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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Analysis of Dynamics and Driving Factors of Wetland Landscape in Zoige,Eastern Qinghai-Tibetan Plateau显示文摘Zoige Wetland is one of the largest plateau wetlands in the world.This paper provides a dynamic analysis of spatial and temporal patterns of the wetland in Zoige, Eastern Qinghai-Tibetan Plateau, supported by ERDAS8.7 and ArcGIS9.0.It is the first comparative analysis of a system of rapidly changing wetland with landscape patterns in Zoige, using 3 classified landsat Thematic Mapper images of 1977, 1994 and 2001.The classified images were used to generate wetland distributing maps, and shape index(S), diversity index(H), dominance index(D), evenness index(E), fragmentation index(F) and fractal dimension(Fd) were calculated and analyzed spatiotemporally across pure grazing area in Zoige for each landscape type and in different periods(before 1977, during 1977~1994 and 1994~2001), as well as the driving forces of natural and anthropogenic.The study shows that for a comprehensive understanding of the shapes and trajectories of the shrinking and desertificated land expansion of the wetland, a spatiotemporal landscape metrics analysis in different periods is an improvement than only with landscape changing rates.This type of analysis can also be used to infer underlying social, economic, and political processes that drive the observed wetland forms.The results indicate that wetland patterns can be changed over relatively short periods of time.Thetotal area of lake reduced by 164.86 km2,grassland extended by 141.74 km2,semi-marsh extended by 105.94 km2 , marsh reduced by 86.00 km2;the number of landscape patches reduced by 56, and their average area decreased by 2.68 km2;the successions within lake, marsh, semi-marsh and grassland were found obviously;S decreased stepwise;D and F increased but H decreased;The changing rate after 1994 was 2.3 to 2.9 times greater than that before.The change of the wetland landscape patterns resulted in the interaction between socio-economic and natural forces of positive and negative aspects;and natural factors affected as assistant aspect.Some important human activities in this period led to the change of the landscape patterns in this region directly.Some measurements made by government and NGO delayed the converting process partly. | QIU Pengfei WU Ning LUO Peng WANG Zuyuan LI Maihe | 2009 | Journal of Mountain Science2009，6，1： | 19 |
| 3 | Chalcogenide glass photonic integration for improved 2μm optical interconnection显示文摘In this work,on-chip chalcogenide glass photonic integrations with several fundamental photonic building blocks are designed and fabricated based on the As2 S3 platform for improved 2μm optical interconnection,achieving a broadened wavelength bandwidth and improved fabrication tolerance.A 600 nm thick As2 S3 strip waveguide has low propagation loss of 1.447 dB/cm at 2μm.Broadband vertical coupling is realized by a grating coupler with 4.3 dB coupling loss.A Bragg grating filter,power splitter,Mach–Zander interferometer,and mode converter for on-chip mode division multiplexing(MDM)are also reported at 2μm with reliable performances.Finally,a record high MDM optical interconnection capacity of 3×80 Gbps at 2μm is experimentally demonstrated based on the proposed As2 S3 chip,drawing promising prospects for future photonic integration and high-speed interconnection at the 2μm waveband. | WEIHONG SHEN PINGYANG ZENG ZELIN YANG DI XIA JIANGBING DU BIN ZHANG KE XU ZUYUAN HE AND ZHAOHUI LI | 2020 | Photonics Research2020，8，9： | 10 |
| 4 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 5 | New small-molecule drug design strategies for fighting resistant influenza A显示文摘In fluenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination and small molecule anti-in fluenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-in fluenza small molecule drugs are more effective for the fi rst line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-in fluenza drugs currently available are admantane-based M2 protein blockers(amantadine and rimantadine) and neuraminidase(NA) inhibitors(oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of in fluenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-in fluenza drugs against resistant forms of in fluenza A virus. In this review,we fi rst give a brief introduction of the molecular mechanisms behind resistance, and then discuss new strategies in small-molecule drug development to overcome in fluenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs. | Zuyuan Shen Kaiyan Lou Wei Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 8 |
| 6 | Non-orthogonal joint diagonalization with diagonal constraints显示文摘Joint diagonalization has attracted much attention and many algorithms have been presented so far.However,some ambiguities still exist in the objective functions for joint diagonalization.In this paper,some criterions are proposed to eliminate the above ambiguities at first,and then a new objective function which satisfies these criterions is presented.The new objective function introduces diagonal con-straints for joint diagonalization,thus the trivial and unbalance solutions are excluded easily.Exactly jointly diagonalizable theorem is built to interpret the reasonableness of the new objective function and the conjugate gradient method is used to provide fast and reliable convergence.Finally,non-orthogonal joint diagonalization algorithm with diagonal constraints(DDiag)is developed.Simulations show that DDiag is ecient and robust. | Guoxu Zhou Zuyuan Yang Zongze Wu Jinlong Zhang | 2008 | Progress in Natural Science:Materials International2008，18，6： | 3 |
| 7 | Practical Pattern Recognition System for Distributed Optical Fiber Intrusion Monitoring Based on Ф-COTDR显示文摘At present, the demand for perimeter security system is in-creasing greatly, especially for such system based on distribut-ed optical fiber sensing. This paper proposes a perimeter se-curity monitoring system based on phase-sensitive coherentoptical time domain reflectometry(Ф-COTDR) with the practi-cal pattern recognition function. We use fast Fourier trans-form(FFT) to exact features from intrusion events and a multi-class classification algorithm derived from support vector ma-chine(SVM) to work as a pattern recognition technique. Fivedifferent types of events are classified by using a classifica-tion algorithm based on SVM through a three-dimensional fea-ture vector. Moreover, the identification results of the patternrecognition system show that an identification accurate rate of92.62% on average can be achieved. | CAO Cong FAN Xinyu LIU Qingwen HE Zuyuan | 2017 | ZTE Communications2017，15，3： | 3 |
| 8 | Navigation-grade resonant fiber-optic gyroscope using ultra-simple white-light multibeam interferometry显示文摘The miniaturization of the gyroscope is critical for spacecrafts,drones,wellbore surveys,etc.The resonant fiberoptic gyroscope(RFOG)is a competitive candidate due to its potential in both miniaturization and high resolution,while its actual performance is well below expectation because of laser-induced noise and complexity.Here we report the first navigation grade RFOG with a bias instability of 0.009°/h and an angle random walk of 0.0093°/√h.The results are realized using a fiber resonator with finesse of 63 containing 100-m long fiber.Compared with the traditional RFOGs using narrow-linewidth lasers,the key feature of the proposed RFOG is that it is driven with a broadband light source.A white-light multibeam interference method is proposed to detect the Sagnac effect,representing the simplest scheme of RFOG to date.The complexity caused by multiple feedback loops and coherent noise suppression in traditional RFOG scheme is avoided.The minimal scheme and simple modulation algorithm will also promote the on-chip waveguide gyroscope. | Shuangxiang Zhao Qingwen Liu Yuanyuan Liu Huilian Ma Zuyuan He | 2022 | Photonics Research2022，10，2： | 3 |
| 9 | Adaptive blind separation of underdetermined mixtures based on sparse component analysis显示文摘The independence priori is very often used in the conventional blind source sepa-ration (BSS). Naturally, independent component analysis (ICA) is also employed to perform BSS very often. However, ICA is difficult to use in some challenging cases, such as underdetermined BSS or blind separation of dependent sources. Recently, sparse component analysis (SCA) has attained much attention because it is theo- retically available for underdetermined BSS and even for blind dependent source separation sometimes. However, SCA has not been developed very sufficiently. Up to now, there are only few existing algorithms and they are also not perfect as well in practice. For example, although Lewicki-Sejnowski’s natural gradient for SCA is superior to K-mean clustering, it is just an approximation without rigorously theo- retical basis. To overcome these problems, a new natural gradient formula is pro- posed in this paper. This formula is derived directly from the cost function of SCA through matrix theory. Mathematically, it is more rigorous. In addition, a new and robust adaptive BSS algorithm is developed based on the new natural gradient. Simulations illustrate that this natural gradient formula is more robust and reliable than Lewicki-Sejnowski’s gradient. | YANG ZuYuan HE ZhaoShui XIE ShengLi FU YuLi | 2008 | Science in China(Series F)2008，51，4： | 3 |
| 10 | Simplified single-end Rayleigh and Brillouin hybrid distributed fiber-optic sensing system显示文摘Dear editor,Distributed fiber-optic sensing(DFOS) technology has been widespread applications in many fields. It is mainly realized by analyzing three kinds of backscattering in optical fibers: Rayleigh, Brillouin, and Raman [1]. Conventionally,the sensing system can only measure one type of parameter:a static one like temperature and strain or a dynamic one like vibration. However, for several applications, such as railway safety monitoring systems, both static and dynamic parameters must be measured simultaneously not only for early warning applications but also for collecting static signals to perform long-term analysis. | Linjing HUANG Zuyuan HE Xinyu FAN | 2023 | Science China(Information Sciences)2023，66，2： | 2 |
| 11 | Nyström-based spectral clustering using airborne LiDAR point cloud data for individual tree segmentation显示文摘The spectral clustering method has notable advantages in segmentation.But the high computational complexity and time consuming limit its application in large-scale and dense airborne Light Detection and Ranging(LiDAR)point cloud data.We proposed the Nyström-based spectral clustering(NSC)algorithm to decrease the computational burden.This novel NSC method showed accurate and rapid in individual tree segmentation using point cloud data.The K-nearest neighbour-based sampling(KNNS)was proposed for the Nyström approximation of voxels to improve the efficiency.The NSC algorithm showed good performance for 32 plots in China and Europe.The overall matching rate and extraction rate of proposed algorithm reached 69%and 103%.For all trees located by Global Navigation Satellite System(GNSS)calibrated tape-measures,the tree height regression of the matching results showed an value of 0.88 and a relative root mean square error(RMSE)of 5.97%.For all trees located by GNSS calibrated total-station measures,the values were 0.89 and 4.49%.The method also showed good performance in a benchmark dataset with an improvement of 7%for the average matching rate.The results demonstrate that the proposed NSC algorithm provides an accurate individual tree segmentation and parameter estimation using airborne LiDAR point cloud data. | Yong Pang Weiwei Wang Liming Du Zhongjun Zhang Xiaojun Liang Yongning Li Zuyuan Wang | 2021 | International Journal of Digital Earth2021，14，10： | 2 |
| 12 | Sub-femtometer-resolution absolute spectroscopy with sweeping electro-optic combs显示文摘Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-resolution and absolute frequency,in which two electro-optic frequency combs are swept.Electrically-modulated stabilized laser enables ultrahigh resolution of 0.16 fm(or 20 k Hz in optical frequency)and single-shot measurement in 90 ms.Total 20 million points are recorded spanning 3.2 nm(or 400 GHz)bandwidth,corresponding to a spectral sampling rate of 2.5×10^(8)points/s under Nyquist-limitation.Besides,considering the trade-off between the measurement time and spectral resolution,a fast single-shot measurement is also realized in 1.6 ms with 8 fm(or 1 MHz)resolution.We demonstrate the 25-averaged result with 30.6 d B spectral measurement signal-to-noise ratio(SNR)by reducing the filter bandwidth in demodulation.The results show great prospect for precise measurement with flexibly fast refresh time,high spectral resolution,and high SNR. | Bingxin Xu Xinyu Fan Shuai Wang Zuyuan He | 2022 | Opto-Electronic Advances2022，5，12： | 2 |
| 13 | Online blind source separation based on joint diagonalization显示文摘A new algorithm is proposed for joint diagonalization. With a modified objective function, the new algorithm not only excludes trivial and unbalanced solutions successfully, but is also easily optimized. In addition, with the new objective function, the proposed algorithm can work well in online blind source separation (BSS) for the first time, although this family of algorithms is always thought to be valid only in batch-mode BSS by far. Simulations show that it is a very competitive joint diagonalization algorithm. | Li Ronghua Zhou Guoxu Yang Zuyuan Xie Shengli | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 2 |
| 14 | New method for signal encryption using blind source separation based on subband decomposition显示文摘A novel cryptosystem based on subband decomposition independent component analysis(SDICA)is proposed in this work,where no assumption of independence for the ciphers and the plaintexts is required.In the proposed cryptosystem,the encryption is asynchronous,i.e.the plaintexts are mixed mutually firstly and then mixed with the ciphers.In addition,the decryption is asynchronous,such that the decryption accuracy of the plaintexts can be enhanced.Some special information about the original mixing matrix is used for solving the indeterminacy of the permutation and scale of columns of the recovered mixing matrix in SDICA,instead of the characteristics of the plaintexts.Simulations are given to illustrate security and availability of our cryptosystem. | Zuyuan Yang Guoxu Zhou Zongze Wu Jinlong Zhang | 2008 | Progress in Natural Science:Materials International2008，18，6： | 2 |
| 15 | Ultrahigh Resolution Fiber-Optic Quasi-Static Strain Sensors for Geophysical Research显示文摘 | Zuyuan HE Qingwen LIU Tomochika TOKUNAGA | 2013 | Photonic Sensors2013，3，4： | 2 |
| 16 | Source number estimation and separation algorithms of underdetermined blind separation显示文摘Recently,sparse component analysis (SCA) has become a hot spot in BSS re-search. Instead of independent component analysis (ICA),SCA can be used to solve underdetermined mixture efficiently. Two-step approach (TSA) is one of the typical methods to solve SCA based BSS problems. It estimates the mixing matrix before the separation of the sources. K-means clustering is often used to estimate the mixing matrix. It relies on the prior knowledge of the source number strongly. However,the estimation of the source number is an obstacle. In this paper,a fuzzy clustering method is proposed to estimate the source number and mixing matrix simultaneously. After that,the sources are recovered by the shortest path method (SPM). Simulations show the availability and robustness of the proposed method. | YANG ZuYuan TAN BeiHai ZHOU GuoXu ZHANG JinLong | 2008 | Science in China(Series F)2008，51，10： | 2 |
| 17 | Study of 3D micro-ultrasonic machining显示文摘 | Yu Zuyuan Rajurkar K P Tandon A | | 0，，04： | 1 |
| 18 | The stability of weakly braced frames 显示文摘 | Tong Genshu Shi Zuyuan | 2001 | Advances in Structural Engineering2001，4，4： | 1 |
| 19 | High aspect ratio micro-hole drilling aided with ultrasonic vibration and planetary movement of electrode by micro-EDM显示文摘 | Yu Zuyuan Zhang Y Li J | 2009 | CIRP Annals Manufacturing Technology2009，58，1： | 1 |
| 20 | Micro-EDM for three-dimensional cavities development of uniform wear method显示文摘 | Yu Zuyuan Masuzawa T Fujino M | 1998 | Annals of the CIRP1998，47，1： | 1 |
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