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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Climate sensitivities of two versions of FGOALS model to idealized radiative forcing显示文摘Projections of future climate change by climate system models depend on the sensitivities of models to specified greenhouse gases.To reveal and understand the different climate sensitivities of two versions of LASG/IAP climate system model FGOALS-g2 and FGOALS-s2,we investigate the global mean surface air temperature responses to idealized CO2 forcing by using the output of abruptly quadrupling CO2 experiments.The Gregory-style regression method is used to estimate the'radiative forcing'of quadrupled CO2 and equilibrium sensitivity.The model response is separated into a fast-response stage associated with the CO2 forcing during the first 20 years,and a slow-response stage post the first 20 years.The results show that the radiative forcing of CO2 is overestimated due to the positive water-vapor feedback and underestimated due to the fast cloud processes.The rapid response of water vapor in FGOALS-s2 is responsible for the stronger radiative forcing of CO2.The climate sensitivity,defined as the equilibrium temperature change under doubled CO2 forcing,is about 3.7 K in FGOALS-g2 and4.5 K in FGOALS-s2.The larger sensitivity of FGOALS-s2 is due mainly to the weaker negative longwave clear-sky feedback and stronger positive shortwave clear-sky feedback at the fast-response stage,because of the more rapid response of water vapor increase and sea-ice decrease in FGOALS-s2 than in FGOALS-g2.At the slow-response stage,similar to the fast-response stage,net negative clear-sky feedback is weaker in FGOALS-s2.Nevertheless,the total negative feedback is larger in FGOALS-s2 due to a larger negative shortwave cloud feedback that involves a larger response of total cloud fraction and condensed water path increase.The uncertainties of estimated forcing and net feedback mainly come from the shortwave cloud processes. | CHEN XiaoLong ZHOU TianJun GUO Zhun | 2014 | Science China Earth Sciences2014，57，6： | 19 |
| 3 | An improved diagnostic stratocumulus scheme based on estimated inversion strength and its performance in GAMIL2显示文摘Based on satellite data and the estimated inversion strength(EIS) derived by Wood et al.(2006), a feasible and uncomplicated stratocumulus scheme is proposed, referred to as EIS scheme. It improves simulation of cloud radiative forcing(CRF) in the Grid-point Atmospheric Model of IAP/LASG version 2(GAMIL2.0) model. When compared with the original lower troposphere stability(LTS) scheme, the EIS scheme reproduces more reasonable climatology distributions of clouds and CRF. The parameterization partly corrects CRF underestimation at mid and high latitudes and overestimation in the convective region. Such improvements are achieved by neglecting the effect of free-tropospheric stratification changes that follow a cooler moist adiabat at middle and high latitude, thereby improving simulated cloudiness. The EIS scheme also improves simulation of the CRF interannual variability. The positive net CRF and negative stratiform anomaly in the East Asian and western North Pacific monsoon regions(EAWNPMR) are well simulated. The EIS scheme is more sensitive to sea surface temperature anomalies(SSTA) than the LTS. Therefore, under the effect of a warmer SSTA in the EAWNPMR, the EIS generates a stronger negative stratiform response, which reduces radiative heating in the low and mid troposphere, in turn producing strong subsidence and negative anomalies of both moisture and cloudiness. Consequent decreases in cloud reflection and shading effects ultimately improve simulation of incoming surface shortwave radiative fluxes and CRF. Because of the stronger subsidence, a stronger anomalous anticyclone over the Philippines Sea is simulated by the EIS run, which leads to a better positive precipitation anomaly in eastern China during ENSO winter. | GUO Zhun ZHOU TianJun | 2014 | Science China Earth Sciences2014，57，11： | 11 |
| 4 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 5 | Physclon, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma显示文摘Physcion 是在繁体中文药根值 et 根茎 Rhei 的主要 bioactive 成分,它有 anthraquinone 化学药品结构并且展出包括的许多药理学活动缓泻, hepatoprotective,反煽动性,抗菌剂和 anti-proliferative 效果。在这研究,我们在 vitro 并且在位于反肿瘤 action.Methods 下面的 vivo,以及机制在人的鼻咽的癌上调查了 physcion 的效果:鼻咽的癌房间线 CNE2 与 physcion 被对待,并且房间生存能力用 MTT 和殖民地形成试金被检测。流动 cytometry 被用来估计房间周期拘捕, mitochondrial 膜潜力损失, apoptosis, autophagy 和细胞内部的 ROS 产生。Apoptotic 房间死亡被 TUNEL 试金也证实。目标或标记分子的表示用西方的弄污被决定。caspase-3 的活动, 8,和 9 与一个 ELISA 工具包被检测。异种皮移植鼠科的模型被用来评估在里面 physcion 的 vivo 反肿瘤行动,老鼠被管理 physcion (10, 20 mg 畬楳湯?? | Ming-jie PANG Zhun YANG Xing-lin ZHANG Zhao-fang LIU Jun FAN Hong-ying ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 9 |
| 6 | Identification and screening of nitrogenefficient cotton genotypes under low and normal nitrogen environments at the seedling stage显示文摘Background: Large quantities of nitrogen(N) fertilizer applied to cotton cropping systems support high yields but cause adverse environmental impacts such as N_20 emission and water eutrophication. The development of cotton cultivars with higher N use efficiencies suitable for low-N conditions is therefore important for sustainable production. In this study, we evaluated 100 cotton genotypes in 2016 for N use efficiency and related traits at the seedling stage.Methods: Sand culture experiment was conducted with low N levels(0.01 g·kg^(-1)) or normal N levels(0.1 g·kg^(-1)).We investigated plant height, SPAD value(soil plant analysis development chlorophyll meter), dry weight, N accumulation, N utilization efficiency, and N uptake efficiency. Through descriptive statistics, principal component analysis and heatmap clustering analysis, we confirmed the evaluation index system of N-efficient genotypes and the classification of N-efficient genotypes.Results: Significant differences were observed among N levels and genotypes for all agronomic traits and N levels.Coefficients of variation varied greatly and ranged from 6.7~28.8 and 7.4~20.8 under low-N and normal-N treatment, respectively. All traits showed highly significant positive correlations with each other, except SPAD value.The principal components under both N levels were similar, showing that total dry weight, aboveground dry weight, total N accumulation, and N uptake efficiency were important components. We confirmed these four traits as suitable screening indexes for low N tolerance. Based on the results of heatmap clustering and scatter diagram analysis of N efficiency value, 10 genotypes were found low-N tolerant, in which five varieties were inefficient under both low and normal N conditions, while four varieties were found efficient under low-N conditions but inefficient under normal-N conditions. Only one variety was efficient under both low and normal-N conditions. Meanwhile, 20 genotypes were identified as low-N sensitive ones, in which 19 genotypes were inefficient under low-N conditions but efficient under normal-N conditions, one variety was inefficient under both low and normal-N conditions.Conclusion: We preliminarily identified Kashi as a low-N tolerant and N-efficient cotton genotype, and CCRI 64 as a lowN sensitive and N-inefficient cotton genotype. Further studies should be carried out to verify the yield and heritability effect of specific genotypes in the field. | ZHANG Hengheng FU Xiaoqiong WANG Xiangru GUI Huiping DONG Qiang PANG Nianchang WANG Zhun ZHANG Xiling SONG Meizhen | 2018 | Journal of Cotton Research2018，1，2： | 9 |
| 7 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 8 | Analysis of finite-element-based methods for reducing the ill-posedness in the reconstruction of fluorescence molecular tomography显示文摘The major issue in reconstruction of optical imaging might be the ill-posedness of the problem. In this paper, four different algorithms, including singular value decomposition (SVD), the truncated SVD, Tikhonov regularization and adaptive regularization, are analyzed and applied for solving the matrix equation generated from diffuse equation based on finite-element method in fluorescence molecular tomography. Results illustrate the need for either imposition of regularization term or elimination of too small singular values in reducing the illposedness. The results also suggest that the adaptive-regularization method offers superior performance in the reconstruction among the four methods in most cases even if the initially selected regularization parameter is not optimal, thus providing the convenience for the reconstruction. | Zhun Xu, Jing Bai Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，4： | 6 |
| 9 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 10 | Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma显示文摘AIM:To investigate the promoter region methylation status of retinoblastoma protein-interacting zinc finger gene 1(RIZ1) in the human esophageal squamous cell carcinoma(ESCC) cell lines and tissues and verify the relationship between methylation of RIZ1 and oncogenesis,tumor progression and metastasis etc of ESCC.METHODS:Methylation-specific polymerase chain reaction(MSP) was used to investigate the promoter region methylation status of RIZ1 in 6 ESCC cell lines.One cell line where RIZ1 promoter region methylation was detected was selected for the next study,where the cell line was treated with 5-aza-CdR.Real-time polymerase chain reaction was used to investigate its influence on the transcription of RIZ1.Experiments using frozenpathological specimens from 47 ESCC patients were performed using the same MSP methodology.RESULTS:Promoter methylation of RIZ1 gene was detected in TE13,CaEs17 and EC109 cell lines and the cell line TE13 was chosen for further study.The expression of RIZ1 mRNA in TE-13 was up-regulated after treatment with 5-aza-CdR.The rate of methylation in carcinomas tissues was significantly higher than those in matched neighboring normal and distal ending normal tissue,and the deviation of data was statistically significant(χ 2 = 24.136,P < 0.01).Analysis of the gender,age familial history,tumour deviation,tumour saturation,lymph gland displacement and clinical staging of 47 samples from ESCC patients showed that the fluctuation of data was not statistically significant.CONCLUSION:Promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human ESCC.RIZ1 is considered to be a potential tumor suppressor gene and may be a biological parameter for testing early stage human ESCC. | Shang-Wen Dong Peng Zhang Yi-Mei Liu Yuan-Tao Cui Shuo Wang Shao-Jie Liang Zhun He Pei Sun Yuan-Guo Wang | 2012 | World Journal of Gastroenterology2012，18，6： | 6 |
| 11 | Autophagy Attenuates MnCl2-induced Apoptosis in Human Bronchial Epithelial Cells显示文摘Objective To investigate the role of autophagy in MnC l2-induced apoptosis in human bronchial epithelial 16 HBE cells.Methods Cell proliferation was measured by MTT assay.Mitochondrial membrane potential(MMP) and apoptosis were measured by flow cytometry.Autophagic vacuoles were detected by fluorescence microscopy.Cellular levels of apoptosis and autophagy-related proteins were measured by western blotting.Results 16 HBE cell proliferation was inhibited by Mn Cl2 in a dose-and time-dependent manner.Mn Cl2-induced 16 HBE cell growth inhibition was related to MMP depolarization prior to the induction of apoptosis.Our data revealed that Mn Cl2-induced apoptosis in 16 HBE cells was mediated by decreased expression of Bcl-2 and increased levels of cleaved caspase-3.It was observed that when we exposed 16 HBE cells to MnCl_2 in a dose-dependent manner,the formation of autophagic vacuoles and the levels of LC-3B-II were elevated.RNA interference of LC3 B in these Mn Cl2-exposed cells demonstrated that MMP loss and apoptosis were enhanced.Additionally,the pan-caspase inhibitor Z-VAD-FMK increased the cellular levels of Bcl-2 and decreased apoptosis,but did not affect the cellular levels of LC3 B in Mn Cl2-treated 16 HBE cells.Conclusion Mn Cl2 dose-and time-dependently inhibits 16 HBE cell proliferation and induces MMP loss and apoptosis.Autophagy acts in a protective role against Mn Cl2-induced apoptosis in 16 HBE cells. | YUAN Zhun YING Xian Ping ZHONG Wei Jian TIAN Shi Min WANG Yu JIA Yong Rui CHEN Wen FU Juan Ling ZHAO Peng ZHOU Zong Can | 2016 | Biomedical and Environmental Sciences2016，29，7： | 5 |
| 12 | Seasonal Variation and Physical Properties of the Cloud System over Southeastern China Derived from Cloud Sat Products显示文摘Based on the National Centers for Environmental Prediction(NCEP) and Climate Prediction Center(CPC) Merged Analysis of Precipitation(CMAP) data and Cloud Sat products, the seasonal variations of the cloud properties, vertical occurrence frequency, and ice water content of clouds over southeastern China were investigated in this study. In the Cloud Sat data, a significant alternation in high or low cloud patterns was observed from winter to summer over southeastern China. It was found that the East Asian Summer Monsoon(EASM) circulation and its transport of moisture leads to a conditional instability, which benefits the local upward motion in summer, and thereby results in an increased amount of high cloud. The deep convective cloud centers were found to coincide well with the northward march of the EASM, while cirrus lagged slightly behind the convection center and coincided well with the outflow and meridional wind divergence of the EASM. Analysis of the radiative heating rates revealed that both the plentiful summer moisture and higher clouds are effective in destabilizing the atmosphere. Moreover, clouds heat the mid-troposphere and the cloud radiative heating is balanced by adiabatic cooling through upward motion, which causes meridional wind by the Sverdrup balance. The cloud heating–forced circulation was observed to coincide well with the EASM circulation, serving as a positive effect on EASM circulation. | GUO Zhun ZHOU Tianjun | 2015 | Advances in Atmospheric Sciences2015，32，5： | 5 |
| 13 | Fig fruit ripening is regulated by the interaction between ethylene and abscisic acid显示文摘Fleshy fruit ripening is typically regulated by ethylene in climacteric fruits and abscisic acid(ABA)in non-climacteric fruits.Common fig(Ficus carica)shows a dual-ripening mechanism,which is not fully understood.Here,we detected separate peaks of ethylene and ABA in fig fruits at the onset-and onripening stages,in conjunction with a sharp rise in glucose and fructose contents.In a newly-designed split-fruit system,exogenous ethylene failed to rescue fluridone-inhibited fruit ripening,whereas exogenous ABA rescued 2-amino-ethoxy-vinyl glycine(AVG)-inhibited fruit ripening.Transcriptome analysis revealed changes in the expression of genes key to both ABA and ethylene biosynthesis and perception during fig fruit ripening.At the degreening stage,downregulation of FcACO2 or FcPYL8 retarded ripening,but downregulation of FcETR1/2 did not;unexpectedly,downregulation of FcAAO3 promoted ripening,but it inhibited ripening only before the de-greening stage.Furthermore,we detected an increase in ethylene emissions in the FcAAO3-RNAi ripening fruit and a decrease in ABA levels in the FcACO2-RNAi unripening fruit.Importantly,FcPYL8 can bind to ABA,suggesting that it functions as an ABA receptor.Our findings support the hypothesis that ethylene regulates the fig fruit ripening in an ABA-dependent manner.We propose a model for the role of the ABA-ethylene interaction in climacteric/non-climacteric processes. | Han Qiao Han Zhang Zhun Wang Yuanyue Shen | 2021 | Journal of Integrative Plant Biology2021，63，3： | 5 |
| 14 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 15 | Reactive power optimization of a distribution network with high-penetration of wind and solar renewable energy and electric vehicles显示文摘As high amounts of new energy and electric vehicle(EV)charging stations are connected to the distribution network,the voltage deviations are likely to occur,which will further affect the power quality.It is challenging to manage high quality voltage control of a distribution network only relying on the traditional reactive power control mode.If the reactive power regulation potentials of new energy and EVs can be tapped,it will greatly reduce the reactive power optimization pressure on the network.Keeping this in mind,our reasearch first adds EVs to the traditional distribution network model with new forms of energy,and then a multi-objective optimization model,with achieving the lowest line loss,voltage deviation,and the highest static voltage stability margin as its objectives,is constructed.Meanwihile,the corresponding model parameters are set under different climate and equipment conditions.Ultimately,the optimization model under specific scenarios is obtained.Furthermore,considering the supply and demand relation-ship of the network,an improved technique for order preference by similarity to an ideal solution decision method is proposed,which aims to judge the adaptability of different algorithms to the optimized model,so as to select a most suitable algorithm for the problem.Finally,a comparison is made between the constructed model and a model without new energy.The results reveal that the constructed model can provide a high quality reactive power regula-tion strategy. | Biao Xu Guiyuan Zhang Ke Li Bing Li Hongyuan Chi Yao Yao Zhun Fan | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
| 16 | Computational functionality-driven design of semiconductors for optoelectronic applications显示文摘The rapid development of the semiconductor industry has motivated researchers passion for accelerating the discovery of advanced optoelectronic materials.Computational functionality-driven design is an emerging branch of material science that has become effective at making material predictions.By combining advanced solid-state knowledge and high-throughput firstprinciples computational approaches with intelligent algorithms plus database development,experts can now efficiently explore many novel materials by taking advantage of the power of supercomputer architectures.Here,we discuss a set of typical design strategies that can be used to accelerate inorganic optoelectronic materials discovery from computer simulations:In silico computational screening;knowledge-based inverse design;and algorithm-based searching.A few representative examples in optoelectronic materials design are discussed to illustrate these computational functionality-driven modalities.Challenges and prospects for the computational functionality-driven design of materials are further highlighted at the end of the review. | Zhun Liu Guangren Na Fuyu Tian Liping Yu Jingbo Li Lijun Zhang | 2020 | InfoMat2020，2，5： | 4 |
| 17 | Deceptive jamming discrimination based on range-angle localization of a frequency diverse array显示文摘针对电子对抗中的欺骗干扰鉴别问题,提出了基于频率分集阵列(frequency diverse array,FDA)的干扰鉴别方法。FDA波束具有距离—角度二维耦合特性,当波束聚焦距离与真实目标不一致时,会产生角误差信号,即干扰角度在相控阵中与真实目标一致,而在FDA中与真实目标不一致。因此,利用相控阵和FDA分别进行参数测量,比对测量结果即可实现干扰鉴别。提出了基于FDA进行干扰鉴别的具体流程,给出了两种双波束测量的实现方案,并对各方案的目标检测及参数估计性能进行了理论分析。仿真结果证明了该方法的有效性。 | Zhao-jian ZHANG Jun-wei XIE Chuan SHENG Zhun TANG | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，9： | 4 |
| 18 | Isolation of protoplast from callus of Populus euphratica and H^+ fluxes across plasma membrane under NaCl stress显示文摘We used callus of Populus euphratica Olive to isolate protoplasts, and H+ fluxes across plasma membrane were investi-gated. The concentration of enzymes for protoplast isolation, e.g. cellulase, pectolyase, macerozyme, hemicellulase, and sorbitol content, incubation time were systemically studied. High yield and viability of protoplast was achieved after 6-8 hours incubation of P. euphratica callus in enzyme solution containing 1.5% (w:v) cellulase R-10, 0.1% (w:v) pectolyase Y-23, 0.2% (w:v) macerozyme R-10, 0.05% (w:v) hemicellulase and 0.75-0.80 mol·L-1 sorbitol. Non-invasively ion selective microelectrode technique was used to access proton fluxes in the absence and presence of NaCl (20 mmol·L-1). Salt-induced transient net H+ efflux was observed in the plasma membrane of P. euphratica cells. The shift of H+ flux response to NaCl shock and the relevance to salt tolerance were discussed. | Gao Zhun Dai Song-xiang Chen Shao-liang Shen Xin Wang Rui-gang | 2007 | Forestry Studies in China2007，9，3： | 4 |
| 19 | A Robustness Analysis of CMIP5 Models over the East Asia-Western North Pacific Domain显示文摘 | Tianjun Zhou Xiaolong Chen Bo Wu Zhun Guo Yong Sun Liwei Zou Wenmin Man Lixia Zhang Chao He | 2017 | Engineering2017，3，5： | 4 |
| 20 | Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling显示文摘Objective:To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model,and the underlying mechanisms were partly dissected in vivo and in vitro.Methods:Thirty-two male mice were randomly divided into 4 groups,including control,model,low-and high-dose amygdalin-treated groups,8 mice in each group.Except the control group,mice in the other groups were injected intraperitoneally with 10%carbon tetrachloride(CCl4)-olive oil solution 3 times a week for 6 weeks to induce liver fibrosis.At the first 3 weeks,amygdalin(1.35 and 2.7 mg/kg body weight)were administered by gavage once a day.Mice in the control group received equal quantities of subcutaneous olive oil and intragastric water from the fourth week.At the end of 6 weeks,liver tissue samples were harvested to detect the content of hydroxyproline(Hyp).Hematoxylin and eosin and Sirius red staining were used to observe the inflammation and fibrosis of liver tissue.The expressions of collagenⅠ(Col-Ⅰ),alpha-smooth muscle actin(α-SMA),CD31 and transforming growth factorβ(TGF-β)/Smad signaling pathway were detected by immunohistochemistry,quantitative real-time polymerase chain reaction and Western blot,respectively.The activation models of hepatic stellate cells,JS-1and LX-2 cells induced by TGF-β1 were used in vitro with or without different concentrations of amygdalin(0.1,1,10μmol/L).The effect of different concentrations of amygdalin on the expressions of liver sinusoidal endothelial cells(LSECs)dedifferentiation markers CD31 and CD44 were observed.Results:High-dose of amygdalin significantly reduced the Hyp content and percentage of collagen positive area,and decreased the mRNA and protein expressions of Col-Ι,α-SMA,CD31 and p-Smad2/3 in liver tissues of mice compared to the model group(P<0.01).Amygdalin down-regulated the expressions of Col-Ⅰandα-SMA in JS-1 and LX-2 cells,and TGFβR1,TGFβR2 and p-Smad2/3 in LX-2 cells compared to the model group(P<0.05 or P<0.01).Moreover,1 and 10μmol/L amygdalin inhibited the mRNA and protein expressions of CD31 in LSECs and increased CD44 expression compared to the model group(P<0.05 or P<0.01).Conclusions:Amygdalin can dramatically alleviate liver fibrosis induced by CCl4 in mice and inhibit TGF-β/Smad signaling pathway,consequently suppressing HSCs activation and LSECs dedifferentiation to improve angiogenesis. | XIAO Zhun JI Qiang FU Ya-dong GAO Si-qi HU Yong-hong LIU Wei CHEN Gao-feng MU Yong-ping CHEN Jia-mei LIU Ping | 2023 | Chinese Journal of Integrative Medicine2023，29，4： | 3 |
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