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| 1 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 2 | C-reactive Protein Level,Apolipoprotein B-to-apolipoprotein A-1 Ratio,and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China显示文摘Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1(ApoB/ApoA-1) ratio on the incidence of ischemic stroke(IS) or coronary heart disease(CHD) in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein(CRP) level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios(HRs) and 95% confidence intervals(CIs) for the IS and CHD events in all the subgroups.Results The HRs(95% CI) for IS and CHD were 1.33(0.84-2.12),1.14(0.69-1.88),and 1.91(1.17-3.11) in the ‘low CRP level with high ApoB/ApoA-1',‘high CRP level with low ApoB/ApoA-1',and ‘high CRP level with high ApoB/ApoA-1' subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1' subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1' subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population. | TIAN Yun Fan ZHOU Yi Peng ZHONG Chong Ke BUREN Batu XU Tian LI Hong Mei ZHANG Ming Zhi WANG Ai Li ZHANG Yong Hong | 2016 | Biomedical and Environmental Sciences2016，29，7： | 12 |
| 3 | Correlation of Seven Biological Factors(Hsp90α,p53,MDM2,Bcl-2,Bax,Cytochrome C,and Cleaved caspase3)with Clinical Outcomes of ALK+ Anaplastic Large-cell Lymphoma显示文摘Objective To explore correlation of seven apoptosis‐related proteins (Hsp90α,p53,MDM2,Bcl‐2,Bax,Cytochrome C,and Cleaved caspase3) with clinical outcomes of ALK+ anaplastic large‐cell lymphoma (ALCL).Methods Using immunohistochemistry and immunofluorescence double staining methods,the expressions of these seven apoptosis‐associated proteins were studied to clarify their relationship with clinical outcomes of 36 ALK+ and 25 ALK‐ systemic ALCL patients enrolled between 1996 and 2006.The relationship of these apoptosis‐regulating proteins with NPM‐ALK status was also evaluated with the tyrosine inhibitor herbimycin A (HA) in vitro by immunocytochemistry,Western blotting and flow cytometric assays.Results The presence of Hsp90α‐,MDM2‐,Bax‐,Cytochrome C,and Cleaved caspase3‐positive tumor cells was found significantly different in ALK+ and ALK‐ ALCLs ,which was correlated with highly favorable clinical outcome.The Bcl‐2‐ and p53‐positive tumor cells were found in groups of patients with unfavorable prognosis.Inhibition of NPM‐ALK by HA could reactivate the p53 protein and subsequent apoptosis‐related proteins and therefore induced apoptosis in ALK+ ALCL cells.Conclusion Our results suggest that these seven proteins might be involved in apoptosis regulation and associated with clinical outcome of ALK+ systemic ALCLs.We also reveal a dynamic chain relation that NPM‐ALK regulates p53 expression and subsequent apoptosis cascade in ALK+ ALCLs. | LI Hui Ling HUANG Xue Ping ZHOU Xin Hua JI Tian Hai WU Zi Qing WANG Zhi Qiang JIANG Hui Yong LIU Fan Rong ZHAO Tong | 2011 | Biomedical and Environmental Sciences2011，24，6： | 9 |
| 4 | Alcohol Drinking, Dyslipidemia, and Diabetes: A Population-based Prospective Cohort Study among Inner Mongolians in China显示文摘Objective No previous studies have evaluated the association between dyslipidemia,alcohol drinking,and diabetes in an Inner Mongolian population.We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population.Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China.Participants were classified into four subgroups according to their drinking status and dyslipidemia.Multivariate logistic regression analysis and receiver operating characteristic(ROC) curves were used to evaluate the association between alcohol drinking,dyslipidemia,and diabetes.Results During the follow-up period,203 participants were found to have developed diabetes.The multivariable-adjusted odds ratios(95% confidence interval) for the incidence of non-dyslipidemia/drinkers,dyslipidemia/non-drinkers,and dyslipidemia/drinkers in diabetic patients were 1.40(0.82-2.37),1.73(1.17-2.55),and 2.31(1.38-3.87),respectively,when compared with non-dyslipidemia/non-drinkers.The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors(AUC=0.746) was significantly(P=0.003) larger than the one containing only conventional factors(AUC=0.711).Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes,and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population.These findings suggest that dyslipidemia and drinking status may be valuable in predicting diabetes incidence. | LIANG Zhu QIU Qiao Yan WU Jia Hui ZHOU Jing Wen XU Tian ZHANG Ming Zhi ZHANG Yong Hong ZHANG Shao Yan | 2016 | Biomedical and Environmental Sciences2016，29，8： | 7 |
| 5 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 6 | Combined Effects of A Body Shape Index and Serum C-reactive Protein on Ischemic Stroke Incidence among Mongolians in China显示文摘Objective We aimed to evaluate the combined effects of a high body shape index(ABSI) and a high serum C-reactive protein(CRP) level on the incidence of ischemic stroke in a Mongolian population in China. Methods A prospective cohort study was conducted among 2,589 participants from June 2002 to July 2012 in Inner Mongolia, China. The participants were categorized into 4 groups according to their level of ABSI and CRP. Cox proportional hazards models were used to assess the hazard ratios(HRs) and 95% confidence intervals(CIs) for ischemic stroke among all groups. Results The multivariate adjusted HRs(95% CI) of ischemic stroke for high ABSI and high CRP level were 1.46(0.89-2.39) and 1.63(0.95-2.79), respectively. Compared with the low ABSI/low CRP level group, the multivariate adjusted HRs(95% CI) of ischemic stroke in the low ABSI/high CRP, high ABSI/low CRP, and high ABSI/high CRP groups were 1.04(0.46-2.35), 1.06(0.58-1.95) and 2.52(1.27-5.00), respectively. The HR of ischemic stroke for the high ABSI/high CRP level group was the highest and most statistically significant. Conclusion We found that participants with simultaneously high ABSI and high CRP levels had the highest risk of ischemic stroke in the Mongolian population. Our findings suggest that the combination of high ABSI and high CRP levels may increase the risk of ischemic stroke. | WANG Guang Li ZHANG Rui ZHOU Yi Ting WANG Ai Li XU Tian ZHANG Ming Zhi LI Hong Mei ZHANG Yong Hong | 2019 | Biomedical and Environmental Sciences2019，32，3： | 4 |
| 7 | Synthesis,DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives显示文摘二新奇 mononaphthalimide 人亚精胺衍生物(2a, 2b ) 与是的三或四个甲又单位,连接对人的白血病 K562,鼠科的黑瘤 B16 和汉语为细胞毒性被综合并且评估仓鼠卵巢 CHO 房间线。人亚精胺主题的存在能极大地提高 1,8-naphthalimide 的力量。结合 2b,更长的分隔符比 2a 在 vitro 细胞毒性更高展出了。脱氧核糖核酸有约束力的实验显示那结合 2b 能绑在鲱鱼精子脱氧核糖核酸。topoisomerase II 毒物试用表明 2b 能禁止顶的活动。II。 | Zhi Yong Tian Hong Xia Ma Song Qiang Xie Xue Wang Jin Zhao Chao Jie Wang Wen Yuan Gao | 2008 | Chinese Chemical Letters2008，19，5： | 3 |
| 8 | Serosurvey of Avian metapneumovirus, Orithobacterium rhinotracheale, and Chlamydia psittaci and Their Potential Association with Avian Airsacculitis显示文摘Seasonal outbreaks of airsacculitis in China's poultry cause great economic losses annually.This study tried to unveil the potential role of Avian metapneumovirus(AMPV),Ornithobacterium rhinotracheale(ORT) and Chlamydia psittaci(CPS) in avian airsacculitis.A serological investigation of 673 breeder chickens and a case-controlled study of 430 birds were undertaken.Results showed that infection with AMPV,ORT,and CPS was highly associated with the disease.The correlation between AMPV and CPS were positively robust in both layers and broilers.Finally,we determined the co-infection with AMPV,ORT,and CPS was prevalent in the sampled poultry farms suffering from respiratory diseases and the outbreak of airsacculitis was closely related to simultaneous exposure to all three agents. | ZUO Zong Hui ZHANG Tian Yuan GUO Yong Xia CHU Jun QU Guang Gang MIAO Li Zhong SHEN Zhi Qiang HE Cheng | 2018 | Biomedical and Environmental Sciences2018，31，5： | 3 |
| 9 | Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China显示文摘Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease(CVD) and high serum C‐reactive protein(CRP) on the stroke incidence in an Inner Mongolian population in China. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio(HR) of 1.78 [95% confidence interval(CI), 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14(95% CI, 1.09‐4.20; P = 0.027) of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant(all P > 0.05). Conclusion Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD. | ZHU Zheng Bao HUANGFU Xin Feng ZHONG Chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong | 2017 | Biomedical and Environmental Sciences2017，30，9： | 2 |
| 10 | The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study显示文摘Tuberculosis (TB) is a formidable global health problem and ranks above HIV as the leading cause of death worldwide. In 2017, a total number of 10.0 million cases of TB were reported, which resulted in 1.3 million TB deaths. Resistance to standard anti-TB drugs poses a major threat to control of TB, and 450, 000 cases of multidrug-resistant TB (MDR-TB) were estimated in 2017, which indicates the severity of the problem[1]. Pneumonia is one of the common infectious diseases that cause morbidity and mortality in China, causing approximately 2.5 million new cases and 125, 000 deaths annually[2]. Particularly, a high risk of pneumonia in TB was observed among patients with TB compared to that in the general population[3]. Regarding patients with MDR-TB, the extensive for the focus of lung[4] and lung dysbacteriosis[5] further increase the risk of secondary pneumonia, and the role of secondary pneumonia in the efficacy of anti-TB treatment needs to be delineated. | TAN Shou Yong LIANG Zhuo Zhi Gift Chiwala KUANG Hao Bin HUANG Zhi Pei QIN Hong Juan LI Yan LI Yan Qiong H.M.Adnan Hameed ZHANG Tian Yu | 2018 | Biomedical and Environmental Sciences2018，31，12： | 2 |
| 11 | Use of Network Pharmacology and Molecular Docking to Investigate the Mechanism by Which Ginseng Ameliorates Hypoxia显示文摘Hypoxia is a common pathological process in various clinical diseases and is characterized by abnormal changes in metabolism,function,and morphological structure of tissues resulting from insufficient oxygen supply or oxygen barriers in tissues.In particular,hypoxia in vital organs such as the brain and heart is an important cause of death[1].The prevention of tissue hypoxia and the treatment of hypoxia-induced tissue damage are urgent issues. | WANG Tao LI Hao Tian WEI Shi Zhang CAI Hua Dan ZHU Yun LIU Hong Hong LI Yong Zhi WANG Jia Ping ZOU Wen Jun ZHAO Yan Ling | 2018 | Biomedical and Environmental Sciences2018，31，11： | 2 |
| 12 | Comparative Study of the Genetic Diversity, Antimicrobial Resistance, and Pathogenicity of Aeromonas Isolates from Clinical Patients and Healthy Individuals显示文摘Objective This study was performed to compare the genetic diversity,virulence,and antimicrobial resistance of Aeromonas strains isolated from patients and healthy individuals.Methods A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma’anshan City,Anhui Province.Their taxonomy was investigated using concatenated gyrB-cpn60 sequences,and their resistance to 12 antibiotics was evaluated.The pathogenicity of these strains was examined through beta-hemolysis,protease activity,and virulence gene assays.Results The 57 Aeromonas strains were divided into 55 sequence types.Of these types,21 were novel,suggesting that their genetic diversity was high.These Aeromonas isolates could be divided into 7 species,and the positive rates of beta-hemolysis and protease activity were 49.1%and 73.7%,respectively.The detection rate of clinical patients in terms of beta-hemolysis and protease activity was higher than that of healthy individuals.Among the four most common Aeromonas strains,A.dhakensis had the highest detection rate of virulence genes.The multidrug resistance rate of the clinical isolates was much higher than that of the strains isolated from healthy individuals.Conclusions The taxonomy,virulence properties,and antibiotic resistance of Aeromonas isolates from patients differ from those of the isolates from healthy individuals. | MENG Shuang DU Xiao Li WANG Yong Lu QU Feng Tian XIE Gui Lin ZHOU Hai Jian HU Jin Rui QIN Zheng WANG Yue KAN Biao CUI Zhi Gang | 2021 | Biomedical and Environmental Sciences2021，34，6： | 2 |
| 13 | Genome?wide analysis of DNA methylation in rat lungs with lipopolysaccharide?inducedacute lung injury显示文摘 | Xiao?Qiang Zhang Chang?Jun Lv Xiang?Yong Liu Dong Hao Jing Qin Huan?Huan Tian Yan Li Xiao?Zhi Wang | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 14 | Hopf Bifurcation and Stability Analysis on the Mill Drive System显示文摘 | Zhi Ying Gao Yong Zang Tian Han | 2011 | Applied Mechanics and Materials2011，1514，121126： | 1 |
| 15 | Hope bifurca tion and stability analysis on the mill drive system显示文摘 | ZHI YING GAO YONG ZANG TIAN HAN | 2011 | Applied Mechanics and Materials2011，，12： | 1 |
| 16 | A novel polymorphism of GDF5 gene and its association with body measurement traits in Bos taurus and Bos indicus breeds显示文摘 | Yong Feng Liu Lin Sen Zan Kui Li Shuan Ping Zhao Ya Ping Xin Qing Lin Wan Qiang Tian Zhi Wei Wang | 2010 | Molecular Biology Reports2010，，1： | 1 |
| 17 | Liver dynamic contrast‐enhanced MRI for staging liver fibrosis in a piglet model显示文摘 | Li Zhou Tian‐wu Chen Xiao‐ming Zhang Zhi Yang Hong‐jie Tang Dan Deng Nan‐lin Zeng Li‐ying Wang Xiao‐li Chen Hang Li Chun‐ping Li Li Li Xian‐yong Xie Jiani Hu | 2014 | J. Magn. Reson. Imaging2014，，4： | 1 |
| 18 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 19 | The Synthesis of a New Type of Calixarene with Chiral Pendant显示文摘Two new chiral calixarenes were synthesized by condensing 1,3 bis chlorocarbomethyl calixarenes with (1S, 2S) 2 amino 1 (4 nitrophenyl) 1,3 propanediol, a by product from antibiotic industry , and were characterized by 1H NMR , MS FAB, and elemental analysis. The 1H NMR spectra show that those molecules assume a cone conformation in solution. | He Yong bing, Li Jian feng, Meng Ling zhi, Xiao Yuan jing, Yu Tian\|xiang, Wu Cheng tai College of Chemistry and Molecule Science,Wuhan University, Wuhan,430072 China | 2001 | Wuhan University Journal of Natural Sciences2001，6，3： | 0 |
| 20 | Beneficial Effects of ( - )clausenamide in Experimental Models of Alzheimer's Disease显示文摘 | Cheng Yong Qu Zhi - Wei Zhang Jun - Tian | 2005 | 中国药理通讯2005，22，4： | 0 |
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