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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 3 | Inferring three-dimensional surface displacement field by combining SAR interferometric phase and amplitude information of ascending and descending orbits显示文摘Conventional Interferometric Synthetic Aperture Radar(InSAR) technology can only measure one-dimensional surface displacement(along the radar line-of-sight(LOS) direction).Here we presents a method to infer three-dimensional surface displacement field by combining SAR interferometric phase and amplitude information of ascending and descending orbits.The method is realized in three steps:(1) measuring surface displacements along the LOS directions of both ascending and descending orbits based on interferometric phases;(2) measuring surface displacements along the azimuth directions of both the ascending and descending orbits based on the SAR amplitude data;and(3) estimating the three-dimensional(3D) surface displacement field by combining the above four independent one-dimensional displacements using the method of least squares and Helmert variance component estimation.We apply the method to infer the 3D surface displacement field caused by the 2003 Bam,Iran,earthquake.The results reveal that in the northern part of Bam the ground surface experienced both subsidence and southwestward horizontal movement,while in the southern part uplift and southeastward horizontal movement occurred.The displacement field thus determined matches the location of the fault very well with the maximal displacements reaching 22,40,and 30 cm,respectively in the up,northing and easting directions.Finally,we compare the 3D displacement field with that simulated from the Okada model.The results demonstrate that the method presented here can be used to generate reliable and highly accurate 3D surface displacement fields. | HU Jun LI ZhiWei ZHU JianJun REN XiaoChong DING XiaoLi | 2010 | Science China Earth Sciences2010，53，4： | 21 |
| 4 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 5 | Late Mesozoic-Cenozoic dcollement structure and its deep geological background in western Shandong,China显示文摘Data from seismic reflection profiles, drilling, stratigraphy, structural deformation studies and physical rock properties reveal the existence of dcol1ement structures in both shallow and deep levels in western Shandong, China. The most outstanding shallow dcol1ement structures occur along the regional unconformity surface between the Cambrian and Archean, and the disconformity surface between the Carboniferous and Ordovician. The dcollement structure surface manifests as a fault zone with cataclastic rocks and asymmetrical folds. Some of the cataclastic rocks underwent dynamic metamorphism and hydrothermal alteration, including silicification, marbleization and specularite mineralization. Above the dcol1ement structure, the bottom of the Cambrian might be missing or overprinted because of dcollement. The striations, asymmetrical folds and boudinage structures indicate the direction of the main dcollement to the NNW and NNE. A deep level dcollement structure occurs at a depth of 12-22 km and up to 30 km distance to the south. The early Cretaceous and Eocene are two main periods of activity, with the Cretaceous dcollement probably initiated by mantle upwelling derived from subduction and collision of the Yangtze Plate with the North China Plate along the Tancheng-Lujiang Fault in the late Triassi-early Jurassic. This circumstance implies a multidirection of subduction and collision of these two plates in the early late Mesozoic. | Li, Li Zhong, Dalai Shi, Xiupeng Tang, Zibo Hu, Qiuyuan Xu, Yi Li, Zhiwei | 2009 | Progress in Natural Science:Materials International2009，19，5： | 12 |
| 6 | Outcome of Stretta radiofrequency and fundoplication for GERD- related severe asthmatic symptoms显示文摘这研究试图与 Stretta radiofrequency (SRF ) 或 laparoscopic 尼森式小屋 fundoplication (LNF ) 调查治疗的结果。137 gastroesophageal 倒流疾病(GERD ) 的一个总数为气喘对医疗不充分地作出回应的有严重气喘的症状的病人被调查。病人在 SRF 以后在 1 年和 5 年上面被跟随(n = 82 ) 或 LNF (n = 55 ) 治疗。盖住 29 的一张问询表联系了症状,药使用被采用。消化,呼吸,并且 ear-nose-throat (ENT ) 症状分数显著地在 antireflux 治疗以后减少了。症状分数分别地从 17.2 敲獳癩? 晥敦瑣 ? 潰獳扩祬戠 ? 湩捡楴慶楴杮琠敨 ? 慣整楮 ? 变化了 ???? 湡 ???? 瑫猠杩慮楬杮瀠瑡睨祡? 牯戠 ? 污整楲杮? 慣整楮 ?? 慣桤牥湩洭摥慩整 ? 散汬' 獩 D? 摡敨楳湯椠 ? 牢慥瑳挠湡散 ?散汬s 吗? | Zhiwei Hu Jimin Wu Zhonggao Wang Yu Zhang Weitao Liang Chao Yan | 2015 | Frontiers of Medicine2015，9，4： | 10 |
| 7 | Effect of cavity flow control on high-speed train pantograph and roof aerodynamic noise显示文摘The pantograph and its recess on the train roof are major aerodynamic noise sources on high-speed trains.Reducing this noise is particularly important because conventional noise barriers usually do not shield the pantograph.However,less attention has been paid to the pantograph recess compared with the pantograph.In this paper,the flow features and noise contribution of two types of noise reduction treatments rounded and chamfered edges are studied for a simplified high-speed train pantograph recess,which is represented as a rectangular cavity and numerically investigated at 1/10 scale.Improved delayed detached-eddy simulations are performed for the near-field turbulent flow simulation,and the Ffowcs Williams and Hawkings aeroacoustic analogy is used for far-field noise prediction.The highly unsteady flow over the cavity is significantly reduced by the cavity edge modifications,and consequently,the noise radiated from the cavity is reduced.Furthermore,effects of the rounded cavity edges on the flow and noise of the pantographs(one raised and one folded)are investigated by comparing the flow features and noise contributions from the cases with and without rounding of the cavity edges.Different train running directions are also considered.Flow analysis shows that the highly unsteady flow within the cavity is reduced by rounding the cavity edges and a slightly lower flow speed occurs around the upper parts of the raised pantograph,whereas the flow velocity in the cavity is slightly increased by the rounding.Higher pressure fluctuations occur on the folded pantograph and the lower parts of the raised pantograph,whereas weaker fluctuations are found on the panhead of the raised pantograph.This study shows that by rounding the cavity edges,a reduction in radiated noise at the side and the top receiver positions can be achieved.Noise reductions in the other directions can also be found. | Hogun Kim Zhiwei Hu David Thompson | 2020 | Railway Engineering Science2020，28，1： | 10 |
| 8 | Correcting ionospheric effects and monitoring two-dimensional displacement fields with multiple-aperture InSAR technology with application to the Yushu earthquake显示文摘Differential synthetic aperture radar interferometry (D-InSAR) can only measure one-dimensional surface displacements along the line-of-sight (LOS) direction which greatly inhibits its development and application.In this paper, we introduce a novel approach to measuring two-dimensional (2-D) surface displacements by exploiting a single InSAR pair, which is called multi-aperture InSAR (MAI) technology.We study the effects of baseline errors and the ionosphere on MAI technology and develop a directional filter and interpolator to minimize the ionospheric effects.A PALSAR image pair covering the 2010 Yushu earthquake is used to estimate the 2-D displacement fields of the earthquake using the MAI approach.The experimental results show that MAI is superior to conventional Offset-Tracking and therefore has great potential in co-seismic displacement measurement and source parameter inversion. | HU Jun LI ZhiWei ZHANG Lei DING XiaoLi ZHU JianJun SUN Qian DING Wei | 2012 | Science China Earth Sciences2012，55，12： | 9 |
| 9 | 基于 DDES 算法的有扰流片腔体气动噪声分析显示文摘为了进一步了解腔体流场的物理特性以及锯齿形扰流片这种被动控制方法对腔体噪声振荡的抑制效果,对马赫数0.85下、长深比为5∶1的矩形腔体进行了气动声学分析。分析过程采用了基于Spalart-Allmaras单方程模型的延迟分离涡模拟(DDES)的CFD方法。计算结果以声压级(SPL)形式与英国QinetiQ基地进行的实验研究结果进行比较。计算准确地预测出了第二阶和第三阶主导模态的声调噪声幅值,其误差均不超过2dB。为了验证腔体前缘安装扰流片这种广泛应用的腔体噪声被动控制方法,计算重点分析了带有锯齿形扰流片的腔体结构噪声等级。计算分析结果与空腔结果对比分析后认为前缘锯齿形扰流片可以降低第二阶主导模态的峰值噪声等级10dB以上,其它频率下的腔体噪声等级可降低接近5dB,降噪效果较好。 | 刘瑜 童明波 Zhiwei Hu | 2015 | 空气动力学学报2015，33，5： | 7 |
| 10 | Complete three-dimensional coseismic displacements due to the 2021 Maduo earthquake in Qinghai Province,China from Sentinel-1 and ALOS-2 SAR images显示文摘On 22 nd May 2021(local time),an earthquake of M_(s)7.4 struck Maduo county in Qinghai Province,China.This was the largest earthquake in China since the 2008 Wenchuan earthquake.In this study,ascending/descending Sentinel-1 and advanced land observation satellite-2(ALOS-2)synthetic aperture radar(SAR)images were used to derive the three-dimensional(3-D)coseismic displacements of this earthquake.We used the differential interferometric SAR(In SAR,DIn SAR),pixel offset-tracking(POT),multiple aperture In SAR(MAI),and burst overlap interferometry(BOI)methods to derive the displacement observations along the line-of-sight(LOS)and azimuth directions.To accurately mitigate the effect of ionospheric delay on the ALOS-2 DIn SAR observations,a polynomial fitting method was proposed to optimize range-spectrum-split-derived ionospheric phases.In addition,the 3-D displacement field was obtained by a strain model and variance component estimation(SM-VCE)method based on the high-quality SAR displacement observations.Results indicated that a left-lateral fault slip with the largest horizontal displacement of up to 2.4 m dominated this earthquake,and the small-magnitude vertical displacement with an alternating uplift/subsidence pattern along the fault trace was more concentrated in the near-fault regions.Comparison with the global navigation satellite system data indicated that the SM-VCE method can significantly improve the accuracy of the displacements compared to the classical weighted least squares method,and the incorporation of the BOI displacements can substantially benefit the accuracy of north-south displacement.In addition to the displacements,three coseismic strain invariants calculated based on the strain model parameters were also investigated.It was found that the eastern and western parts of the faults suffered more significant strains compared with the epicenter region. | Jihong LIU Jun HU Zhiwei LI Zhangfeng MA Lixin WU Weiping JIANG Guangcai FENG Jianjun ZHU | 2022 | Science China Earth Sciences2022，65，4： | 6 |
| 11 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 12 | Recent advances on electroactive CNT-based membranes for environmental applications:The perfect match of electrochemistry and membrane separation显示文摘Global climate change,growing population,and environmental pollution underscore the need for a greater focus on providing advanced water treatment technologies.Although electrochemical basedprocesses are becoming promising solutions,they still face challenges owing to mass transport and upscaling which hinder the exploitation of this technology.Electrode design and reactor configuration are key factors for achieving operational improvements.The electroactive membrane has proven to be a breakthrough technology integrating electrochemistry and membrane separation with an enhanced mass transport by convection.In this review article,we discuss recent progress in environmental applications of electroactive membranes with particular focus on those composed of carbon nanotubes(CNT)due to their intriguing physicochemical prope rties.Their applications in degradation of refractory contaminants,detoxification and sequestration of toxic heavy metal ions,and membrane fouling alleviations are systematically reviewed.We then discuss the existing limitations and opportunities for future research.The development of advanced electroactive systems depends on interdisciplinary collaborations in the areas of materials,electrochemistry,membrane development,and environmental sciences. | Yanbiao Liu Fuqiang Liu Ning Ding Xuemei Hu Chensi Shen Fang Li Manhong Huang Zhiwei Wang Wolfgang Sand Chong-Chen Wang | 2020 | Chinese Chemical Letters2020，31，10： | 6 |
| 13 | Numerical study on flow and heat transfer characteristics of microchannel designed using topological optimizations method显示文摘Microchannel has demonstrated advantages in the thermal management of integrated chip. In this study, the topology optimization method is applied for designing a topological microchannel to optimize the performances of both heat dissipation and pressure drop. To validate the performance of the topological structure, the flow and heat transfer characteristics of topological microchannel under non-uniform heating flux are numerically studied. The topological structure is designed to cool a heating area of 10 mm×10 mm with 4 hotspots. Heat flux is 40 W/cm^2 in the hotspot area, while it is only 15 W/cm^2 in the rest heating area. The results of heat dissipation performance and pressure drop are compared with those of conventional straight microchannel. Numerical result shows that, compared to the straight microchannel, the hotspot temperature and pressure drop of topological microchannel can be reduced by 4 and 0.6 k Pa, respectively, under the flow rate of 2.2×10^-4 kg/s. The coefficient of performance(COP) of topological microchannel can be 16.1% better than that of straight microchannel, which can be attributed to the effects of optimized bifurcation and confluence structural of topological microchannel. | HU DingHua ZHANG ZhiWei LI Qiang | 2020 | Science China(Technological Sciences)2020，63，1： | 5 |
| 14 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 15 | Luminescent properties of Dy^3+/Eu^3+ doped fluorescent glass for white LED based on oxyfluoride matrix显示文摘Rare earth ion-doped fluorescent glass has become a hotspot due to its characteristics.This work shows that the prepared Dy^3+and Dy^3+/Eu^3+doped glasses have white light emission under ultraviolet excitation.There is a higher yellow light/blue light(Y/B)value,indicating an increase in the covalentity of Dy-O,and decrease in the symmetry with the increasing concentration of dopants(Dy^3+).The correlated color temperature(CCT)can be effectively reduced by the red light emission of Eu^3+,and the order of influence of excitation wavelength on CCT is 395 nm>382 nm>365 nm.The delay curve demonstrates the energy transfer from Dy^3+to Eu^3+.The glass has the characteristics of anti-blue light damage and wide tunable color temperature,which illustrates that it has potential application in the field of white LED. | Jingxi An Shuang Zhang Ruiwang Liu Guangxu Hu Zhiwei Zhang Yiyu Qiu Yanyan Zhou Fanming Zeng Zhongmin Su | 2021 | Journal of Rare Earths2021，39，1： | 5 |
| 16 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 17 | Synthesis of polycrystalline γ-AlON powders by novel wet chemical processing显示文摘The synthesis of polycrystalline aluminum oxynitride (AlON) powders was investigated by the carbothermal reduction and nitridation (CRN) of amorphous precursor obtained by wet chemical processing. Co-precipitation processing was employed to achieve amorphous precursor from Al(NO3)3 solution dispersed by nanosized carbon particles, which was composed of Al(OH)3 and C particles homogeneously. The effects of the content of carbon black, pH value, and calcination temperature on formation of AlON phase were investigated by means of XRD, SEM and TEM, respectively. It was found that single phase AlON powder could be synthesized when the resultant precursors were calcined at 1750°C for 2 hours under flowing N2 . Under optimal additional content of C (5.6wt%), the resultant AlON powders exhibited the primary particle size of about 1-3 μm with a specific surface area of 3.2m2/g, which were superior to that of carbothermal reduction of immediate mixture of γ-Al2O3/C powders. | LEI JingXuan MA FeiZhong SHI Ying XIE JianJun HU Wei SHI ZhiWei | 2012 | Science China(Technological Sciences)2012，55，12： | 4 |
| 18 | Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca^(2+) channel internalization in mesenchymal stem cells显示文摘The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain,chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells(BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific(Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δsubunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP. | Bei Li Xiaoning He Zhiwei Dong Kun Xuan Wei Sun Li Gao Shiyu Liu Wenjia Liu Chenghu Hu Yimin Zhao Songtao Shi Yan Jin | 2020 | Bone Research2020，8，2： | 4 |
| 19 | Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles:A randomized clinical trial显示文摘OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool(PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.RESULTS: Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group(12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group(12.9 ± 2.6 vs 10.3 ± 1.6, P <0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group(8.6 ± 3.2 vs10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs(12.9 ± 2.2) mm, P =0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.CONCLUSION: These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule,and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE. | Peng Longping Hong Zhiwei Shen Jiaming Hu Xuechun Shao Yong Jing Jun Lu Jinchun Yao Bing | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 3 |
| 20 | Accelerated design and characterization of non-uniform cellular materials via a machine-learning based framework显示文摘Cellular materials,widely found in engineered and nature systems,are highly dependent on their geometric arrangement.A nonuniform arrangement could lead to a significant variation of mechanical properties while bringing challenges in material design.Here,this proof-of-concept study demonstrates a machine-learning based framework with the capability of accelerated characterization and pattern generation.Results showed that the proposed framework is capable of predicting the mechanical response curve of any given geometric pattern within the design domain under appropriate neural network architecture and parameters.Additionally,the framework is capable of generating matching geometric patterns for a targeted response through a databank constructed from our machine learning model.The accuracy of the predictions was verified with finite element simulations and the sources of errors were identified.Overall,our machine-learning based framework can boost the design efficiency of cellular materials at unit level,and open new avenues for the programmability of function at system level. | Chunping Ma Zhiwei Zhang Benjamin Luce Simon Pusateri Binglin Xie Mohammad H.Rafiei Nan Hu | 2020 | npj Computational Materials2020，，1： | 3 |
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