|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 2 | DRAGON-Lab―Next generation internet technology experiment platform显示文摘Testbed technology is very important in the development of the Internet. Similar to the present internet,next generation internet also starts from testbed. There are two kinds of testbeds,testbed networks like CNGI-CERNET2,Internet2,Geant;testbed systems like PlanetLab,NS2. DRAGON-Lab can be viewed as both testbed network and testbed system. DRAGON-Lab is an independent AS(autonomous system) and connected to multiple real networks. On the other hand,DRAGON-Lab integrates many resources of its own,partners' and internet's,so as to provide open service. DRAGON-Lab has a large scale,provides open service,supports remote visualized experiments and programmable experiments. More details will be introduced in this paper. | WANG JiLong LI ZhongHui LV GuoHan JIANG CaiPing LI Xing ZHANG QianLi | 2008 | Science in China(Series F)2008，51，11： | 6 |
| 3 | Morphology,composition,and sources of individual aerosol particles at a regional background site of the YRD,China显示文摘Aerosol samples were collected at Lin'an, a background site of Yangtze River Delta(YRD).Morphology, size, composition, and mixing state of individual aerosol particles were characterized by transmission electron microscopy(TEM) coupled with energy dispersive X-ray spectroscopy(EDS), and the soluble ions of PM_(1.0) were studied by aerosol mass spectrometer(AMS). The daily average AMS mass concentrations of sulfate, nitrate, and ammonium were about 5.8, 8.6, and 5.6 μg/m^3, respectively. Individual aerosol particles were classified into seven types: S-rich, K-rich, organic matter(OM), soot, fly ash, metal, and mineral. S-rich particles were dominant in all size bins, and 51%(by number) of S-rich particles were internally mixed with other particles. The fraction of organic coating particles was 13.7% in morning, 25.2% in afternoon, and 11% in evening, suggesting that the strong photochemical process during afternoon produced more secondary organic aerosols(SOA) on the surface of inorganic particles. Fly ash and metal particles were abundant during the day, suggesting the influence of emissions from coal-fired power plants and steel plants. The results indicate that the intense industrial emissions in the YRD significantly transported to the background areas. PM_(2.5) concentration may be lower in background air than in urban air but complex mixing state of aerosol particles indicates that the long-range transported particles substantially influenced the background air quality. | Liang Xu A.P.Lingaswamy Yinxiao Zhang Lei Liu Yuanyuan Wang Jian Zhang Qianli Ma Weijun Li | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 4 | Specific heat treatment of selective laser melted Ti-6AI-4V for biomedical applications显示文摘 | Qianli HUANG Xujie LIU Xing YANG Ranran ZHANG Zhijian SHEN Qingling FENG | 2015 | Frontiers of Materials Science2015，9，4： | 5 |
| 5 | Incorporation of silica nanoparticles to PLGA electrospun fibers for osteogenic differentiation of human osteoblast-like cells显示文摘The development of bone tissue engineering scaffolds still remains a challenging field,although various biomaterials have been developed for this purpose.Electrospinning is a promising approach to fabricate nanofibers with an interconnected porous structure,which can support cell adhesion,guide cell proliferation and regulate cell differentiation.The aim of this study is to fabricate composite fibers composed of poly(lactic-co-glycolic acid)(PLGA)and silica nanoparticles(NPs)via electrospinning and investigate the effect of PLGA/SiO_(2)composite fibers on the cellular response of osteoblast-like cells(SaOS-2 cells).SEM and EDX analysis showed that silica NPs were homogenously dispersed in the composite fibers.The mechanical behavior of the fibers showed that silica NPs acted as reinforcements at concentrations of 2.5 and 5 mg/ml.The incorporation of silica NPs led to enhancement of cell attachment and spreading on PLGA/SiO_(2)composite fibers.SaOS-2 cells cultured on PLGA/SiO_(2)composite fibers exhibited increased alkaline phosphatase activity,collagen secretion and bone nodules formation.The bone nodules formation of SaOS-2 cells increased along with the amount of incorporated silica NPs.The present findings indicate that PLGA/SiO_(2)composite fibers can stimulate osteogenic differentiation of SaOS-2 cells and may be a promising candidate scaffold for bone tissue engineering. | Xing Yang Yuanyuan Li Xujie Liu Qianli Huang Ranran Zhang Qingling Feng | 2018 | Regenerative Biomaterials2018，5，4： | 4 |
| 6 | Photoinduced large polaron transport and dynamics in organic-inorganic hybrid lead halide perovskite with terahertz probes显示文摘Organic-inorganic hybrid metal halide perovskites(MHPs)have attracted tremendous attention for optoelectronic applications.The long photocarrier lifetime and moderate carrier mobility have been proposed as results of the large polaron formation in MHPs.However,it is challenging to measure the effective mass and carrier scattering parameters of the photogenerated large polarons in the ultrafast carrier recombination dynamics.Here,we show,in a one-step spectroscopic method,that the optical-pump and terahertz-electromagnetic probe(OPTP)technique allows us to access the nature of interplay of photoexcited unbound charge carriers and optical phonons in polycrystalline CH_(3)NH_(3)PbI_(3)(MAPbI_(3))of about 10μm grain size.Firstly,we demonstrate a direct spectral evidence of the large polarons in polycrystalline MAPbI_(3).Using the Drude-Smith-Lorentz model along with the Frӧhlich-type electron-phonon(e-ph)coupling,we determine the effective mass and scattering parameters of photogenerated polaronic carriers.We discover that the resulting moderate polaronic carrier mobility is mainly influenced by the enhanced carrier scattering,rather than the polaron mass enhancement.While,the formation of large polarons in MAPbI_(3)polycrystalline grains results in a long charge carrier lifetime at room temperature.Our results provide crucial information about the photo-physics of MAPbI3 and are indispensable for optoelectronic device development with better performance. | Zuanming Jin Yan Peng Yuqing Fang Zhijiang Ye Zhiyuan Fan Zhilin Liu Xichang Bao Heng Gao Wei Ren Jing Wu Guohong Ma Qianli Chen Chao Zhang Alexey VBalakin Alexander PShkurinov Yiming Zhu Songlin Zhuang | 2022 | Light(Science & Applications)2022，11，8： | 4 |
| 7 | Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014–2015显示文摘Dear Editor,Avian influenza viruses (AIVs) have posed a serious threat to poultry production and public health. To date, more than fourteen AIV subtypes that are able to infect human beings have been documented. Also, it is suggested that new subtypes may be reported in the future, owing to the migration of wild birds and live poultry transportation (Gao, 2018).Poultry may act as a potential incubator for novel subtypes of avian influenza virus (Bi et al., 2016a; Bi et al., 2016b; Liu et al., 2014a; Su et al., 2017). Up to date, the H7N9 AIV emerged in February 2013 has caused 1,567 human cases,with a fatality rate of 39.2%(http://www.who.int/influenza/ | Chuansong Quan Ting Huang Xiuwei Chen Jie Zhang Qianli Wang Cheng Zhang Tiyan Zhang Lijun Zhou Liumei Shu Chunrong Long Lei Yang Xunbo Du Yingze Zhao Peipei Liu Hao Song Weifeng Shi Yuhai Bi Qiang Lv William J.Liu George F.Gao | 2018 | Science China(Life Sciences)2018，61，9： | 4 |
| 8 | A Survey on Low Complexity Detectors for OTFS Systems显示文摘The newly emerging orthogonal time frequency space(OTFS)modulation can ob⁃tain delay-Doppler diversity gain to significantly improve the system performance in high mobility wireless communication scenarios such as vehicle-to-everything(V2X),high-speed railway and unmanned aerial vehicles(UAV),by employing inverse symplectic finite Fouri⁃er transform(ISFFT)and symplectic finite Fourier transform(SFFT).However,OTFS modu⁃lation will dramatically increase system complexity,especially at the receiver side.Thus,de⁃signing low complexity OTFS receiver is a key issue for OTFS modulation to be adopted by new-generation wireless communication systems.In this paper,we review low complexity OTFS detectors and provide some insights on future researches.We firstly present the OTFS system model and basic principles,followed by an overview of OTFS detector structures,classifications and comparative discussion.We also survey the principles of OTFS detection algorithms.Furthermore,we discuss the design of hybrid OTFS and orthogonal frequency di⁃vision multiplexing(OFDM)detectors in single user and multi-user multi-waveform commu⁃nication systems.Finally,we address the main challenges in designing low complexity OT⁃FS detectors and identify some future research directions. | ZHANG Zhengquan LIU Heng WANG Qianli FAN Pingzhi | 2021 | ZTE Communications2021，19，4： | 3 |
| 9 | Evolution and protein interactions of AP2 proteins in Brassicaceae: Evidence linking development and environmental responses显示文摘Plants have evolved a large number of transcription factors(TF), which are enriched among duplicate genes,highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes,we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition,the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A.thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins,with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an antherdefective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses,including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study. | Liping Zeng Yue Yin Chenjiang You Qianli Pan Duo Xu Taijie Jin Bailong Zhang Hong Ma | 2016 | Journal of Integrative Plant Biology2016，58，6： | 3 |
| 10 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 11 | Investigation of frost heave prevention using permeable subgrade structure显示文摘This paper set up a series of comprehensive targets based on the concept of 'anti-freeze filler', which include reasonable water retention rate, frost heave characteristics, and compaction characteristics of filling material. Then, a type of permeable graded gravel is proposed, suitable for high-speed railway subgrade. A series of in-door water retention, permeability, and frost heave tests were performed under different graded conditions. Water retention, permeability, and frost heave characteristic of different graded filling materials can be determined, in order to define the gradation range of permeable graded gravel. Relying on the frost-heave monitoring record of high speed railway in Northeast China, a series of experimental studies were performed, which included on-site filler production, compaction test, and the anti-frost effect test, in order to improve the production and compaction techniques of permeable graded gravel. From the research of this paper, the use of permeable graded gravel subgrade as the anti-frost structure for the high-speed railway subgrade in cold areas is feasible. | DeGou Cai JianPing Yao HongYe Yan QianLi Zhang AiJun Cheng Jie Liu | 2015 | Research in Cold and Arid Regions2015，7，5： | 3 |
| 12 | Nuclear factor κB represses the expression of latent membrane protein 1 in Epstein-Barr virus transformed cells显示文摘AIM: To investigate the role of nuclear factor κB(NF-κB) in the regulation of Epstein-Barr virus(EBV) latent membrane protein 1(LMP1) in EBV transformed cells. METHODS: LMP1 expression was examined in EBV transformed human B lymphocytes with modulation of NF-κB activity. RESULTS: EBV infection is associated with several human cancers. EBV LMP1 is required for efficient transformation of adult primary B cells in vitro, and is expressed in several pathogenic stages of EBVassociated cancers. Regulation of EBV LMP1 involves both viral and cellular factors. LMP1 activates NF-κB signaling pathway that is a part of the EBV transformation program. However, the relation between NF-κB and LMP1 expression is not well established yet. In this report, we found that blocking the NF-κB activity by Inhibitor of κB stimulated LMP1 expression, while the overexpression of NF-κB repressed LMP1 expression in EBV-transformed IB4 cells. In addition, LMP1 repressed its own promoter activities in reporter assays, and the repression was associated with the activation of NF-κB. Moreover, NF-κB alone is sufficient to repress LMP1 promoter activities. CONCLUSION: Our data suggest LMP1 may repress its own expression through NF-κB in EBV transformed cells and shed a light on LMP1 regulation during EBV transformation. | Mingxia Cao Qianli Wang Amy Lingel Luwen Zhang | 2014 | World Journal of Virology2014，3，4： | 2 |
| 13 | Synthesis and characterization of prussian blue modified magnetite nanoparticles and its application to the electrocatalytic reduction of H2O2显示文摘 | ZHAO Ge FENG Jiuju ZHANG Qianli | 2005 | Chem Mater2005，17，12： | 1 |
| 14 | Ionic liquid surfactant-mediated ultrasonicassisted extraction coupled to HPLC:Application to analysis of tanshinones in Salvia miltiorrhiza bunge 显示文摘 | Wu Kangkang Zhang Qianli Liu Qian | 2009 | Journal of Separation Science2009，32，14： | 1 |
| 15 | Synthesis and Characterization of Prussian Blue Modified Magnetite Nanoparticles and Its Application to the Electrocatalytic Reduction of H2O2显示文摘 | Zhao Ge Feng Jiuju Zhang Qianli | 2005 | Chem Mater2005，17，： | 1 |
| 16 | Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021显示文摘Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current situation.What is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and 2021.Despite an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal. | Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu | 2023 | China CDC weekly2023，5，17： | 1 |
| 17 | Synthesis and characterization of prussian blue modified magnetite nanoparti- cles and its application to the electrocatalytic reduction of H202显示文摘 | Zhao Ge Feng Jiuju Zhang Qianli | 2005 | Chemistry of Materials2005，17，12： | 1 |
| 18 | Synthesis and heavy metal immobilization behaviors of slag based geopolymer显示文摘 | Zhang Yunsheng Sun Wei Chen Qianli Chen Lin | 2006 | Journal of Hazardous Materials2006，，1： | 1 |
| 19 | A simulation - based decision model for designing contract period in building energy performance contracting显示文摘 | QIANLI DENG LIMAO ZHANG QINGBIN CUI | 2014 | Building and Environment2014，71，： | 1 |
| 20 | Synthesis and heavy metal immobilization behaviors of slag based geopolymer显示文摘 | Zhang Yunsheng Sun Wei Chen Qianli | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员