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| 1 | The CAMS Climate System Model and a Basic Evaluation of Its Climatology and Climate Variability Simulation显示文摘A new coupled climate system model(CSM) has been developed at the Chinese Academy of Meteorological Sciences(CAMS) by employing several state-of-the-art component models. The coupled CAMS-CSM consists of the modified atmospheric model [ECmwf-HAMburg(ECHAM5)], ocean model [Modular Ocean Model(MOM4)], sea ice model [Sea Ice Simulator(SIS)], and land surface model [Common Land Model(CoLM)]. A detailed model description is presented and both the pre-industrial and 'historical' simulations are preliminarily evaluated in this study.The model can reproduce the climatological mean states and seasonal cycles of the major climate system quantities,including the sea surface temperature, precipitation, sea ice extent, and the equatorial thermocline. The major climate variability modes are also reasonably captured by the CAMS-CSM, such as the Madden–Julian Oscillation(MJO), El Ni?o–Southern Oscillation(ENSO), East Asian Summer Monsoon(EASM), and Pacific Decadal Oscillation(PDO).The model shows a promising ability to simulate the EASM variability and the ENSO–EASM relationship. Some biases still exist, such as the false double-intertropical convergence zone(ITCZ) in the annual mean precipitation field,the overestimated ENSO amplitude, and the weakened Bjerknes feedback associated with ENSO; and thus the CAMS-CSM needs further improvements. | Xinyao RONG Jian LI Haoming CHEN Yufei XIN Jingzhi SU Lijuan HUA Tianjun ZHOU Yanjun QI Zhengqiu ZHANG Guo ZHANG Jianduo LI | 2018 | Journal of Meteorological Research2018，32，6： | 15 |
| 2 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 3 | Wasserstein GAN-Based Small-Sample Augmentation for New-Generation Artificial Intelligence: A Case Study of Cancer-Staging Data in Biology显示文摘It is essential to utilize deep-learning algorithms based on big data for the implementation of the new generation of artificial intelligence. Effective utilization of deep learning relies considerably on the number of labeled samples, which restricts the application of deep learning in an environment with a small sample size. In this paper, we propose an approach based on a generative adversarial network (GAN) combined with a deep neural network (DNN). First, the original samples were divided into a training set and a test set. The GAN was trained with the training set to generate synthetic sample data, which enlarged the training set. Next, the DNN classifier was trained with the synthetic samples. Finally, the classifier was tested with the test set, and the effectiveness of the approach for multi-classification with a small sample size was validated by the indicators. As an empirical case, the approach was then applied to identify the stages of cancers with a small labeled sample size. The experimental results verified that the proposed approach achieved a greater accuracy than traditional methods. This research was an attempt to transform the classical statistical machine-learning classification method based on original samples into a deep-learning classification method based on data augmentation. The use of this approach will contribute to an expansion of application scenarios for the new generation of artificial intelligence based on deep learning, and to an increase in application effectiveness. This research is also expected to contribute to the comprehensive promotion of new-generation artificial intelligence. | Yufei Liu Yuan Zhou Xin Liu Fang Dong Chang Wang Zihong Wang | 2019 | Engineering2019，5，1： | 11 |
| 4 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 5 | Catalyst design strategies towards highly shape-selective HZSM-5 for paraxylene through toluene alkylation显示文摘With the shape selective zeolite catalyst,toluene alkylation with methanol to para-xylene(MTPX)technology could produce highly pure para-xylene(PX)in one step.The lower feedstock cost and less energy consumption in products separation make it more competitive compared to the current toluene disproportionation route.Thus,MTPX is regarded as the most reasonable production route for PX production.This article reviews the strategies that applied to the preparation of high-performance catalysts for MTPX,with special focus on the precise control of pore dimension and acid sites distribution in zeolite to achieve the highest selectivity to PX.The outlook of the MTPX catalyst is also proposed to guide the catalyst development in the field. | Xin Huang Ruizhuang Wang Xu Pan Chuanfu Wang Maohong Fan Yufei Zhu Yonggang Wang Jin Peng | 2020 | Green Energy & Environment2020，5，4： | 10 |
| 6 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 7 | A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model显示文摘Collagen is widely used in biomedical applications due to its outstanding properties.In this study,highly porous sponge scaffolds were developed by using porcine skin-derived collagen(PSC)and fish scale-derived collagen(FSC),respectively.The morphology and composition of these PSC and FSC scaffolds were compared.The water uptake ratio of FSC scaffolds reached 47.8,which is 1.7 times of PSC scaffolds.The water vapour transmission rates(WVTR)of PSC and FSC scaffolds were 952.6655.5 and 1090.9677.1 g/m2/day,which could produce a moist healing environment for wounds.Both scaffolds show non-toxicity to L929 fibroblast cells.The burn wound healing efficiency of these two scaffolds was examined in vivo using rabbits.No scars around the wounds were observed after applying PSC and SFC scaffolds.Histopathological studies reveal that the wound treated with PSC and FSC scaffolds showed much better wound recovery than gauze and vaseline gauze groups.It was suggested that FSC scaffolds have great potential as same as PSC to be used as burn wound dressing materials. | Yufei Shi Hongjian Zhang Xin Zhang Zhan Chen Dan Zhao Jun Ma | 2020 | Regenerative Biomaterials2020，7，1： | 6 |
| 8 | Response of the East Asian climate system to water and heat changes of global frozen soil using NCAR CAM model显示文摘在陆地空气热和水保存的条件下面,一套敏感数字实验被设置调查东方亚洲气候系统的反应到全球冻结的土壤变化。这被介绍 supercooled 土壤水过程进社区陆地模型(CLM3.0 ) 做,它被联合了到大气的研究社区空气模型(CAM3.1 ) 的国家中心。结果显示出那:(1 ) 在在 CLM3.0 的土壤冰和土壤水之间的比率被 supercooled 土壤水过程清楚地改变。地面表面温度和土壤温度也被影响。(2 ) 欧亚(包括的东方亚洲人) 气候系统在冻结的土壤区域对热和水的变化敏感。在 1 月,阿留申群岛之土人低海水平压力发行量被加强,在 500 hPa 高堵住的乌拉尔变弱,并且东方亚洲马槽变弱。在 7 月,在阿留申群岛之土人岛区域上的海水平压力显著地被减少;在东方亚洲海洋上有在东方亚洲大陆,和积极异例上的 500 hPa geopotential 高度的否定异例。(3 ) 在 1 月,在东亚上的 850 hPa 风地的南方的部件增加,显示削弱的冬季季风。在 7 月,当在海洋上有逆旋风的异例时,气旋的异例出现在东方亚洲大陆上,加强的东方海岸夏天季风反射。(4 ) 在东亚的夏天降雨显著地变化了,包括南部的 Qinghai 西藏高原,中央长江盆,和东北中国上的实质的降水增加。夏天降雨显著地在华南和海南岛减少了,但是稍微减少了在中央并且北方中国。进一步的分析沿着 30 显示出可观的上面的空气运动吗?? | XIN YuFei WU BingYi BIAN LinGen LIU Ge ZHANG Lin LI Ren | 2012 | Chinese Science Bulletin2012，57，34： | 5 |
| 9 | Geological and geochemical characteristics and metallogenic model of the Wenquan molybdenum deposit显示文摘The Wenquan molybdenum deposit is a kind of large-sized porphyry molybdenum deposit found in re-cent years.In this paper,on the basis of deposit geology,geochemistry and isotope geochronology data,the metal-logenic model of this deposit was established.The Wenquan granitic batholith belongs to the K-rich(alkali-rich) calc-alkaline rock series,which is the mineralization parent rock.The rock massif shows the characteristics of both crust-remelting granite and mantle-source granite.At the same time,the data of REE contents,hydrogen and oxygen isotopes and inclusion temperatures showed that the metallogenic hydrothermal solution is a mixed mesothermal solution of magmato-hydrothermal fluid and meteoric water.Mineralization was dated at 214±7.1 Ma,basically identical with the parent rock's age(207-226 Ma).This reflects that molybdenum mineralization has a close relation to tectonic magmatism evoked by orogenic processes,and molybdenum mineralization occurred mainly at the petrogenesis stage at the late stage of magma emplacement.Mixing with meteoric water led to a decrease in the sa-linity of magmato-hydrothermal solution and changes in other physical and chemical properties.During the tectonic process,ore-bearing hydrothermal solution ascended along favorable fault structure channels.With physicochemical changes,it filled in the surrounding rock joints on both sides of faults,forming ore deposits. | WU Zicheng LIU Jishun HAN Haitao DONG Xin OUYANG Yufei | 2011 | Chinese Journal Of Geochemistry2011，30，3： | 4 |
| 10 | Obtaining More Information about Precipitation Biases over East Asia from Hourly-Scale Evaluation of Model Simulation显示文摘The hourly summer precipitation simulations over East Asia by the Chinese Academy of Meteorological Science Climate System Model(CAMS-CSM)high-resolution Atmospheric Model Intercomparison Project(AMIP)runs(T255,~50 km)were evaluated based on the merged hourly precipitation product released by the China Meteorological Administration(CMA).The results show that the simulation biases are closely related to the topography,with the precipitation amount and frequency overestimated(underestimated),and duration of precipitation events being longer(shorter),over the western high-altitude(eastern plain)regions of China.Six regions with large discrepancies were further analyzed.In terms of the frequency-intensity structure,the overestimation of precipitation frequency is mainly due to the excessive simulated weak precipitation over the four regions with positive biases:the southern edge of the Tibetan Plateau(STP),the northeastern edge of the Tibetan Plateau(NETP),the eastern periphery of the Tibetan Plateau(EPTP),and the mountainous area of North China(NCM);while the underestimation of frequency is mainly due to the insufficient precipitation with moderate intensity over the two regions with negative biases:lower reaches of the Yangtze River(LYR)and the South China coast(SCC).Based on the duration-diurnal structure analysis,two kinds of precipitation events with different natures can be distinguished.The long-duration night to early morning precipitation events have a significant contribution to the precipitation amount biases for all the six key regions,and this kind of precipitation mainly affects the precipitation diurnal variation over the mountainous areas or steep terrain.Although the short-duration afternoon precipitation events only have a greater contribution to the precipitation amount biases over the SCC region,this kind of precipitation affects the diurnal variation over the NCM region and the two key regions with negative biases.Such a detailed hourly-scale evaluation is helpful for enriching the understanding of simulation biases and to further improve model performance. | Nina LI Jian LI Xinyao RONG Haoming CHEN Yufei XIN Jingzhi SU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 11 | Ultrafine monolayer Co-containing layered double hydroxide nanosheets for water oxidation显示文摘For many two-dimensional(2D)materials,low coordination edges and corner sites offer greatly enhanced catalytic performance compared to basal sites,motivating the search for new synthetic approaches towards ultrathin and ultrafine 2D nanomaterials with high specific surface areas.To date,the synthesis of catalysts that are both ultrathin(monolayer)and ultrafine(lateral size<10nm)has proven extremely challenging.Herein,using a facile ultrasonic exfoliation procedure,we describe the successful synthesis of ultrafine ZnCo-LDH nanosheets(denoted as ZnCo-UF)with a size^3.5 nm and thickness^0.5 nm.The single layer ZnCo-UF nanosheets possess an abundance of oxygen vacancies(Vo)and unsaturated coordination s让es,thereby affording outstanding electrocatalytic water oxidation performance.DFT calculations confirmed that Vo on the surface of ZnCo-UF enhanced H20 adsorption via increasing the electropositivity of the nanosheets. | Xiaodan Jia Xin Zhang Jiaqing Zhao Yufei Zhao Yunxuan Zhao Geoffrey I.N.Waterhouse Run Shi Li-Zhu Wu Chen-Ho Tung Tierui Zhang | 2019 | Journal of Energy Chemistry2019，28，7： | 3 |
| 12 | The CMIP6 Historical Simulation Datasets Produced by the Climate System Model CAMS-CSM显示文摘This paper describes the historical simulations produced by the Chinese Academy of Meteorological Sciences(CAMS)climate system model(CAMS-CSM),which are contributing to phase 6 of the Coupled Model Intercomparison Project(CMIP6).The model description,experiment design and model outputs are presented.Three members’historical experiments are conducted by CAMS-CSM,with two members starting from different initial conditions,and one excluding the stratospheric aerosol to identify the effect of volcanic eruptions.The outputs of the historical experiments are also validated using observational data.It is found that the model can reproduce the climatological mean states and seasonal cycle of the major climate system quantities,including the surface air temperature,precipitation,and the equatorial thermocline.The long-term trend of air temperature and precipitation is also reasonably captured by CAMS-CSM.There are still some biases in the model that need further improvement.This paper can help the users to better understand the performance and the datasets of CAMS-CSM. | Xinyao RONG Jian LI Haoming CHEN Jingzhi SU Lijuan HUA Zhengqiu ZHANG Yufei XIN | 2021 | Advances in Atmospheric Sciences2021，38，2： | 2 |
| 13 | Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study显示文摘Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident frailty.Therefore,we examined the cross-sectional associations of thyroid hormones(THs)with frailty as well as the five components characterizing frailty(fatigue,resistance,ambulation,number ofillnesses,and loss of weight)among the oldest-old.Methods:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District,Beijing,participated in our recruitment campaign between April 2019 and May 2020.The primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale(Fatigue,Resistance,Ambulation,Illnesses,Loss of weight)and a positive score for each frailty subdomain.Demographic information(age,sex,marital status,and educational status),comorbidities,and details on the participants lifestyles were recorded.Serum THs including free triodothyronin(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4)and thyroid stimulating hormone(TSH)levels were also measured at the beginning of our study.Logistic regressions were conducted to screen for potential risk factors for frailty and its subdomains.Results:Among the total 487 subjects at enrollment,60(12.23%)of them were diagnosed with subclinical hypothyroidism and 110(22.59%)of the total population scored positive for frailty.Logistic regression analyses adjusted for all potential confounders,showed that frailty was significantly associated with the serum TSH concentration(odds ratio[OR]:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism score(OR:2.18).The association between fT4 and frailty was absent in our observational study.The fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with frailty.Conclusion:Subclinical hypothyroidism,higher TSH level,lower fT3 level,and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among the community-dwelling oldest-old,suggesting a relevant role of thyroid function in aging.Future longitudinal studies are warranted to determine the casual relationship between thyroid dysfunction and frailty in the oldest-old. | Bo Guan Jiakun Luo Xin Huang Fan Tian Shasha Sun Yufei Ma Yan Yu Ruihan Liu Jian Cao Li Fan | 2022 | Chinese Medical Journal2022，135，16： | 2 |
| 14 | Effects of water stress on quality and sugar metabolism in'Gala'apple fruit显示文摘Sugar plays an important role in apple fruit development,appearance and quality as well as contributing to a plant’s water stress response.Trehalose and the trehalose biosynthetic metabolic pathways are part of the sugar signaling system in plants,which are important regulator of water stress response in apple.The effect of water stress treatments applied to apple trees and the corresponding effects of ABA on developmental fruit quality were examined for indicators of fruit quality during fruit development.The results indicated that the severe water stress treatment(W2)occurring after the last stage of fruit cell division caused a decrease in the color and size of fruit.The moderate water stress(W1)occurring after the last stage of fruit cell enlargement(S2)caused an increase in the content of fructose and sorbitol while the apple fruit shape was not affected.These changes in sugar are related to the activity of sugar metabolic enzymes.While the enzymatic activity of vacuolar acid invertase(vAINV)was higher,that of sucrose-phosphate synthase(SPS)was lower in water stress treated fruit throughout the developmental period.This indicates that enhanced sucrose degradation and reduced sucrose synthesis leads to an overall reduced sucrose content during times of drought.Thus,water stress reduced sucrose content.Whereas the content of endogenous trehalose and ABA were the highest in water stress treated fruit.A moderate water stress(W1)imposed on apple trees via water restriction(60%–65%of field capacity)after the fruit cell enlargement phase of fruit development yielded sweeter fruit of higher economic value. | Hongxia Tao Hanqing Sun Yufei Wang Xin Wang Yanping Guo | 2023 | Horticultural Plant Journal2023，9，1： | 2 |
| 15 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 16 | Selective catalytic oxidation of H 2 S over iron oxide supported on alumina-intercalated Laponite clay catalysts显示文摘 | Xin Zhang Guangyu Dou Zhuo Wang Li Li Yufei Wang Hailin Wang Zhengping Hao | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 17 | Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer显示文摘Background:Although programmed cell death-ligand 1(PD-L1)plays a wellknown function in immune checkpoint response by interacting with programmed cell death-1(PD-1),the cell-intrinsic role of PD-L1 in tumors is still unclear.Here,we explored the molecular regulatory mechanism of PD-L1 in the progression and metastasis of ovarian cancer.Methods:Immunohistochemistry of benign tissues and ovarian cancer samples was performed,followed by migration,invasion,and angiogenesis assays in PDL1-knockdown ovarian cancer cells.Immunoprecipitation,mass spectrometry,and chromatin immunoprecipitation were conducted along with zebrafish and mouse experiments to explore the specific functions and mechanisms of PD-L1 in ovarian cancer.Results:Our results showed that PD-L1 induced angiogenesis,which further promoted cell migration and invasion in vitro and in vivo of ovarian cancer.Mechanistically,PD-L1 was identified to directly interact with vascular endothelial growth factor receptor-2(VEGFR2)and then activated the FAK/AKT pathway,which further induced angiogenesis and tumor progression,leading to poor prognosis of ovarian cancer patients.Meanwhile,PD-L1 was found to be regulated by the oncogenic transcription factor c-JUN at the transcriptional level,which enhanced the expression of PD-L1 in ovarian cancer.Furthermore,we demonstrated that PD-L1 inhibitor durvalumab,combined with the antiangiogenic drug,apatinib,could enhance the effect of anti-angiogenesis and the inhibition of cell migration and invasion.Conclusion:Our results demonstrated that PD-L1 promoted the angiogenesis and metastasis of ovarian cancer by participating in the c-JUN/VEGFR2 signaling axis,suggesting that the combination of PD-L1 inhibitor and antiangiogenic drugs may be considered as a potential therapeutic approach for ovarian cancer patients. | Yufei Yang Lingfang Xia Yong Wu Hongyu Zhou Xin Chen Haoran Li Midie Xu Zihao Qi Ziliang Wang Huizhen Sun Xi Cheng | 2021 | Cancer Communications2021，41，6： | 1 |
| 18 | An Assessment of CAMS-CSM in Simulating Land–Atmosphere Heat and Water Exchanges显示文摘The Chinese Academy of Meteorological Sciences(CAMS)has been devoted to developing a climate system model(CSM)to meet demand for climate simulation and prediction for the East Asian region.In this study,we evaluated the performance of CAMS-CSM in regard to sensible heat flux(H),latent heat flux(LE),surface temperature,soil moisture,and snow depth,focusing on the Atmospheric Model Intercomparison Project experiment,with the aim of participating in the Coupled Model Intercomparison Project phase 6.We systematically assessed the simulation results achieved by CAMS-CSM for these variables against various reference products and ground observations,including the FLUXNET model tree ensembles H and LE data,Climate Prediction Center soil moisture data,snow depth climatology data,and Chinese ground observations of snow depth and winter surface temperature.We compared these results with data from the ECMWF Interim reanalysis(ERA-Interim)and Global Land Data Assimilation System(GLDAS).Our results indicated that CAMS-CSM simulations were better than or comparable to ERA-Interim reanalysis for snow depth and winter surface temperature at regional scales,but slightly worse when simulating total column soil moisture.The root-mean-square differences of H in CAMS-CSM were all greater than those from the ERA-Interim reanalysis,but less than or comparable to those from GLDAS.The spatial correlations for H in CAMS-CSM were the lowest in nearly all regions,except for North America.CAMS-CSM LE produced the lowest bias in Siberia,North America,and South America,but with the lowest spatial correlation coefficients.Therefore,there are still scopes for improving H and LE simulations in CAMS-CSM,particularly for LE. | Guo ZHANG JiANDuo LI Xinyao RONG Yufei XIN Jian LI Haoming CHEN Jingzhi SU Lijuan HUA | 2018 | Journal of Meteorological Research2018，32，6： | 1 |
| 19 | Autophagy-related protein ATG5 regulates histone H2B mono-ubiquitylation by translational control of RNF20显示文摘Autophagy is an evolutionarily conserved lysosome-mediated catabolic process(Klionsky,2007).Autophagy is believed to be essential for cell survival,especially when cells were exposed to stresses,such as nutrient starvation.The activation of autophagy under starvation allows cells to survive by providing essential crudes for cell construction via degrading intracellular | Xin Huang Lu Yang Feng-Feng Cai Yufei Wang Ping Chen Jiangsheng Mi Chenghua Yu Jianghua Lai Xiaojun Zhang Shuguang Wei Wen Cui Su Chen | 2017 | Journal of Genetics and Genomics2017，44，10： | 1 |
| 20 | Simulation and evaluation of 2-m temperature over Antarctica in polar regional climate model显示文摘The European Centre for Medium-Range Weather Forecasts Reanalysis ERA40,National Centers for Environmental Prediction(NCEP) 20th-century reanalysis,and three station observations along an Antarctic traverse from Zhongshan to Dome-A stations are used to assess 2-m temperature simulation skill of a regional climate model.This model(HIRHAM) is from the Alfred Wegener Institute for Polar and Marine Research in Germany.Results show:(1) The simulated multiyear averaged 2-m temperature field pattern is close to that of ERA40 and NCEP;(2) the cold bias relative to ERA40 over all of Antarctic regions is 1.8℃,and that to NCEP reaches 5.1℃;(3) bias of HIRHAM relative to ERA40 has seasonal variation,with a cold bias mainly in the summer,as much as 3.4℃.There is a small inland warm bias in autumn of 0.3℃.Further analysis reveals that the reason for the cold bias of 2-m temperature is that physical conditions of the near-surface boundary layer simulated by HIRHAM are different from observations:(1) During the summer,observations show that near-surface atmospheric stability conditions have both inversions and non-inversions,which is due to the existence of both positive and negative sensible heat fluxes,but HIRHAM almost always simulates a situation of inversion and negative sensible heat flux;(2) during autumn and winter,observed near-surface stability is almost always that of inversions,consistent with HIRHAM simulations.This partially explains the small bias during autumn and winter. | XIN YuFei BIAN LinGen Annette RINKE Klaus DETHLOFF | 2014 | Science China Earth Sciences2014，57，4： | 1 |
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