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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy显示文摘技术开发总是是在生物医学的研究驾驶突破的力量之一。自从托马斯·摩根的时间起,一步一步地, Drosophilists 为操作并且机能上地把开发了强大的基因工具为改进这些技术并且开发新技术的果蝇染色体,而是房间仍然大,今天特别作为生物学家开始系统地学习不同模型有机体的功能的 genomics ,包括人,以一种高产量的方式。这里,我们报导,第一次在果蝇,为借助于改进抄写在很高的效率修改果蝇染色体的一个快速、容易、高度特定的方法像使活跃之物的受动器核酸酶(TALEN ) 策略。我们利用了最近发达的单位集会策略装配设计修改黄基因的二特定的 TALEN (在性染色体上) 并且新奇正染色体的基因。TALEN 的 mRNAs 随后被注入果蝇胚胎。从 31.2% 注射 F0 肥沃的苍蝇,我们检测了包含黄基因的可继承的修正。从到可继承的修正的察觉的特定的 TALEN 的建设的全部过程能在一个月以内被完成。在果蝇的这个调停 TALEN 的染色体修正方法的潜在的应用程序被讨论。 | Jiyong Liu Changqing Li Zhongsheng Yu Peng Huang Honggang Wu Chuanxian Wei Nannan Zhu Yan Shen Yixu Chen Bo Zhang Wu-Min Deng Renjie Jiao | 2012 | Journal of Genetics and Genomics2012，39，5： | 43 |
| 3 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 4 | Chromosomal Constitutions and Reactions to Powdery Mildew and Stripe Rust of Four Novel Wheat-Thinopyrum intermedium Partial Amphiploids显示文摘As a staple food crop for one-third of the world's population,common wheat(Triticum aestivum L.,2n=6x=42,AABBDD)plays an important role in humans'food security.However,the genetic variation of cultivated wheat has been dramatically narrowed by genetic erosion under the modern cultivation system,resulting in vulnerability to biotic and abiotic stresses(Jiang et al.,1994;Friebe et al.,1996).The wild relatives of wheat | Yinguang Bao Xia Wu Chao Zhang Xingfeng Li Fang He Xiaolei Qi Honggang Wang | 2014 | Journal of Genetics and Genomics2014，41，12： | 10 |
| 5 | Small-sized tungsten nitride anchoring into a 3D CNT- rGO framework as a superior bifunctional catalyst for the methanol oxidation and oxygen reduction reactions显示文摘直接甲醇燃料房间(DMFC ) 的申请被磅催化剂被高费用,低活动,和差的公司忍耐妨碍。此处,我们由抛锚的钨设计了一个花式的 3D 混血儿氮化物(WN ) nanoparticles (NP ) 在尺寸的大约 3 nm,进 3D 碳用一条集会线路的减少 nanotube 的 graphene 氧化物框架(CNT-rGO ) 。在扔磅以后,联系了并且强烈联合了 PtWN NP 被形成,从磅导致电子转移到 WN。3D PtWN/CNT-rGO 混血儿能为两甲醇氧化反应(粗腐殖质) 和氧减小反应(ORR ) 被用作 bifunctional electrocatalyst。在粗腐殖质,催化剂显示出优秀公司忍耐和 702.4 妈慰物漠的一项高集体的活动吗? | Haijing Yan Meichen Meng Lei Wang Aiping Wu Chungui Tian Lu Zhao Honggang Fu | 2016 | Nano Research2016，9，2： | 9 |
| 6 | In-situ structure reconstitution of NiCo2Px for enhanced electrochemical water oxidation显示文摘Gaining insight into the structure evolution of transition-metal phosphides during anodic oxidation is significant to understand their oxygen evolution reaction(OER) mechanism, and then design highefficiency transition metal-based catalysts. Herein, NiCo_2P_x nanowires(NWs) vertically grown on Ni foam were adopted as the target to explore the in-situ morphology and chemical component reconstitution during the anodic oxidation. The major factors causing the transformation from NiCo_2P_x into the hierarchical NiCo_2P_x@CoNi(OOH)_x NWs are two competing reactions: the dissolution of NiCo_2P_x NWs and the oxidative re-deposition of dissolved Co^(2+) and Ni^(2+) ions, which is based primarily on the anodic bias applied on NiCo2 Px NWs. The well balance of above competing reactions, and local pH on the surface of NiCo_2P_x NW modulated by the anodic oxidation can serve to control the anodic electrodeposition and rearrangement of metal ions on the surface of NiCo_2P_x NWs, and the immediate conversion into CoNi(OOH)_x. Consequently, the regular hexagonal CoNi(OOH)_x nanosheets grew around NiCo_2P_x NWs.Benefiting from the active catalytic sites on the surface and the sufficient conductivity, the resultant NiCo_2P_x@CoNi(OOH)_x arrays also display good OER activity, in terms of the fast kinetics process, the high energy conversion efficiency, especially the excellent durability. The strategy of in-situ structure reconstitution by electrochemical reaction described here offers a reliable and valid way to construct the highly active systems for various electrocatalytic applications. | Xue Bai Zhiyu Ren Shichao Du Huiyuan Meng Jun Wu Yuzhu Xue Xiaojun Zhao Honggang Fu | 2017 | Science Bulletin2017，62，22： | 8 |
| 7 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 8 | Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection显示文摘无酶的氢过氧化物(H < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处,一个维的公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires,由小 nanoparticles 集合了,与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点,电子的面向的传播,和未受阻碍的小径,它资助公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果,获得的公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 氧化和高度敏感察觉。在生理的条件下面, H 的氧化电流<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 与 1.14 妈的敏感从 0.015~0.675 公里关于它的集中线性地变化?????????????? | Lingjun Kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu | 2015 | Nano Research2015，8，2： | 7 |
| 9 | 构建分级结构碳包覆的MoSSe纳米片/多孔碳微球复合材料显著提升储钾性能显示文摘研发能够有效缓解储钾过程中巨大的体积变化和加快反应动力学的先进负极材料,对于钾离子电池的实际应用至关重要.为此,本文报道了一种新颖分级结构薄层碳包覆的MoSSe纳米片/多孔碳微球复合负极材料Cs@MoSSe@C,能够显著提升储钾性能.在这种新颖结构中,多孔碳微球骨架上锚定的分级MoSSe纳米片具有较大的层间距和丰富的阴离子空位,有利于钾离子的快速嵌入、脱出,并能提供丰富的钾离子存储活性位点.同时,薄碳层和高度多孔的碳微球骨架可有效缓解充放电过程中体积膨胀和加快反应动力学,并维持电极结构稳定性.因此,研发的Cs@MoSSe@C负极材料及其组配的全电池都表现出了优异的循环稳定性和出色的倍率性能.此外,通过原位透射电镜技术、原位拉曼技术和非原位显微技术结合理论模拟揭示了其嵌入-转化反应储钾机理和获得优异电化学性能的本质原因.该工作为高性能过渡金属硫族化合物储钾负极材料的构筑与性能优化提供了实验依据和新策略. | Mengting Cai Hehe Zhang Yinggan Zhang Bensheng Xiao Lei Wang Miao Li Ying Wu Baisheng Sa Honggang Liao Li Zhang Shuangqiang Chen Dong-Liang Peng Ming-Sheng Wang Qiaobao Zhang | 2022 | Science Bulletin2022，67，9： | 6 |
| 10 | Improved single image dehazing using dark channel prior显示文摘An improved single image dehazing method based on dark channel prior and wavelet transform is proposed. This proposed method employs wavelet transform and guided filter instead of the soft matting procedure to estimate and refine the depth map of haze images. Moreover, a contrast enhancement method based on just noticeable difference(JND) and quadratic function is adopted to enhance the contrast for the dehazed image, since the scene radiance is usually not as bright as the atmospheric light,and the dehazed image looks dim. The experimental results show that the proposed approach can effectively enhance the haze image and is well suitable for implementing on the surveillance and obstacle detection systems. | Zhizhong Fu Yanjing Yang Chang Shu Yuan Li Honggang Wu Jin Xu | 2015 | Journal of Systems Engineering and Electronics2015，26，5： | 6 |
| 11 | Strongly coupled Ag/TiO2 heterojunctions for effective and stable photothermal catalytic reduction of 4-nitrophenol显示文摘 | Ying Gu Yanqing Jiao Xiaoguang Zhou Aiping Wu Bater Buhe Honggang Fu | 2018 | Nano Research2018，11，1： | 5 |
| 12 | Surface curvature-confined strategy to ultrasmall nickel-molybdenum sulfide nanoflakes for highly efficient deep hydrodesulfurization显示文摘Size-controlled synthesis of two-dimensional(2D)catalysts with low stacking numbers and small nanoflake lengths is crucial for promoting the catalytic performance in diverse heterogeneous catalysis.Herein,we report a facile and general“surface curvature-confined synthesis”strategy to modulate the slab lengths and stacking numbers of 2D transition metal sulfides by controlling the strain induced by different surface curvature of supports.An efficient NiMo sulfide with shorter slab length(average 3.71 nm),less stacking number(1–2 layers)and more edge active sites is synthesized onto ZSM-5 zeolites with the average size of 100 nm,which shows superior kHDS value of dibenzothiophene(14.05×10^−7 mol/(g·s)),enhanced stability up to 80 h,and high direct desulfurization selectivity(>95%).This design concept is also proved to be generally applicable to modulate the slab lengths and stacking numbers of other 2D catalysts such as MoS2 and WS2 nanoflakes,which shows great potentials for developing more ultrasmall 2D catalysts with controlled sizes and excellent catalytic activities. | Xin Kang Jiancong Liu Chungui Tian Dongxu Wang Yaorui Li Hongyan Zhang Xusheng Cheng Aiping Wu Honggang Fu | 2020 | Nano Research2020，13，3： | 5 |
| 13 | Multivalent Sn species synergistically favours the CO_(2)-into-HCOOH conversion显示文摘Although Sn-based catalysts have recently achieved considerable improvement in selective electro-catalyzing CO_(2)into HCOOH,the role of various valence Sn species is not fully understood due to the complexity and uncertainty of their evolution during the reaction process.Here,inspired by the theoretical simulations that the concomitant multivalent Sn(Sn^(0),Sn^(Ⅱ)and Sn^(Ⅳ))can significantly motivate the intrinsic activity of Sn-based catalyst,the Sn/SnO/SnO_(2)nanosheets were proposed to experimentally verify the synergistic effect of multivalent Sn species on the CO_(2)-into-HCOOH conversion.During CO_(2)reduction reaction,the Sn/SnO/SnO_(2)nanosheets,which are prepared by the sequential hydrothermal reaction,calcined crystallization and low-temperature H_(2)treatment,exhibit a high FEHCOOH of 89.6%at-0.9 VRHE as well as a large cathodic current density.Systematic experimental and theoretical results corroborate that multivalent Sn species synergistically energize the CO_(2)activation,the HCOO*adsorption,and the electron transfer,which make Sn/SnO/SnO_(2)favour the conversion from CO_(2)into HCOOH in both thermodynamics and kinetics.This proof-of-concept study establishes a relationship between the enhanced performance and the multivalent Sn species,and also provides a practicable and scalable avenue for rational engineering high-powered electrocatalysts. | Jun Wu Xue Bai Zhiyu Ren Shichao Du Ziehen Song Lei Zhao Bowen Liu Guiling Wang Honggang Fu | 2021 | Nano Research2021，14，4： | 4 |
| 14 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 15 | SCF^SImb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila显示文摘 | Hongtao Zhang Changqing Li Hanqing Chen Chuanxian Wei Fei Dai Honggang Wu Wen Dui Wu-Min Deng Renjie Jiao | 2015 | Cell Research2015，25，1： | 3 |
| 16 | Vertical α-FeOOH nanowires grown on the carbon fiber paper as a free-standing electrode for sensitive H2O2 detection显示文摘高度敏感、选择、稳定的氢过氧化物(H 2 用基于 nanozyme 的催化剂的 O 2) 察觉为实际应用是合乎需要的。此处,垂直 -FeOOH nanowires 成功地经由一个低温度的热水的过程在碳纤维纸(CFP ) 的表面上被种。垂直 -FeOOH nanowires 的形成被归功于到钠 dodecyl 硫酸盐的指导结构的角色。结果自立的电极与一个维(1D ) nanowires 为快费用转移,在 electrocatalyst 之间的优秀电的接触和水流提供面向的隧道收集者,和好机械稳定性和重制度。因此,它能为减小和 H 2 O 2 。H 2 有集中的 O 2 从有 0.194 mA/ 的敏感的 0.05 ~ 0.5 公里是线性的(公里 ?? | Shichao Du Zhiyu Ren Jun Wu Wang Xi Honggang Fu | 2016 | Nano Research2016，9，8： | 3 |
| 17 | Current Density Distribution in Double-Sided GTAW Process显示文摘A three dimensional current density distribution in double-sided gas tungsten arc welding (GTAW) proces is performed. The current density distribution field is evaluated by numerically solving Maxwell equations in the domain of the workpiece. In the boundary condition, the current density on. the workpiece surface is assumed as Gaussian distribution. Results show that the current distribution in DSAW is different from single side arc welding, it is more concentrated and the relative location of the two torches influence the current distribution greatly. | Hongming GAO Lin WU and Honggang DONG National Key Laboratory of Advanced Welding Production Technology, Harbin institute of Technology, Harbin 150001, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 2 |
| 18 | A dual-active Co-CoO heterojunction coupled with Ti_(3)C_(2)-MXene for highly-performance overall water splitting显示文摘Development of cost-effective and highly-efficient bifunctional hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts is crucial for overall water splitting in practical utilization.Herein,we proposed a novel non-noble metal bifunctional,HER/OER electrocatalyst by synergistically coupling a dual-active Co-based heterojunction(Co-CoO)with high conductive and stable two-dimensional Ti_(3)C_(2)-MXene(defined as Co-CoO/Ti^(3)CrMXene).A series of characterizations and theoretical calculations'verify that the synergistic effect of metallic Co with HER activity and Coo with OER performance leads to superb bifunctional catalytic performance,and Ti_(3)C_(2)-MXene can enhance electrical conductivity and prevent the aggregation of the Co-based catalysts,thereby improving both the activity arid stability.Co-Co0/Ti_(3)C_(2)-MXene presents low onset potential(11onse1)of 8 mV and,Tafel slope of 47 mV·dec^(-1) for HER(close to that of Pt/C)and 17onset of 196 mV and Tafel slope of 47 mV·dec^(-1) for OER(superior to:that of Ru02).Assembled as an electrolyzer,Co-CoO/Ti_(3)C_(2)-MXene shows a low voltage of 1.55 V at 10 mA·cm^(-2),high Faradaic efficiency and remarkable stability.It can be driven by a solar cell of-1.55 V for consecutive production of hydrogen and oxygen gases. | Dezheng Guo Xin Li Yanqing Jiao Haijing Yan Aiping Wu Ganceng Yang Yu Wang Chungui Tian Honggang Fu | 2022 | Nano Research2022，15，1： | 2 |
| 19 | The confined growth of few-layered and ultrashort-slab Ni-promoted MoS_(2)on reduced graphene oxide for deep-degree hydrodesulfurization显示文摘Hydrodesulfurization(HDS)is an essential process in clean fuel oil production,however,the huge challenge is the synthesis of the catalyst with plentiful active sites.Here,we have shown the design of few-layered,ultrashort Ni-Mo-S slabs dispersed on reduced graphene oxide(Ni-Mo-S/rGO-A)based on anchoring[PMo_(12)O_(40)]3−clusters and Ni^(2+)on polyethyleneimine(PEI)-modified graphite oxide.Structural characterizations(transmission electron microscopy(TEM),X-ray absorption fine structure(XAFS),etc.)show that Ni-Mo-S slabs with predominant monolayer and partial substitution of edge Mo atoms by isolated Ni atoms have rich accessible edge Ni-Mo-S sites and high sulfurization degree.All virtues endow it with plentiful edge-active sites,and consequently,the enhanced performance for hydrodesulfurization of dibenzothiophene(DBT).The hydrodesulfurization proceeds via a more-favorable direct desulfurization(DDS)route with a reaction rate constant(kHDS)of 48.6×10^(−7)mol·g^(−1)·s^(−1)over Ni-Mo-S/rGO-A catalyst,which is 4.3 times greater than that over traditional Ni-Mo-S/Al_(2)O_(3)catalyst and at the forefront of reported catalysts. | Dongxu Wang Lei Wang Yanqing Jiao Aiping Wu Haijing Yan Xin Kang Chungui Tian Jiancong Liu Honggang Fu | 2022 | Nano Research2022，15，8： | 2 |
| 20 | Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares显示文摘With recent advances in biotechnology, genome-wide association study(GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression(LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression(PC-LR), partial least squares-based logistic regression(PLS-LR), have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor?mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism(SNP) set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis.On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data. | Honggang Yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
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