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| 1 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 2 | Effects of dynamic ventilatory factors on ventilatorinduced lung injury in acute respiratory distress syndrome dogs显示文摘BACKGROUND:Mechanical ventilation is a double-edged sword to acute respiratory distress syndrome(ARDS) including lung injury,and systemic inflammatory response high tidal volumes are thought to increase mortality.The objective of this study is to evaluate the effects of dynamic ventilatory factors on ventilator induced lung injury in a dog model of ARDS induced by hydrochloric acid instillation under volume controlled ventilation and to investigate the relationship between the dynamic factors and ventilator-induced lung injuries(VILI) and to explore its potential mechanisms.METHODS:Thirty-six healthy dogs were randomly divided into a control group and an experimental group.Subjects in the experimental group were then further divided into four groups by different inspiratory stages of flow.Two mL of alveolar fluid was aspirated for detection of IL-8 and TNF-α.Lung tissue specimens were also extracted for total RNA,IL-8 by western blot and observed under an electronic microscope.RESULTS:IL-8 protein expression was significantly higher in group B than in groups A and D.Although the IL-8 protein expression was decreased in group C compared with group B,the difference was not statistically significant.The TNF-α ray degree of group B was significantly higher than that in the other groups(P<0.01),especially in group C(P>0.05).The alveolar volume of subjects in group B was significantly smaller,and cavity infiltration and cell autolysis were marked with a significant thicker alveolar septa,disorder of interval structures,and blurring of collagenous and elastic fiber structures.A large number of necrotic debris tissue was observed in group B.CONCLUSION:Mechanical ventilation with a large tidal volume,a high inspiratory flow and a high ventilation frequency can cause significant damage to lung tissue structure.It can significantly increase the expression of TNF-α and IL-8 as well as their mRNA expression.Furthermore,the results of our study showed that small tidal ventilation significantly reduces the release of proinflammatory media.This finding suggests that greater deterioration in lung injury during ARDS is associated with high inspiratory flow and high ventilation rate. | Rui-lan Wang Kan Xu Kang-long Yu Xue Tang Hui Xie | 2012 | World Journal of Emergency Medicine2012，3，4： | 8 |
| 3 | Effects of cefodizime on chemokines of liver tissues in mice with immunological hepatic injury显示文摘背景长期的肝的发炎被淋巴细胞的累积在感染的地点在织物以内从血和保留作为增加的招募的后果描绘。CXC chemokine ligand 16 (CXCL16 ) mRNA 被检测了在发炎并且正常的肝纸巾并且强烈在在一个鼠科的模型的受伤的肝纸巾的 upregulated。这研究的目的是与免疫学的在老鼠在肝纸巾的 CXCL16 mRNA 上调查 cefodizime 的效果肝的 injury.Methods 免疫学的鼠科的模型肝的损害被杆菌 Calmette Guerin 和 Lipoposaccharide 导致。有肝的损害随机被分到模型组, cefodizime 组和 ceftriaxone 组的免疫学的老鼠。三个组连续地被给代理人七天,肝织物的 CXCL16 mRNA 与正常对待的控制组一起坚定、对比盐。反向的抄写聚合酶链反应在 CXCL16 mRNA 的表达式是的肝 tissues.Results 习惯于试金 CXCL16 mRNA 层次显著地,更高,在模型,组和 ceftriaxone 比在控制组和 cefodizime 组( P 0.05 )组织,显示在模型组和 ceftriaxone 组的鼠标是 immunodeficient 。在在控制组和 cefodizime 组之间的 CXCL16 mRNA 的表情没有统计差别。同样,在在模型组和 ceftriaxone 组之间的 CXCL16 mRNA 的表达式的统计差别都没被检测(P 0.05 ).Conclusion Cefodizime 有效地把淋巴细胞的渗入简化为肝纸巾并且与免疫学的在鼠标在肝纸巾由减少的 CXCL16 mRNA 减轻肝损坏肝的损害。 | WANG Peng KAN Quan-cheng YU Zu-jiang LI Ling PAN Xue | 2011 | Chinese Medical Journal2011，，5： | 8 |
| 4 | Functional Analysis of Slow Myosin Heavy Chain 1 and Myomesin-3 in Sarcomere Organization in Zebrafish Embryonic Slow Muscles显示文摘Myofibrillogenesis, sarcomere 形成的过程,要求 sarcomeric 蛋白质的靠近的相互作用和 sarcomere 结构的各种各样的部件。肌浆球蛋白厚细丝和 M 线是 sarcomere 的二个关键部件。M 线的 myomesin 蛋白质与肌浆球蛋白和 titin 蛋白质交往并且使,这被建议了厚并且有序的 titin 细丝。然而,在 myofibrillogenesis 和 sarcomere 组织的 myomesin 的功能仍然保持大部分神秘。没有猛烈或击倒的动物模型被报导了阐明在 sarcomere 组织 in vivo 的 myomesin 的角色。在这研究,由在 zebrafish 胚胎使用基因特定的击倒的途径,我们执行了 myomesin-3 和慢肌浆球蛋白的 loss-of-function 分析重链(smyhc1 ) 1 在慢肌肉明确地表示了。我们表明了那废除的 smyhc1 击倒在慢肌肉的 myomesin-3 的 sarcomeric 本地化。相反, myomesin-3 的损失没在厚、薄的细丝以及 M 线和 Z 线结构的 sarcomeric 组织上有效果。一起,这些研究显示那肌浆球蛋白厚细丝为 M 线组织和 myomesin-3 的 M 线本地化被要求。相反, myomesin-3 为在慢肌肉的 sarcomere 组织是非必需的。 | Jin Xu Jie Gao Junling Li Liangyi Xue Kan J. Clark Stephen C. Ekker Shao Jun Du | 2012 | Journal of Genetics and Genomics2012，39，2： | 6 |
| 5 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 6 | New WHO global air quality guidelines help prevent premature deaths in China显示文摘The air quality guidelines (AQGs) issued by the World Health Organization (WHO) in 2005 are key references for the National Ambient Air Quality Standards (NAAQSs) in China.On 22September 2021,the WHO issued new AQGs (NAQGs)[1],which propose more stringent targets to control exposure to multiple air pollutants,including fine particulate matter (PM_(2.5)) and ozone (O_(3)),to which,in 2019,451 million premature deaths,globally,were attributable [2]. | Tao Xue Guannan Geng Xia Meng Qingyang Xiao Yixuan Zheng Jicheng Gong Jun Liu Wei Wan Qiang Zhang Haidong Kan Shiqiu Zhang Tong Zhu | 2022 | National Science Review2022，9，4： | 3 |
| 7 | Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data显示文摘AIM To explore the expression profiles of microRNAs(miRNAs), long non-coding RNAs(lncRNAs), and mRNAs in oesophageal squamous cell carcinoma(ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA(ceRNA) network.METHODS In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.RESULTS CeRNAs have the ability to reduce the targeting activityof miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.CONCLUSION This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers. | Wen-Hua Xue Zhi-Rui Fan Li-Feng Li Jing-Li Lu Bing-Jun Ma Quan-Cheng Kan Jie Zhao | 2018 | World Journal of Gastroenterology2018，24，1： | 3 |
| 8 | Laparoscopic vs.open lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction:An exploratory,observational,prospective,IDEAL stage2b cohort study(CLASS-10 study)显示文摘Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open group.Interventions:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.Primary and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall survival.Conclusions:The study will provide data for the guidance and development of surgical treatment strategies for AEG.Trial registration number:The study has been registered in ClinicalTrials.gov(No.NCT04443478). | Shuangxi Li Xiangji Ying Fei Shan Yongning Jia Zhemin Li Kan Xue Rulin Miao Yinkui Wang Zhaode Bu Xiangqian Su Ziyu Li Jiafu Ji | 2022 | Chinese Journal of Cancer Research2022，34，4： | 3 |
| 9 | Detection of H_2O_2 at a composite film modified electrode with highly dispersed Ag nanoparticles in Nafion显示文摘Ag nanoparticles 被使用在电极上与电气化学的减小相结合的 Nafion 的离子交换准备。Ag nanoparticles 高度与 4.0 的一种平均尺寸在 Nafion 电影被驱散 ?? 輅蔆????????? 郱?????? | Mei Xiu Kan Xue Ji Wang Hui Min Zhang | 2011 | Chinese Chemical Letters2011，22，4： | 2 |
| 10 | Stability and deformation of surrounding rock in pillarless gob-side entry retaining显示文摘 | Nong Zhang Liang Yuan Changliang Han Junhua Xue Jiaguang Kan | 2011 | Safety Science2011，，4： | 2 |
| 11 | An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip显示文摘CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid,portable and accurate features.However,cleavage of the amplicons and primers by the cis-and trans-activity of Cas12a hinders the attempts to integrate the amplification and detection into a single reaction.Through phosphorothioate modification of primers,we realized onepot detection with high sensitivity using plasmids of SARS-CoV-2,HPV16 and HPV18.We also identified the activated Cas12a has a much higher affinity to C nucleotide-rich reporter than others.By applying such reporters,the reaction time required for a lateral-flow readout was significantly reduced.Furthermore,to improve the specificity of the strip-based assay,we created a novel reporter and,when combined with a customized gold-nanopaticle strip,the readout was greatly enhanced owing to the elimination of the nonspecific signal.This established system,termed Targeting DNA by Cas12a-based Eye Sight Testing in an Onepot Reaction(TESTOR),was validated using clinical cervical scrape samples for human papillomaviruses(HPVs)detection.Our system represents a general approach to integrating the nucleic acid amplification and detection into a single reaction in CRISPR-Cas systems,highlighting its potential as a rapid,portable and accurate detection platform of nucleic acids. | Jiaojiao Gong Lijuan Kan Xiuming Zhang Ying He Jiaqiang Pan Liping Zhao Qianyun Li Menghao Liu Jie Tian Sili Lin Zhouyu Lu Liang Xue Chaojun Wang Guanghui Tang | 2021 | Bioactive Materials2021，6，12： | 1 |
| 12 | Stability and deformation of surrounding rock in pillarless gob-side entry retaining显示文摘 | Nong Zhang Liang Yuan Changliang Han Junhua Xue Jiaguang Kan | 2011 | Safety Science2011，，4： | 1 |
| 13 | Stromal cell- derived factor-1 ( SDF-1 ) enhances cells invasion by cxv136 integrin- mediated signaling in ovarian cancer显示文摘 | XUE Bao-yao WU Wei-guang HUANG Kan | 2013 | Mol Cell Biochem2013，380，12： | 1 |
| 14 | Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel:An Open-Label,Blank-Controlled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022显示文摘Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro studies.What is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019(COVID-19)infection in medical personnel for the first time.What are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of COVID-19 infection.The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak. | Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong | 2023 | China CDC weekly2023，5，10： | 1 |
| 15 | MicroRNA‐103a inhibits gastric cancer cell proliferation, migration and invasion by targeting c‐Myb显示文摘 | Jinlong Liang Xianfeng Liu Hongpeng Xue Bing Qiu Bin Wei Kan Sun | 2015 | Cell Prolif2015，，1： | 1 |
| 16 | Design and parameter optimization of spiral-dragon type straw chopping test rig显示文摘In order to address the problems of large chop length,high energy consumption and poor chopping effect that were associated with a horizontal total mixed rations(TMR)mixer,a straw chopping device was designed;further,its structure and working principle were analyzed.In this study,wheat straw was chosen as the test object.The number of processing times,number of fixed blades,cutting speed,number of tooth plates and the inclined angle of the box were considered as the test factors.The standard straw length rate and average power were used as evaluation indices for conducting the orthogonal rotation combination experiment with five factors and five levels of quadratic regression.The experimental results denoted that the order of influencing factors on the standard straw length rate can be given as follows:the number of processing times,number of fixed blades,cutting speed,number of tooth plates and inclined angle of the box.The order of the influence of each factor on the average power can be given as follows:the cutting speed,number of fixed blades and number of tooth plates.Further,the optimum structural and working parameters of the device can be determined as follows:linear cutting speed of 17-20 m/min,box inclined angle of 70°-80°,20-23 fixed blades,5-6 processing times and 4-7 tooth plates.Under such a circumstance,the standard straw length rate reached up to 70.5%-77.4%and the average power was low at 5.8-7 kW.The results can be used as reference for designing a chopping device for a TMR mixer. | Pengbo Ma Liqiao Li Baoqin Wen Yunheng Xue Za Kan Jingbin Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 1 |
| 17 | Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy显示文摘Background:Arteriosclerosis obliterans(ASO)is a major cause of adult limb loss worldwide.Autophagy of vascular endothelial cell(VEC)contributes to the ASO progression.However,the molecular mechanism that controls VEC autophagy remains unclear.In this study,we aimed to explore the role of the GRB2 associated binding protein 1(GAB1)in regulating VEC autophagy.Methods:In vivo and in vitro studies were applied to determine the loss of adapt protein GAB1 in association with ASO progression.Histological GAB1 expression was measured in sclerotic vascular intima and normal vascular intima.Gain-and loss-of-function of GAB1 were applied in VEC to determine the effect and potential downstream signaling of GAB1.Results:The autophagy repressor p62 was significantly downregulated in ASO intima as compared to that in healthy donor(0.80 vs.0.20,t=6.43,P<0.05).The expression level of GAB1 mRNA(1.00 vs.0.24,t=7.41,P<0.05)and protein(0.72 vs.0.21,t=5.97,P<0.05)was significantly decreased in ASO group as compared with the control group.Loss of GAB1 led to a remarkable decrease in LC3II(1.19 vs.0.68,t=5.99,P<0.05),whereas overexpression of GAB1 significantly led to a decrease in LC3II level(0.41 vs.0.93,t=7.12,P<0.05).Phosphorylation levels of JNK and p38 were significantly associated with gain-and loss-of-function of GAB1 protein.Conclusion:Loss of GAB1 promotes VEC autophagy which is associated with ASO.GAB1 and its downstream signaling might be potential therapeutic targets for ASO treatment. | Meng Ye Xiang-Jiang Guo Ke-Jia Kan Qi-Hong Ni Jia-Quan Chen Han Wang Xin Qian Guan-Hua Xue Hao-Yu Deng Lan Zhang | 2021 | Chinese Medical Journal2021，，1： | 1 |
| 18 | Construct of Job Performance: Evidence from Chinese Military Soldiers 显示文摘 | Zheng - Xue Luo Kan Shi Wen - Dong Li Dan - Min Miao | 2008 | Asian Journal of Social Psychology2008，11，3： | 1 |
| 19 | Effect of inhibitors on Zn-dendrite formation for zine-polyaniline secondary battery 显示文摘 | KAN Jinqing XUE Huaiguo MU Shaolin | 1998 | Journal of Power Sources1998，74，： | 1 |
| 20 | Stability and deformation of surrounding rock in pillarless gob-side entry retaining显示文摘 | Nong Zhang Liang Yuan Changliang Han Junhua Xue Jiaguang Kan | 2011 | Safety Science2011，，4： | 1 |
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