|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Geological Characteristics and Ore-forming Time of the Dexing Porphyry Copper Ore Mine in Jiangxi Province显示文摘The Dexing porphyry copper ore mine is located in the Qin-Hang metallogenic belt between the Yangtze block and the Cathaysia block. It is a giant porphyry copper mine in China, including 3 ore districts: Tongchang, Fujiawu and Zhushahong. Our analyses of Re in molybdenite indicate that the ore-forming material of the copper ore deposits in Dexing should be mainly mantle-derived. Our study fills in a gap in the study of formation time of the Dexing copper mine, and further proves that the copper ore deposits in the three ore districts should be formed simultaneously, about 170 Ma, belonging to the early Yanshan period, and that the formation time of the copper ore deposits should be consistent with the formation time of granodiorite porphyry in which the copper ore deposits are hosted. Promising areas for seeking porphyry copper ore deposits is predicated to be the west or southwest of Dexing. | GUO Shuo ZHAO Yuany QU Huanchun WU Dexin XU Hong LI Chao LIU Yan ZHU Xiaoyun WANG Zengke | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 28 |
| 2 | Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy显示文摘Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%–71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far. Chronic cigarette smoking is the most proven consistently risk living habits for AMD. Deep learning algorithm has been developed based on image recognition to distinguish wet AMD and normal macula with high accuracy. Currently, anti-vascular endothelial growth factor (VEGF) therapy is highly effective at treating wet AMD. Several new generation AMD drugs and iPSC-derived RPE cell therapy are in the clinical trial stage and are promising to improve AMD treatment in the near future. | Yanhui Deng Lifeng Qiao Mingyan Du Chao Qu Ling Wan Jie Li Lulin Huang | 2022 | Genes & Diseases2022，9，1： | 17 |
| 3 | On the 2~m-variable symmetric Boolean functions with maximum algebraic immunity显示文摘<正>The properties of the 2~m-variable symmetric Boolean functions with maximum al- gebraic immunity are studied in this paper.Their value vectors,algebraic normal forms,and algebraic degrees and weights are all obtained.At last,some necessary conditions for a symmetric Boolean function on even number variables to have maximum algebraic immunity are introduced. | QU LongJiang LI Chao | 2008 | Science in China(Series F)2008，51，2： | 12 |
| 4 | Geodynamic Background of Intracontinental Cenozoic Alkaline Volcanic Rocks in Laojiezi, Western Yangtze Craton: Constraints from Sr-Nd-Hf-O Isotopes显示文摘The Laojiezi alkaline volcanic rocks, which are located in the intraplate region of the Yangtze craton, coincide with the formation of the Jinshajiang-Ailaoshan-Red River alkaline rock belt. Although this belt has been widely studied by geologists because of its porphyry-related Pb-Ag-Au polymetallic deposit and geotectonic location, the material sources of this belt are still debate. Whole-rock analyses show that these rocks have high total alkali contents(3.73–11.08 wt%), and their aluminum saturation index(ASI) values widely vary from 0.82 to 3.07, which comprise a metaluminous-peraluminous magma series. These rocks are characterized by high K(K2 O/Na2 O>1) and low Ti and Mg contents; enrichment in large-ion lithophile elements, such as Rb, Ba, K and light rare earth elements; and depletion in high field strength elements, such as Ta, Nb, P, and Ti. These rocks exhibit moderate Eu(Eu/Eu*=0.86–1.04) and Ce(Ce/Ce*=0.63–0.96) anomalies. Their(87 Sr/86 Sr)i, εNd(t), zircon εHf(t) and δ18 O values range from 0.70839 to 0.71013, from-10.16 to-12.45, from-19.6 to-5.8, and from 5.69‰ to 8.54‰, respectively, and their Nd and Hf two-stage model ages(TDM2) are 1.67–1.86 Ga and 1.27–2.02 Ga, respectively. These data reflect the primary partial melting of Paleoproterozoic to Mesoproterozoic lower crust with minor residual continental lithospheric mantle and supracrustal metasediments. The lithosphere was likely thickened along the southeastern margin of the Tibetan Plateau following the Indian-Asian continentcontinent collision(65–41 Ma). During the post-collision phase(36–16 Ma), the transition from a compressional to extensional setting triggered the convective removal of the over-thickened CLM beneath the Yangtze craton, which led to the upwelling of asthenospheric materials. This process created alkali-rich and high-K magma through the partial melting of the thickened lower crust. Magma that carried Cu-Au-Pb-Ag minerals was emplaced by strike-slip motion along the E-to W-or ENE-to WSWtrending tectonically weak zone, finally forming an alkaline porphyry Cu-Au-Pb-Ag polymetallic deposit. | YAN Qinggao JIANG Xiaojun LI Chao ZHOU Limin WANG Zhongqiang Sultan Baig SHER QU Wenjun DU ANDao | 2018 | Acta Geologica Sinica(English Edition)2018，92，6： | 12 |
| 5 | Rosiglitazone reduces fatty acid translocase and increases AMPK in skeletal muscle in aged rats: a possible mechanism to prevent high-fat-induced insulin resistance显示文摘是的背景 peroxisome 的收缩筋激活 proliferator 的 receptor-gamma (PPARy ) ,然而, rosiglitazone 能在老鼠阻止尖锐丰满的导致酸的胰岛素抵抗 rosiglitazone 由减轻高脂肪的饮食导致的胰岛素抵抗的精确机制需要是 23-24 星期的进一步的 investigated.Methods Wistar 老鼠被划分成三个组:(1 ) 使控制组(OC ) 变老,(2 ) 高脂肪的食谱(HF ) 组并且(3 ) 加 rosiglitazone maleate 药片(HF+Rosi ) 的高脂肪的饮食处理组(在每个组的 n=20 ) 。胰岛素敏感被有意识的 hyperinsulinemic-euglycemic 评估夹钳技术。丰满的酸 translocase (FAT/CD36 ) 的 mRNA 层次,激活安培的蛋白质 kinase 1 (AMPK1 ) ,老鼠的 AMPK2 和乙酰 CoA carboxylase (ACC ) 骨胳的肌肉用即时 PCR 被决定,当肌肉 camitine palmitoyltransferase-1 (CPT-1 ) 用半量的 PCR 是坚定的时。 FAT/CD36 的蛋白质表示层次, AMPK phosphorylation (思考 AMPK 活动), P-ACC (与 ACC 活动相反地相关)并且在老鼠的肌肉 CPT-1M 骨胳的肌肉食谱富人在脂肪喂导致的超过 8 个星期的老鼠用西方的 blotting.Results 被测量血浆类脂化合物的重要增加,与年老的老鼠相比的肌内的 triglyceride 和长链的丰满的 acyl-CoA ( LCACoA )由正常食物饮食( OC )( P 0.05 )喂了的骨胳的肌肉,它可能相关与更低(减少在未经治疗的 HF 年老的老鼠(P 0.01 ) 和高脂肪的饮食增加的 FAT/CD36 蛋白质集中和 mRNA 层次在老鼠在 P-AMPK, P-ACC, CPT-1M 蛋白质集中和 AMPK2 和 CPT-1 mRNA 层次导致了重要减少骨胳的肌肉(P 0.05 ) 。在 AMPK1 mRNA 层次的变化都没在 HF group.Conclusion 被观察在年老的老鼠的高脂肪的饮食导致类脂化合物累积和随后的胰岛素抵抗,当 rosiglitazone 能由象提高 lipometabolism 一样减少丰满的酸举起减轻胰岛素抵抗时。 | SONG Guang-yao GAO Yu WANG Chao HU Shu-guo WANG Jing QU Dong-ming MA Hui-juan | 2010 | Chinese Medical Journal2010，，17： | 11 |
| 6 | Porous nitrogen-doped carbon/MnO coaxial nanotubes as an efficient sulfur host for lithium sulfur batteries显示文摘As a promising candidate for next generation energy storage devices, lithium sulfur (Li-S) batteries still confrant rapid capacity degradation and low rate capability. Herein, we report a well-architected porous nitrogen-doped carbon/MnO coaxial nanotubes (MnO@PNC) as an efficient sulfur host material. The host shows excellent electron conductivity, sufficient ion transport channels and strong adsorption capability for the polysulfides, resulting from the abundant nitrogen-doped sites and pores as well as MnO in the carbon shell of MnO@PNC. The MnO@PNC-S composite electrode with a sulfur content of 75 wt.% deliveries a specific capacity of 802 mAh·g^-1 at a high rate of 5.0C and outstanding cycling stability with a capacity retention of 82% after 520 cycles at 1.0C. | Chao Lin Longbing Qu Jiantao Li Zhengyang Cai Haoyun Liu Pan He Xu Xu Liqiang Mai | 2019 | Nano Research2019，12，1： | 10 |
| 7 | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway显示文摘 | Libin Song Xiangyuan Chen Peng Wang Song Gao Chao Qu Luming Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 10 |
| 8 | Re-Os dating of auriferous pyrite from the Zhenyuan super-large gold deposit in Ailaoshan gold belt,Yunnan Province,Southwestern China显示文摘Zhenyuan gold deposit is the largest super large gold deposit in the Ailaoshan gold belt,but its precise mineralization age is still lack.Re-Os isotopic age of the auriferous pyrite from the Zhenyuan gold deposit was determined by using a high-resolution inductively coupled plasma mass spectrometry(HR-ICP-MS).The pyrite samples were decomposed in carius tubes,Os was separated by distillation and Re was extracted by acetone,respectively.The results show that the Re-Os isochron age is 229±38 Ma(MSWD=2.0,confidence level is 95%),with an initial 187 Os/188 Os value of 0.68±0.24 and a corresponding Os value of 442±91.The Re/Os ratios of the pyrite vary from 40.8 to 100.5.The data suggest that at least one important ore-forming event was occurred during Indosinian epoch,and the ore-forming materials probably derived from mixed sources of crustal and mantle,while the later dominated.The Ailaoshan composite orogen experienced complicated evolutional processes,including formation of Precambrian-Early Paleozoic basement,subduction and orogenesis of Late Paleozoic era,collisional orogenesis of Late Hercynian-Indosinain epoch,and extensional or striking orogenesis of Yanshainan-Cenozoic epoch.The polycycle tectonic evolution and magmatism in this area caused multi-stage and superposition metallization characteristics of the Zhenyuan gold deposit:the mineralization probably occur mainly during the Indosinian collisional orogeny,while the minor gold ores of altered granite-porphyry and altered lamprophyre may be formed in the late superposition metallization. | SHI GuiYong SUN XiaoMing PAN WeiJian HU BeiMing QU WenJun DU AnDao LI Chao | 2012 | Chinese Science Bulletin2012，57，35： | 9 |
| 9 | New Re-Os Isotopic Constrains on the Formation of the Metalliferous Deposits of the Lower Cambrian Niutitang Formation显示文摘The Terreneuvian Epoch(541–521 Ma)is also an important period for metallogenesis in South China, as was represented by the widespread occurrences of Ni-Mo polymetallic layers on the antecedent shallow platform margin and the V-enriched black shales in deeper slope-basin settings. In this study, we have measured Re-Os isochron ages of Ni-Mo polymetallic layers(Songlin, Niuchang, Sancha, Chuanpengwan), V-rich black shales(Bahuang), and non-metalliferous black shales(Shuidong) in the basal Niutitang Formation in Guizhou and Hunan province, South China. The Ni-Mo polymetallic layers and V-enriched black shales have similar Re-Os isochron ages, suggesting concurrent deposition of these two types of metalliferous ores. This suggestion is consistent with the traditional stratigraphic correlation by using the nodular phosphorite bed directly underlying these metalliferous layers as a stratigraphic marker. Furthermore, the metalliferous ores and non-metalliferous black shales have similar initial ^(187)Os/^(188) Os ratios of 0.8–0.9, arguing for a dominant seawater origin with minor contribution of hydrothermal activity. Furthermore, Re-Os isotopic data also imply that Ni-Mo and V ore might have derived from the same source. We suggest that the spatial distribution of metalliferous ores can be explained by the development of non-sulfidic anoxic-suboxic wedge(NSASW) in the slope-basin and sulfidic wedge in the previous platform margin. Upwelling of deep water first transects the mildly reduced, organic rich NSASW, in which V(V) is reduced to V(IV), and is preferentially removed from seawater by organometallic complex formation. As a result, V-rich black shale deposits in the slope-basin of Yangtze Platform. Further movement of deep water into the sulfidic platform margin results in Ni-Mo polymetallic layer formation. | Yong Fu Lin Dong Chao Li Wenjun Qu Haoxiang Pei Wenlang Qiao Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 9 |
| 10 | Effect of proteolytic starter culture isolated from Chinese Dong fermented pork(Nanx Wudl)on microbiological,biochemical and organoleptic attributes in dry fermented sausages显示文摘The effect of a proteolytic starter culture isolated from Nanx Wudl,on microbiological,biochemical and organoleptic attributes of dry fermented sausages was investigated during processing.Based on preliminary screening,the combination of Staphylococcus xylosus SX16 and Lactobacillus plantarum CMRC6,showing excellent proteolytic activity in vitro,was selected as the multi-strain starter(starter LS).For comparison,the single-strain starter culture of L.plantarum CMRC6(starter LB)and non-inoculated control were also tested.During fermentation,lactic acid bacteria and staphylococci dominated the microbiota and suppressed the Enterobacteriaceae growth in LS-inoculated sausages.The addition of LS starter accelerated acidification and proteolysis during ripening,improving the contents of total free amino acids and several essential free amino acids(Phe,Ile and Leu).Volatile compounds analysis revealed that LS-fermented sausage showed the highest abundance of 3-methyl-1-butanol,probably due to the inoculated S.xylosus.The inoculation of LS starter improved the sensory properties of sausages,especially the flavor attribute.Therefore,S.xylosus SX16 and L.plantarum CMRC6 are promising candidates for inclusion as multi-strain starters in the manufacture of gourmet fermented dry sausage. | Xi Chen Ruifang Mi Biao Qi Suyue Xiong Jiapeng Li Chao Qu Xiaoling Qiao Wenhua Chen Shouwei Wang | 2021 | Food Science and Human Wellness2021，10，1： | 9 |
| 11 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 12 | On the number of rotation symmetric Boolean functions显示文摘Rotation symmetric Boolean functions (RSBFs) have been used as components of different cryptosystems. This class of functions are invariant under circular translation of indices. In this paper, we investigated balanced RSBFs and 1st order correlation immune RSBFs. Based on constructive techniques, we give an accurate enumeration formula for n-variable balanced RSBFs when n is a power of a prime. Furthermore, an original and efficient method to enumerate all n-variable (n prime) 1st order correlationimmune functions is presented. The exact number of 1st order correlation immune RSBFs with 11 variables is 6925047156550478825225250374129764511077684773805520800 and the number of 13 variables has 189 digits. Then for more variables, we also provide a significant lower bound on the number of 1st order correlation immune RSBFs. | FU ShaoJing LI Chao QU LongJiang | 2010 | Science China(Information Sciences)2010，53，3： | 8 |
| 13 | A wearable noncontact free-rotating hybrid nanogenerator for self-powered electronics显示文摘Self-powerability is a new trend in the development of portable devices.Harvesting biomechanical energy to power personal information electronics is of great significance.In this work,we report a wearable noncontact freerotating hybrid nanogenerator(WRG),which is constituted by a triboelectric nanogenerator and an electromagnetic generator.A continuous output over 2 seconds can be achieved during one instantaneous incentive by external force,which is improved by two orders of magnitude compared to other wearable nanogenerators due to its unique mechanical energy storage design.The WRG can be integrated into shoes to generate an output energy of 14.68 mJ in each stepping,which meets the power requirements of most personal information electronics.The wireless sensor,GPS,and smartphone can be powered by the WRG continuously.The WRG is expected to be applied in self-powered information electronics extensively in the future. | Dongjie Jiang Han Ouyang Bojing Shi Yang Zou Puchuan Tan Xuecheng Qu Shengyu Chao Yuan Xi Chaochao Zhao Yubo Fan Zhou Li | 2020 | InfoMat2020，2，6： | 8 |
| 14 | Flame-retardant concentrated electrolyte enabling a Li F-rich solid electrolyte interface to improve cycle performance of wide-temperature lithium–sulfur batteries显示文摘Lithium–sulfur batteries have been regarded as the most promising high-energy electrochemical energy storage device owing to the high energy density, low cost and environmental friendliness. However, traditional lithium–sulfur batteries using ether-based electrolytes often suffer from severe safety risks(i.e. combustion). Herein, we demonstrated a novel kind of flame-retardant concentrated electrolyte(6.5 M lithium bis(trifluoromethylsulphonyl)imide/fluoroethylene carbonate) for highly-safe and widetemperature lithium–sulfur batteries. It was found that such concentrated electrolyte showed superior flame retardancy, high lithium-ion transference number(0.69) and steady lithium plating/stripping behavior(2.5 m Ah cm^(-2) over 3000 h). Moreover, lithium–sulfur batteries using this flame-retardant concentrated electrolyte delivered outstanding cycle performance in a wide range of temperatures(-10 °C, 25 °C and 90 °C). This superior battery performance is mainly attributed to the LiF-rich solid electrolyte interphase formed on lithium metal anode, which can effectively suppress the continuous growth of lithium dendrites. Above-mentioned fascinating characteristics would endow this flame-retardant concentrated electrolyte a very promising candidate for highly-safe and wide-temperature lithium–sulfur batteries. | Zhe Yu Jianjun Zhang Chao Wang Rongxiang Hu Xiaofan Du Ben Tang Hongtao Qu Han Wu Xin Liu Xinhong Zhou Xiaoyan Yang Guanglei Cui | 2020 | Journal of Energy Chemistry2020，29，12： | 7 |
| 15 | In situ detection of tumor infiltrating lymphocytes expressing perforin and fas-ligand genes in human HCC显示文摘NTRODUCTIONCytotoxicTlymphocytes(CTLs)playamajorroleinkilingtumorcels.Twopathwayshavebeendescribedbywhichacytotoxiccelmayind... | QIAN Qi Jun, XUE Hui Bin, QU Zeng Qiang, FANG Shi Gang, CAO Hui Fang and WU Meng Chao | 1999 | World Journal of Gastroenterology1999，5，1： | 7 |
| 16 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 17 | Using multi-satellite microwave remote sensing observations for retrieval of daily surface soil moisture across China显示文摘The objective of this study was to retrieve daily composite soil moisture by jointly using brightness temperature observations from multiple operating satellites for near real-time application with better coverage and higher accuracy.Our approach was to first apply the single-channel brightness radiometric algorithm to estimate soil moisture from the respective brightness temperature observations of the SMAP,SMOS,AMSR2,FY3B,and FY3C satellites on the same day and then produce a daily composite dataset by averaging the individual satellite-retrieved soil moisture.We further evaluated our product,the official soil moisture products of the five satellites,and the ensemble mean (i.e.,arithmetic mean) of the five official satellite soil moisture products against ground observations from two networks in Central Tibet and Anhui Province,China.The results show that our product outperforms the individual released products of the five satellites and their ensemble means in the two validation areas.The root mean square error (RMSE ) values of our product were 0.06 and 0.09 m3/m3 in Central Tibet and Anhui Province,respectively.Relative to the ensemble mean of the five satellite products,our product improves the accuracy by 9.1% and 57.7% in Central Tibet and Anhui Province,respectively.This demonstrates that jointly using brightness temperature observations from multiple satellites to retrieve soil moisture not only improves the spatial coverage of daily observations but also produces better daily composite products. | Ke Zhang Li-jun Chao Qing-qing Wang Ying-chun Huang Rong-hua Liu Yang Hong Yong Tu Wei Qu Jin-yin Ye | 2019 | Water Science and Engineering2019，12，2： | 7 |
| 18 | The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant显示文摘The anthocyanin content in apple skin determines its red coloration,as seen in a Fuji apple mutant.Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant.A novel R2R3-MYB transcription factor,MdMYB90-like,was uncovered as the key regulatory gene for enhanced coloration in the mutant.The expression of MdMYB90-like was 21.3 times higher in the mutant.MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis.MdMYB90-like bound to the promoters of both structural genes(MdCHS and MdUFGT)and other transcription factor genes(MdMYB1 and MdbHLH3)in the yeast one-hybrid system,electrophoretic mobility shift assay,and dual-luciferase assay.Transgenic analysis showed that MdMYB90-like was localized in the nucleus,and its overexpression induced the expression of other anthocyanin-related genes,including MdCHS,MdCHI,MdANS,MdUFGT,MdbHLH3,and MdMYB1.The mutant had reduced levels of DNA methylation in two regions(−1183 to−988 and−2018 to−1778)of the MdMYB90-like gene promoter,which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin. | Chao Sun Chunming Wang Wang Zhang Shuai Liu Weiyao Wang Xinyi Yu Tao Song Maxwell Yu Weichang Yu Shenchun Qu | 2021 | Horticulture Research2021，8，1： | 6 |
| 19 | Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis显示文摘AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in Pub Med,Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios(ORs) and 95%confidence intervals(95% CIs) were analyzed for singlenucleotide polymorphisms(SNPs) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted by Egger's test.RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model(CC vs CG+GG, P =0.03) and in heterozygous model(CG vs GG,P =0.04), but not in other models.CONCLUSION: This Meta-analysis shows that COL1A1 rs2269336(CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association. | Bo Gong Chao Qu Xiao-Fang Huang Zi-Meng Ye Ding-Ding Zhang Yi Shi Rong Chen Yu-Ping Liu Ping Shuai | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 5 |
| 20 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员