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| 1 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 2 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 3 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 4 | Oxidation-Induced C--H Functionalization: A Formal Way for C--H Activation显示文摘 | Yichang Liu Hong Yi Aiwen Lei | 2018 | Chinese Journal of Chemistry2018，36，8： | 8 |
| 5 | Electrochemical Intramolecular C-H/O-H Cross-Coupling of 2-Arylbenzoic Acidst显示文摘 | Ailong Shao Na Li Yong Gao Jirui Zhan Chien-Wei Chiang Aiwen Lei | 2018 | Chinese Journal of Chemistry2018，36，7： | 7 |
| 6 | A soil water and heat transfer model including changes in soil frost and thaw fronts显示文摘Freeze-thaw processes in soils,including changes in frost and thaw fronts(FTFs),are important physical processes.The movement of FTFs affects soil hydrothermal characteristics,as well as energy and water exchanges between the land surface and the atmosphere and hydrothermal processes in the land surface.This paper reduces the issue of soil freezing and thawing to a multiple moving-boundary problem and develops a soil water and heat transfer model which considers the effects of FTF on soil hydrothermal processes.A local adaptive variable-grid method is used to discretize the model.Sensitivity tests based on the hierarchical structure of the Community Land Model(CLM)show that multiple FTFs can be continuously tracked,which overcomes the difficulties of isotherms that cannot simultaneously simulate multiple FTFs in the same soil layer.The local adaptive variable-grid method is stable and offers computational efficiency several times greater than the high-resolution case.The simulated FTF depths,soil temperatures,and soil moisture values fit well with the observed data,which further demonstrates the potential application of this simulation to the land-surface process model. | WANG AiWen XIE ZhengHui FENG XiaoBing TIAN XiangJun QIN PeiHua | 2014 | Science China Earth Sciences2014，57，6： | 5 |
| 7 | Electrochemical Oxidative Csp^3—H/S—H Cross-Coupling with Hydrogen Evolution for Synthesis of Tetrasubstituted Olefins显示文摘Tetrasubstituted olefins are significant scaffolds as they are prevalent in many biologically active compounds and versatile building blocks for organic synthesis. Herein, we report an electrochemical oxidative Csp^3—H/S—H cross-coupling reaction, in which various tetrasubstituted olefins were prepared under base-free, transition metal-free, and oxidants-free reaction conditions. | Fangling Lu Zengzhuan Yang Tao Wang Tianhao Wang Yuying Zhang Yong Yuan Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，6： | 5 |
| 8 | Electrochemical Oxidative C-H Sulfenylation of Imidazopyridines with Hydrogen Evolution显示文摘Summary of main observation and conclusion Selective oxidative C-H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell.The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both aryl and aliphatic thiols demonstrate good reactivity for C-S bond formation. | Yong Yuan Yangmin Cao Jin qiao Yueping Lin Xiaomei Jiang Yaqing Weng Shan Tang Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，1： | 5 |
| 9 | Recent Applications of Homogeneous Catalysis in Electrochemical Organic Synthesis显示文摘Although the combination of electrochemistry and homogeneous catalysis has proven to be a powerful strategy for achieving a diverse array of novel transformations,some challenges such as controlling the diffusion of catalyst-related species and the instability of catalysts at electrodes remain to be overcome.Herein,we review recent advances in electrochemical homogeneous catalysis,focusing on electrochemical noble-transition-metal catalysis,photoelectrochemical catalysis,and electrochemical enantioselective catalysis.The topics discussed include:(1)how the noblemetal catalystworks in the presence of cathodic hydrogen evolution,(2)how the photocatalyst gets enhanced redox property,and(3)how the enantioselectivity is regulated in a catalytic electrochemical reaction. | Xu Cheng Aiwen Lei Tian-Sheng Mei Hai-Chao Xu Kun Xu Chengchu Zeng | 2022 | CCS Chemistry2022，4，4： | 5 |
| 10 | Numerical simulation based on two-directional freeze and thaw algorithm for thermal diffusion model显示文摘Freeze-thaw processes significantly modulate hydraulic and thermal characteristics of soil. The changes in the frost and thaw fronts(FTFs) affect the water and energy cycles between the land surface and the atmosphere. Thus, the frozen soil comprising permafrost and seasonally frozen soil has important effects on the land surface hydrology in cold regions. In this study, a two-directional freeze and thaw algorithm is incorporated into a thermal diffusion equation for simulating FTFs. A local adaptive variable-grid method is used to discretize the model. Sensitivity tests demonstrate that the method is stable and FTFs can be tracked continuously. The FTFs and soil temperature at the Qinghai-Tibet Plateau D66 site are simulated hourly from September 1, 1997 to September 22, 1998. The results show that the incorporated model performs much better in the soil temperature simulation than the original thermal diffusion equation,showing potential applications of the method in land-surface process modeling. | Junqiang GAO Zhenghui XIE Aiwen WANG Zhendong LUO | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，11： | 4 |
| 11 | Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation显示文摘We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions. | Zhilin Zhou Yong Yuan Yangmin Cao Jin Qiao Anjin Yao Jing Zhao Wanqing Zuo Wenjie Chen Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，6： | 4 |
| 12 | Tuning radical reactivity for selective radical/radical cross-coupling显示文摘Radical/radical cross-coupling represents a straightforward way for the construction of new chemical bonds in theory and has received more and more attention over the past several years. Until now, it is challenging to achieve the selective bond formation between two transient radicals since selective radical cross-coupling usually happens between persistent radical and transient radical. However, the number of persistent radicals is much less than that of transient radicals. These issues limit the application of radical/radical cross-coupling in the construction of new chemical bonds. To solve this, we proposed a novel strategy ‘‘tuning radical reactivity' that could tune transient radical into persistent radical. This paper will introduce the concept and recent developments of ‘‘tuning radical reactivity'. | Shengchun Wang Shan Tang Aiwen Lei | 2018 | Science Bulletin2018，63，15： | 4 |
| 13 | Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma显示文摘Objective: To analyze the differences in clinicopathologic characteristics and prognosis between mucinous gastric carcinoma (MGC) and signet-ring cell carcinoma (SRCC). Methods: Clinicopathologic and prognostic data of 1,637 patients with histologically confirmed MGC or SRCC who received surgical operations in the Department of Gastroenterological Surgery, Beijing Cancer Hospital between December 2004 and December 2009 were retrospectively collected and analyzed. The clinicopathological features were analyzed statistically using χ 2 test. Survival was analyzed using the Kaplan-Meier method and multivariate analysis of Cox proportional hazards regression model (backward, stepwise). Results: A total of 181 patients with gastric cancer (74 MGC, 107 SRCC) were included. MGC, when compared with SRCC, was featured by senile patients, stage III and IV, upper third stomach, large tumor size, positive lymph node metastasis, and positive lymphatic vascular invasion (P<0.05). The overall 5-year survival rate showed no difference between the two groups (48.8% vs. 44.8%, P>0.05). However, the survival rate for MGC patients was significant lower than that for SRCC patients when compared among the age <60 years, negative distant metastasis, and tumor localized at upper third stomach (P<0.05). Multivariate Cox proportional hazards models revealed that distant metastasis was a significant independent prognostic indicator in MGC group, and lymph node metastasis and distant metastasis was significant independent prognostic indicators in SRCC group. Conclusions: While compared with SRCC, MGC is associated with a more aggressive tumor biologic behavior. There is no statistically significant difference in distant metastasis, an independent prognostic indicator for both MGC and SRCC, which might be the reason for no significant difference of the overall survival rate between the patients with MGC and SRCC. | Zhaode Bu Zhixue Zheng Ziyu Li Xiaojiang Wu Lianhai Zhang Aiwen Wu Xianglong Zong Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 3 |
| 14 | A joint matrix minimization approach for multi-image face recognition显示文摘The Schatten p-quasi-norm regularized minimization problem has attracted extensive attention in machine learning, image recognition, signal reconstruction, etc. Meanwhile, the l_(2,1)-regularized matrix optimization models are also popularly used for its joint sparsity. Naturally, the pseudo matrix norm l_(2,p) is expected to carry over the advantages of both l_p and l_(2,1). This paper proposes a mixed l_(2,q)-l_(2,p) matrix minimization approach for multi-image face recognition. To uniformly solve this optimization problem for any q ∈ [1,2] and p ∈(0,2], an iterative quadratic method(IQM) is developed. IQM is proved to iescend strictly until it gets a stationary point of the mixed l_(2,q)-l_(2,p)matrix minimization. Moreover, a more practical IQM is presented for large-scale case. Experimental results on three public facial image databases show that the joint matrix minimization approach with practical IQM not only saves much computational cost but also achievez better performance in face recognition than state-of-the-art methods. | Liping Wang Aiwen Luo | 2018 | Science China Mathematics2018，61，7： | 2 |
| 15 | State of art of seismic design and seismic hazard analysis for oil and gas pipeline system显示文摘The purpose of this paper is to adopt the uniform confidence method in both water pipeline design and oil-gas pipeline design.Based on the importance of pipeline and consequence of its failure,oil and gas pipeline can be classified into three pipe classes,with exceeding probabilities over 50 years of 2%,5% and 10%,respectively.Performance-based design requires more information about ground motion,which should be obtained by evaluating seismic safety for pipeline engineering site.Different from a city's water pipeline network,the long-distance oil and gas pipeline system is a spatially linearly distributed system.For the uniform confidence of seismic safety,a long-distance oil and pipeline formed with pump stations and different-class pipe segments should be considered as a whole system when analyzing seismic risk.Considering the uncertainty of earthquake magnitude,the design-basis fault displacements corresponding to the different pipeline classes are proposed to improve deterministic seismic hazard analysis(DSHA).A new empirical relationship between the maximum fault displacement and the surface-wave magnitude is obtained with the supplemented earthquake data in East Asia.The estimation of fault displacement for a refined oil pipeline in Wenchuan MS8.0 earthquake is introduced as an example in this paper. | Aiwen Liu Kun Chen Jian Wu | 2010 | Earthquake Science2010，23，3： | 2 |
| 16 | Nomogram for predicting lymph node metastasis rate of submucosal gastric cancer by analyzing clinicopathological characteristics associated with lymph node metastasis显示文摘Background:To combine clinicopathological characteristics associated with lymph node metastasis for submucosal gastric cancer into a nomogram.Methods:We retrospectively analyzed 262 patients with submucosal gastric cancer who underwent D2 gastrectomy between 1996 and 2012.The relationship between lymph node metastasis and clinicopathological features was statistically analyzed.With multivariate logistic regression analysis,we made a nomogram to predict the possibility of lymph node metastasis.Receiver operating characteristic(ROC) analysis was also performed to assess the predictive value of the model.Discrimination and calibration were performed using internal validation.Results:A total number of 48(18.3%) patients with submucosal gastric cancer have pathologically lymph node metastasis.For submucosal gastric carcinoma,lymph node metastasis was associated with age,tumor location,macroscopic type,size,differentiation,histology,the existence of ulcer and lymphovascular invasion in univariate analysis(all P<0.05).The multivariate logistic regression analysis identified that age ≤50 years old,macroscopic type III or mixed,undifferentiated type,and presence of lymphovascular invasion were independent risk factors of lymph node metastasis in submucosal gastric cancer(all P<0.05).We constructed a predicting nomogram with all these factors for lymph node metastasis in submucosal gastric cancer with good discrimination [area under the curve(AUC)=0.844].Internal validation demonstrated a good discrimination power that the actual probability corresponds closely with the predicted probability.Conclusions:We developed a nomogram to predict the rate of lymph node metastasis for submucosal gastric cancer.With good discrimination and internal validation,the nomogram improved individualized predictions for assisting clinicians to make appropriated treatment decision for submucosal gastric cancer patients. | Zhixue Zheng Yinan Zhang Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Yiqiang Liu Zhaode Bu Jiafu Ji | 2015 | Chinese Journal of Cancer Research2015，27，6： | 2 |
| 17 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 18 | Risk factors associated with early recurrence of adenocarcinoma of gastroesophageal junction after curative resection显示文摘Objective: To clarify the important clinicopathological factors affecting the early recurrence of adenocarcinoma of esophagogastric junction (AEG). Methods: We retrospectively reviewed the clinical data of 147 AEG patients who underwent R0 resection during the period from December 1995 to December 2007. Risk factors asssociated with the early recurrence were analyzed by χ2 test and logistic regression test. Results: The mean time to tumor recurrence was 16.3 months after R0 resection, and the 1-year recurrence rate was 48.3%. Univariate analysis showed that the histological grade (poorly and moderately differentiated), number of positive lymph nodes, and vascular invasion were significantly related with the early recurrence (P<0.05). Logistic multivariate regression analysis showed that only histological grade and vascular invasion were independently related with early tumor recurrence (P<0.05). Conclusions: Histological grade and vascular invasion are independent factors for predicting the early tumor recurrence after R0 resection for AEG. | Guodong Wang Aiwen Wu Xiaojing Cheng Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，3： | 2 |
| 19 | Photocatalytic decarboxylative coupling between α-oxocarboxylicacids and alkenes显示文摘Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis.As special acids,α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives.In this article,we have developed a photocatalytic decarboxylative cross-coupling ofα-oxocarboxylic acids and olefins to the synthesis of diverse aryl ketones.Various alkenes andα-oxocarboxylicacids were compatible,generating the desired products in up to 90%yield.Preliminary mechanism studies suggest that a free radical pathway is involved in this process. | Ziyue Chen Fangling Lu Feng Yuan Juanjuan Sun Linyu Du Zhen Li Meng Gao Renyi Shi Aiwen Lei | 2019 | Science China Chemistry2019，62，11： | 2 |
| 20 | Light-dependent phosphate uptake of a submersed macrophyte Myriophyllum spicatum L.显示文摘 | Meng Zhang Te Cao Leyi Ni Ping Xie Guorong Zhu Aiwen Zhong Jun Xu Hui Fu | 2011 | Aquatic Botany2011，，4： | 2 |
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