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| 1 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 2 | Improving CLM4.5 Simulations of Land–Atmosphere Exchange during Freeze–Thaw Processes on the Tibetan Plateau显示文摘Soil is heterogeneous and has different thermal and hydraulic properties, causing varied behavior in heat and moisture transport. Therefore, soil has an important effect on land–atmosphere interactions. In this study, an improved soil parameterization scheme that considers gravel and organic matter in the soil was introduced into CLM4.5(Community Land Model). By using data from the Zoige and Madoi sites on the Tibetan Plateau, the ability of the model to simultaneously simulate the duration of freeze–thaw periods, soil temperature, soil moisture, and surface energy during freeze–thaw processes, was validated. The results indicated that:(1) the new parameterization performed better in simulating the duration of the frozen, thawing, unfrozen, and freezing periods;(2) with the new scheme, the soil thermal conductivity values were decreased;(3) the new parameterization improved soil temperature simulation and effectively decreased cold biases;(4) the new parameterization scheme effectively decreased the dry biases of soil liquid water content during the freezing, completely frozen, and thawing periods, but increased the wet biases during the completely thawed period; and(5) the net radiation, latent heat flux, and soil surface heat flux of the Zoige and Madoi sites were much improved by the new organic matter and thermal conductivity parameterization. | Siqiong LUO Xuewei FANG Shihua LYU Yu ZHANG Boli CHEN | 2017 | Journal of Meteorological Research2017，31，5： | 13 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | Simulated effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region of the Northern Hemisphere显示文摘Soil freeze-thaw process is closely related to surface energy budget,hydrological activity,and terrestrial ecosystems.In this study,two numerical experiments(including and excluding soil freeze-thaw process)were designed to examine the effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region in the Northern Hemisphere based on the state-of-the-art Community Earth System Model version 1.0.5.Results show that in response to soil freeze-thaw process,the area averaged soil temperature in the shallow layer(0.0175−0.0451 m)decreases by 0.35℃in the TP(Tibetan Plateau),0.69℃in CES(Central and Eastern Siberia),and 0.6℃in NA(North America)during summer,and increases by 1.93℃in the TP,2.28℃in CES and 1.61℃in NA during winter,respectively.Meanwhile,in response to soil freeze-thaw process,the area averaged soil liquid water content increases in summer and decrease in winter.For surface heat flux components,the ground heat flux is most significantly affected by the freeze-thaw process in both summer and winter,followed by sensible heat flux and latent heat flux in summer.In the TP area,the ground heat flux increases by 2.82 W/m2(28.5%)in summer and decreases by 3.63 W/m2(40%)in winter.Meanwhile,in CES,the ground heat flux increases by 1.89 W/m2(11.3%)in summer and decreases by 1.41 W/m2(18.6%)in winter.The heat fluxes in the Tibetan Plateau are more susceptible to the freeze-thaw process compared with the high-latitude frozen soil regions.Soil freeze-thaw process can induce significant warming in the Tibetan Plateau in winter.Also,this process induces significant cooling in high-latitude regions in summer.The frozen ground can prevent soil liquid water from infiltrating to deep soil layers at the beginning of thawing;however,as the frozen ground thaws continuously,the infiltration of the liquid water increases and the deep soil can store water like a sponge,accompanied by decreasing surface runoff.The influence of the soil freeze-thaw process on surface hydrologic and thermal fluxes varies seasonally and spatially. | Di Ma SiQiong Luo DongLin Guo ShiHua Lyu XianHong Meng BoLi Chen LiHui Luo | 2021 | Research in Cold and Arid Regions2021，13，1： | 4 |
| 5 | Post COVID-19 burden:focus on the short-term condition显示文摘The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths[1].During the past 2 years,global studies on prevention and therapies for COVID-19 have achieved a series of promising findings,including antiviral drugs(Remdesivir,Molnupiravir,Paxlovid)and monoclonal antibodies(Bamlanivimab and Etesevimab,Sotrovimab,Casirivimab and Imdevimab)[2]. | Fengwen Yang Bo Pang Xinyao Jin Zhe Chen Wentai Pang Qingquan Liu Junhua Zhang Boli Zhang | 2022 | Acupuncture and Herbal Medicine2022，2，3： | 2 |
| 6 | An improvement of soil temperature simulations on the Tibetan Plateau显示文摘The simulation of soil temperature on the Tibetan Plateau(TP) plays a dominant role in the performance of both global climate and numerical weather forecast models. To improve the simulation of soil temperature on the TP, the Johansen soil thermal conductivity parameterization scheme was introduced into Community Land Model 3.5(CLM3.5) and Regional Climatic Model 4(Reg CM4). The improved CLM3.5 and Reg CM4-CLM were utilized to conduct offline and regional simulation experiments on the TP. Comparison of the new and old schemes revealed that CLM3.5 provides high thermal conductivity parameters of mineral soil solid on the TP. The Johansen scheme is more practical for the TP than the soil thermal conductivity parameterization in CLM3.5. The simulation of soil temperature and liquid water content was improved in offline experiment. The improved parameterization scheme can also reduce the simulation error of soil temperature in winter throughout the entire TP. | SiQiong Luo BoLi Chen ShiHua Lyu XueWei Fang JingYuan Wang XianHong Meng LunYu Shang ShaoYing Wang Di Ma | 2018 | Research in Cold and Arid Regions2018，10，1： | 2 |
| 7 | Danhong Injection Inhibits the Development of Atherosclerosis in Both Apoe?/? and Ldlr?/? Mice显示文摘 | Yuanli Chen Mengyang Liu Tao Zhao Buchang Zhao Lifu Jia Yan Zhu Boli Zhang Xiumei Gao Guangliang Li Xiaoju Li Rong Xiang Jihong Han Yajun Duan | 2014 | Journal of Cardiovascular Pharmacology2014，，5： | 1 |
| 8 | Estimationof the repeat-pass ALOS PALSAR interferometricbaseline through direct least-square ellipse fitting显示文摘 | Xiong Boli Chen J M Kuang Gang-yao | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，9： | 1 |
| 9 | A Multicenter Randomized Double-Blind Parallel-Group Placebo-Controlled Study of the Effects of Qili Qiangxin Capsules in Patients with Chronic Heart Failure显示文摘 | Xinli Li Jian Zhang Jun Huang Aiqun Ma Jiefu Yang Weimin Li Zonggui Wu Chen Yao Yuhui Zhang Wenming Yao Boli Zhang Runlin Gao | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 10 | In-plane epitaxial growth of 2D CoSe-WSe2 metalsemiconductor lateral heterostructures with improved WSe2 transistors performance显示文摘The two-dimensional(2D)in-plane(lateral)heterostructures have attracted increasing interest for potential applications in the atomically thin electronics and optoelectronics.While most studies focus on semiconductorsemiconductor lateral heterostructures with highly similar lattice structures between the constituent components,the synthesis of metal-semiconductor lateral heterostructures is much less explored and usually more challenging due to more distinct lattice structures or chemical properties.Herein,a vapor phase epitaxy growth method of high-quality metal-semiconductor lateral heterostructures between tetragonal CoSe and hexagonal WSe2 is reported.The 2D CoSe can selectively nucleate at the edge of pre-grown WSe2 nanosheets to form CoSe-WSe2 metal-semiconductor lateral heterostructures.Optical microscopy(OM),scanning electron microscopy(SEM),and atomic force microscopy(AFM)studies reveal distinct contrast across the heterostructure interface.High-resolution transmission electron microscopy(HRTEM)and selected area electron diffraction(SAED)studies further confirm the microstructure modulation across the heterostructure interface.The field-effect transistors(FETs)of CoSe-WSe2 lateral heterostructures show satisfactory Ohmic contacts and considerably better FET performance over those with deposited Cr/Au contacts,suggesting the in-plane metal-semiconductor junctions may function as improved contacts for the atomically thin electronics. | Huifang Ma Kejing Huang Ruixia Wu Zhengwei Zhang Jia Li Bei Zhao Chen Dai Ziwei Huang Hongmei Zhang Xiangdong Yang BoLi Yuan Liu Xiangfeng Duan Xidong Duan | 2021 | InfoMat2021，3，2： | 1 |
| 11 | A Change Detection Measure Based on a Likelihood Ratio and Statistical Properties of SAR Intensity Images显示文摘 | XIONG Boli CHEN J M KUANG Gangyao | 2012 | Remote Sensing Letters2012，3，3： | 1 |
| 12 | Journal of Instrumental Analysis显示文摘 | Xiao Yanhua Chen Chuanzhi Zuo Boli | 2008 | 27:8562008，27，： | 1 |
| 13 | Qi-Shen-Yi-Qi Dripping Pills for the Secondary Prevention of Myocardial Infarction: A Randomised Clinical Trial显示文摘 | Hongcai Shang Junhua Zhang Chen Yao Baoyan Liu Xiumei Gao Ming Ren Hongbao Cao Guohua Dai Weiliang Weng Sainan Zhu Hui Wang Hongjuan Xu Boli Zhang Hao Xu | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 14 | Letter to the editor: Comment on the Regulatios of the Simplified Registration and Approval Management for Compound Recipe of Classical Prescription of Traditional Chinese Medicine显示文摘To the Editor:On Oct 9,2017,China Food and Drug Administration announced1~ the Regulations of the Simplified Registration and Approval Management for Compound Recipe of Classical Prescription of Traditional Chinese Medicine(Exposure Draft)which has been stirring up intense debate in the West.The article China to Roll Back Regulations for Traditional Medicine Despite Safety Concerns lately | Shilin Chen Aihua Liang Boli Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 1 |
| 15 | siRNA directed against Livin inhibits tumor growth and induces apoptosis in human glioma cells显示文摘 | Bangqing Yuan Boli Ran Shousen Wang Zheng Liu Zhaocong Zheng Hongjie Chen | 2012 | Journal of Neuro-Oncology2012，，1： | 1 |
| 16 | Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent显示文摘Based on excellent experiment results of 99mTcO-MPBDA-Cl, two new ligands MPTDA and MPDAA are synthesized. Then series of 99mTcO3+ complexes are prepared through adding different halide anions, followed by tests of physical chemistry qualities and biodistribution experiments. And results of these experiments show that complexes formed with MPTDA and MPDAA have better lipophilicity than those formed with MPBDA, still maintain the good brain retention ability of this type of compounds, but radioactivity uptake in blood is higher than that of 99m TcO-MPBDA and ratios of brain/blood are reduced. Obvious affections are fetched out on brain uptake and retention if fluoride, bromide or iodide anions are added. Results of experiments can be explained in reason with theoretic computation. It is confirmed that 99m TcO-MPBDA-Cl has potential to develop a new type of brain imaging agent considering integrated factors such as brain uptake, retention and toxicity. | HE Qiange CHEN Xiangji MIAO Yubin LIU Boli | 2004 | Science China Chemistry2004，47，6： | 0 |
| 17 | DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice显示文摘Clinical observations indicate that DanHong Injection(DHI)can increase blood flow and reduce various syndromes in patients with cardiovascular disease.However,it still needs to define the function of DHI and the involved mechanisms in details,such as the protective effect on the development of primary abdominal aortic aneurysms(AAAs).In this study,we determined whether DHI is able to inhibit AAA in apoE knockout(apoE-/-)mice.Thirty apoE-/-male mice on high-fat diet(0.5%cholesterol,21%fat)were randomly divided into two groups and received i.p.injection of saline(100 lL/day)and DHI(100 lL/day),respectively,for 16 weeks.At the end of experiment,we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall,and serum lipid levels.We also determined the expression of monocyte chemoattractant protein-1(MCP-1),MMP-2,and MMP-9mRNA in aortic wall using real-time RT-PCR.Our results indicated that high-fat diet induced the development of AAAs in apoE-/-mice,but the induction was totally blocked by DHI(P\0.01).The result of staining of abdominal aortic cross sections showed that DHI maintained the collagen content in arterial wall,thereby preventing the animals from the development of AAA.Although DHI had little effect on serum total-and LDLcholesterol levels,it reduced the expression of MCP-1,MMP-2,and MMP-9 mRNA in aortic wall(P\0.01).Taken together,our study suggests that DHI can inhibit the high-fat diet-induced AAA formation.The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes.Our study may suggest a new application of DHI in clinics. | Mengyang Liu Yuanli Chen Xiaoxiao Yang Ling Zhang Tao Zhao Buchang Zhao Lifu Jia Yan Zhu Xiumei Gao Boli Zhang Xiaoju Li Rong Xiang Jihong Han Yajun Duan | 2014 | Chinese Science Bulletin2014，59，13： | 0 |
| 18 | Autonomous detection of crop rows based on adaptive multi-ROI in maize fields显示文摘Crop rows detection in maize fields remains a challenging problem due to variation in illumination and weeds interference under field conditions.This study proposed an algorithm for detecting crop rows based on adaptive multi-region of interest(multi-ROI).First,the image was segmented into crop and soil and divided into several horizontally labeled strips.Feature points were located in the first image strip and initial ROI was determined.Then,the ROI window was shifted upward.For the next image strip,the operations for the previous strip were repeated until multiple ROIs were obtained.Finally,the least square method was carried out to extract navigation lines and detection lines in multi-ROI.The detection accuracy of the method was 95.3%.The average computation time was 240.8 ms.The results suggest that the proposed method has generally favorable performance and can meet the real-time and accuracy requirements for field navigation. | Yang Zhou Yang Yang Boli Zhang Xing Wen Xuan Yue Liqing Chen | 2021 | International Journal of Agricultural and Biological Engineering2021，14，4： | 0 |
| 19 | Investigation of welding procedure of 9Cr-1Mo steel for manufacturing petrochemical equipment显示文摘Investigationofweldingprocedureof9Cr-1Mosteelformanufacturingpetrochemicalequipment￥HuangYunqingandChenBoli(TsinghuaUniversit... | Huang Yunqing and Chen Boli(Tsinghua University Beijing) | 1995 | China Welding1995，4，2： | 0 |
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