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| 1 | Effects of cryogenic treatment on the thermal physical properties of Cu_(76.12) Al_(23.88) alloy显示文摘The thermal diffusion coefficient,heat capacity,thermal conductivity,and thermal expansion coefficient of Cu76.12Al23.88 alloy before and after cryogenic treatment in the heating temperature range of 25°C to 600°C were measured by thermal constant tester and thermal expansion instrument.The effects of cryogenic treatment on the thermal physical properties of Cu76.12Al23.88 alloy were investigated by comparing the variation of the thermal parameters before and after cryogenic treatment.The results show that the variation trend of the thermal diffusion coefficient,heat capacity,thermal conductivity,and thermal expansion coefficient of Cu76.12Al23.88 alloy after cryogenic treatment was the same as before.The cryogenic treatment can increase the thermal diffusion coefficient,thermal conductivity,and thermal expansion coefficient of Cu76.12Al23.88 alloy and decrease its heat capacity.The maximum difference in the thermal diffusion coefficient between the before and after cryogenic treatment appeared at 400°C.Similarly,thermal conductivity was observed at 200°C. | WANG Ping LU Wei WANG Yuehui LIU Jianhua ZHANG Ruijun | 2011 | Rare Metals2011，30，6： | 13 |
| 2 | Effects of Friction Heat on the Tribological Properties of the Woven Self-lubricating Liner显示文摘In the dry-sliding process of the woven self-lubricating liner which is used in the self-lubricating spherical plain bearing, the friction heat plays an important role in the tribological performances of the liner. It has important value to study on the relationship between tribological performances of the liner and the friction heat. Unfortunately, up to now, published work on this relationship is quite scarce. Therefore, the effect of friction heat on the tribological performances of the liner was investigated in the present work. The tribological behaviors of the liner were evaluated by using the high temperature end surface wear tester. Scanning electron microscopy (SEM) was utilized to examine the morphologies of worn surfaces of the liner and study the failure modes. Differential scanning calorimetry (DSC) measurement and X-ray diffraction (XRD) analysis were performed to study the behaviors of the wear debris. The temperature rise on the worn surface was calculated according to classical models. SEM observation shows that the dominating wear mechanism for the liner is mainly affected by friction shear force, contact pressure and friction heat. Higher fusion heat for the wear debris than that for the pure polytetrafluroethylene (PTFE) indicates that the PTFE is the main portion of the wear debris, and, the PTFE in the wear debris shows a higher crystallisation degree owing to the effects of friction shear force and the friction heat. Combining the calculated temperature rise results with the wear rate of the liner, it can be concluded that the effects of temperature rise on the tribological performances of the liner become more obvious when the temperature rise exceeds the glass transition temperature (Tg) of the PTFE. The wear resistance of the liner deteriorates dramatically when the temperature rise approaches to the melting point (Ton) of the PTFE. The tribological performances of the liner can be improved when the temperature rise exceeds Tg but is far lower than Ton. The present study on the relationship between the temperature rise and the tribological performances of the liner may provide the basis for further understanding of the wear mechanisms of the liner as well as the relationship between the formation of the PTFE transfer film and the friction heat during the dry-sliding of the liner. | YANG Yulin ZU Dalei ZHANG Ruijun QI Xiaowen | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 12 |
| 3 | Temperature Variable Optimization for Precision Machine Tool Thermal Error Compensation on Optimal Threshold显示文摘Machine tool thermal error is an important reason for poor machining accuracy.Thermal error compensation is a primary technology in accuracy control.To build thermal error model,temperature variables are needed to be divided into several groups on an appropriate threshold.Currently,group threshold value is mainly determined by researchers experience.Few studies focus on group threshold in temperature variable grouping.Since the threshold is important in error compensation,this paper arms to find out an optimal threshold to realize temperature variable optimization in thermal error modeling.Firstly,correlation coefficient is used to express membership grade of temperature variables,and the theory of fuzzy transitive closure is applied to obtain relational matrix of temperature variables.Concepts as compact degree and separable degree are introduced.Then evaluation model of temperature variable clustering is built.The optimal threshold and the best temperature variable clustering can be obtained by setting the maximum value of evaluation model as the objective.Finally,correlation coefficients between temperature variables and thermal error are calculated in order to find out optimum temperature variables for thermal error modeling.An experiment is conducted on a precise horizontal machining center.In experiment,three displacement sensors are used to measure spindle thermal error and twenty-nine temperature sensors are utilized to detect the machining center temperature.Experimental result shows that the new method of temperature variable optimization on optimal threshold successfully worked out a best threshold value interval and chose seven temperature variables from twenty-nine temperature measuring points.The model residual of z direction is within 3 m.Obviously,the proposed new variable optimization method has simple computing process and good modeling accuracy,which is quite fit for thermal error compensation. | ZHANG Ting YE Wenhua LIANG Ruijun LOU Peihuang YANG Xiaolan | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 11 |
| 4 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 5 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 6 | Effects of 4 GPa Pressure Heat Treatment on Thermal Physical Properties of the Cu-AI Alloy显示文摘 | Xiaoping Guan Mengmeng Cheng Guirong Peng Jianhua Liu Ruijun Zhang | 2011 | 材料科学与工程(中英文版)2011，5，4： | 6 |
| 7 | Mechanism of vertical crack formation in Yb_(2)SiO_(5) coatings deposited via plasma spray-physical vapor deposition显示文摘Plasma spray-physical vapor deposition(i.e.,PS-PVD)is a promising method for obtaining advanced environmental barrier coatings(EBCs).The EBCs must meet some requirements in the application,in which the thermal cycle performance affects the service lifetime.The preparation of artificial vertical cracks in Yb_(2)SiO_(5) coatings is an effective approach for meeting the requirements above because vertical cracks provide a strain tolerance.To clarify the formation mechanism of vertical cracks during the PSPVD,the effects of coating thickness and substrate temperature on the formation of vertical cracks were investigated.In addition,the interactions of spray powder and plasma flame during coating deposition were also characterized by optical spectroscopy.It is indicated that vertical cracks are formed due to a thermal expansion mismatch between Yb_(2)SiO_(5) and mullite coating,transient cooling after deposition and the nucleation of evaporated Yb_(2)SiO_(5) as well. | Xiaofeng Zhang Chao Wang Ruijun Ye Chunming Deng Xinghua Liang Ziqian Deng Shaopeng Niu Jinbing Song Guo Liu Min Liu Kesong Zhou Jian Lu Junli Feng | 2020 | Journal of Materiomics2020，6，1： | 6 |
| 8 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 9 | Sliding Wear of the Hybrid Kevlar/PTFE Fabric Reinforced Phenolic Composite Filled with Nano-titania显示文摘The Kevlar/polytetrafluroethylene(Kevlar/PTFE) fabric composite can be used as a self-lubricating liner of the self-lubricating bearing.Many types of nano-particles can improve the tribological performance of the polymer-based composite.Unfortunately,up to now,published work on the effect of nano-particles on the tribological performance of the fabric composite which can be used as a self-lubricating liner is quite scarce.Therefore,for the purpose of exploring a way to significantly improve the tribological performance of the fabric composite,the tribological performance of the Kevlar/PTFE fabric composite filled with nano-titania is evaluated by using the block-on-ring wear tester.The scanning electron microscopy is utilized to observe the morphologies of worn surfaces of the fabric composites and the counterparts.The tensile properties of the composites are evaluated on the universal material testing machine.The test results show that the addition of nano-titania at a proper mass fraction of the matrix resin improves the wear resistance and the tensile strength,decreases the friction coefficient,and makes the wear volume of the composite reach a relative steady state more quickly;plastic deformation and microcutting are important for the wear of the fabric composite;a lubricating layer is formed on the worn surface of the composite during sliding,and the lubricating layer is critical for the tribological performance of the composite;the formation and properties of the lubricating layer are influenced by the nano-titania particles.The proposed study on the effect of nano-titania on the tribological performance of the Kevlar/PTFE fabric composite,especially on the evolution of the worn surface of the composite,provides the basis for further understanding of the influence mechanism of the nano-particles on the tribological performance of the composite and explores a method of improving the tribological performance of the composite. | YANG Yulin HUANG Shijun ZU Dalei ZHANG Ruijun QI Xiaowen | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 4 |
| 10 | Effect of Anodization Parameters on Morphology and Photocatalysis Properties of TiO_2 Nanotube Arrays显示文摘Highly ordered TiO2 nanotube arrays were fabricated via electrochemical anodization of high purity Ti foil in fluoride-containing electrolyte. The effects of applied anodization potential, anodization time on the formation of TiO2 nanotube arrays and the photocatalytic degradation of methylene blue(MB) were discussed. The TiO2 nanotube arrays calcined at 500 °C for 2 h show pure anatase phase. The pore diameters of TiO 2 nanotube arrays can be adjusted from 30 to 90 nm using a different anodization voltage.Anodization time mainly influenced TiO 2 tube length, and by increasing the anodization time, the nanotube length became longer gradually. When the anodization potential was 40 V, the average growth rate of TiO 2 nanotube was about 4.17 μm/h. Both anodization potential and time had important effects on the photocatalytic efficiency. The TiO 2 nanotube arrays obtained at anodization potential of 40 V for 1 h showed the best photocatalytic degradation ratio of MB. | Lianjie Qin Qijing Chen Ruijun Lan Runqian Jiang Xiao Quan Bin Xu Feng Zhang Yongmin Jia | 2015 | Journal of Materials Science & Technology2015，31，10： | 3 |
| 11 | CaMKIIα-driven,phosphatase-checked postsynaptic plasticity via phase separation显示文摘Ca^(2+)/calmodulin-dependent kinase Ila(CaMKIla)is essential for synaptic plasticity and learning by decoding synaptic Ca^(2+)oscillations.Despite decades of extensive research,new mechanisms underlying CaMKIIa's function in synapses are still being discovered.Here,we discover that Shank3 is a specific binding partner for autoinhibited CaMKIla.We demonstrate that Shank3 and GluN2B,via combined actions of Ca^(2+)and phosphatases,reciprocally bind to CaMKIla.Under basal condition,CaMKIla is recruited to the Shank3 subcompartment of postsynaptic density(PSD)via phase separation.Rise of Ca^(2+)concentration induces GluN2Bmediated recruitment of active CaMKIla and formation of the CaMKIIa/GluN2B/PSD-95 condensates,which are autonomously dispersed upon Ca^(2+)removal.Protein phosphatases control the Ca^(2+)-dependent shuttling of CaMKIla between the two PSD subcompartme nts and PSD condensate formation.Activation of CaMKIla further enlarges the PSD assembly and in duces structural LTP.Thus,Ca^(2+)-induced and phosphatase-checked shuttling of CaMKIla between distinct PSD nano-domains can regulate phase separation-mediated PSD assembly and synaptic plasticity. | Qixu Caic Menglong Zeng Xiandeng Wu Haowei Wu Yumeng Zhan Ruijun Tian Mingjie Zhang | 2021 | Cell Research2021，31，1： | 3 |
| 12 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 13 | Effect of 5 GPa Pressure Heat Treatment on the Microstructure and Hardness of Cu-AI Alloy显示文摘 | Yuefeng Wang Qianyu Zhuang Lin Qu Weilong Lu Jianhua Liu Ruijun Zhang | 2011 | 材料科学与工程(中英文A版)2011，1，4X： | 2 |
| 14 | Separation of injectable salidroside by column chromatography of macroporous resins for treating myocardial ischemia显示文摘The objective of the present study is to develop a method for large-scale separating and purifying salidroside from rhodiola kirilowii roots and for preparing injectable medicinal ingredient.Crude extract of salidroside was prepared by water-ethanol system,and purified by column chromatography of macroporous resins.Static adsorption and desorption studies were performed on six kinds of macroporous resins,and SP825 resin was chosen,followed by optimizing process parameters.The optimum sample volume,feed concentration,ratio of diameter to height,and feeding flow rate were 1.5 bed volumes(BV),15 mg/mL,1:10 and 1 BV/h,respectively.Dynamic desorption was performed consecutively with 8 BV of distilled water,3 BV of 5% ethanol and 8 BV of 10% ethanol at a flow rate of 2 BV/h.After three cycles in separating 3.5 tons of rhodiola kirilowii roots,salidroside purity was increased from 3.4% in the crude extract to 93.6% in purified salidroside product.This study provides a novel method to separate salidroside for injectable use. | JU RuiJun HUANG RenJie ZHOU Jia LI RuoJing ZHOU Peng ZHANG ZaoHua XIANG FeiJun XU DongJin LIU WeiXiang MA XingTian ZHANG Qiang LU WanLiang | 2012 | Science China Chemistry2012，55，7： | 2 |
| 15 | Facile fabrication of amphoteric semi-interpenetrating network membranes for vanadium flow battery applications显示文摘For improvement of vanadium redox flow battery(VRB) performance, novel amphoteric semiinterpenetrating membranes(ASIPN) were prepared using poly(ether ether ketone)(PEEK) and polysulfone(PSf), the former bearing sulfonic groups and the latter imidazolium. These two groups form ionic crosslinks between PEEK and PSf; meanwhile, covalent cross links were built between PSf chains with addition of N-(3-aminopropyl)-imidazole. The amphoteric nature of the membrane allows facile proton and anion transport; the IPN structure and the presence of imidazolium cation effectively suppress vanadium ion crossover through the membrane. Therefore, the ASIPN based VRBs show higher Coulombic efficiency and energy efficiency than that assembled with pristine SPEEK and Nafion 212 membranes. Our work demonstrates that the ASIPN membranes are promising for VRB applications. | Ruijun Gan Yanjiao Ma Shanshan Li Fengxiang Zhang Gaohong He | 2018 | Journal of Energy Chemistry2018，27，4： | 2 |
| 16 | Distinct phase transitions and dielectric anomalies in two 4-methylanilinium salts显示文摘Solid-state phase transitions of 4-methylanilinium perchlorate (4-CH 3 C 6 H 4 NH 3 ·ClO 4 , 1) and tetrafluoroborate (4-CH 3 C 6 H 4 - NH 3 ·BF 4 , 2) were investigated with variable-temperature X-ray single-crystal structure analysis and thermal studies. Both 1 and 2 undergo first-order phase transitions and exhibit distinct dielectric anomalies at 385 and 247 K, respectively. | ZHANG Wen XU RuiJun | 2012 | Science China Chemistry2012，55，2： | 2 |
| 17 | Effects of High Pressure Treatment on Microstructure and Electrical Conductivity of CuCrAI Alloy显示文摘 | Xuemei Yang Jingrui Cai Guolong Li Jianhua Liu Ruijun Zhang | 2012 | 材料科学与工程(中英文A版)2012，2，5： | 1 |
| 18 | Monoclonal antibody based Dot-ELISA and indirect fluorescence antibody technique for detecting Edwardsiella ictaluri infection in yellow catfish (Pelteobagrus fulvidraco)显示文摘Edwardsiella ictaluri is known as the etiological agent of Red-head disease of yellow catfish(Pelteobagrus fulvidraco),and is the cause of heavy economic losses in the aquaculture industry.In this study,a DotEnzyme Linked Immunosorbent Assay(Dot-ELISA)and an Indirect Fluorescence Antibody technique(IFAT)for detecting Edwardsiella ictaluri were developed by using a monoclonal antibody,5D11.For DotELISA,the working dilutions of 5D11 and the secondary antisera(enzyme-labeled goat anti-mouse Ig)were 1:320 dilution and 1:3000 dilution,respectively.For IFAT,the working dilutions of 5D11 and goatanti-mouse Ig conjugated with fluorescein isothiocyanate were as respectively 1:80 and 1:256.Both of the methods established were highly sensitivity(Minimum detectable concentration,5107 CFU/mL)and had a high degree of accuracy(positive rate was 100%for both artificial infected fish and spontaneous diseased Pelteobagrus fulvidraco).The two reliable methods developed have high potential for quick and efficient detection of Edwardsiella ictaluri in aquaculture production units. | Ruijun Li Hua Huang Xianyu Zhang Shigen Ye Qiang Li | 2017 | Aquaculture and Fisheries2017，2，5： | 1 |
| 19 | Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE显示文摘Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive treatment was reported to downregulate beneficial Tregs together with pathogenic effector immune cells,which may impede a rapid achievement of optimal therapeutic effects. | Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei Zijun Li Yimin Li Jing He Zhanguo Li Xiaolin Sun | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 20 | Reducing methane emissions and the methanogen population in the rumen of Tibetan sheep by dietary supplementation with coconut oil显示文摘 | Xuezhi Ding Ruijun Long Qian Zhang Xiaodan Huang Xusheng Guo Jiandui Mi | 2012 | Tropical Animal Health and Production2012，，： | 1 |
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