessment and quantitative geological susceptibility model.Furthermore,this review is extended to key scientific problems that contain obtaining accurate fault scale and environmental stress state of reservoir,critical physical process of runaway rupture,complex mechanism of fault activation as well as physical mechanism and modeling of trailing effect.This work in understanding induced earthquake forecasting may contribute to unconventional energy development and production,seismic hazard mitigation,emergency management and scientific research as a reference. | Qian Wang Xinxin Yin Changsheng Jiang Cong Jiang Yan Zhang Hongyu Zhai Yanbao Zhang Guijuan Lai Fengling Yin | 2021 | Earthquake Science2021，34，3： | 1 |
| 18 | Discovery of Kalmane Diterpenoids as Potent Analgesics from the Flowers of Rhododendron dauricum显示文摘Kalmane diterpenoids,featuring a 5/8/5/5 tetracyclic carbon skeleton,are very rare in nature.The flowers of Rhododendron dauricum L.(Ericaceae)were phytochemically investigated for the first time,leading to the isolation of eight kalmane diterpenoids(1-8)including four new ones,named rhodokalmanols A-D(1-4).The structures of 1-8 were elucidated by comprehensive spectroscopic methods and ic NMR-DP4+analysis,and the absolute configurations of 1,2,4,and 5 were defined by single-crystal X-ray diffraction analysis with Cu Kαradiation.Rhodokalmanol A(1)represents the first 5,8-epoxykalmane diterpenoid and also the first kalm-15(16)-ene diterpenoid.Rhodokalmanols BD(2-4)are the first examples of kalm-7(8)-ene,kalm-16(17)-ene,and 8α-methoxykalmane diterpenoids,respectively.All the isolated kalmane diterpenoids 1-8 exhibited significant analgesic effects,and rhodokalmanol C(3)and kalmanoi(8)expressed more potent analgesic activity than morphine at doses of 0.2 and 0.04 mg/kg.The preliminary structure-activity relationships of kalmane diterpenoids as potent analgesics are discussed. | Yuanyuan Feng Suqin Zha Biao Gao Hanqi Zhang Pengfei Jin Guijuan Zheng Yilin Ma Guangmin Yao | 2022 | Chinese Journal of Chemistry2022，40，9： | 1 |
| 19 | Effect of salviae miltiorrhizae and ligustrazine hydrochloride injection on axonal regeneration and nerve growth factor expression in a rat model of sciatic nerve injury显示文摘BACKGROUND: Studies have shown that both salviae miltiorrhizae and ligustrazine can promoteprotein expression of nerve growth factor (NGF) and regeneration of peripheral nerve.OBJECTIVE: To verify the effect of salviae miltiorrhizae and ligustrazine hydrochloride injection onaxonal regeneration and NGF protein expression in a rat model of sciatic nerve injury.DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at theLaboratory of Traditional Chinese Medicine and the Institute of Bioengineering of Jinan Universityfrom July to December 2008.MATERIALS: Salviae miltiorrhizae and ligustrazine hydrochloride injection (containing 20 mgsalviae miltiorrhizae and 100 mg ligustrazine per 100 mL injection) was provided by Guizhou BaitePharmaceutical, China; salviae miltiorrhizae and ligustrazine decoctions (containing 1 g raw drugper 1 mL decoction) were provided by Guangzhou Baiyunshan Factory for Traditional ChineseMedicine, China; rabbit-anti-rat NGF monoclonal antibody was provided by Beijing BiosynthesisBiotechnology, China.METHODS: A total of 80 healthy, male, Sprague Dawley rats were used to establish a sciatic nerveinjury model via neurotomy, and were then randomly assigned to 4 groups: salviae miltiorrhizae andligustrazine hydrochloride injection group (intraperitoneal injection of 35 mL/kg per day salviaemiltiorrhizae and ligustrazine hydrochloride injection), salviae miltiorrhizae group (intragastricperfusion of 2 mL salviae miltiorrhizae), ligustrazine group (intragastric perfusion of 2 mLligustrazine), and model group (intraperitoneal injection of 35 mL/kg per day saline), with 20 rats ineach group. Thereafter, rats in each group were then divided into 4 subgroups according to varyingtime points of 1,2, 4, and 8 weeks post-surgery, with 5 rats in each subgroup.MAIN OUTCOME MEASURES: Axons were quantified using chromotrope 2R-brilliant green andsilver staining combined with image analysis to calculate the axonal regeneration rate; NGFexpression was detected using immunohistochemistry and Western blot analysis; toe interspacewas measured by behavior at 4 and 8 weeks.RESULTS: With increasing time after sciatic nerve injury, the axonal regeneration rate, NGF proteinexpression, and toe interspace gradually increased. At 4 and 8 weeks post-surgery, axonalregeneration rate and NGF protein expression were significantly increased in the injured tissue ofthe salviae miltiorrhizae and ligustrazine hydrochloride injection, salviae miltiorrhizae, andligustrazine groups, compared with the model group (P < 0.05 or P < 0.01), and toe interspace wasremarkably enlarged (P < 0.05 or P < 0.01), especially in the salviae miltiorrhizae and ligustrazinehydrochloride injection group.CONCLUSION: Salviae miltiorrhizae and ligustrazine hydrochloride injection promoted axonalregeneration and NGF protein expression in the injured sciatic nerve, and also enhancedneurofunctional recovery. Its effect was superior to salviae miltiorrhizae or ligustrazine alone. | Min Ma Guijuan Zhang Yi Ma Dehui Li Hening Zhai | 2009 | Neural Regeneration Research2009，4，12： | 1 |
| 20 | Discrimination Between Broadband Underwater Target Echo and Reverberation Based on Signal Spectral Flatness Feature显示文摘Reverberation is the major interference of active detection, discrimination between target echo and reverberation is difficult when the reverberation is very strong. For the distinguishing of underwater target echo with strong interference, the modulation feature of echo and reverberation spectrum are characterized by signal spectral flatness measure, and the relationship between signal spectral flatness and target physical properties are theoretically formed. A method of discrimination between broadband underwater target echo and reverberation that based on signal spectral flatness characteristics difference is proposed and studied. Sea experiment results of complex underwater target broadband acoustic scattering have shown that signal spectral flatness characteristics of underwater target broadband echo and reverberation have obvious differences. Target echo and reverberation can be well distinguished using the proposed method. | CHEN Yunfei LI Sheng JIA Bing ZHANG Yang WANG Zhenshan LI Guijuan | 2019 | Chinese Journal of Electronics2019，28，3： | 0 |
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