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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Analysis of Dynamics and Driving Factors of Wetland Landscape in Zoige,Eastern Qinghai-Tibetan Plateau显示文摘Zoige Wetland is one of the largest plateau wetlands in the world.This paper provides a dynamic analysis of spatial and temporal patterns of the wetland in Zoige, Eastern Qinghai-Tibetan Plateau, supported by ERDAS8.7 and ArcGIS9.0.It is the first comparative analysis of a system of rapidly changing wetland with landscape patterns in Zoige, using 3 classified landsat Thematic Mapper images of 1977, 1994 and 2001.The classified images were used to generate wetland distributing maps, and shape index(S), diversity index(H), dominance index(D), evenness index(E), fragmentation index(F) and fractal dimension(Fd) were calculated and analyzed spatiotemporally across pure grazing area in Zoige for each landscape type and in different periods(before 1977, during 1977~1994 and 1994~2001), as well as the driving forces of natural and anthropogenic.The study shows that for a comprehensive understanding of the shapes and trajectories of the shrinking and desertificated land expansion of the wetland, a spatiotemporal landscape metrics analysis in different periods is an improvement than only with landscape changing rates.This type of analysis can also be used to infer underlying social, economic, and political processes that drive the observed wetland forms.The results indicate that wetland patterns can be changed over relatively short periods of time.Thetotal area of lake reduced by 164.86 km2,grassland extended by 141.74 km2,semi-marsh extended by 105.94 km2 , marsh reduced by 86.00 km2;the number of landscape patches reduced by 56, and their average area decreased by 2.68 km2;the successions within lake, marsh, semi-marsh and grassland were found obviously;S decreased stepwise;D and F increased but H decreased;The changing rate after 1994 was 2.3 to 2.9 times greater than that before.The change of the wetland landscape patterns resulted in the interaction between socio-economic and natural forces of positive and negative aspects;and natural factors affected as assistant aspect.Some important human activities in this period led to the change of the landscape patterns in this region directly.Some measurements made by government and NGO delayed the converting process partly. | QIU Pengfei WU Ning LUO Peng WANG Zuyuan LI Maihe | 2009 | Journal of Mountain Science2009，6，1： | 19 |
| 3 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 4 | New small-molecule drug design strategies for fighting resistant influenza A显示文摘In fluenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination and small molecule anti-in fluenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-in fluenza small molecule drugs are more effective for the fi rst line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-in fluenza drugs currently available are admantane-based M2 protein blockers(amantadine and rimantadine) and neuraminidase(NA) inhibitors(oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of in fluenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-in fluenza drugs against resistant forms of in fluenza A virus. In this review,we fi rst give a brief introduction of the molecular mechanisms behind resistance, and then discuss new strategies in small-molecule drug development to overcome in fluenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs. | Zuyuan Shen Kaiyan Lou Wei Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 8 |
| 5 | Nyström-based spectral clustering using airborne LiDAR point cloud data for individual tree segmentation显示文摘The spectral clustering method has notable advantages in segmentation.But the high computational complexity and time consuming limit its application in large-scale and dense airborne Light Detection and Ranging(LiDAR)point cloud data.We proposed the Nyström-based spectral clustering(NSC)algorithm to decrease the computational burden.This novel NSC method showed accurate and rapid in individual tree segmentation using point cloud data.The K-nearest neighbour-based sampling(KNNS)was proposed for the Nyström approximation of voxels to improve the efficiency.The NSC algorithm showed good performance for 32 plots in China and Europe.The overall matching rate and extraction rate of proposed algorithm reached 69%and 103%.For all trees located by Global Navigation Satellite System(GNSS)calibrated tape-measures,the tree height regression of the matching results showed an value of 0.88 and a relative root mean square error(RMSE)of 5.97%.For all trees located by GNSS calibrated total-station measures,the values were 0.89 and 4.49%.The method also showed good performance in a benchmark dataset with an improvement of 7%for the average matching rate.The results demonstrate that the proposed NSC algorithm provides an accurate individual tree segmentation and parameter estimation using airborne LiDAR point cloud data. | Yong Pang Weiwei Wang Liming Du Zhongjun Zhang Xiaojun Liang Yongning Li Zuyuan Wang | 2021 | International Journal of Digital Earth2021，14，10： | 2 |
| 6 | Sub-femtometer-resolution absolute spectroscopy with sweeping electro-optic combs显示文摘Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy.Here,we propose a fast interleaved dual-comb spectroscopy with sub-femtometer-resolution and absolute frequency,in which two electro-optic frequency combs are swept.Electrically-modulated stabilized laser enables ultrahigh resolution of 0.16 fm(or 20 k Hz in optical frequency)and single-shot measurement in 90 ms.Total 20 million points are recorded spanning 3.2 nm(or 400 GHz)bandwidth,corresponding to a spectral sampling rate of 2.5×10^(8)points/s under Nyquist-limitation.Besides,considering the trade-off between the measurement time and spectral resolution,a fast single-shot measurement is also realized in 1.6 ms with 8 fm(or 1 MHz)resolution.We demonstrate the 25-averaged result with 30.6 d B spectral measurement signal-to-noise ratio(SNR)by reducing the filter bandwidth in demodulation.The results show great prospect for precise measurement with flexibly fast refresh time,high spectral resolution,and high SNR. | Bingxin Xu Xinyu Fan Shuai Wang Zuyuan He | 2022 | Opto-Electronic Advances2022，5，12： | 2 |
| 7 | Color-and Texture-Besed Image Segmen-tation for Improoved Forest Delineation显示文摘 | Boesch R | 2007 | IEEE Transaction on Ge-oscience and Remote Sensing2007，45，10： | 1 |
| 8 | Hydrogen storage properties of nanocomposite Mg-Ni-Cu-CrCl3 prepared by mechanical alloying 显示文摘 | Yu Zhenxin Liu Zuyuan Wang Erde | 2002 | Materials Science and Engineering A2002，335，： | 1 |
| 9 | Facile postsynthesis of visible-light-sensitive titanium dioxide/mesoporous SBA15显示文摘 | WANG Zuyuan ZHANG Fuxiang YANG Yali | 2007 | Chem Mater2007，19，： | 1 |
| 10 | Reduction of polarization-fluctuation induced drift in resonator fiber optic gyro by a resonator with twin 90° polarization-axis rotated splice显示文摘 | Wang Xijing He Zuyuan Hotate K | | 0，，02： | 1 |
| 11 | Nanodiamond films deposited at moderate temperature on pure titanium substrate pretreated by ultrasonic scratching in diamond powder suspension显示文摘Nanocrystalline diamond (NCD) film deposition on pure titanium and Ti alloys is extraordinarily difficult because of the high diffusion coefficient of carbon in Ti, the large mismatch in their thermal expansion coefficients, the complex nature of the inter-layer formed during diamond deposition, and the difficulty to achieve very high nucleation density. In this investigation, NCD films were successfully deposited on pure Ti substrate by using a novel substrate pretreatment of ultrasonic scratching in a diamond powder-ethanol suspension and by a two-step process at moderate temperature. It was shown that by scratching with a 30-μm diamond suspension for 1 h, followed by a 10-h diamond deposition, a continuous NCD film was obtained with an average grain size of about 200 nm. Detailed experimental results on the preparation, characterization, and successful deposition of the NCD films on Ti were discussed. | Syed Jawid Askari Fanxiu Lv Akhtar Farid Fengying Wang Qi He Zuyuan Zhou | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 0 |
| 12 | A NEW TEXTURE IMAGE RETRIEVAL WAY显示文摘This paper proposes a new texture image retrieval method for the considering of the population search and random information exchange merits of evolving programming which can be used to optimize image feature vector extraction. The experimental results show that this way can efficiently improve the retrieval accuracy and realize fasttips with the advantage of evolving programming algorithm. | Wang Zuyuan Luo Lin Zhuang Zhenquan(Dept. of Electronic Science and Technology, University of Science & Technology of China, Hefei 230026) | 2001 | Journal of Electronics(China)2001，18，4： | 0 |
| 13 | Aromaticity Concerto in Polycyclic Conjugated Hydrocarbons:Fusion Pattern on Combined Aromaticity Strategy Leads to Distinctive Excited State Photophysics of Dinaphthopentalenes显示文摘Understanding the structure-property relationships in polycyclic conjugated hydrocarbons(PCHs)is crucial in controlling their electronic properties and developing new optically functional materials.Aromaticity is a fundamentally important and intriguing property of numerous organic chemical structures and has stimulated a myriad of experimental and theoretical investigations.Exploiting aromaticity rules for the rational design of optoelectronic materials with the desired photophysical characteristics is a challenging yet fascinating task.Herein we present an in-depth computational and spectroscopic study on the structure-property relationships of dinaphthopentalenes(DNPs).Results highlight that the different fusion patterns between 4nπand 4n+2πunits endow these PCHs with the tunable aromaticity in the ground state/excited state,which leads to the diverse electronic structures and consequently the distinctive excited state photophysics.Accordingly,we propose a combined aromaticity design strategy for rationally modulating and tailoring electronic and optical properties of PCH skeletons.These outcomes not only present a full picture of the excited state dynamics of the DNP system and afford a new class of efficient singlet fission-active materials but also provide some basic guidelines for exploiting aromaticity rules to design and develop new optical function materials. | Long Wang Lu Lin Teng-Shuo Zhang Shaoting Guo Zuyuan Liu Mengfan Zhang Senhao Wang Ganglong Cui Wei-Hai Fang Jun Zhu Hongbing Fu Jiannian Yao | 2023 | CCS Chemistry2023，5，10： | 0 |
| 14 | Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients显示文摘Background and Objective:Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients who undergo liver transplantation(LT).Whereas there is huge data on NAFLD,little is known about NAFLD in LT.In this review,we aim to explore extrahepatic organs and their potential mechanisms in the development of NAFLD in LT patients and discuss current limitations in preclinical and clinical scenarios with suggestions for future study.Methods:The following keywords,such as NAFLD,NASH,liver transplant,therapy,pathogenesis and biomarkers,were set for literature retrieval.The articles which were published articles in English till 25th June 2020 in PubMed database were included,and there is no limit for the study design type.Key Content and Findings:Following LT,there are significant shifts in the microbiota and farnesoid X receptor may be a potential therapeutic target for NAFLD in LT settings.The roles of probiotics and diet on NALFD remain inconclusive in LT background.Nevertheless,the adipokines and cytokines disorder and local insulin resistance of adipose tissue may contribute to NAFLD process.Bariatric surgeries are promising in controlling de novo and recurrent NAFLD with significant reduction in abdominal adipose tissue,despite the optimal timing is inconclusive in LT cases.Furthermore,circumstantial evidence indicates that miRNA-33a may function as a mediator bridging sarcopenia and NAFLD of post-LT.β-Hydroxy-β-Methyl-Butyrate treatment could improve muscle status in graft recipients and shows protective potential for NAFLD in LT settings.Conclusions:Gut,adipose tissue and muscle are intricately intertwined in promoting NAFLD in LT cases.Further animal studies are needed to deepen our understanding of mechanisms in multi-organ crosstalk.High quality clinical trials are warrant for making guidelines and developing management strategies on NAFLD after LT. | Renyi Su Xuyong Wei Qiang Wei Di Lu Zuyuan Lin Shuo Wang Chuxiao Shao Xiao Xu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 0 |
| 15 | 20736-node weighted max-cut problem solving by quadrature photonic spatial Ising machine显示文摘The max-cut problem is one of the fundamental NP-hard problems in combinatorial optimization,which can describe the practical applications such as data clustering,machine scheduling,and image recognition.This problem can be formulated into an equivalent Ising model without local fields. | Xin YE Wenjia ZHANG Shaomeng WANG Xiaoxuan YANG Zuyuan HE | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 16 | Highly reliable integrated W-band transmitter based on an on-chip dual-mode DFB laser and cascaded microring modulators显示文摘We propose an integrated W-band transmitter enabled by an integrated dual-mode distributed feedback(DFB)laser and cascaded silicon photonic microring modulators for next-generation wireless communication.10 Gb/s error-free intensity modulation and direct detection W-band transmission are achieved in experiments by using the dual-mode DFB laser and two free-running lasers.Moreover,we conduct an experiment of dual-carrier modulation based on cascaded microring modulators,achieving 3 dB signal-to-noise ratio improvement and better signaling integrity for wireless communication.The proposed photonic integrated W-band transmitter will be a viable solution for a high-speed and low-power wireless communication system. | XUYING LIU WENJIA ZHANG YUE JIANG HAN WANG DAN LU FAN YANG ZUYUAN HE | 2023 | Photonics Research2023，11，8： | 0 |
| 17 | AN EFFICIENT SHAPE RETRIEVAL WAY显示文摘By using the generalized Gaussian density model, this letter puts forward a new shape retrieval way based on the wavelet coefficients. Experimental results show that the proposed shape feature description is superior to the traditional invariant moment algorithm. Moreover, this algorithm provides the important invariant trait to image's size and rotation, which can retrieve images based on shape with more similar results comparing with invariant moment method. | Wang Zuyuan (Dept. of Computer Science and Technology, USTC, Hefei 230026) | 2003 | Journal of Electronics(China)2003，20，2： | 0 |
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