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| 1 | Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis显示文摘Forkhead box C1(FOXC1)is required for neural crest and ocular development,and mutations in FOXC1 lead to inherited Axenfeld-Rieger syndrome.Here,we find that FOXC1 and paired box 6(PAX6)are co-expressed in the human limbus and central corneal epithelium.Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers.FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2.FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells,but also disrupts the collagen metabolic process and interferon signaling pathways.Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer.Collectively,our results reveal a FOXC1.mediated regulatory network responsible for corneal epithelial homeostasis and provide a potential therapeutic target for corneal ulcer. | Mingsen Li Liqiong Zhu Jiafeng Liu Huaxing Huang Huizhen Guo Li Wang Lingyu Li Sijie Gu Jieying Tan Jing Zhong Bowen Wang Zhen Mao Yong Fan Chunqiao Liu Jin Yuan Hong Ouyang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 2 |
| 2 | D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration显示文摘Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the elderly.However,an effective therapy for this disease is lacking.Here,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE cells.Surprisingly,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein.The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model.These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD. | Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 4 | Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy显示文摘 | Haiyan Chen Bowen Li Xueyan Ren Shengnan Li Yuxiang Ma Sisi Cui Yueqing Gu | 2012 | Biomaterials2012，，33： | 1 |
| 5 | Synergistic effect of size-dependent PtZn nanoparticles and zinc single-atom sites for electrochemical ozone production in neutral media显示文摘Electrochemical ozone production(EOP) via water electrolysis represents an attractive method for the generation of high-purity O3. Herein, the X-PtZn/Zn-N-C electrocatalysts show a strong structural sensitive behavior depends on the size of the PtZn nanoparticles and their EOP activity exhibits a volcano-type dependence for the O3 performance in neutral media. The 7.7-PtZn/Zn-N-C exhibits EOP current efficiency of 4.2%, and shows the prominent performance in the production of gaseous O3 with a value of 1647 ppb at 30 min, which is almost 4-fold compared to 2.2-Pt Zn/Zn-N-C. Based on the experiments and theoretical calculations, the performance of the EOP process was determined by the nanoparticle size-effect and the synergistic effect between the PtZn nanoparticles and atomically dispersed Zn-N-C. Furthermore, the fivemembered cyclic structure of O3 can be stabilized between the PtZn nanoparticle and the Zn-N-C support,indicating that O3 is produced at the interface. | Bowen Yuan Zihao Yao Chenlong Qiu Haiyang Zheng Yilong Yan Qiaoqiao Zhang Xiang Sun Yu Gu Xing Zhong Jianguo Wang | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 6 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 7 | Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition显示文摘 | Bowen RS Zhang Y Gu Y | 2005 | Placenta2005，26，： | 1 |
| 8 | Microvascular exchange during bum injury: Ⅰ: a Reviex 显示文摘 | Bert J Bowen B Gu X | 1989 | Cir Shock1989，28，： | 1 |
| 9 | Ⅱ: Formation and Vali ela- tion of a mathematical mode 显示文摘 | Bert J Bowen B Gu X | 1989 | Cir Shock1989，28，： | 1 |
| 10 | Ⅲ: implication of the model 显示文摘 | Bowen B Bert J Gu X | 1989 | CirShpck1989，，28： | 1 |
| 11 | Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition 显示文摘 | Bowen RS Zhang Y Gu Y | 2005 | Placenta2005，26，5： | 1 |
| 12 | Hypoxia promote sinterleukin-6 and 8but reduces interleukin-10 production by placental trophoblast cells From preeclamptic pregnancies 显示文摘 | Bowen RS Gu Y Zhang Y | 2005 | J Soc Gynecol Investig2005，12，6： | 1 |
| 13 | Rederivation of AB Scattering Cross Section by the Method of Path Integration显示文摘Taking advantage of the calculation based on the original fundamental ideas of Aharonov and Bohm(AB)on the one hand,and making some necessary revisions on the other hand,this paper rederives the famous AB scattering cross section from the known propagator by the path integral method. | GU Zhiyu XIE Yuan HUANG Bowen QIAN Shangwu | 1993 | Chinese Physics Letters1993，10，4： | 0 |
| 14 | The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis显示文摘Meiosis is essential for fertility in sexually reproducing species and this sophisticated process has been extensively studied.Notwithstanding these efforts,key factors involved in meiosis have not been fully characterized.In this study,we investigate the regulatory roles of zinc finger protein 541(ZFP541)and its interacting protein potassium channel tetramerization domain containing 19(KCTD19)in spermatogenesis.ZFP541 is expressed from leptotene to the round spermatid stage,while the expression of KCTD19 is initiated in pachytene.Depletion of Zfp541 or Kctd19 leads to infertility in male mice and delays progression from early to mid/late pachynema.In addition,Zfp541^(-/-)spermatocytes show abnormal programmed DNA double-strand break repair,impaired crossover formation and resolution,and asynapsis of the XY chromosomes.ZFP541 interacts with KCTD19,histone deacetylase 1/2(HDAC1/2),and deoxynucleotidyl transferase terminal-interacting protein 1(DNTTIP1).Moreover,ZFP541 binds to and activates the expression of genes involved in meiosis and post-meiosis including Kctd19;in turn,KCTD19 promotes the transcriptional activation activity of ZFP541.Taken together,our studies reveal that the ZFP541/KCTD19 signaling complex,acting as a key transcription regulator,plays an indispensable role in male fertility by regulating pachytene progression. | Yushan Li Ranran Meng Shanze Li Bowen Gu Xiaotong Xu Haihang Zhang Xinshui Tan Tianyu Shao Jiawen Wang Dan Xu Fengchao Wang | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 15 | Overview of Recombinant Skin Models and Progress in Their Application in Vitro Assessment of Toxicity and Efficacy显示文摘A recombinant skin model is a model in which skin cells are grown in vitro on a bioactive scaffold and provided with adequate nutrition to promote cell proliferation and differentiation to produce a mock skin structure and biological features. The development of recombinant skin models allows for effective and scientifically sound in vitro evaluation tests. This review briefly summarizes the overview of recombinant skin models and the progress of their application in in vitro evaluation which focuses on three aspects: skin irritation, skin corrosivity, and anti-skin aging. Moreover, an outlook on the future development of recombinant skin models is also provided in this review. | Zhang Bowen Xu Qiufeng GU Wu Zhang Zhichun Dai Yumeng Han Zhiyang Xu Mingkai Wang Yu | 2023 | China Detergent & Cosmetics2023，8，1： | 0 |
| 16 | A 0.82 μVrms ultralow 1/f noise bandgap reference for a MEMS gyroscope显示文摘High-precision microelectromechanical system(MEMS)gyroscopes are significant in many applications.Bias instability(BI)is an important parameter that indicates the performance of a MEMS gyroscope and is affected by the 1/f noise of the MEMS resonator and readout circuit.Since the bandgap reference(BGR)is an important block in the readout circuit,reducing its 1/f noise is key to improving a gyroscope's Bl.In a traditional BGR,the error amplifer is applied to provide a virtual short-circuit point,but it introduces the main low-frequency noise sources.This paper proposes an ultralow 1/f noise BGR by removing the error amplifer and applying an optimized circuit topology.In addition,a simplified but accurate noise model of the proposed BGR is obtained to optimize the BGR's output noise performance.To verify this design,the proposed BGR has been implemented in a 180 nm CMOS process with a chip area of 545×423μm.The experimental results show that the BGR's output integrated noise from 0.1 to 10 Hz is 0.82μV and the thermal noise is 35 nV/√Hz.Furthermore,bias stability tests of the MEMS gyroscope fabricated in our laboratory with the proposed BGR and some commercial BGRs are carried out.Statistical results show that reducing the BGR's 1/f noisecannearly linearly improvethegyroscope's Bl. | Junjun Zou Qi Wei Chunge Ju Hua Liao Haoyu Gu Bowen Xing Bin Zhou Rong Zhang | 2023 | Microsystems & Nanoengineering2023，9，2： | 0 |
| 17 | Boosting overall saline water splitting by constructing a strain-engineered high-entropy electrocatalyst显示文摘High-entropy materials(HEMs),which are newly manufactured compounds that contain five or more metal cations,can be a platform with desired properties,including improved electrocatalytic performance owing to the inherent complexity.Here,a strain engineering methodology is proposed to design transition-metal-based HEM by Li manipulation(LiTM)with tunable lattice strain,thus tailoring the electronic structure and boosting electrocatalytic performance.As confirmed by the experiments and calculation results,tensile strain in the LiTM after Li manipulation can optimize the d-band center and increase the electrical conductivity.Accordingly,the asprepared LiTM-25 demonstrates optimized oxygen evolution reaction and hydrogen evolution reaction activity in alkaline saline water,requiring ultralow overpotentials of 265 and 42 mV at 10 mA cm−2,respectively.More strikingly,LiTM-25 retains 94.6%activity after 80 h of a durability test when assembled as an anion-exchange membrane water electrolyzer.Finally,in order to show the general efficacy of strain engineering,we incorporate Li into electrocatalysts with higher entropies as well. | Ateer Bao Yaohang Gu Yuxuan Zhang Bowen Zhang Juncheng Wu Bo Ni Xiaoyan Zhang Haijun Pan Xiwei Qi | 2024 | Carbon Energy2024，6，2： | 0 |
| 18 | Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer显示文摘Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy.Cannabidiol(CBD)is a non-psychoactive natural active ingredient from the cannabis plant that has various pharmacological effects,including neuroprotective,antiemetic,anti-inflammatory,and antineoplastic activities.This study aimed to elucidate the specific anticancer mechanism of CBD by single-cell RNA sequencing(scRNA-seq)and single-cell ATAC sequencing(scATAC-seq)technologies.Here,we report that CBD inhibits colorectal cancer progression by modulating the suppressive tumor microenvironment(TME).Our single-cell transcriptome and ATAC sequencing results showed that CBD suppressed M2-like macrophages and promoted M1-like macrophages in tumors both in strength and quantity.Furthermore,CBD significantly enhanced the interaction between M1-like macrophages and tumor cells and restored the intrinsic anti-tumor properties of macrophages,thereby preventing tumor progression.Mechanistically,CBD altered the metabolic pattern of macrophages and related anti-tumor signaling pathways.We found that CBD inhibited the alternative activation of macrophages and shifted the metabolic process from oxidative phosphorylation and fatty acid oxidation to glycolysis by inhibiting the phosphatidylinositol 3-kinase-protein kinase B signaling pathway and related downstream target genes.Furthermore,CBD-mediated macrophage plasticity enhanced the response to anti-programmed cell death protein-1(PD-1)immunotherapy in xenografted mice.Taken together,we provide new insights into the anti-tumor effects of CBD. | Xiaofan Sun Lisha Zhou Yi Wang Guoliang Deng Xinran Cao Bowen Ke Xiaoqi Wu Yanhong Gu Haibo Cheng Qiang Xu Qianming Du Hongqi Chen Yang Sun | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 0 |
| 19 | Enhanced electrochemical CO_(2)-to-C_(2+) conversion from synergistic interaction between terrace and step sites on monocrystalline highindex Cu facets显示文摘1. Introduction The increasing global demand for sustainable energy sources and emerging environmental issues have pushed the development of energy conversion and storage technologies to the forefront of chemical research [1,2]. In particular, electrochemical CO_(2) reduction(CO_(2) R) to value-added fuels and chemicals presents a feasible pathway for renewable energy storage and could help mitigate the ever-increasing CO_(2) emissions [3]. | Chenyuan Zhu Zhibin Zhang Lixiang Zhong Siwen Zhao Guoshuai Shi Bowen Wu Huoliang Gu Jing Wu Xinyang Gao Kaihui Liu Liming Zhang | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
| 20 | Long short-term memory deep learning model for predicting the dynamic performance of automotive PEMFC system显示文摘As a high efficiency hydrogen-to-power device,proton exchange membrane fuel cell(PEMFC)attracts much attention,especially for the automotive applications.Real-time prediction of output voltage and area specific resistance(ASR)via the on-board model is critical to monitor the health state of the automotive PEMFC stack.In this study,we use a transient PEMFC system model for dynamic process simulation of PEMFC to generate the dataset,and a long short-term memory(LSTM)deep learning model is developed to predict the dynamic per-formance of PEMFC.The results show that the developed LSTM deep learning model has much better perfor-mance than other models.A sensitivity analysis on the input features is performed,and three insensitive features are removed,that could slightly improve the prediction accuracy and significantly reduce the data volume.The neural structure,sequence duration,and sampling frequency are optimized.We find that the optimal sequence data duration for predicting ASR is 5 s or 20 s,and that for predicting output voltage is 40 s.The sampling frequency can be reduced from 10 Hz to 0.5 Hz and 0.25 Hz,which slightly affects the prediction accuracy,but obviously reduces the data volume and computation amount. | Bowen Wang Zijun Yang Mingxi Ji Jing Shan Meng Ni Zhongjun Hou Jun Cai Xin Gu Xinjie Yuan Zhichao Gong Qing Du Yan Yin Kui Jiao | 2023 | Energy and AI2023，14，4： | 0 |
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