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| 1 | Sequential and Concomitant Therapy With Four Drugs Is Equally Effective for Eradication of H pylori Infection显示文摘 | Deng–Chyang Wu Ping–I. Hsu Jeng–Yih Wu Antone R. Opekun Chao–Hung Kuo I.–Chen Wu Sophie S.W. Wang Angela Chen Wen–Chun Hung David Y. Graham | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 7 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 4 | Sequential and Concomitant Therapy With Four Drugs Is Equally Effective for Eradication of H pylori Infection显示文摘 | Deng–Chyang Wu Ping–I. Hsu Jeng–Yih Wu Antone R. Opekun Chao–Hung Kuo I.–Chen Wu Sophie S.W. Wang Angela Chen Wen–Chun Hung David Y. Graham | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 2 |
| 5 | Does your intelligence help to survive in a foreign jungle? The effects of cultural intelligence and emotional intelligence on cross-cultural adjustment显示文摘 | Yi-chun Lin Angela Shin-yih Chen Yi-chen Song | 2012 | International Journal of Intercultural Relations2012，，4： | 2 |
| 6 | Embedded software-based self-test for programmable core-base designs显示文摘 | Angela Krstic Chen Li | 2002 | Design and Test of Computer IEEE2002，，7： | 1 |
| 7 | Self-reported health- related quality of life and sleep disturbances in taiwanese people with heart failure显示文摘 | Chen H M Angela P Tsai L M | 2010 | J Cardiovas Nuts2010，25，6： | 1 |
| 8 | Tumor-derived CD4 + CD25 + regulatory T cell suppression of dendritic cell function involves TGF- β and IL-10显示文摘 | Nicolas Larmonier Marilyn Marron Yi Zeng Jessica Cantrell Angela Romanoski Marjan Sepassi Sylvia Thompson Xinchun Chen Samita Andreansky Emmanuel Katsanis | 2006 | Cancer Immunology, Immunotherapy2006，，1： | 1 |
| 9 | Cell-free fetal DNA levels in matemal plasma after elective first - trimester termination of pregnancy显示文摘 | Tuangsit Wataganara MD Angela Y Chen MD | 2004 | Reproductive Endocrindoqy2004，81，3： | 1 |
| 10 | Choud computing as an innovation:Per- cepetton,attitude,and adoption显示文摘 | Angela Lin Nan-Chou Chen | 2012 | International Joural of Information Management2012，32，： | 1 |
| 11 | Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls显示文摘 | Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeb?ller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lew | 2013 | Human Genetics2013，，： | 1 |
| 12 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan显示文摘 | Lin Angela Yu Chen Yu Tsung Hsien Lateef Shaik Khaja | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 13 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 14 | Pharmacokinetic comparison of two nicotine transdermal systems, a 21 rag/24 Hour Patch and a 25 mg/16-Hour Patch:A randomized, open-label, single-dose, two-way crossover study in adult smokers 显示文摘 | Angela M DeVeaugh-Geiss Lilan H Chen Mitchell L Kotler | 2010 | Clinical Therapeutics2010，32，6： | 1 |
| 15 | Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10显示文摘 | Nicolas Larmonier Marilyn Marron Yi Zeng Jessica Cantrell Angela Romanoski Marjan Sepassi Sylvia Thompson Xinchun Chen Samita Andreansky Emmanuel Katsanis | 2007 | Cancer Immunology Immunotherapy2007，，1： | 1 |
| 16 | Embedded software-based self-test for programmable core-based designs 显示文摘 | Angela Krstic CHEN Li LAI Wei-cheng | 2002 | IEEE Design and Test of Computers2002，，7： | 1 |
| 17 | Cloud computing asan innovation : perception, attitude,and adoption 显示文摘 | ANGELA LIN NAN-CHOU CHEN | 2012 | In-ternational Journal of Information Management2012，，32： | 1 |
| 18 | Occurrence of pharmaceuticals in Taiwan’s surface waters:impact of waste streams from hospitals and pharmaceutical production facilities显示文摘 | Lin Angela Yu Chen Tsai Yu Ting | 2009 | Sci Total Environ2009，407，12： | 1 |
| 19 | Phototransformation of cephalosporin antibiotics in an aqueous environment re- sults in higher toxicity 显示文摘 | Wang Xiao-huan Angela Yu Chen Lin | 2012 | Environmental Science and Tech- nology2012，46，12： | 1 |
| 20 | Cloud computing as an inno- vation : Percepetion, attitude, and adoption 显示文摘 | LIN Angela CHEN Nan-Chou | 2012 | International Journal of Information Management2012，32，6： | 1 |
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