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| 1 | Quaternary glacier development and the relationship between the climate change and tectonic uplift in the Helan Mountain显示文摘孤立拉长 Helan 山脉山岳的 NE-SW,分开从 Tenggeli 沙漠的 Ordos 高原的适度的草地,是在西方中国学习冰河发展的一个关键位置以及气候的联合条件随着变化构造高举。冰川的地形和存款包括冰斗,山峰,刀口山脉,侧面的冰碛,和终端冰碛在 Helan 山的中间的部分在 2800 m a.s.l 上面散布。这分布显示这曾经是 glaciated 在期间晚第四级。形态学特征证明形成事件的风景的一个清楚的序列发生在整个 Helan 山。实验室光学地刺激了光(OSL ) 和标明日期的加速器团 spectrometry 放射性碳(AMS 14C ) 结果显示冰川的进展的迟了的历史。在 Helan 山的中间的部分的迟了的更新世冰河进展了接近他们的位置至少四次,并且冰川的序列能作为最后一个冰川的周期的中间的阶段被分配(MIS3b, 43.2 ????????? ′ ? 錸? 錸?@ | ZHANG Wei HE MingYue LI YongHua CUI ZhiJiu WANG ZhiLin YU Yang | 2012 | Chinese Science Bulletin2012，57，34： | 14 |
| 2 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 3 | Sedimentary and geochemical evidence of Eocene climate change in the Xining Basin, northeastern Tibetan Plateau显示文摘The northeastern Tibetan Plateau began to grow during the Eocene and it is important to understand the climatic history of Asia during this period of so-called ‘doubthouse' conditions. However, despite major advances in the last few decades,the evolutionary history and possible mechanisms of Eocene climate change in the northeastern Tibetan Plateau remain unclear.The Xining Basin in the northeastern Tibetan Plateau contains a continuous sequence of Early to Late Eocene non-marine sediments which provides the opportunity to resolve long-term climate changes during this period. In this study, we report the results of analyses of lithofacies, sediment color and geochemistry of bulk samples collected from the Xijigou section of the Xining Basin. An abrupt lithofacies change between the Early(~52–40 Ma) and Late Eocene(~40–34 Ma) indicates a change in the depositional environment from a shallow lake to a playa lake in response to a significant climatic shift. During ~52–40 Ma,higher values of sediment redness(a*), redness/lightness(a*/L*) and higher modified Chemical Index of Weathering(CIW′)indicate a relatively warm and humid climate, while from ~40–34 Ma the lower values of a*, a*/L*and lower CIW′ imply subhumid to semi-arid climatic conditions. The paleoclimatic records indicate a long-term(~52–34 Ma) trend of decreasing chemical weathering, consistent with global climate change. An abrupt sharp excursion of the proxy records during ~42–40 Ma suggests a relatively brief warm interval, corresponding to the Middle Eocene Climatic Optimum(MECO). We suggest that global cooling substantially reduced humidity in inner Asia, resulting in sub-humid to semi-arid climatic conditions after 40 Ma in the Xining Basin, which may have been responsible for the long-term trend of decreasing chemical weathering during the Eocene. | Abu Sadat Md SAYEM Zhengtang GUO Haibin WU Chunxia ZHANG Fan YANG Guoqiao XIAO Zhilin HE | 2018 | Science China Earth Sciences2018，61，9： | 6 |
| 4 | Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques显示文摘New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection of recovered patients and the efficiencies of vaccines designed based on epidemic strains in early 2020. | Rong Li Xiancai Ma Jieyi Deng Qier Chen Weiwei Liu Zhilin Peng Yidan Qiao Yingtong Lin Xin He Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，4： | 4 |
| 5 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 6 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 7 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 8 | Epoxy microcapsules for high-performance self-healing materials using a novel method via integrating electrospraying and interfacial polymerization显示文摘The high-efficiency fabrication of high-quality microcapsules containing epoxy is crucial to the further development of the potential practical self-healing epoxy systems based on microencapsulated two-part epoxy-amine chemistry.Herein,a novel microencapsulation technique based on non-equilibrium droplets via integrating electrospraying and interfacial polymerization(ES-IP)was established to efficiently microencapsulate epoxy monomers.The ES-IP technique,consisting of three continuous steps,i.e.electrospraying to massively generate droplets,enwrapping every single droplet through instant interfacial polymerization,and thickening shell at an elevated temperature,has great flexibility to regulate the microencapsulation process and the microcapsule quality.The fabricated core-shell structured epoxy microcapsules(Ep-MCs)were comprehensively characterized for their properties,showing that they have high cleanness with rare impurities,controllable and tunable size,good thermal stability and tightness,and high effective core fraction.The high-quality Ep-MCs were adopted to formulate a self-healing epoxy based on the microencapsulated epoxy-amine chemistry.The highest healing efficiency,in terms of the recovered mode I fracture toughness,of 110±17%was achieved after being healed at room temperature(~25℃)for 48 h.While the developed ES-IP technique facilitates the microencapsulation technique based on non-equilibrium droplets,the fabricated high-quality Ep-MCs greatly promote the further developments of the practical self-healing materials. | He Zhang Kaibin Xiao Zhilin Lin Shengyu Shi | 2022 | Journal of Materials Science & Technology2022，，17： | 1 |
| 9 | Deforming TC6 titanium alloys at ultrahigh strain rates during multiple laser shock peening显示文摘 | Liucheng Zhou Yinghong Li Weifeng He Guangyu He Xiangfan Nie Donglin Chen Zhilin Lai Zhibin An | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 10 | Enzymatic production of biodiesel from pistacia chinensis bge seed oil using immobilized lipase 显示文摘 | Li Xun He Xiaoyun Li Zhilin | 2011 | Fuel2011，92，1： | 1 |
| 11 | ZrO 2 insulator modified by a thin Al 2 O 3 film to enhance the performance of InGaZnO thin-film transistor显示文摘 | Xingwei Ding Jianhua Zhang Hao Zhang He Ding Chuanxin Huang Jun Li Weimin Shi Xueyin Jiang Zhilin Zhang | 2014 | Microelectronics Reliability2014，，： | 1 |
| 12 | Preparation of cinnamic hydroxamic acid collector and study on flotation characteristics and mechanism of scheelite显示文摘In this paper,using methyl cinnamate as raw material,the new cinnamic hydroxamic acid collector(CIHA)was synthesized by the hydroxylamine method.The collector performance of hydroxamic acid was investigated for scheelite and gangue calcite,and the flotation separation test of scheelite and calcite was carried out with CIHA as the collector.The interaction mechanism between hydroxamic acid and scheelite minerals has also been investigated through zeta potential,Fourier transform infrared spectroscopy(FTIR)experiments,X-ray photoelectron spectroscopy(XPS)experiments,and density functional theory(DFT)calculation.The single mineral flotation test and artificially mixed ore showed that CIHA had an excellent collection effect and selectivity.Zeta potential,FTIR,and XPS showed that CIHA was adsorbed on the scheelite surface by strong chemical adsorption.The active group of CIHA was analyzed through quantum chemical calculation.It was speculated that C=O and N-O bonds could synthesize a five-membered chelated hydroxamic acid group with Ca element chelate on scheelite surface,changing hydrophobicity and making it more likely to emerge from the pulp. | Xiang Yao Xinyang Yu Liping Wang Yuhui Zeng Linghan Mao Shanming Liu Honghui Xie Guichun He Zhiqiang Huang Zhilin Liu | 2023 | International Journal of Mining Science and Technology2023，33，6： | 1 |
| 13 | Boosting anapole-exciton strong coupling in all-dielectric heterostructures显示文摘The light manipulation beyond the diffraction limit plays an invaluable role in modern physics and nanophotonics.In this work,we have demonstrated a strong coupling with a large Rabi splitting of 151 me V between bulk WS_(2)excitons and anapole modes in the WS_(2)-Si nanodisk heterostructure array with nanoholes as small as 50 nm radius.This result is acquired by introducing anapole modes to suppress radiative losses to confine light into subwavelength volumes and large spatial overlapping between excitons and strong optical fields.Our work shows that anapole modes may serve as a powerful way to enhance the interaction between light and matter at nanoscales,and it should pave an avenue toward high-performance all-dielectric optoelectronic applications. | JINGYU WANG WEIMIN YANG GUOYA SUN YONGLIN HE PEIWEN REN ZHILIN YANG | 2022 | Photonics Research2022，10，7： | 0 |
| 14 | Reconstructing early Eocene(~55 Ma) paleogeographic boundary conditions for use in paleoclimate modelling显示文摘The early Eocene is a period with very high atmospheric CO2 levels, which receives many interests from climate modelling aspects. To simulate the early Eocene paleoclimate, a realistic reconstruction for land-sea distribution, paleotopography and paleobathymetry is the fundamental step. Here, we present global paleogeographic reconstructions for the early Eocene(~55 Ma), based on integrated paleogeographic data set, the plate-tectonic reconstruction software(GPlates) and geographic information system software(ArcGIS). Comparing with previous paleogeographic reconstructions, we improve the reconstructions by incorporating many recent geologic data and data set, including:(1) Better representations of the Tethys Sea,some marginal or inland seas in the East and Southeast Asia, Atlantic and Arctic region, and the Drake Passage and Tasmanian Gateway;(2) integrated paleoelevation data of global high plateaus and mountains, especially the paleotopography of East Asia,and adopting the latest paleotopographic reconstruction data of the Antarctica;and(3) using the latest data set of oceanic crust paleo-age and oceanic sediment thickness to reconstruct the paleobathymetry. | Zhilin HE Zhongshi ZHANG Zhengtang GUO | 2019 | Science China Earth Sciences2019，62，9： | 0 |
| 15 | A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19显示文摘Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort. | Bo Gong Lulin Huang Yongquan He Wen Xie Yi Yin Yi Shi Jialing Xiao Ling Zhong Yi Zhang Zhilin Jiang Fang Hao Yu Zhou Huan Li Li Jiang Xingxiang Yang Xiangrong Song Yan Kang Lin Tuo Yi Huang Ping Shuai Yuping Liu Fang Zheng Zhenglin Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
| 16 | Multilayer dielectric grating pillar-removal damage induced by a picosecond laser显示文摘Multilayer dielectric gratings typically remove multiple-grating pillars after picosecond laser irradiation;however,the dynamic formation process of the removal is still unclear.In this study,the damage morphologies of multilayer dielectric gratings induced by an 8.6-ps laser pulse were closely examined.The damage included the removal of a single grating pillar and consecutive adjacent grating pillars and did not involve the destruction of the internal high-reflection mirror structure.Comparative analysis of the two damage morphological characteristics indicated the removal of adjacent pillars was related to an impact process caused by the eruption of localized materials from the left-hand pillar,exerting impact pressure on its adjacent pillars and eventually resulting in multiple pillar removal.A finite-element strain model was used to calculate the stress distribution of the grating after impact.According to the electric field distribution,the eruptive pressure of the dielectric materials after ionization was also simulated.The results suggest that the eruptive pressure resulted in a stress concentration at the root of the adjacent pillar that was sufficient to cause damage,corresponding to the experimental removal of the adjacent pillar from the root.This study provides further understanding of the laser-induced damage behavior of grating pillars and some insights into reducing the undesirable damage process for practical applications. | Kun Shuai Xiaofeng Liu Yuanan Zhao Keqiang Qiu Dawei Li He Gong Jian Sun Li Zhou Youen Jiang Yaping Dai Jianda Shao Zhilin Xia | 2022 | High Power Laser Science and Engineering2022，10，6： | 0 |
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