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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | A realistic appraisal of boron neutron capture therapy as a cancer treatment modality显示文摘Boron neutron capture therapy(BNCT)is a binary therapeutic modality based on the nuclear capture and fission reac-tions that occur when the stable isotope boron-10 is irradiated with neutrons to produce high-energy alpha particles and recoiling lithium-7 nuclei.In this Commentary we will focus on a number of papers that were presented at a Sym-posium entitled“Current Clinical Status of Boron Neutron Capture Therapy and Paths to the Future”,which was held in September 2017 at the China National Convention Center in Beijing.Results were presented by clinicians from Japan,Finland,the United States,the China mainland and Taiwan,China who have been working in the multiple disciplines that are required for carrying out clinical BNCT.The main focus was on the treatment of patients with malignant brain tumors,recurrent tumors of the head and neck region,and cutaneous melanomas.The results obtained in treating these patients were reported in detail and,although most of the patients with brain tumors and head and neck cancer were not cured,there was evidence of some clinical efficacy.Although there are a number of problems that must be addressed,further clinical studies to evaluate the efficacy of BNCT are warranted.First,despite considerable effort by numerous investigators over the past 40 years,there still are only two boron-containing drugs in clinical use,l-boronophenylalanine(BPA)and sodium borocaptate(BSH).Therefore,until new and more effective boron delivery agents are developed,efforts should be directed to improving the dosing and delivery of BPA and BSH.Second,due to a variety of reasons,nuclear reactor-based BNCT has ended except for its use in the China mainland and Taiwan.Therefore,the future of BNCT depends upon the results of the ongoing Phase II clinical trials that are being carried out in Japan and the soon to be initiated trials that will be carried out in Finland.If the results obtained from these clinical trials are sufficiently promising,then BNCT will have a clear path to the future,especially for patients with the thera-peutically challenging malignancies that in the past have been treated with reactor-based BNCT. | Rolf F.Barth Zizhu Zhang Tong Liu | 2018 | Cancer Communications2018，38，1： | 9 |
| 3 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 4 | A Hierarchically Porous Metal-Organic Framework from Semirigid Ligand for Gas Adsorption显示文摘层次地多孔的材料在便于集体运输和吸附和分离过程的改善效率起一个重要作用。在这份报纸,新策略被建议认识到一个层次地多孔的金属器官的框架([Cu 2(OH)(L)]·(DMF)0.8(FJU-11, H 3L=3,5-(4-carboxybenzyloxy ) 安息香的酸, DMF=N, N-dimethylformamide ) 经由使用半硬的多羧基的酸。有趣地, FJU-11 向公司 2 拥有大吸附能力和小 isosteric 热。为 FJU-11 的列突破实验在烟道气体的分离加亮它的潜在的申请。 | Lizhen Liu Yingxiang Ye Zizhu Yao Liuqin Zhang Ziyin Li Lihua Wang Xiuling Ma Qian-Huo Chen Zhangjing Zhang Shengchang Xiang | 2016 | Chinese Journal of Chemistry2016，34，2： | 4 |
| 5 | High proton conductivity in metalloring-cluster based metalorganic nanotubes显示文摘Two novel anionic single-walled metal-organic nanotubes(MONTs),[(CH_(3))_(2)NH_(2)][ln(cdc)(thb)].2DMF.9.5H_(2)O(FJU-105)and[(CH_(3))_(2)NH_(2)][ln(cdc)(H-btc)]-2DMA·11H_(2)O(FJU-106)(H_(2)cdc=9H-carbazole-3,6-dicarboxylic acid,H_(2)thb=2,5-thiophene dicarboxylic acid,H3btc=1,3,5-benzene tricarboxylic acid),are achieved by employing[ln_(6)(cdc)_(6)]^(6+)metalloring cluster with largest diameter as the secondary building blocks(SBUs).The inner surface of FJU-106 is functionalized by uncoordinated-COOH groups of the H-btc linkers,leading to a higher proton conduction than FJU-105.At 70℃,FJU-106 displays the proton conduction performances among MONTs,up to 1.80×10^(-2)S·cm(^-1).And FJU-105 and FJU-106 are the first examples of MONT proton conductors operating at subzero temperature. | Quanjie Lin Yingxiang Ye Lizhen Liu Zizhu Yao Ziyin Li Lihua Wang Chulong Liu Zhangjing Zhang Shengchang Xiang | 2021 | Nano Research2021，14，2： | 2 |
| 6 | 硼中子俘获治疗作为癌症治疗方式的现实评估显示文摘硼中子俘获治疗(boron neutron capture therapy,BNCT)是一种基于核俘获和裂变反应的二元治疗方式,裂变反应发生于稳定的同位素硼-10被中子辐射时产生高能α粒子和反冲锂-7核。本评论聚焦了2017年9月在北京国家会议中心举办的名为'硼中子俘获治疗癌症回顾与展望研讨会'上报告的一些文章。来自日本、芬兰、美国、中国大陆和中国台湾地区的临床医生报告了他们的研究结果,他们一直从事BNCT临床应用所需的多学科工作。主要的研究焦点为恶性脑肿瘤、复发性头颈部肿瘤和皮肤黑色素瘤患者的治疗。他们对这些患者的治疗结果进行了详细报道,虽然多数脑肿瘤和头颈癌的患者未被治愈,但获得的证据支持了该疗法具有一定的临床疗效。虽然仍有很多问题须被解决,但评价BNCT疗效的进一步临床研究是可以开展的。首先,尽管过去40年大量研究人员进行了相当大的努力,但临床使用的含硼药物仍只有两种:二羟基苯丙氨酸硼(l-boronophenylalanine,BPA)和巯基硼烷(sodium borocaptate,BSH)。因此,在新的更有效的硼携带剂研发出来之前,改善BPA和BSH的剂量和给药应是努力的方向。第二,由于多种原因,基于核反应堆的BNCT已经在除中国大陆和台湾地区之外的地区停止使用。因此,BNCT的未来取决于日本正在进行的II期临床试验以及芬兰即将启动的试验结果。如果这些临床试验的结果有足够前景,那么BNCT将有一条通往未来的清晰路径,特别是对治疗上具有挑战的恶性肿瘤患者,这些恶性肿瘤类型过去应用反应堆基BNCT进行过治疗。 | Rolf F.Barth Zizhu Zhang Tong Liu | 2018 | 癌症2018，37，7： | 2 |
| 7 | Local linear discriminantanalysis framework using sample neighbors显示文摘 | Fan Zizhu Xu Yong Zhang David | 2011 | IEEETransactions on Neural Networks2011，22，7： | 1 |
| 8 | Facile strategy for carbon foam fabrication with lignin as sole feedstock and its applications显示文摘This research is a follow-up to our recent discovery of a facile strategy for directly converting lignin powder into carbon foam.In this work,we report that the thermal pretreatment parameters in air can remarkably influence the formation and properties of the derived carbon foam.Thermal pretreatment parameters(heating rate,temperature,and residence time)were systematically investigated and a conversion mechanism into carbon foam was proposed.During the thermal pretreatment,relatively low temperatures,low heating rates,and short residence time hindered the formation of smooth and well-connected structures in the carbon foam.The overall product yields were similar regardless of the thermal pretreatment conditions.The densities of the different carbon foams ranged 0.27–0.83 g∙cm^(−3).The carbon foams with the highest compressive strengths(>10 MPa)were KLPC280-2-5,KLPC300-0-5,and KLPC300-2-2.5.KLPC280-2-5 exhibited a high iodine sorption value(182 mg∙g^(−1)).KLPC300-2-5 exhibited a specific capacitance of 158 F∙g^(−1) at a current density of 0.05 A∙g^(−1).The maximum evaporation rates in the solar vapor generation experiments were 1.05 and 1.38 kg∙m^(−2)∙h^(−1) under 100 and 150 mW∙cm^(−2) irradiation,respectively.The good performances are attributed to the robust,porous,and continuous structure. | Linghong Yin Zizhu Zhao Meng Han Wangda Qu | 2023 | Frontiers of Chemical Science and Engineering2023，17，8： | 1 |
| 9 | Using the idea of the sparse representation to perform coarse-to-fine face recognition显示文摘 | Yong Xu Qi Zhu Zizhu Fan David Zhang Jianxun Mi Zhihui Lai | 2013 | Information Sciences2013，，： | 1 |
| 10 | Supervised sparse rep- resentation method with a heuristic strategy and face recognition experiments 显示文摘 | Xu Yong Zuo Wangmeng Fan Zizhu | 2012 | Neurocomputing2012，79，1： | 1 |
| 11 | Mathematical models for the temperature and water-heat transfer in the percolation zone of a glacier 显示文摘 | Cai Baolin Xie Zizhu Huang Maohuan | 1988 | Cold Regions Science and Technology1988，12，1： | 1 |
| 12 | Construction of Porcine Growth Hormone Eukaryotic Expression Vector and Its Transfection Mediated by Cationic Liposome in Mice显示文摘 | Chenchen Peng Lihong Wang Zizhu Chen Lei Ma Yan Wei Zhangfu Long | 2011 | Animal Biotechnology2011，，4： | 1 |
| 13 | Weighted sparse repre- sentation for face recognition 显示文摘 | Fan Zizhu Ni Ming Zhu Qi | 2015 | Neurocomputing2015，151，1： | 1 |
| 14 | Using the idea of thesparse representation to perform coarse to fine facerecognition显示文摘 | Xu Yong Zhu Qi Fan Zizhu | 2013 | Information Science2013，238，： | 1 |
| 15 | Supervised Sparse Represen-tation Method with a Heuristic Strategy and Face Recognition Experi-ments显示文摘 | Xu Yong Zuo Wangmeng Fan Zizhu | | 0，，01： | 1 |
| 16 | Selection of Suitable Area and Analysis of Adaptability Difference of Prunus humilis显示文摘This paper delves into and assesses the differences in biological traits and fruit nutritional composition of 3 varieties of Prunus humilis introduced from 2 different regions.Results showed that(i)the contents of protein,total sugar,and calcium of No.5 variety were higher those of the other 2 varieties,which was recognized as the most suitable variety for fresh fruit;(ii)the comparison of leaf areas index and fruit shape index of 3 varieties shows that the fruit shape index and individual fruit weight of the introduced varieties were higher than those of the control,the diameter of individual fruit of the introduced varieties higher than that of the control indicated that they had a higher fruit hardness,more dry matter accumulation and better fruit quality,and that the introduction region was more suitable for scale-up of P.humilis;(iii)there was a positive correlation with the number of fruiting branches and there was a significant negative correlation with individual fruit weight,while the leaf area had a significant negative correlation with the number of fruiting branches.The introduced varieties can develop normally in the 2 testing areas,notably,No.5 variety performed better than No.4 and No.6.Improving management is the prerequisite for maintaining proper number of fruiting branches and high yield. | Ze YAO Shengxiu JIANG Zizhu YAN Qi WANG Dawei WANG | 2024 | Asian Agricultural Research2024，16，3： | 0 |
| 17 | Dual-functional hydrogen-bonded organic frameworks for aniline and ultraviolet sensitive detection显示文摘A novel hydrogen-bonded organic frameworks(HOFs)FJU-200 has been constructed from N,N’-bis(5-isophthalic acid)naphthalimide(H_(4)L).FJU-200 has a good dual-function of aniline and ultraviolet detection.FJU-200 is the first case of HOF with dual sensing of visual color changes and photoluminescence quenching for aniline detection,and the detection limit of aniline can reach5.5 x 10^(-4)mol/L.Under ultraviolet FJU-200 will rapidly change from light yellow to rustic brown,which makes it possible to use FJU-200 to achieve minute-level ultraviolet detection.Moreover,for more convenient use,FJU-200 test papers are prepared.Using them,convenient and fast aniline or ultraviolet detection can be realized.The single-crystal X-ray structures show that compared with the original FJU-200,both PhNH_(2)@FJU-200 and UV-FJU-200 have larger pore sizes,and the dihedral angles of the H_(2)L^(2-)in framework has been changed. | Zhijun Ke Kexin Chen Zhenzhen Li Jie Huang Zizhu Yao Wen Dai Xiaofan Wang Chulong Liu Shengchang Xiang Zhangjing Zhang | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 18 | Opportunities and Challenges for Smart City Development in China显示文摘Based on case study of the practice of smart city development around the world,which has achieved a lot to make our life more convenient,through analysis of advantages and disadvantages,conclusion of some principles could be reached in a qualitative way.After studying the policy and economy environment of China,this paper concludes some features,identifies opportunities and challenges for smart city under the background of“The Belt and Road Initiative”,and provides suggestions on the development of China. | Lei Zhang Zizhu Zhang Qian Xiang Biao Liu | 2018 | Journal of Civil Engineering and Architecture2018，12，4： | 0 |
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