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| 1 | Relative pollen productivities of typical steppe species in northern China and their potential in past vegetation reconstruction显示文摘The Relative Pollen Productivities(RPPs)of common steppe species are estimated using Extended R-value(ERV)model based on pollen analysis and vegetation survey of 30 surface soil samples from typical steppe area of northern China.Artemisia,Chenopodiaceae,Poaceae,Cyperaceae,and Asteraceae are the dominant pollen types in pollen assemblages,reflecting the typical steppe communities well.The five dominant pollen types and six common types(Thalictrum,Iridaceae,Potentilla,Ephedra,Brassicaceae,and Ulmus)have strong wind transport abilities;the estimated Relevant Source Area of Pollen(RSAP)is ca.1000 m when the sediment basin radius is set at 0.5 m.Ulmus,Artemisia,Brassicaceae,Chenopodiaceae,and Thalictrum have relative high RPPs;Poaceae,Cyperaceae,Potentilla,and Ephedra pollen have moderate RPPs;Asteraceae and Iridaceae have low RPPs.The reliability test of RPPs revealed that most of the RPPs are reliable in past vegetation reconstruction.However,the RPPs of Asteraceae and Iridaceae are obviously underestimated,and those of Poaceae,Chenopodiaceae,and Ephedra are either slightly underestimated or slightly overestimated,suggesting that those RPPs should be considered with caution.These RPPs were applied to estimating plant abundances for two fossil pollen spectra(from the Lake Bayanchagan and Lake Haoluku)covering the Holocene in typical steppe area,using the'Regional Estimates of Vegetation Abundance from Large Sites'(REVEALS)model.The RPPs-based vegetation reconstruction revealed that meadow-steppe dominated by Poaceae,Cyperaceae,and Artemisia plants flourished in this area before 6500–5600 cal yr BP,and then was replaced by present typical steppe. | XU QingHai CAO XianYong TIAN Fang ZHANG ShengRui LI YueCong LI ManYue LI Jie LIU YaoLiang LIANG Jian | 2014 | Science China Earth Sciences2014，57，6： | 13 |
| 2 | Surface pollen assemblages of human-disturbed vegetation and their relationship with vegetation and climate in Northeast China显示文摘Pollen assemblages of 53 surface pollen samples from farmlands and wastelands in Northeast China were analyzed. Tree pollen percentages were usually higher than 30%, with Pinus (26.9%), Quercus (0.9%), Betula (0.9%) and Populus (0.7%) as the major types, and herb pollen percentages were usually higher than 50%, with weedy Poaceae (8.7%), Chenopodiaceae (7.1%), Artemisia (1.9%) and Compositae (3.5%) as the major taxa. Thus, the pollen assemblages were consistent with the regional vegetation compositions. However, there were differences in pollen assemblages among regions, especially among different geomorphological units. For example, in the mountains, there were more types of tree pollen and higher total percentages (average 42%) than in other areas, while cereal pollen percentages were lowest (11.2%). In the hills and high plains, herbs made up more than 60% of the pollens, with cereals (average 53.6%) the dominant type. In the low plains, pollen types were similar to those in the hills and high plains, but total pollen concentrations and the proportion of Concentricystes were much higher, while cereal pollen percentages were slightly lower (average 41.6%). Pollen assemblages in different land use types also differed. For example, in farmland, cereal pollen percentages were more than 40% and Chenopodiaceae was usually less than 2.5%, while in wasteland, weedy Poaceae was usually less than 10% and Chenopodiaceae was usually higher than 25%. Total pollen concentrations in farmland (average 3909 grains/g) were much lower than in wasteland (average 15074 grains/g). Redundancy analysis revealed that pollen assemblages were significantly negatively correlated with mean annual temperature (-0.73) and July mean temperature (-0.81) and significantly positively correlated with mean annual precipitation (0.48), indicating that pollen assemblages in the artificial or human-disturbed vegetation reflect regional climate well. Comparison of pollen assemblages in different areas of northern China showed that pollen concentrations reflect the intensities of human impact to some degree. For example, pollen concentrations decrease as human impacts increase in intensity. The cereal pollen proportions in farmland differed by area. In Northeast China, cereal pollen proportions were distinctly higher than in most other areas of northern China, suggesting differences in planting habits and climate. | LI ManYue LI YueCong XU QingHai PANG RuiMing DING Wei ZHANG ShengRui HE ZhiGuo | 2012 | Chinese Science Bulletin2012，57，5： | 10 |
| 3 | Behaviors of Leucine and Isoleucine in Ion Mobility- Quadrupole Time of Flight Mass Spectrometry显示文摘在这研究,离子活动性分离结合了双人脚踏车团 spectrometry (IM 双人脚踏车 MS ) 被利用包括白氨酸和异白氨酸调查二氨基酸的电离行为。在 electrospray 电离(ESI ) 下面模式,在各分子的 sturcture 的二个 protonation 地点引起了 protomer 的二种形式。一个人产生了从氨基从 carboxyl 的 protonated (amino-protomer ) 和其它正在是 protonated (carboxyl-protomer ) 。在里面二维(飘移时间, m/z ) 光谱, protomers 有一样的团,而是可区分的飘移时间和破碎模式。为描述目的, protomers 的理论碰撞十字节(CCS ) 价值被计算并且证明与一致试验性。而且,在氨基酸之间的确定的关系和他们的 protomers 被评估。它证明 carboxyl-protomer 是的许多与氨基酸的集中成正比,而 amino-protomer 的没有一样的趋势。在气压化学药品电离(APCI ) 下面模式,仅仅 carboxyl-protomer 被观察。另外, amino-protomer 和在 ESI 下面观察的簇离子完全是不在的。结果证明电离模式不仅在 therir protomers 的形式上而且在确定的关系上重重地影响白氨酸和异白氨酸的电离行为。 | Su Guo Fang Zhang Haoyang Wang Manyu Zhang Zhixu Zhang Xiang Zhang Yinlong Guo | 2015 | Chinese Journal of Chemistry2015，33，12： | 4 |
| 4 | Spatial patterns of vegetation and climate in the North China Plain during the Last Glacial Maximum and Holocene climatic optimum显示文摘Reconstructing the spatial patterns of regional climate and vegetation during specific intervals in the past is important for assessing the possible responses of the ecological environment under future global warming scenarios. In this study, we reconstructed the history of regional vegetation and climate based on six radiocarbon-dated pollen records from the North China Plain. Combining the results with existing pollen records, we reconstruct the paleoenvironment of the North China Plain during the Last Glacial Maximum(LGM) and the Holocene Climatic Optimum(HCO). The results show that changes in the regional vegetation since the LGM were primarily determined by climatic conditions, the geomorphic landscape and by human activity.During the LGM, the climate was cold and dry;mixed broadleaf-coniferous forest and deciduous-evergreen broadleaf forest developed in the southern mountains, and cold-resistant coniferous forest and mixed broadleaf-coniferous forest were present in the northern mountains. The forest cover was relatively low, with mesophytic and hygrophilous meadow occupying the southern part of the plain, and temperate grassland and desert steppe were distributed in the north;Chenopodiaceae-dominated halophytes grew on the exposed continental shelf of the Bohai Sea and Yellow Sea. During the HCO, the climate was warm and wet;deciduous broadleaf forest and deciduous-evergreen broadleaf forest, with subtropical species, developed in the southern mountains, and deciduous broadleaf forest with thermophilic species was present in northern mountains. Although the degree of forest cover was greater than during the LGM, the vegetation of the plain area was still dominated by herbs, while halophytes had migrated inland due to sea level rise. In addition, the expansion of human activities, especially the intensification of cultivation,had a significant influence on the natural vegetation. Our results provide data and a scientific basis for paleoclimate modelling and regional carbon cycle assessment in north China, with implications for predicting changes in the ecological environment under future global warming scenarios. | Manyue LI Shengrui ZHANG Qinghai XU Jule XIAO Ruilin WEN | 2019 | Science China Earth Sciences2019，62，8： | 4 |
| 5 | Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma显示文摘Objective: To explore the effect of cytosolic phospholipase A2α(cPLA2α) on hepatocellular carcinoma(HCC) cell adhesion and the underlying mechanisms.Methods: Cell adhesion, detachment, and hanging-drop assays were utilized to examine the effect of cPLA2α on the cell-matrix and cell-cell adhesion. Downstream substrates and effectors of cPLA2α were screened via a phospho-antibody microarray.Associated signaling pathways were identified by the functional annotation tool DAVID. Candidate proteins were verified using Western blot and colocalization was investigated via immunofluorescence. Western blot and immunohistochemistry were used to detect protein expression in HCC tissues. Prognosis evaluation was conducted using Kaplan-Meier and Cox-proportional hazards regression analyses.Results: Our findings showed that cPLA2α knockdown decreases cell-matrix adhesion but increases cell-cell adhesion in HepG2 cells. Microarray analysis revealed that phosphorylation of multiple proteins at specific sites were regulated by cPLA2α. These phosphorylated proteins were involved in various biological processes. In addition, our results indicated that the focal adhesion pathway was highly enriched in the cPLA2α-relevant signaling pathway. Furthermore, cPLA2α was found to elevate phosphorylation levels of FAK and paxillin, two crucial components of focal adhesion. Moreover, localization of p-FAK to focal adhesions in the plasma membrane was significantly reduced with the downregulation of cPLA2α. Clinically, cPLA2α expression was positively correlated with p-FAK levels. Additionally, high expression of both cPLA2α and p-FAK predicted the worst prognoses for HCC patients.Conclusions: Our study indicated that cPLA2α may promote cell-matrix adhesion via the FAK/paxillin pathway, which partly explains the malignant cPLA2α phenotype seen in HCC. | Piao Guo Yuchao He Lu Chen Lisha Qi Dongming Liu Ziye Chen Manyu Xiao Liwei Chen Yi Luo Ning Zhang Hua Guo | 2019 | Cancer Biology & Medicine2019，16，2： | 2 |
| 6 | Polymermonolith microextraction online coupled to hydrophilicinteraction chromatography/mass spectrometry for a-nalysis ofβ2-agonist in human urine显示文摘 | Zheng Mingming Zhang Manyu Feng Yuqi | 2009 | J Sep Sci2009，32，11： | 1 |
| 7 | The effect of LyPRP/collagen composite hydrogel on osteogenic differentiation of rBMSCs显示文摘Although platelet-rich plasma(PRP)plays a significant role in the orthopedic clinical application,it still faces two major problems,namely,uncontrollable factors release,frequent preparation and extraction processes as well as the inconvenient form of usage.To overcome these shortcomings,freeze-dried PRP(LyPRP)was encapsulated into bioactive Col I hydrogel to induce osteogenic dif-ferentiation of rabbit bone marrow mesenchymal stem cells(rBMSCs).And PRP/Col I composite hydrogel was prepared as a control.Compared with Col I hydrogel,the introduction of platelets significantly improved the mechanical properties of hydrogels.Meanwhile,platelets were evenly distributed in the composite hydrogels network.The sustainable release of related factors in the composite hydrogels could last for more than 14days to maintain its long-term biological activity.Further cell experiments confirmed that PRP and LyPRP could effectively alleviate the contraction of collagen hydrogel in vitro,and promote the adhesion,proliferation and osteogenesis differentia-tion of rBMSCs.The results of osteogenic gene expression indicated that the 10%LyPRP/Col I composite hydrogel could facilitate the early expression of BMP-2 and late osteogenic associated protein formation with higher expression of alkaline phosphatase and Osteocalcin(OCN).These results might provide new insights for the clinical application of 10%LyPRP/Col I composite hydro-gel as practical bone repair injection. | Manyu Chen Quanying Liu Yang Xu Yuxiang Wang Xiaowen Han Zhe Wang Jie Liang Yong Sun Yujiang Fan Xingdong Zhang | 2021 | Regenerative Biomaterials2021，8，1： | 1 |
| 8 | Targeting fibrosis: mechanisms and clinical trials显示文摘Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response.Multiple organs can develop fibrosis,including the liver,kidney,heart,and lung.Fibrosis such as liver cirrhosis,idiopathic pulmonary fibrosis,and cystic fibrosis caused substantial disease burden.Persistent abnormal activation of myofibroblasts mediated by various signals,such as transforming growth factor,platelet-derived growth factor,and fibroblast growh factor,has been recongized as a major event in the occurrence and progression of fibrosis.Although the mechanisms driving organ-specific fibrosis have not been fully elucidated,drugs targeting these identified aberrant signals have achieved potent anti-fibrotic efficacy in clinical trials.In this review,we briefly introduce the aetiology and epidemiology of several fibrosis diseases,including liver fibrosis,kidney fibrosis,cardiac fibrosis,and pulmonary fibrosis.Then,we summarise the abnormal cells(epithelial cells,endothelial cells,immune cells,and fibroblasts)and their interactions in fibrosis.In addition,we also focus on the aberrant signaling pathways and therapeutic targets that regulate myofibroblast activation,extracellular matrix cross-linking,metabolism,and inflammation in fibrosis.Finally,we discuss the anti-fibrotic drugs based on their targets and clinical trials.This review provides reference for further research on fibrosis mechanism,drug development,and clinical trials. | Manyu Zhao Liqun Wang Mengzhu Wang Shijie Zhou Ying Lu Huijie Cui Alexandra C.Racanelli Ling Zhang Tinghong Ye Bisen Ding Ben Zhang Jinliang Yang Yuqin Yao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 9 | Maternal genetic structure of a neolithic population of the Yangshao culture显示文摘The Yangshao culture is one of the most influential Neolithic cultures in East Asia.The populations associated with the Yangshao culture were widely distributed along the Yellow River basin and were suggested to play a profound role in the present-day East Asians.To date,the population of the Yangshao culture is largely investigated through archaeological studies. | Bo Miao Yichen Liu Wanfa Gu Qingli Wei Qian Wu Wenjun Wang Ming Zhang Manyu Ding Tianyi Wang Juncen Liu Feng Liu Peng Cao Qingyan Dai Ruowei Yang Xiaotian Feng Wanjing Ping Weihong Hou Haibing Yuan Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，8： | 0 |
| 10 | Song variation of a native songbird in a modified habitat by invasive plant显示文摘Habitat structure has been considered as an important factor affecting the acoustic evolution of birds,and bird songs are increasingly affected by artificial environmental variation.Invasive plants sometimes can dramatically alter native habitats,but the song variation of native songbirds migrating into invaded habitats has received little attention.The invasion of smooth cordgrass Spartina alterniflora in the coastal wetlands of eastern China has drastically altered the vegetation structure and some small passerines have begun to use invaded habitats to breed.In this study,we compared the song type prevalence and the song characteristics of male plain prinia Prinia inornata to identify differences in vocal behavior between native and invaded habitats.We also tested for differences in vocal behavior in relation to singing perch and wind speed variation between different habitats.The results indicated that males of plain prinia in invaded habitats sang shorter songs than those in native habitats and had a lower song diversity.The homogeneous vegetation structure and higher wind speed in invaded habitats likely leads to males changing the traditional perched singing style.The song variation may be related to the founder effect,the alteration of vegetation structure and microclimate in invaded habitats.This finding highlights the need for better understanding the behavioral evolution of native species in the process of adapting to the invaded habitat.In the future,experimental manipulation is needed to ascertain how the invasive plant drove these vocal behavior changes of native songbirds. | Pan CHEN Taiyu CHEN Bin LIU Manyu ZHANG Changhu LU | 2022 | Integrative Zoology2022，17，1： | 0 |
| 11 | Reverse engineering a predictive signature characterized by proliferation,DNA damage,and immune escape from stage I lung adenocarcinoma recurrence显示文摘Identifying early-stage cancer patients at risk for progression is a major goal of biomarker research.This report describes a novel 19-gene signature(19-GCS)that predicts stage I lung adenocarcinoma(LAC)recurrence and responseto therapy and performs comparably in pancreatic adenocarcinoma(PAC),which shares LAC molecular traits.Kaplan-Meier,Cox regression,and cross-validation analyses were used to build the signature from training,test,and validation sets comprising 831 stage I LAC transcriptomes from multiple independent data sets.A statistical analysis was performed using the R Ianguage.Pathway and gene set enrichment were used to identify underlying mechanisms.19-GCS strongly predicts overall survival and recurrence-free survival in stage I LAC(P=0.002 and P<0.001,respectively)and in stage l-ll PAC(P<0.0001 and Pv0.0005,respectively).A multivariate cox regression analysis demonstrated the independence of 19-GCS from significant clinical factors.Pathway analyses revealed that 19-GCS high-risk LAC and PAC tumors are characterized by increased proliferation,enhanced sternness,DNA repair deficiency,and compromised MHC class I and II antigen presentation along with decreased immune infiltration.Importantly,high-risk LAC patients do not appear to benefit from adjuvant cisplatin while PAC patients derive additi onal ben efit from FOLFIRINOX compared with gemcitabi ne-based regimens.Whe n validated prospectively,this proof-of-c on cept biomarker may con tribute to tailoring treatment,recurrence reduction,and survival improvements in early-stage lung and pancreatic cancers. | Jiannan Yao Xinying Xue Dongfeng Qu C.Benedikt Westphalen Yang Ge Liyang Zhang Manyu Li Tianbo Gao Parthasarathy Chandrakesan Kenneth J.Vega Jun Peng Guangyu An Nathaniel Weygant | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 12 | Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway显示文摘Background:Myocardial infarctions(MI)is a major threat to human health especially in people exposed to cold environment.The polarization of macrophages towards different functional phenotypes(M1 macrophages and M2 macrophages)is closely related to MI repairment.The growth differentiation factor 11(GDF11)has been reported to play a momentous role in inflammatory associated diseases.In this study,we examined the regulatory role of GDF11 in macrophage polarization and elucidated the underlying mechanisms in MI.Methods:In vivo,the mice model of MI was induced by permanent ligation of the left anterior descending coronary artery(LAD),and mice were randomly divided into the sham group,MI group,and MI+GDF11 group.The protective effect of GDF11 on myocardial infarction and its effect on macrophage polarization were verified by echocardiography,triphenyl tetrazolium chloride staining and immunofluorescence staining of heart tissue.In vitro,based on the RAW264.7 cell line,the effect of GDF11 in promoting macrophage polarization toward the M2 type by inhibiting the Notch1 Signaling pathway was validated by qRT-PCR,Western blot,and flow cytometry.Results:We found that GDF11 was significantly downregulated in the cardiac tissue of MI mice.And GDF11 supplementation can improve the cardiac function.Moreover,GDF11 could reduce the proportion of M1 macrophages and increase the accumulation of M2 macrophages in the heart tissue of MI mice.Furthermore,the cardioprotective effect of GDF11 on MI mice was weakened after macrophage clearance.At the cellular level,application of GDF11 could inhibit the expression of M1 macrophage(classically activated macrophage)markers iNOS,interleukin(IL)-1β,and IL-6 in a dose-dependent manner.In contrast,GDF11 significantly increased the level of M2 macrophage markers including IL-10,CD206,arginase 1(Arg1),and vascular endothelial growth factor(VEGF).Interestingly,GDF11 could promote M1 macrophages polarizing to M2 macrophages.At the molecular level,GDF11 significantly down-regulated the Notch1 signaling pathway,the activation of which has been demonstrated to promote M1 polarization in macrophages.Conclusions:GDF11 promoted macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway. | Manyu Gong Xuewen Yang Yaqi Wang Yanying Wang Dongping Liu Haodong Li Yunmeng Qu Xiyang Zhang Yanwei Zhang Han Sun Lei Jiao Ying Zhang | 2023 | Frigid Zone Medicine2023，3，1： | 0 |
| 13 | Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway显示文摘Objective:Myocardial ischemia-reperfusion injury(MIRI)is one of the leading causes of death from cardiovascular disease in humans,especially in individuals exposed to cold environments.Long non-coding RNAs(lncRNAs)regulate MIRI through multiple mechanisms.This study explored the regulatory effect of lncRNA-AK138945 on myocardial ischemia-reperfusion injury and its mechanism.Methods:In vivo,8-to 12-weeks-old C57BL/6 male mice underwent ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion for 48 hours.In vitro,the primary cultured neonatal mouse ventricular cardiomyocytes(NMVCs)were treated with 100μmol/L hydrogen peroxide(H_(2)O_(2)).The knockdown of lncRNA-AK138945 was evaluated to detect cardiomyocyte apoptosis,and a glucose-regulated,endoplasmic reticulum stress-related protein 94(GRP94)inhibitor was used to detect myocardial injury.Results:We found that the expression level of lncRNA-AK138945 was reduced in MIRI mouse heart tissue and H2O2-treated cardiomyocytes.Moreover,the proportion of apoptosis in cardiomyocytes increased after lncRNA-AK138945 was silenced.The expression level of Bcl2 protein was decreased,and the expression level of Bad,Caspase 9 and Caspase 3 protein was increased.Our further study found that miR-1a-3p is a direct target of lncRNA-AK138945,after lncRNA-AK138945 was silenced in cardiomyocytes,the expression level of miR-1a-3p was increased while the expression level of its downstream protein GRP94 was decreased.Interestingly,treatment with a GRP94 inhibitor(PU-WS13)intensified H2O2-induced cardiomyocyte apoptosis.After overexpression of FOXO3,the expression levels of lncRNA-AK138945 and GRP94 were increased,while the expression levels of miR-1a-3p were decreased.Conclusion:LncRNA-AK138945 inhibits GRP94 expression by regulating miR-1a-3p,leading to cardiomyocyte apoptosis.The transcription factor Forkhead Box Protein O3(FOXO3)participates in cardiomyocyte apoptosis induced by endoplasmic reticulum stress through up-regulation of lncRNA-AK138945. | Yanying Wang Jian Huang Han Sun Jie Liu Yingchun Shao Manyu Gong Xuewen Yang Dongping Liu Zhuo Wang Haodong Li Yanwei Zhang Xiyang Zhang Zhiyuan Du Xiaoping Leng Lei Jiao Ying Zhang | 2024 | Frigid Zone Medicine2024，4，1： | 0 |
| 14 | Vinous-throated parrotbills breed in invasive smooth cordgrass habitat:Can native birds avoid the potential ecological trap?显示文摘Native animals are facing long-term coexistence with invasive plants worldwide,the impacts of which on animal behavior remain poorly known.Potential ecological traps could threaten native birds breeding in invasive plant habitats,but behavioral strategies for birds to avoid such risks are few concerned.The invasion of Smooth Cordgrass(Spartina alterniflra) has seriously varied the vegetation landscape in the coastal wetlands of eastern China,and affected the habitat selection of native birds.Here,we investigated the nesting and breeding characteristics of a common native passerine,the Vinous-throated Parrotbill(Sinosuthora webbiana),in habitats dominated by native Common Reed(Phragmites australis) and exotic cordgrass.We found that parrotbills could complete their breeding cycle in cordgrass habitat.Most nest failure was attributed to predation in native habitat but tide inundation in cordgrass habitat.However,the nest success rate and daily survival rate(DSR) in cordgrass habitat were higher.Moreover,nest height was markedly higher in cordgrass habitat and was the most important influencing variable(positively correlated with the DSR).These results suggest that cordgrass habitat is a potential ecological trap due to the tide inundation,but some parrotbills seem to effectively avoid this risk by increasing nest height.Our study reveals that a native passerine changes its nesting behavior to accommodate invasive plant habitat and highlights that habitat changes caused by invasive plants may drive the adaptive evolution of native animal behavior.The limitation of these results must be acknowledged for the small sample size,and there is a need for a larger sample and long-term data for further verification. | Pan Chen Yanhong Chen Huimin Chen Taiyu Chen Bin Liu Manyu Zhang Silu Wang Changhu Lu | 2023 | Avian Research2023，14，3： | 0 |
| 15 | Study on Comprehensive Efficiency Evaluation of Rural Power Grid under Rural Revitalization Strategy Considering Regional Differences显示文摘As an essential infrastructure,the rural power grid is vital in promoting agricultural and rural carbon sequestration and improving rural energy electrification.It is necessary to carry out in-depth research on its comprehensive efficiency.Based on the requirements of“double carbon”and rural revitalization strategy for the rural Power Grid,this paper focuses on the modernization and low-carbon transformation of the rural Power Grid.It constructs an input-output index system for the investment efficiency of the rural Power Grid in China under the new situation.It uses the primary data of the rural Power Grid of 30 prefecture-level cities in China from 2019 to 2021 to evaluate the investment efficiency of the rural Power Grid in China through a three-stage DEA model.The empirical results show that:considering the regional differences,the comprehensive efficiency of the rural Power Grid in backward areas is significantly improved;that is,the three-stage DEA method can more objectively evaluate the comprehensive efficiency of the rural Power Grid.In the context of the continued promotion of the rural revitalization strategy,to improve the comprehensive efficiency of the rural Power Grid,it is necessary to improve the technical level of the rural Power Grid further and appropriately expand the scale of investment in the rural Power Grid. | Huiru Zhao Manyu Yao Zhenqi Bai Yue Zhang Zhihua Ding Zhenda Hu | 2023 | Energy Engineering2023，120，10： | 0 |
| 16 | A Gaussian process regression‐based surrogate model of the varying workpiece dynamics for chatter prediction in milling of thin‐walled structures显示文摘Since the dynamics of thin‐walled structures instantaneously varies during the milling process,accurate and efficient prediction of the in‐process workpiece(IPW)dynamics is critical for the prediction of chatter stability of milling of thin‐walled structures.This article presents a surrogate model of the IPW dynamics of thin‐walled structures by combining Gaussian process regression(GPR)with proper orthogonal decomposition(POD)when IPW dynamics at a large number of cutting positions has to be predicted.The GPR method is used to learn the mapping between a set of the known IPW dynamics and the corresponding cutting positions.POD is used to reduce the order of the matrix assembled by the mode shape vectors at different cutting positions,before the GPR model of the IPW mode shape is established.The computation time of the proposed model is mainly composed of the time taken for predicting a known set of IPW dynamics and the time taken for training GPR models.Simulation shows that the proposed model requires less computation time.Moreover,the accuracy of the proposed model is comparable to that of the existing methods.Comparison between the predicted stability lobe diagram and the experimental results shows that IPW dynamics predicted by the proposed model is accurate enough for predicting the stability of milling of thin‐walled structures. | Yun Yang Yang Yang Manyu Xiao Min Wan Weihong Zhang | 2022 | International Journal of Mechanical System Dynamics2022，2，1： | 0 |
| 17 | Scalable Core–Sheath Yarn for Boosting Solar Interfacial Desalination Through Engineering Controllable Water Supply显示文摘Tailoring water supply to achieve confined heating has proven to be an effective strategy for boosting solar interfacial evaporation rates.However,because of salt clogging during desalination,a critical point of constriction occurs when controlling the water rate for confined heating.In this study,we demonstrate a facile and scalable weaving technique for fabricating core-sheath photothermal yarns that facilitate controlled water supply for stable and efficient interracial solar desalination.The core-sheath yarn comprises modal fibers as the core and carbon fibers as the sheaths.Because of the core-sheath design,remarkable liquid pumping can be enabled in the carbon fiber bundle of the dispersed superhydrophilic modal fibers.Our woven fabrics absorb a high proportion(92%)of the electromagnetic radiation in the solar spectrum because of the weaving structure and the carbon fiber sheath.Under one-sun(1 kW·m^(-2))illumination,our woven fabric device can achieve the highest evaporation rate(of 2.12kg·m^(-2)·h^(-1) with energy conversion efficiency:93.7%)by regulating the number of core-sheath yarns.Practical application tests demonstrate that our device can maintain high and stable desalination performance in a 5 wt%NaCl solution. | Xingfang Xiao Luqi Pan Tao Chen Manyu Wang Lipei Ren Bei Chen Yingao Wang Qian Zhang Weilin Xu | 2023 | Engineering2023，，11： | 0 |
| 18 | Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice显示文摘Influenza A virus(IAV)continues to pose a pandemic threat to public health,resulting a high mortality rate annually and during pandemic years.Posttranslational modification of viral protein plays a substantial role in regulating IAV infection.Here,based on immunoprecipitation(IP)-based mass spectrometry(MS)and purified virus-coupled MS,a total of 89 phosphorylation sites distributed among 10 encoded viral proteins of IAV were identified,including 60 novel phosphorylation sites.Additionally,for the first time,we provide evidence that PB2 can also be acetylated at site K187.Notably,the PB2 S181 phosphorylation site was consistently identified in both IP-based MS and purified virus-based MS.Both S181 and K187 are exposed on the surface of the PB2 protein and are highly conserved in various IAV strains,suggesting their fundamental importance in the IAV life cycle.Bioinformatic analysis results demonstrated that S181E/A and K187Q/R mimic mutations do not significantly alter the PB2 protein structure.While continuous phosphorylation mimicked by the PB2 S181E mutation substantially decreases viral fitness in mice,PB2 K187Q mimetic acetylation slightly enhances viral virulence in mice.Mechanistically,PB2 S181E substantially impairs viral polymerase activity and viral replication,remarkably dampens protein stability and nuclear accumulation of PB2,and significantly weakens IAV-induced inflammatory responses.Therefore,our study further enriches the database of phosphorylation and acetylation sites of influenza viral proteins,laying a foundation for subsequent mechanistic studies.Meanwhile,the unraveled antiviral effect of PB2 S181E mimetic phosphorylation may provide a new target for the subsequent study of antiviral drugs. | Jiao Hu Zixiong Zeng Xia Chen Manyu Zhang Zenglei Hu Min Gu Xiaoquan Wang Ruyi Gao Shunlin Hu Yu Chen Xiaowen Liu Daxin Peng Xiufan Liu | 2024 | Virologica Sinica2024，39，1： | 0 |
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