|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy显示文摘技术开发总是是在生物医学的研究驾驶突破的力量之一。自从托马斯·摩根的时间起,一步一步地, Drosophilists 为操作并且机能上地把开发了强大的基因工具为改进这些技术并且开发新技术的果蝇染色体,而是房间仍然大,今天特别作为生物学家开始系统地学习不同模型有机体的功能的 genomics ,包括人,以一种高产量的方式。这里,我们报导,第一次在果蝇,为借助于改进抄写在很高的效率修改果蝇染色体的一个快速、容易、高度特定的方法像使活跃之物的受动器核酸酶(TALEN ) 策略。我们利用了最近发达的单位集会策略装配设计修改黄基因的二特定的 TALEN (在性染色体上) 并且新奇正染色体的基因。TALEN 的 mRNAs 随后被注入果蝇胚胎。从 31.2% 注射 F0 肥沃的苍蝇,我们检测了包含黄基因的可继承的修正。从到可继承的修正的察觉的特定的 TALEN 的建设的全部过程能在一个月以内被完成。在果蝇的这个调停 TALEN 的染色体修正方法的潜在的应用程序被讨论。 | Jiyong Liu Changqing Li Zhongsheng Yu Peng Huang Honggang Wu Chuanxian Wei Nannan Zhu Yan Shen Yixu Chen Bo Zhang Wu-Min Deng Renjie Jiao | 2012 | Journal of Genetics and Genomics2012，39，5： | 43 |
| 2 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 3 | VARIATIONAL PRINCIPLFS OF NONLINEAR PIEZOTHERMOELASTIC MEDIA显示文摘Through the phenomenological approach,the nonlinear constitutive equations couplingthe electro/magnetic therrnoelastic media are derived.Several nonlinear variational principles forpiezothermoelastic continua are presented and employed to formulate the incremental variational princi-ples which are of important significance in practical applications such as the nonlinear finite elementanalysis,the buckling,postbuckling and dynamic stability analyses of piezoelectric smart structures. | Chen Changqing Shen Yapeng Tian Xiaogeng (Department of Engineering Mechanics,Xi’an Jiaotong University,Xi’an 710049,China) | 1998 | Acta Mechanica Solida Sinica1998，11，1： | 4 |
| 4 | A Facile Self-assembly Synthesis of Hexagonal ZnO Nanosheet Films and Their Photoelectrochemical Properties显示文摘Here, large-scale and uniform hexagonal zinc oxide(ZnO) nanosheet films were deposited onto indium tin oxide(ITO)-coated transparent conducting glass substrates via a facile galvanic displacement deposition process. Compared with other commonly used solution methods, this process avoids high temperature and electric power as well as supporting agents to make it simple and cost-effective. The as-fabricated ZnO nanosheet films have uniform hexagonal wurtzite structure. The photoelectrochemical(PEC) cell based on ZnO nanosheet film/ITO photoelectrode was also fabricated and its performance was improved by optimizing the solution concentration. A higher photocurrent density of*500 l A cm^(-2)under AM 1.5 G simulated illumination of 100 m W cm^(-2)with zero bias potential(vs. Ag/AgCl electrode) was obtained, which may ascribe to the increased surface-to-volume ratio of disordered Zn O nanosheet arrays. Our developed method may be used to deposit other oxide semiconductors, and the Zn O nanosheet film/ITO PEC cell can be used to design low-cost optoelectronic and photoelectrochemical devices. | Bin Zhang Faze Wang Changqing Zhu Qiang Li Jingnan Song Maojun Zheng Li Ma Wenzhong Shen | 2016 | Nano-Micro Letters2016，8，2： | 3 |
| 5 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 3 |
| 6 | Synchronous chirp mode extraction: A promising tool for fault diagnosis of rolling element bearings under varying speed conditions显示文摘As critical components in modern aerospace productions,rolling element bearings(REBs)generally work under varying speed conditions,which brings great challenges to their operating health monitoring.Some novel time–frequency decomposition(TFD)algorithms are established recently to extract nonlinear features from the non-stationary signals effectively,which are promising for realizing fault diagnosis of REBs under varying speed conditions.However,numerous personal experiences must be incorporated and the anti-noise performance of these methods needs to be further enhanced.Given these issues,a synchronous chirp mode extraction(SCME)-based REB fault diagnosis method is proposed for the health monitoring of REBs under varying speed conditions in this study.It mainly consists of following two parts.(a)The shaft rotational frequency(SRF)is initially estimated from the low-frequency band of the vibration signal.Simultaneously,an adaptive refining strategy is incorporated to obtain a suitable bandwidth parameter.(b)A cycle-one-step estimation frame is constructed to extract synchronous modes from the envelope waveform of the vibration signal.Meanwhile,a synchronous mode spectrum(SMS)is generated using the information of the extracted synchronous modes,which is a novel REBs fault diagnosis technique with tacholess and resampling-free.In contrast to the current TFD algorithms,the proposed method needs fewer input parameters and owns a well anti-noise performance because there is no iterative optimization in the procedure of construction of SMS.As a result,the health conditions of REBs are evaluated by detecting the exhibited features in the SMS.Simulations and experiments are conducted to validate the effectiveness of the proposed method in terms of REB fault diagnosis.Analysis results demonstrate that the proposed method outperforms the current TFD algorithm and the conventional order tracking technique for fault diagnosis of REB under varying speed conditions. | Xingxing JIANG Qiang HUANG Changqing SHEN Qian WANG Kun XU Jie LIU Juanjuan SHI Zhongkui ZHU | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 7 | Spatial-temporal Distribution Characteristics of Global Seismic Clusters and Associated Spatial Factors显示文摘Earthquakes exhibit clear clustering on the earth. It is important to explore the spatial-temporal characteristics of seismicity clusters and their spatial heterogeneity. We analyze effects of plate space, tectonic style, and their interaction on characteristic of cluster.Based on data of earthquakes not less than moment magnitude(M_w) 5.6 from 1960 to 2014, this study used the spatial-temporal scan method to identify earthquake clusters. The results indicate that seismic spatial-temporal clusters can be classified into two types based on duration: persistent clusters and burst clusters. Finally, we analysed the spatial heterogeneity of the two types. The main conclusions are as follows: 1) Ninety percent of the persistent clusters last for 22-38 yr and show a high clustering likelihood;ninety percent of the burst clusters last for 1-1.78 yr and show a high relative risk. 2) The persistent clusters are mainly distributed in interplate zones, especially along the western margin of the Pacific Ocean. The burst clusters are distributed in both intraplate and interplate zones, slightly concentrated in the India-Eurasia interaction zone. 3) For the persistent type, plate interaction plays an important role in the distribution of the clusters’ likelihood and relative risk. In addition, the tectonic style further enhances the spatial heterogeneity. 4) For the burst type,neither plate activity nor tectonic style has an obvious effect on the distribution of the clusters’ likelihood and relative risk. Nevertheless,interaction between these two spatial factors enhances the spatial heterogeneity, especially in terms of relative risk. | YANG Jing CHENG Changxiu SONG Changqing SHEN Shi ZHANG Ting NING Lixin | 2019 | Chinese Geographical Science2019，29，4： | 2 |
| 8 | Criteria for the growth of large-area adlayer-free monolayer graphene films by chemical vapor deposition显示文摘Homogeneity is important to material applications for good performance of individual devices,for making AB-stacked bilayer graphene in a layer-by-layer stacking order,and from the point of view of industrial production.Among many properties to be controlled,for the case of graphene,the thickness(or layer number)uniformity is the prerequisite.Chemical vapor deposition(CVD)of C precursors on Cu substrates is the most popular method to produce large-area graphene films.To date,precise control on the number of graphene layers as well as the uniformity over a large area is still very challenging.In this work,with a further understanding of the factors affecting adlayer growth,the synthesis of large-area adlayer-free monolayer graphene(MLG)films was achieved up to tens of squared centimeters in area by just using untreated Cu foil and a normal CVD process.We found that keeping equal C precursor concentration on the two sides of the Cu substrate is a criterion in addition to other factors such as the ratio of H:C and the substrate surface morphology for the growth of adlayer-free MLG.This finding is not only of great significance for the industrial production of large-area adlayer-free MLG films but also instructive for the synthesis of homogeneous few-layer graphene. | Changqing Shen Xingzhou Yan Fangzhu Qing Xiaobin Niu Richard Stehle Samuel S.Mao Wanli Zhang Xuesong Li | 2019 | Journal of Materiomics2019，5，3： | 2 |
| 9 | A time domain correction method for Doppler-distortion signal from acoustic moving source显示文摘Doppler effect widely exists in the signal from the moving acoustic source.In order to solve such problems as frequency shift and frequency band expansion,a time domain correction method is presented in this paper.First,the discrete time vector for interpolation and the amplitude restoration formula is derived based on the moving relationship and the Morse acoustic theory,then the amplitude weights are corrected and the distortion signal is interpolated.Every point of the discrete signal is operated separately in time domain.Compared with the existing frequency domain methods,this method does not need to know the characteristic frequency beforehand and would not be influenced by the blending of the frequency band.Hence,this method can be employed to correct multiple frequency signals and it is also a simple and effective Doppler effect reduction method. | LIU Fang HE Qingbo SHEN Changqing HU Fei ZHANG Ao KONG Fanrang | 2014 | Chinese Journal of Acoustics2014，33，1： | 2 |
| 10 | Cross-national Perspectives on Using Sustainable Development Goals(SDGs) Indicators for Monitoring Sustainable Development: A Database and Analysis显示文摘Sustainable development is the theme of the 21st century. To monitor the progress of sustainable development, the United Nations launched Sustainable Development Goals(SDGs) in 2015. Subsequently, nations of the world have drawn up a list of localized indicators regarding the United Nations SDGs as a paradigm. We established a database including SDGs indicator systems of 11 economies by collecting and determining a large number of materials. Based on this database, we analyzed SDGs indicators by designing a conceptual framework of comparative analysis that included three views. We found that the SDGs indicator systems of 11 economies are different between the number of indicators, the proportion of different categories, and the connotation of indicators. Although the SDGs indicator systems among economies regarded the United Nations SDGs as a framework and included the major social problems related to sustainability, the inconsistency between SDGs indicator systems is large. It is a major reason why scholars lack the systematic method for developing indicators. There are challenges faced in data accessibility. The framework for comparative analysis could be applied to different economies. | WANG Xiangyu SONG Changqing CHENG Changxiu YE Sijing SHEN Shi | 2021 | Chinese Geographical Science2021，31，4： | 2 |
| 11 | A general and simple method for evaluating the electrical transport performance of graphene by the van der Pauw–Hall measurement显示文摘Expected for many promising applications in the field of electronics and optoelectronics, a reliable method for the characterization of graphene electrical transport properties is desired to predict its device performance or provide feedback for its synthesis.However, the commonly used methods of extracting carrier mobility from graphene field effect transistor or Hall-bar is time consuming, expensive, and significantly affected by the device fabrication process other than graphene itself.Here we reported a general and simple method to evaluate the electrical transport performance of graphene by the van der Pauw–Hall measurement.By annealing graphene in vacuum to remove the adsorbed dopants and then exposing it in ambient surroundings, carrier mobility as a function of density can be measured with the increase of carrier density due to the dopant re-adsorption from the surroundings.Further, the relationship between the carrier mobility and density can be simply fitted with a power equation to the first level approximation, with which any pair of measured carrier mobility and density can be normalized to an arbitrary carrier density for comparison.We experimentally demonstrated the reliability of the method, which is much simpler than making devices and may promote the standard making for graphene characterization. | Fangzhu Qing Yang Shu Linsen Qing Yuting Niu He Guo Shuyi Zhang Chunlin Liu Changqing Shen Wanli Zhang Samuel S.Mao Wenjuan Zhu Xuesong Li | 2018 | Science Bulletin2018，63，22： | 2 |
| 12 | A direct finite element method study of general- ized thermoelastic problems 显示文摘 | TIAN Xiaogeng SHEN Yapeng CHEN Changqing | 2006 | International Journal of Solids and Structures2006，43，78： | 1 |
| 13 | Structural stability and Raman scattering of CoPt and NiPt hollow nanospheres under high pressure显示文摘This paper reports that the high pressure in situ angle dispersive x-ray diffraction and Raman scattering studies on CoPt and NiPt hollow nanospheres are performed by means of a diamond anvil cell for generating external pressure at room temperature.The crystal structures of both the CoPt and NiP hollow nanospheres keep stable up to about 41 GPa.Moreover,it shows that the hollow nanospheres possess higher bulk moduli than their bulk counterparts by using the frst-principles density functional theory. | Xi Shen Qian Sun Jie Zhu Yuan Yao Jing Liu Changqing Jin Richeng Yu Rongming Wang | 2013 | Progress in Natural Science:Materials International2013，23，4： | 1 |
| 14 | MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways显示文摘 | Longlong Bao Yan Yan Can Xu Weidan Ji Shuwen Shen Gaoya Xu Yong Zeng Bin Sun Haihua Qian Lei Chen Mengchao Wu Changqing Su Jie Chen | 2013 | Cancer Letters2013，，2： | 1 |
| 15 | Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration显示文摘 | Xuetao Xie Yang Wang Cunju Zhao Shangchun Guo Shen Liu Weitao Jia Rocky S. Tuan Changqing Zhang | 2012 | Biomaterials2012，，29： | 1 |
| 16 | Boosting High-Voltage and Ultralong-Cycling Performance of Single-Crystal LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) Cathode Materials via Three-in-One Modification显示文摘LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) is extensively researched as one of the most widely used commercially materials for Li-ion batteries at present.However,the poor high-voltage performance(≥4.3 V)with low reversible capacity limits its replacement for LiCoO_(2) in high-end digital field.Herein,three-in-one modification,Na-doping and Al_(2)O_(3)@Li_(3)BO_(3) dual-coating simultaneously,is explored for single-crystalline LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(N-NCM@AB),which exhibits excellent high-voltage performance.N-NCM@AB displays a discharge-specific capacity of 201.8 mAh g^(−1) at 0.2 C with a high upper voltage of 4.6 V and maintains 158.9 mAh g^(−1) discharge capacity at 1 C over 200 cycles with the corresponding capacity retention of 87.8%.Remarkably,the N-NCM@AB||graphite pouch-type full cell retains 81.2% of its initial capacity with high working voltage of 4.4 V over 1600 cycles.More importantly,the fundamental understandings of three-in-one modification on surface morphology,crystal structure,and phase transformation of N-NCM@AB are clearly revealed.The Na+doped into the Li–O slab can enhance the bond energy,stabilize the crystal structure,and facilitate Li+transport.Additionally,the interior surface layer of Li^(+)-ions conductor Li_(3)BO_(3) relieves the charge transfer resistance with surface coating,whereas the outer surface Al_(2)O_(3) coating layer is beneficial for reducing the active materials loss and alleviating the electrode/electrolyte parasite reaction.This three-in-one strategy provides a reference for the further research on the performance attenuation mechanism of NCM,paving a new avenue to boost the high-voltage performance of NCM cathode in Li-ion batteries. | Bao Zhang Jixue Shen Qi Wang Changqing Hu Bi Luo Yun Liu Zhiming Xiao Xing Ou | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 17 | Fast Growth of Highly Ordered TiO2 Nanotube Arrays on Si Substrate under High-Field Anodization显示文摘Highly ordered TiO_2 nanotube arrays(NTAs) on Si substrate possess broad applications due to its high surfaceto-volume ratio and novel functionalities, however, there are still some challenges on facile synthesis. Here, we report a simple and cost-effective high-field(90–180V) anodization method to grow highly ordered TiO_2 NTAs on Si substrate,and investigate the effect of anodization time, voltage, and fluoride content on the formation of TiO_2 NTAs. The current density–time curves, recorded during anodization processes, can be used to determine the optimum anodization time. It is found that the growth rate of TiO_2 NTAs is improved significantly under high field, which is nearly 8 times faster than that under low fields(40–60 V). The length and growth rate of the nanotubes are further increased with the increase of fluoride content in the electrolyte. | Jingnan Song Maojun Zheng Bin Zhang Qiang Li Faze Wang Liguo Ma Yanbo Li Changqing Zhu Li Ma Wenzhong Shen | 2017 | Nano-Micro Letters2017，9，2： | 1 |
| 18 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 19 | A fast and adaptive varying-scale morphological analysis method for rolling element bearing fault diagnosis显示文摘 | SHEN Changqing HE Qingbo KONG Fanrang | 2012 | Journal of Mechanical Engineering Science2012，227，6： | 1 |
| 20 | On the Christoffel-Minkowski problem of Firey’s p-sum显示文摘 | Changqing Hu Xi-Nan Ma Chunli Shen | 2004 | Calculus of Variations2004，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员