|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 3 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 4 | Time-space transform:A novel signal processing approach for an acoustic vector-sensor显示文摘A new signal processing method using a single vector hydrophone is proposed for solving the problem of azimuth angle estimation for multiple targets based on a small aperture underwater platform.The method extends the aperture from a single vector hydrophone into a half wavelength distance uniform linear array by decomposing the time-domain sample data from different channels of the hydrophone.The extended array has a narrower space beam pattern than a single vector hydrophone.The azimuths of spatial multiple targets are estimated by using the appended array snapshots under the condition of broadband or narrow band signals.The new method is robust because there is no need to correct the array manifold.Theoretical analysis and computer simulations show that,the new algorithm has the ability to distinguish two incoherent targets with either narrow band or broadband signals in an isotropic noise field.The algorithm provides a non-biased estimate with a high signal-to-noise ratio. | LIANG GuoLong MA Wei WANG YiLin | 2013 | Science China(Information Sciences)2013，56，4： | 3 |
| 5 | 2D organic semiconductors, the future of green nanotechnology显示文摘The discovery of 2D organic semiconductors of atomically thin structures has attracted great attention due to their emerging optical, electronic, optoelectronic and mechatronic properties. Recent progress in such organic nanostructures has opened new opportunities for engineering material properties in many ways, such as, 0D/1D/2D nanoparticles hybridization, strain engineering, atomic doping etc. Moreover, 2D organic nanostructures exhibit a unique feature of bio–functionality and are highly sensitive to bio-analytes. Such peculiar behavior in 2D organics can be utilized to design highly-efficient bio-sensors. Also, a bio-molecular integrated electronic/optoelectronic device with enhanced performance can be attained. Furthermore, the bio-degradable, biocompatible, biometabolizable, non-toxic behaviour and natural origin of organic nanomaterials can address the current ecological concerns of increasing inorganic material based electronic waste. This review highlights the benefits of 2D organic semiconductors. Considering the importance of strategic techniques for growing thin 2D organic layers,this review summarizes progress towards this direction. The possible challenges for long-time stability and future research directions in 2D organic nano electronics/optoelectronics are also discussed. We believe that this review article provides immense research interests in organic 2D nanotechnology for exploiting green technologies in the future. | Guru Prakash Neupane Wendi Ma Tanju Yildirim Yilin Tang Linglong Zhang Yuerui Lu | 2019 | Nano Materials Science2019，1，4： | 3 |
| 6 | Two haplotype-resolved,gap-free genome assemblies for Actinidia latifolia and Actinidia chinensis shed light on the regulatory mechanisms of vitamin C and sucrose metabolism in kiwifruit显示文摘Kiwifruit is a recently domesticated horticultural fruit crop with substantial economic and nutritional value,especially because of the high content of vitamin C in its fruit.In this study,we de novo assembled two telomere-to-telomere kiwifruit genomes from Actinidia chinensis var.‘Donghong’(DH)and Actinidia latifolia‘Kuoye’(KY),with total lengths of 608327852 and 640561626 bp for 29 chromosomes,respectively.With a burst of structural variants involving inversion,translocations,and duplications within 8.39 million years,the metabolite content of DH and KY exhibited differences in saccharides,lignans,and vitamins.A regulatory ERF098 transcription factor family has expanded in KY and Actinidia eriantha,both of which have ultra-high vitamin C content.With each assembly phased into two complete haplotypes,we identified allelic variations between two sets of haplotypes,leading to protein sequence variations in 26494 and 27773 gene loci and allele-specific expression of 4687 and 12238 homozygous gene pairs.Synchronized metabolome and transcriptome changes during DH fruit development revealed the same dynamic patterns in expression levels and metabolite contents;free fatty acids and flavonols accumulated in the early stages,but sugar substances and amino acids accumulated in the late stages.The AcSWEET9b gene that exhibits allelic dominance was further identified to positively correlate with high sucrose content in fruit.Compared with wild varieties and other Actinidia species,AcSWEET9b promoters were selected in red-flesh kiwifruits that have increased fruit sucrose content,providing a possible explanation on why red-flesh kiwifruits are sweeter.Collectively,these two gap-free kiwifruit genomes provide a valuable genetic resource for investigating domestication mechanisms and genome-based breeding of kiwifruit. | Xue Han Yilin Zhang Qiong Zhang Ni Ma Xiaoying Liu Wenjing Tao Zhiying Lou Caihong Zhong Xing Wang Deng Dawei Li Hang He | 2023 | Molecular Plant2023，16，2： | 3 |
| 7 | Study on the distribution law of random code structure of irregular LDPC codes and its application in eliminating short cycles显示文摘The distribution law of the random code structure of randomly constructed irregu- lar low-density parity-check (LDPC) codes is studied. Based on the Progressive Edge-Growth (PEG) algorithm, a new algorithm which can both eliminate short cy- cles and keep the distribution of the random code structure is presented. The ex- perimental results show that the performance of the irregular LDPC codes con- structed by the new algorithm is superior to that of the PEG algorithm. | MA LinHua CHANG YiLin Wang ShengDa | 2007 | Science in China(Series F)2007，50，1： | 2 |
| 8 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 9 | UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway显示文摘Cardiac hypertrophy is considered to be a leading factor in heart function-related deaths.In this study,we explored the potential mechanism underlying cardiac hypertrophy induced by isoproterenol.Our results showed that isoproterenol induced cardiac hypertrophy in AC16 cells,as reflected by the increased cell surface area and increased hypertrophic markers,which was accompanied by increased ubiquitin-protein ligase E3a(UBE3A)expression.Moreover,UBE3A knockdown by siRNAs accelerated cardiac hypertrophy,suggesting that increased UBE3A expres sion induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.Our study also revealed that UBE3A knockdown increased the protein expression of the TLR4/MMP-9 pathway that has been shown to be associated with cardiac hypertrophy,which suggested that UBE3A-mediated protection is likely to be associated with the blockade of the TLR4/MMP-9 signaling pathway.UBE3A might be thus a potential target gene for the treatment of cardiac hypertrophy. | Yanfei Li Linlin Ma Sijie Gu Jiewen Tian Yilin Cao Zi Jin Jingyi Chen Bingbing Gu Jiayin Tu Zhixiao Wang Xinming Li Zhongping Ning Yueling Jin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 1 |
| 10 | Refinements to the particle-into-liquid sampler (PILS) for ground and airborne measurements of water soluble aerosol composition显示文摘 | Douglas A. Orsini Yilin Ma Amy Sullivan Berko Sierau Karsten Baumann Rodney J. Weber | 2003 | Atmospheric Environment2003，，9： | 1 |
| 11 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 12 | Mesenchymal stromal cells attenuate post-stroke infection by preventing caspase-1-dependent splenic marginal zone B cell death显示文摘Dear Editor,Spontaneous infection is one of the most common complications of acute ischemic stroke(AIS)and leads to increased morbidity and mortality in stroke patients.However,current interventions fail to improve clinical outcomes in these patients.Since stroke-induced immunodeficiency is thought to contribute to the risk of infection,1 we hypothesized that mesenchymal stromal cell(MSC)therapy,which harnesses potent immunomodulatory capacities,could be a potential solution.Here,we show that intravenously administered MSCs preferentially migrate to the marginal zone(MZ)of the spleen,preserve the injured MZ B cells and ameliorate post-stroke infection and mortality in the mouse middle cerebral artery occlusion(MCAO)model of AIS. | Yinong Huang Jiancheng Wang Xiaofan Lai Yuan Qiu Jianye Cai Yuanchen Ma Yilin Liu Wei Qiu Zhengqi Lu Andy Peng Xiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 13 | 3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α显示文摘 | Lijie Ma Yilin Zhao Beixi Li Qingwei Wang Xueying Liu Xiangjun Chen Yandong Nan Li Liang Ruijing Chang Lifeng Liang Peipei Li Faguang Jin | 2013 | Respiratory Physiology & Neurobiology2013，，3： | 1 |
| 14 | Development of low-coherence high-power laser drivers for inertial confinement fusion显示文摘The use of low-coherence light is expected to be one of the effective ways to suppress or even eliminate the laser–plasma instabilities that arise in attempts to achieve inertial confinement fusion.In this paper,a review of low-coherence high-power laser drivers and related key techniques is first presented.Work at typical low-coherence laser facilities,including Gekko XII,PHEBUS,Pharos III,and Kanal-2 is described.The many key techniques that are used in the research and development of low-coherence laser drivers are described and analyzed,including low-coherence source generation,amplification,harmonic conversion,and beam smoothing of low-coherence light.Then,recent progress achieved by our group in research on a broadband low-coherence laser driver is presented.During the development of our low-coherence high-power laser facility,we have proposed and implemented many key techniques for working with low-coherence light,including source generation,efficient amplification and propagation,harmonic conversion,beam smoothing,and precise beam control.Based on a series of technological breakthroughs,a kilojoule low-coherence laser driver named Kunwu with a coherence time of only 300 fs has been built,and the first round of physical experiments has been completed.This high-power laser facility provides not only a demonstration and verification platform for key techniques and system integration of a low-coherence laser driver,but also a new type of experimental platform for research into,for example,high-energy-density physics and,in particular,laser–plasma interactions. | Yanqi Gao Yong Cui Lailin Ji Daxing Rao Xiaohui Zhao Fujian Li Dong Liu Wei Feng Lan Xia Jiani Liu Haitao Shi Pengyuan Du Jia Liu Xiaoli Li Tao Wang Tianxiong Zhang Chong Shan Yilin Hua Weixin Ma Xun Sun Xianfeng Chen Xiuguang Huang Jian Zhu Wenbing Pei Zhan Sui Sizu Fu | 2020 | Matter and Radiation at Extremes2020，5，6： | 1 |
| 15 | Budgeting for Accountability: A Comparative Study of Budget Reforms in the United States during the Progressive Era and in Contemporary China显示文摘 | JUN MA YILIN HOU | 2009 | Public Administration Review2009，，： | 1 |
| 16 | Generation of neotendon using synthetic polymers seeded with tenocytes显示文摘 | Cao Yilin Vacanti J P Ma X | 1994 | Transplation Proceeding1994，26，6： | 1 |
| 17 | Resistance of strains producing extended-spectrum β-lactamases and genotype distribution in China显示文摘 | Yunsong Yu Shujuan Ji Yagang Chen Weilin Zhou Zeqing Wei Lanjuan Li Yilin Ma | 2006 | Journal of Infection2006，，1： | 1 |
| 18 | Genome-wide Analysis of a Plant AT-rich Sequence and Zinc-binding Protein (PLATZ) in Triticum Aestivum显示文摘Plant AT-rich sequence and zinc-binding protein(PLATZ)is a plant transcription factor that has been studied in corn.PLATZ can non-specifically bind to sequences rich in A/T bases to induce transcriptional repression.It is involved in the regulation of dehydration tolerance in seeds.In this study,we performed bioinformatics analysis to identify and characterize wheat PLATZ(TaPLATZ)genes.We identified 49 wheat PLATZ genes by searching the wheat genome by using known PLATZ gene sequences from rice,Arabidopsis,and maize.Phylogenetic analysis on PLATZ gene sequences from different species was performed.We found that PLATZs could be divided into three groups.The chromosome(chr)distribution analysis revealed that the 49 identified wheat PLATZ genes are distributed in 15 chrs.Gene structure and motif analyses indicated that most PLATZ genes possess conserved exon/intron arrangements and motif compositions.Our analysis of transcriptional data indicated that several wheat PLATZ genes may play an important role in abiotic stress resistance given that they are expressed under salt stress.The results of qRT-PCR further confirmed that TaPLATZ is involved in plant abiotic stress and is also related to the cell differentiation of plant tissues.Our results lay the foundation for further studies on the function of the wheat PLATZ gene family. | Xiaohang He Minjie Liu Zhengwu Fang Dongfang Ma Yilin Zhou Junliang Yin | 2021 | Phyton-International Journal of Experimental Botany2021，90，3： | 1 |
| 19 | Types, distribution and play targets of Lower Cretaceous tight oil in Jiuquan Basin, NW China显示文摘Based on drilling and laboratory data, the formation conditions of tight oil reservoirs in the Jiuquan basin were comprehensively analyzed and the exploration domains were sorted out. The Jiuquan basin underwent three cycles of lake level fluctuation in early Cretaceous, leaving three sets of high-quality source rocks, the Zhonggou, Xiagou and Chijinbao Formations in the Lower Cretaceous. There are two types of reservoir assemblages, source-reservoir in one type and source below reservoir type, and two types of tight reservoirs, argillaceous dolomite and conglomerate. The 'sweet spots' control the enrichment of oil and gas. Argillaceous dolomite tight oil reservoirs have the characteristic of 'integrated source-reservoir', with fractures connecting the matrix micro-pores, pore-fracture type and fracture-pore type 'sweet spots' distributed in large scale. The sandy conglomerate tight oil reservoirs were formed by source-reservoir lateral connection, and can be divided into source below reservoir type, source-reservoir side by side type and 'sandwich' type. The overlapping areas of the favorable facies belts of fan-delta front and the secondary pore developing belts are the 'sweet spot' sites. The favorable areas for seeking conglomerate tight oil are fan-delta front deposits around the Qingxi, Ying'er and Huahai sags, with an exploration area of 550 km^2; while the area to seek argillaceous dolomite tight oil is the NW fracture developed belt in Qingxi sag, with an exploration area of 100 km^2. | CHEN Qilin DENG Yilin WEI Jun MA Guofu LONG Liwen XIAO Wenhua LI Wei ZHANG Liping | 2018 | Petroleum Exploration and Development2018，45，2： | 1 |
| 20 | Discovery of Kalmane Diterpenoids as Potent Analgesics from the Flowers of Rhododendron dauricum显示文摘Kalmane diterpenoids,featuring a 5/8/5/5 tetracyclic carbon skeleton,are very rare in nature.The flowers of Rhododendron dauricum L.(Ericaceae)were phytochemically investigated for the first time,leading to the isolation of eight kalmane diterpenoids(1-8)including four new ones,named rhodokalmanols A-D(1-4).The structures of 1-8 were elucidated by comprehensive spectroscopic methods and ic NMR-DP4+analysis,and the absolute configurations of 1,2,4,and 5 were defined by single-crystal X-ray diffraction analysis with Cu Kαradiation.Rhodokalmanol A(1)represents the first 5,8-epoxykalmane diterpenoid and also the first kalm-15(16)-ene diterpenoid.Rhodokalmanols BD(2-4)are the first examples of kalm-7(8)-ene,kalm-16(17)-ene,and 8α-methoxykalmane diterpenoids,respectively.All the isolated kalmane diterpenoids 1-8 exhibited significant analgesic effects,and rhodokalmanol C(3)and kalmanoi(8)expressed more potent analgesic activity than morphine at doses of 0.2 and 0.04 mg/kg.The preliminary structure-activity relationships of kalmane diterpenoids as potent analgesics are discussed. | Yuanyuan Feng Suqin Zha Biao Gao Hanqi Zhang Pengfei Jin Guijuan Zheng Yilin Ma Guangmin Yao | 2022 | Chinese Journal of Chemistry2022，40，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员