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| 1 | B-box proteins:Pivotal players in light-mediated development in plants^FA显示文摘Light signals mediate a number of physio-logical and developmental processes in plants, such as flowering, photomorphogenesis, and pigment accu-mulation. Emerging evidence has revealed that a group of B-box proteins (BBXs) function as central players in these light-mediated developmental processes. B-box proteins are a class of zinc-coordinated transcription factors or regulators that not only directly mediate the transcription of target genes but also interact with various other factors to create a complex regulatory network involved in the precise control of plant growth and development. This review summarizes and highlights the recent findings concerning the critical regulatory functions of BBXs in photoperiodic flow-ering, light signal transduction and light-induced pigment accumulation and their molecular modes of action at the transcriptional and post-translational levels in plants. | Zhaoqing Song Yeting Bian Jiujie Liu Yuting Sun Dongqing Xu | 2020 | Journal of Integrative Plant Biology2020，62，9： | 5 |
| 2 | Current understanding of osteoarthritis pathogenesis and relevant new approaches显示文摘Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA. | Liping Tong Huan Yu Xingyun Huang Jie Shen Guozhi Xiao Lin Chen Huaiyu Wang Lianping Xing Di Chen | 2022 | Bone Research2022，10，4： | 4 |
| 3 | Discussion on Evolution of Land-use Planning in China | CAI Yumei,Land Planning Department,Land Investigation and Planning Institute of China,Beijing,P.R.China. ZHANG Wenxin,Geography and RS Science School,Beijing Normal University,Beijing,P.R.China. ZHAO Yanwen,Resource and Environment Science College,Nanjing Agricultural University,Nanjing,P.R.China. SHI Ke | 2009 | China City Planning Review2009，18，1： | 4 |
| 4 | Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants显示文摘Dear Editor,The spread of the SARS-CoV-2 variants,especially the global variants of concern(VOCs),could seriously dampen our efforts to tackle the COVID-19 pandemic.The SARS-CoV-2 spike protein recognizes the host angiotensin-converting enzyme 2(ACE2)via its receptor-binding domain(RBD)to mediate viral entry into the cells.Several notorious mutations have been identified in the spike RBD of the VOCs.For example,B.1.1.7(Alpha),B.1.351(Beta),and P.1(Gamma)all contain the N501Y mutation,which increases the binding affinity for human ACE2 and confers higher infectivity in mice. | Shuo Du Pulan Liu Zhiying Zhang Tianhe Xiao Ayijiang Yasimayi Weijin Huang Youchun Wang Yunlong Cao Xiaoliang Sunney Xie Junyu Xiao | 2021 | Cell Research2021，31，10： | 3 |
| 5 | Research Progress and the Main Achievements of The Regional Geology of China Preface显示文摘Introduction to The Regional Geology of China In 2008, a new project concerning the recompilation of The Regional Geology of China (RGC) was assigned by the Chinese Geological Survey (CGS) and undertaken by the Institute of Geology, Chinese Academy of Geological Sciences (CAGS). Li Tingdong, an academician of the Chinese Academy of Sciences (CAS), is the chief leader and chief scientist of the project. The last time The Regional Geology of China was compiled was in the 1980s (Cheng, 1994). | DING Xiaozhong ZHANG Kexin GAO Linzhi LU Songnian PAN Guitang XIAO Qinghui LIU Yong PANG Jianfeng | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 3 |
| 6 | Identification of long noncoding RNAs involved in resistance to downy mildew in Chinese cabbage显示文摘Brassica downy mildew,a severe disease caused by Hyaloperonospora brassicae,can cause enormous economic losses in Chinese cabbage(Brassica rapa L.ssp.pekinensis)production.Although some research has been reported recently concerning the underlying resistance to this disease,no studies have identified or characterized long noncoding RNAs involved in this defense response.In this study,using high-throughput RNA sequencing,we analyzed the disease-responding mRNAs and long noncoding RNAs in two resistant lines(T12–19 and 12–85)and one susceptible line(91–112).Clustering and Gene Ontology analysis of differentially expressed genes(DEGs)showed that more DEGs were involved in the defense response in the two resistant lines than in the susceptible line.Different expression patterns and proposed functions of differentially expressed long noncoding RNAs among T12–19,12–85,and 91–112 indicated that each has a distinct disease response mechanism.There were significantly more cis-and trans-functional long noncoding RNAs in the resistant lines than in the susceptible line,and the genes regulated by these RNAs mostly participated in the disease defense response.Furthermore,we identified a candidate resistance-related long noncoding RNA,MSTRG.19915,which is a long noncoding natural antisense transcript of a MAPK gene,BrMAPK15.Via an agroinfiltration-mediated transient overexpression system and virus-induced gene silencing technology,BrMAPK15 was indicated to have a greater ability to defend against pathogens.MSTRG.19915-silenced seedlings showed enhanced resistance to downy mildew,probably because of the upregulated expression of BrMAPK15.This research identified and characterized long noncoding RNAs involved in resistance to downy mildew,laying a foundation for future in-depth studies of disease resistance mechanisms in Chinese cabbage. | Bin Zhang Tongbing Su Peirong Li Xiaoyun Xin Yunyun Cao Weihong Wang Xiuyun Zhao Deshuang Zhang Yangjun Yu Dayong Li Shuancang Yu Fenglan Zhang | 2021 | Horticulture Research2021，8，1： | 3 |
| 7 | The grouping characteristics of sea waves in the Shijiu Port显示文摘A review concerning the methods of studying and describing wave groups is presented in this paper. After analysing 78 field records collected in the Shijiu Port, China, the measured parameters of wave groups and some factors describing wave groupness and their variations are given. Moreover, these results are compared with those of theory. | Yu Yuxiu and Liu Shuxue Dalian University of Technology, Dalian, 116024, China | 1991 | Acta Oceanologica Sinica1991，10，3： | 2 |
| 8 | Lipidomic and transcriptomic analysis reveals reallocation of carbon flux from cuticular wax into plastid membrane lipids in a glossy“Newhall”navel orange mutant显示文摘Both cuticle and membrane lipids play essential roles in quality maintenance and disease resistance in fresh fruits.Many reports have indicated the modification of alternative branch pathways in epicuticular wax mutants;however,the specific alterations concerning lipids have not been clarified thus far.Here,we conducted a comprehensive,timeresolved lipidomic,and transcriptomic analysis on the“Newhall”navel orange(WT)and its glossy mutant(MT)“Gannan No.1”.The results revealed severely suppressed wax formation accompanied by significantly elevated production of 36-carbon plastid lipids with increasing fruit maturation in MT.Transcriptomics analysis further identified a series of key functional enzymes and transcription factors putatively involved in the biosynthesis pathways of wax and membrane lipids.Moreover,the high accumulation of jasmonic acid(JA)in MT was possibly due to the need to maintain plastid lipid homeostasis,as the expression levels of two significantly upregulated lipases(CsDAD1 and CsDALL2)were positively correlated with plastid lipids and characterized to hydrolyze plastid lipids to increase the JA content.Our results will provide new insights into the molecular mechanisms underlying the natural variation of plant lipids to lay a foundation for the quality improvement of citrus fruit. | Haoliang Wan Hongbo Liu Jingyu Zhang Yi Lyu Zhuoran Li Yizhong He Xiaoliang Zhang Xiuxin Deng Yariv Brotman Alisdair RFernie Yunjiang Cheng Weiwei Wen | 2020 | Horticulture Research2020，7，1： | 2 |
| 9 | 洛克教育思想的未解之谜——以Some Thoughts Concerning Education为线索显示文摘近年来国内兴起了新一轮的洛克研究热潮,主要集中于洛克政治哲学方面的研究。洛克流亡荷兰期间,出版了其生前唯一一本以'教育'一词命名的著作——Some Thoughts Concerning Education,到目前为止,此书仍未有一个统一认可的汉语译名。这实际透露出洛克的教育论说此前在教育学界并未得到真正符合其本义的透彻理解。经梳理与分析后认为:Some Thoughts Concerning Education其实尤为洛克本人所重视!它与《人类理解论》《政府论》等一同构成了洛克学说的整体核心部分。从洛克政治哲学的整体设计高度上看待他的家庭幼儿教育理论与实践,是以往研究未能充分关注到的。 | 韦永琼 | 2017 | 高等理科教育2017，，3： | 2 |
| 10 | Water-soluble artemisinin derivatives as promising therapeutic immunosuppressants of autoimmune diseases显示文摘Artemisinin,which contains a sesquiterpene trioxane skeleton,was originally isolated from Artemisia annua L.,a traditional Chinese medicine with antimalarial activity.The 2015 Nobel Prize in Physiology or Medicine was awarded to Youyou Tu for her discoveries concerning a novel therapy against malaria.Over the past several decades,a series of novel artemisinin derivatives have been synthesized and evaluated for antimalarial and immunosuppressive activities.1 Artesunate,artemether and dihydroartemisinin have expanded the clinical applications of artemisinin,which has indeed become a gift from traditional Chinese medicine to the world.Our groups have identified several water-soluble artemisinin derivatives that exhibit strong immunosuppressive activity,among which SM905 and SM934 exert notable antiinflammatory effects in vitro and in vivo. | Heng Li Jianping Zuo Wei Tang | 2017 | Cellular & Molecular Immunology2017，14，11： | 2 |
| 11 | PREDICTION OF THE AERODYNAMIC PERFORMANCE OF HORIZONTAL AXIS WIND TURBINES IN CONDITION OF UNIFORM WIND显示文摘The classical momentum-blade element theory is improved by using the empirical formula while part of rotor blades enters into the turbulent wake state, and the performance of a horizontal-axis wind turbine (HAWT) at all speed ratios can be predicted. By using an improved version of the so-called secant method, the convergent solutions of the system of two-dimensional equations concerning the induced velocity factors a and a’ are guaranteed. Besides, a solving method of multiple solutions for a and a’ is proposed and discussed. The method provided in this paper can be used for computing the aerodynamic performance of HAWTs both ofrlow solidity and of high solidity. The calculated results coincide well with the experimental data. | Wang Tongguang Tang Ruiyuan Nanjing Aeronautical Institute Nanjing 210016, P.R. of China | 1991 | Chinese Journal of Aeronautics1991，6，2： | 1 |
| 12 | THE TEXTURAL CLASSIFICATION OF FAULT TECTONITE显示文摘The fault tectonites (also called dynamo-metamorphic rocks) are customarily named as fault rocks abroad. They are not only of significance in the study of faults of various mechanic properties, but also closely related to various deposits. Some fault rocks are even ores themselves. Early in 1880 Kjerulf proposed the 'cataclastic' texture and in 1885, C. Lapworth gave the name mylonite. But there have been widely different views concerning the classification and nomenclature of fault tectonites. Based on the observation on thin sections of more than 1500 samples | 孙岩 沈修志 | 1983 | Chinese Science Bulletin1983，28，6： | 1 |
| 13 | EFFECT OF HYDRATION ON THE THERMAL STABILITY OF ENZYME显示文摘The thermal stability of New Zealand culture rabbit muscle aldolase wasinvestigated by differential scanning calorimetry in the water content range0.23-3.70 g water per g protein.The experimental results showed that at watercontents below 0.47g/g,an endothermic peak was observed and at water contentsabove 0.57g/g,an endothermic and an exothermic peak were both observed on DSCthermogram.Thermal denaturation result of the enzyme and the relationshipbetween two transition temperatures and water contents were first reported inthis paper.Up to now we have not seen any similar reports concerning theexothermic transition. | Yun Na LIU Fu TAN Institute of Chemistry,Academia Sinica,Beijing 100080 | 1990 | Chinese Chemical Letters1990，1，3： | 1 |
| 14 | THE CYCLICITY OF MULTIPLE HOPF BIFURCATION IN THE PLANAR CUBIC DIFFERENTIAL SYSTEM:M(3)≥7显示文摘In some recent work concerning the number of limit cycles of the planar polynomial differential system, by using the different methods and examples, N. G. Lloyd et al., D. M. Wang, and LIU Yi-rong have successively shown that there exist at least six limit cycles bifurcated from the origin in the planar cubic differential system (E3). Namely, the value of cyclicity of multiple Hopf bifurcation (in the sense of Bautin) satisfies M(3)≥6. | 李继彬 白敬新 | 1990 | Chinese Science Bulletin1990，35，23： | 1 |
| 15 | PALEOPLATE TECTONICS IN NEI MONGGOL OF CHINA显示文摘In accordance with the studies concerning the tectonics of Nei Monggolmade by Huang Jiqing and others, two tectonic units occur in this area:Sino-Korean Platform to the south and Nei Monggol-Greater Khingan Mtsfold system to the north. The dividing line between the two units lies fromBaiyun’ebo on the west to Chifeng on the east. Geophysical studies demonst-rate that there are two gravity gradient zones trending ENE in the northernmargin of the North China Platform. The northern zone is a linear anomalyzone of--50 to--45 mGal extending from Baiyun’ebo in the west to theeast of Chifeng. The southern zone, 60--70km wide, lies from Guyang throughJining to Longhua in the east and its amplitude of gravity gradient amountsto 60 mGal. Field geological survey indicates that there are two main faultedzones. Our recent investigations suggests that there are two Proterozoic riftsof E-W trend in the northern margin of the North China Platform. | Wang Quan, Liu Xueya, and Li Jinyi(Institute of Geology, CAGS) | 1991 | 地球学报1991，18，1： | 1 |
| 16 | Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins显示文摘The spread of the latest SARS-CoV-2 variant Omicron is particularly concerning because of the large number of mutations present in its genome and lack of knowledge about how these mutations would affect the current SARS-CoV-2 vaccines and treatments.Here,by performing phylogenetic analysis using the Omicron spike(S)protein sequence,we found that the Omicron S protein presented the longest evolutionary distance in relation to the other SARS-CoV-2 variants.We predicted the structures of S,M,and N proteins of the Omicron variant using AlphaFold2 and investigated how the mutations have affected the S protein and its parts,S1 NTD and RBD,in detail.We found many amino acids on RBD were mutated,which may influence the interactions between the RBD and ACE2,while also showing the S309 antibody could still be capable of neutralizing Omicron RBD.The Omicron S1 NTD structures display significant differences from the original strain,which could lead to reduced recognition by antibodies resulting in potential immune escape and decreased effectiveness of the existing vaccines.However,this study of the Omicron variant was mainly limited to structural predictions,and these findings should be explored and verified by subsequent experiments.This study provided basic data of the Omicron protein structures that lay the groundwork for future studies related to the SARS-CoV-2 Omicron variant. | Qiangzhen Yang Ali Alamdar Shah Syed Aamir Fahira Yongyong Shi | 2021 | Research2021，，1： | 1 |
| 17 | 《交换人生》:换身喜剧的混合术显示文摘英国哲学家约翰·洛克(JohnLocke)曾在出版于1690年的《人类理解论》(AnEssayconcerning HumanUnderstanding)中,提出过一个饶有趣味的问题:“如果一个王子的灵魂进入一个鞋匠的身体,一旦鞋匠被自己的灵魂抛弃,只对王子的行为负责,他们还是同一个人吗?”(1)如果我们将这段话视作一个完整的故事创意,换身叙事已有长达三百多年的历史。 | 谢建华 | 2023 | 当代电影2023，，3： | 1 |
| 18 | NATIONAL FIELD TRIAL OF THE CHINESE CLASSIFICATION AND DIAGNOSTIC CRITERIA OF MENTAL DISORDERS: COMPREHENSIBILITY, ACCEPTABILITY AND APPLICABILITY显示文摘The Chinese Neurology and Psychiatry Association conducted a national field trial of its Chinese Classification and Diagnostic Criteria of Mental Disorders (CCMD-2) involoviag 26 provinces and municipalities, 80 psychiatric insititutes, and 224 professionals. The results were as follows: (1)95.2% of researchers considered the comprehensibility, of the CCMD-2 diagnstic criteria good. Within the ten major categories, comprehensibility ranged from 85.7% to 100%. (2) Of those surveyed concerning the acceptibility of the CCCMD-2 diagnostic criteria, 85.9% considered them acceptable. In individual classifications, the rate ranged from 74.1% to 95.2%. (3) 1498 cases were tested. The overall applicability rate which indicated the consistency between the CCMD-2 result and the actual clinical diagnoses was found to be 87.6%, (averaging Kappa=0.82, P<0.01), better than those obtained from non-Chinese systems of diagnosis. | 张明圆 杨德森 金华 吴文源 何燕玲 | 1994 | Chinese Medical Journal1994，，2： | 1 |
| 19 | “送礼”广告的模因论阐释显示文摘近年来'送礼'广告呈泛滥之势。从模因论的视角,探讨'送礼'广告成为强势模因的原因,阐释社会文化与'送礼'广告模因之间的相互关系,发现'送礼'广告模因反映了社会文化,并对社会文化、价值观等产生影响。 | 韩世霞 贾小绪 | 2010 | 宁波教育学院学报2010，12，6： | 1 |
| 20 | Orthopaedic tissue engineering and stem cells -an unfulfilled promise显示文摘Despite being over thirty years since there was proof that the hypothetical osteogenic stem cell existed,1 demonstration of any dramatic value for the use of such cells in orthopaedic clinical practice by tissue engineering approaches has not yet been realised.This is notwithstanding extensive studies concerning the likely nature and potentials of these cells in countless in vitro and in vivo investigations.In part,this is based on the confusion caused by exaggeration of claims by unreliable,or at best naïve,investigators and opportunistic entrepreneurs who have grossly misinterpreted data from many ill-conceived studies.2,3 This pseudo-science has been harmful,especially to the stem cell field,both academically and commercially. | James T.Triffitt | 2021 | Biomaterials Translational2021，2，2： | 1 |
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