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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 3 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 4 | Polymer-layered silicate nanocomposites:an overview显示文摘 | Peter C Lebaron Zhen Wang Thomas J Pinnavaia | 1999 | Applied Clay Science1999，15，： | 1 |
| 5 | Experimental determination of automotive system response characteristics显示文摘 | Zhen J T Lim T C Lu G Q | 2001 | Automotive Engineering International Journal of Passenger Cars:Mechanical System2001，110，6： | 1 |
| 6 | The thin sectional anatomy of the temporal bone correlated with multislice spiral CT 显示文摘 | Zhen J Liu C Wang S | 2007 | Surg Radiol Anat2007，29，5： | 1 |
| 7 | Model-Set Adaptation Using a Fuzzy Kalman Filter显示文摘 | Ding Zhen Henry L Keith C | 2001 | Mathematical and Computer Modeling2001，34，： | 1 |
| 8 | Battery performance and photocatalytic activity of mesoporous anatase TiO2 nanospheres/graphene composites by template-free self-assembly 显示文摘 | Li N Liu G Zhen C Li F Zhang L L Cheng H M | 2011 | Advanced Functional Materials2011，21，9： | 1 |
| 9 | Effects of the ancillary ligands of polypyridyl ruthenium (II) : complexes on the DNA-binding and photocleavage behaviors 显示文摘 | TAN L F CHAO H ZHEN K C | 2007 | Polyhedron2007，26，18： | 1 |
| 10 | Polymer-layered silicate nanocomposites: An overview显示文摘 | LeBaron Peter C Wang Zhen Pinnavaia Thomas J | 1999 | Appl Clay Sci1999，15，12： | 1 |
| 11 | A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family显示文摘 | Ponzetto C Bardelli A Zhen Z | 1994 | Cell1994，77，2： | 1 |
| 12 | Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis 显示文摘 | ZHEN M C WANG Q HUANG X H | 2007 | J Nutr Biochem2007，18，12： | 1 |
| 13 | PrestigeRank: a new evalua- tion method for papers and journals 显示文摘 | SU C PAN Y ZHEN Y | 2011 | Journal of Informet- rics2011，5，1： | 1 |
| 14 | A comparative analysis of serpin genes in the silkworm genome显示文摘 | Zhen Z Zhao P C Hua W | 2009 | Genomies2009，93，4： | 1 |
| 15 | Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals显示文摘 | BIN L SHANGWU C ZHEN C | 2007 | Molecular Immunology2007，44，4： | 1 |
| 16 | Structure and properties of thermoplastic saponite/poly(vinyl alcohol) nanocomposites显示文摘 | Zhen W J Lu C H Li C Y | 2012 | Applied Clay Science2012，57，： | 1 |
| 17 | Effects of Proton Irradiation on Struc- ture of NdFeB Permanent Magnets Studied by X-ray Diffraction and X-ray Absorption Fine Structure显示文摘 | Yang L Zhen L Xu C Y | 2011 | Journal of Magnetism and Mag- netic Materials2011，323，： | 1 |
| 18 | A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family显示文摘 | Ponzetto C Bardelli A Zhen Z | | 0，，02： | 1 |
| 19 | Synthesis,characterization and electromagnetic properties of Fel-xCoxalloy flower-like microparticles 显示文摘 | Yan S J Zhen L Xu C Y | 2011 | Journal of Magnetism and Magnetic Materials2011，323，5： | 1 |
| 20 | Injury-activatedtransforming growth factor beta controls mobilizationof mesenchymal stem cells for tissue remodeling显示文摘 | Wan M Li C Zhen G | 2012 | Stem Cells2012，30，11： | 1 |
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