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| 1 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 2 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 3 | Energy dependence on modes of electric activities of neuron driven by different external mixed signals under electromagnetic induction显示文摘Energy supply and release play an important role in individual neuron and neural network. In this paper, the electrical activities and Hamilton energy of neuron are investigated when external mixed signals(i.e., the periodic stimulus current and the periodic electromagnetic field) are imposed on the neuron under the electromagnetic induction. As a result, the Hamilton energy is much dependent on the mode transition, the multiple electric activity modes and the numerical analysis of Hamilton energy are more complicated under various parameters. When the periodic high-low frequency electromagnetic radiation is imposed in neuron, it is found that the electrical activities are more complex, and the changing of energy is obvious. In addition, the response of electrical activity and Hamilton energy is much dependent on the changing of amplitude A, B when the external high-low frequency signal is imposed on the neuron, meanwhile, the energy of bursting state is lower than the one of spiking state. It can be used for investigation about the energy coding in the neuron even the neuron networks. | LU LuLu JIA Ya XU Ying GE MengYan YANG LiJian ZHAN Xuan | 2019 | Science China(Technological Sciences)2019，62，3： | 8 |
| 4 | Pathways related to PMA-differentiated THP1 human monocytic leukemia cells revealed by RNA-Seq显示文摘Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate(PMA). However, little is known about the mechanism responsible for regulating this differentiation process. Here, we performed high-throughput RNA-Seq analysis to investigate the genes differently expressed in THP1 cells treated with and without PMA and examined those that may be responsible for the PMA-induced differentiation of monocytes into macrophages. We found 3,000 genes to be differentially expressed after PMA treatment. Gene ontology analysis revealed that genes related to cellular processes and regulation of biological processes were significantly enriched. KEGG analysis also demonstrated that the differentially expressed genes(DEGs) were significantly enriched in the PI3K/AKT signaling pathway and phagosome pathway. Importantly, we reveal an important role of the PI3K/AKT pathway in PMA-induced THP1 cell differentiation. The identified DEGs and pathways may facilitate further study of the detailed molecular mechanisms of THP1 differentiation. Thus, our results provide numerous potential therapeutic targets for modulation of the differentiation of this disease. | ZENG ChengWu WANG WenTao YU XiBao YANG LiJian CHEN ShaoHua LI YangQiu | 2015 | Science China(Life Sciences)2015，58，12： | 7 |
| 5 | Capillary blood flow in patients with dysmenorrhea treated with acupuncture显示文摘OBJECTIVE: To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into variousTraditional Chinese Medicine(TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu(LI 4), adding other acupoints based on syndrome. Laser speckle was used to compare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu(LI 4) before and during the treatment. Each subject was required to finish the period pain symptoms observation form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxiety scale, and numerical rating scale before and after treatments. RESULTS: After 10 sessions, the symptom scores, pain index(PI), and visual analog scale(VAS) decreased significantly in treatment group. The volume of blood flow in Hegu(LI 4) declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vasomotor amplitude at Hegu(LI 4) increased remarkably. CONCLUSION: Acupuncture can increase the capillary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief. | Tao Huang Lijian Yang Shuyong Jia Xiang Mu Mozheng Wu Hang Ye Weizhe Liu Xinnong Cheng | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 6 | Review of the decomposition characteristics of eco-friendly insulation gas显示文摘As one of the major concerns of climate change,identifying a proper eco‐friendly insulation gas for replacing sulphur hexafluoride(SF_(6))becomes a prominent research topic in recent years.c-C_(4)F_(8),CF_(3)I,C_(5)F_(10O),C_(6)F_(12O)and C4F7N are some potential al-ternatives that are proved to have excellent characteristics,including high insulation strengths and low Global Warming Potentials(GWPs).Beyond these key factors,the decomposition products of these alternatives are closely related to the gases'insulation performance,as well as the safety of operators and the compatibility with other materials.In addition,the type and content of decomposition products can be used for fault diagnosis.Therefore,a number of studies were carried out to reveal the decomposition mechanism of these alternative gases,and then to explore the gases'application feasibility and strategy.The recent advances obtained in these studies,including theoretical calcu-lation methods,detection of gas decomposition products,decomposition mechanism are reviewed,and some perspectives for future works are proposed.It is concluded that the phenomenon of solid matter precipitation in c-C_(4)F_(8)and CF_(3)I gas decomposition cannot be ignored and that more research is needed to reveal the influence of buffer gases,micro‐aerobic,micro‐water and other impurities on the gas decomposition process. | Yuan Yang Keli Gao Lijian Ding Jiangang Bi Shuai Yuan Xianglian Yan | 2021 | High Voltage2021，6，5： | 3 |
| 7 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 8 | Improved Photovoltaic Performance of MEH-PPV/PCBM Solar Cells via Incorporation of Si Nanocrystals显示文摘当器官的体积异质接面太阳能电池的性能上的第三个部件创作了,我们学习了硅 nanocrystals (SiNCs ) 的效果 poly [2-methoxy,5-(2-ethylhexyloxy )-1,4-phenylene vinylene ](MEH-PPV ):[6,6 ]-phenyl-C61-butyric 酸甲基酉旨(PCBM ) 混合电影。由增加 SiNCs 的合适的数量进 MEH-PPV : PCBM 混合,象外部量效率那样的设备表演,短路电流密度(JSC ) ,和功率变换效率(PCE ) 改善了。在混合的 2.5% SiNCs 的加入导致了 JSC 的 13.6% 改进,它接着导致了 PCE 的 18% 改进直到 2.28% 。改进表演在阴极在从 MEH-PPV/SiNCs 和费用收集的接口的费用产生两个都主要由于改进。 | Quanxiang Yan Lijian Zuo Zhuowei Gu Ligong Yang Rong Wang Mang Wang Hongzheng Chen | 2013 | Chinese Journal of Chemistry2013，31，11： | 2 |
| 9 | Adjuvant chemotherapy may improve outcome of patients with non-small-cell lung cancer with metastasis of intrapulmonary lymph nodes after systematic dissection of N1 nodes显示文摘Objective: Survival benefit of adjuvant chemotherapy(AC) of patients with intrapulmonary lymph node(IPLN)metastasis(level 12-14) needs investigation.We evaluated the impact of AC on patients whose metastatic nodes were limited to intrapulmonary levels after systematic dissection of N1 nodes.Methods: First,155 consective cases of lung cancer confirmed as pathologic N1 were collected and evaluated.Patients received systematic dissection of N2 and N1 nodes.For patients with IPLN metastasis,survival outcomes were compared between those receiving AC and those not receiving AC.Results: In this group,112 cases(72.3%) had IPLN metastasis and 55 cases(35.5%) had N1 involvement limited to level 13-14 without further disease spread to higher levels.Patients with IPLN involvement had a better prognosis than that of patients with hilar-interlobar involvement.For the intrapulmonary N1 group(level 12-14-positive,level 10-11-negative or unknown,n=112),no survival benefit was found between the AC group and nonAC group [5-year overall survival(OS): 54.6±1.6 vs.50.4±2.4 months,P=0.177].However,76 of 112 cases for whom harvesting of level-10 and level-11 nodes was done did not show cancer involvement in pathology reports(level 12-14-positive,level 10-11 both negative),oncologic outcome was better for patients receiving AC than those not receiving AC in this subgroup(5-year OS: 57.3±1.5 vs.47.1±3.2 months,P=0.002).Conclusions: Oncologic outcome may be improved by AC for patients with involvement of N1 nodes limited to intrapulmonary levels after complete examination of N1 nodes. | Xing Wang Shi Yan Yaqi Wang Xiang Li Chao Lyu Yuzhao Wang Jia Wang Shaolei Li Lijian Zhang Yue Yang Nan Wu | 2018 | Chinese Journal of Cancer Research2018，30，6： | 2 |
| 10 | A New Family of Galeaspids(Jawless Stem-Gnathostomata) from the Early Silurian of Chongqing, Southwestern China显示文摘A new genus and species of agnathan Eugaleaspidiformes(Galeaspida), Yongdongaspis littoralis gen. et sp. nov., is described from the Llandovery(lower Silurian) Huixingshao Formation at Yongdong Town, Xiushan County, Chongqing, southwestern China. This new Telychian taxon morphologically exhibits some transitional states between Sinogaleaspidae and a cluster of higher eugaleaspidiforms containing Tridensaspidae, Eugaleaspidae, Yunnanogaleaspis, and Nochelaspis, which we term here as the ’eugaleaspid cluster’. Phylogenetic analysis of an extended character matrix of Galeaspida reveals Yongdongaspis, on which Yongdongaspidae fam. nov. is erected, as the sister taxon of this ’eugaleaspid cluster’, supported by two synapomorphies, the presence of one median transverse canal, and two lateral transverse canals leaving from the infraorbital canal. As the first fish described from the Llandovery Huixingshao Formation in Chongqing, Yongdongaspis provides new fossil evidence for the subdivision and correlation of the Upper Red Beds in South China. | CHEN Yang GAI Zhikun LI Qiang WANG Jianhua PENG Lijian WEI Guangbiao ZHU Min | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 2 |
| 11 | Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer显示文摘A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large core fibers and a focus lens,and a highly sensitive spectrum meter.The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality.A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed,based on the differences in half-height width(HHW)in 1200cm^-1 to 1400cm^-1 frequency band and the ratios of the spectral integral energy between 1600cm^-1-1700cm^-1 and 1500cm^-1- 1600cm^-1 band.It shows a high specificity and effectivity for the diagnosis of esophageal cancer. | Jianhua DAI Xiu HE Zhuoyue LI Kang LI Tingting YANG Zengling RAN Lijian YIN Yao CHEN Xiang ZOU Dianchun FANG Guiyong PENG | 2019 | Photonic Sensors2019，9，1： | 2 |
| 12 | Nonparametric lag selection for time series显示文摘 | Rolf Tschernig and Lijian Yang | 2000 | Journal of Time Series analysis2000，4，： | 1 |
| 13 | A Semiparametric GARCH Model for Foreign Exchange Volatility显示文摘 | Yang Lijian | 2006 | Journal of Econometrics2006，130，2： | 1 |
| 14 | The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways显示文摘 | Yu Peng Huixiang Yang Tingting Zhu Menghua Zhao Yuexia Deng Bin Liu Hong Shen Gaoyun Hu Zhaohe Wang Lijian Tao | 2013 | Eur J Clin Invest2013，，4： | 1 |
| 15 | Wireless positioning and path tracking for a mobile platform in greenhouse显示文摘In order to realize intelligent greenhouse,an automatic navigation method for a mobile platform based on ultra-wideband(UWB)positioning technology was proposed and validated in this study.The time difference of arrival(TDOA)approach was used to monitor and track the UWB positioning to obtain the localization information of the mobile platform working in a greenhouse.After applying polynomial fitting for positioning error correction,the system accuracy was within 5 mm.A fuzzy controller model was constructed by incorporating the lateral and heading deviations as input variables and the steering angle of front wheel as the output variable.A fuzzy rule was established based on domain knowledge,as well as the steering angle of front wheel offline query table,which was applied to alleviate the calculative load of the controller.Experimental results confirmed that the automatic navigation method proposed in this study performed satisfactorily,with a steady-state error ranging from 41 mm to 79 mm when tracking straight line,and an average error of 185 mm and an average maximum error of 532 mm when tracking polygon.In addition,the maximum error occurred at the polygonal corner which could meet the needs of driving on the narrow road in the greenhouse.The method proposed in this study provides a new systematic approach for the research of greenhouse automatic navigation. | Lijian Yao Dong Hu Chao Zhao Zidong Yang Zhao Zhang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，1： | 1 |
| 16 | Opportunities and challenges of using big data for global health显示文摘The past two decades have witnessed the burgeoning of enormous digital technologies and data collected via countless channels.They are combined in numerous ways in different fields,including epidemiology,mHealth and modeling of health systems,with the intention to improve human health(e.g.,clinical decision support,electronic medical record management)[1-6].However,this is a new interdisciplinary area where no single scientific discipline knows how to take full advantage of these data and technologies to solve health problems[1]. | Peng Jia Hong Xue Shiyong Liu Hao Wang Lijian Yang Therese Hesketh Lu Ma Hongwei Cai Xin Liu Yaogang Wang Youfa Wang | 2019 | Science Bulletin2019，64，22： | 1 |
| 17 | A semiparametric GARCH model for foreign exchange volatility 显示文摘 | LIJIAN YANG | 2006 | Journal of Econometrics2006，130，2： | 1 |
| 18 | Experimental Study of ELID Grinding Based on the Active Con- trol of Oxide Layer显示文摘 | Yang Lijian Ren Chengzu Jin Xinmin | 2010 | Journal of Materials Pro eessing Teehnology2010，210，： | 1 |
| 19 | The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways显示文摘 | Yu Peng Huixiang Yang Tingting Zhu Menghua Zhao Yuexia Deng Bin Liu Hong Shen Gaoyun Hu Zhaohe Wang Lijian Tao | 2013 | Eur J Clin Invest2013，，4： | 1 |
| 20 | Noise-induced bursting and coherence resonance in minimal cytosolic Ca2+ oscil- lation model显示文摘 | Jia Ya Yang Lijian Wu Dan | 2004 | Chin Phys Lett2004，21，8： | 1 |
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